Abstract:
:Serum levels of immunosuppressive acidic protein (IAP) were determined in 68 patients undergoing resection of colorectal cancer and 21 healthy subjects. Eighteen patients had perioperative transfusion of allogeneic blood (transfused patients) and 50 patients had no blood transfusion (nontransfused patients). Transfused patients had a higher incidence of nodal involvement, advanced disease, and noncurative surgery compared to nontransfused patients, but the difference did not reach a statistical significance. Hemoglobin concentration and serum albumin level were lower in transfused patients, although there was no statistically significant difference. Preoperative serum IAP level was higher in the patients with nodal involvement and advanced disease and those with moderately or poorly differentiated tumor, though this was not statistically significant. The preoperative serum IAP level was higher in patients than in controls, but the difference did not reach statistical significance. Serum IAP level rose immediately after the operation. In nontransfused patients, the serum IAP level returned to the preoperative value by three months after the operation. In contrast, the serum IAP level of transfused patients remained significantly higher than the preoperative value (P < 0.05) at three months after the operation. These findings indicated that perioperative transfusion of allogeneic blood elevated the serum IAP level for a considerable period after the operation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Iwanaga T,Suzuki Hdoi
10.1023/a:1026619111897subject
Has Abstractpub_date
1999-08-01 00:00:00pages
1601-4issue
8eissn
0163-2116issn
1573-2568journal_volume
44pub_type
临床试验,杂志文章abstract::Pharmacological agents that might influence the poststimulus rebound contractile response (PSRR) through an action on the intrinsic inhibitory innervation of the circular muscle coat were studied in the large intestine of the piebald mouse model for Hirschsprung's disease. Tetrodotoxin (0.3-3 microM) suppressed, in a ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296453
更新日期:1986-07-01 00:00:00
abstract::Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its development. Bacterial infections also remain the most common precipitant of acute-on-chronic liver failure, wi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-019-05943-6
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The overwhelming majority of reported duodenal and colonic SEMS placements in the literature have used the 0.035″ guidewire almost to the exclusion of guidewires of other diameters. AIMS:The purpose of this study was to compare technical and clinical outcomes in patients undergoing duodenal or colonic SEMS ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1932-3
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND AIM:Atelectasis is one of the pulmonary complications associated with anesthesia. Little is known about atelectasis following endoscopic procedures under deep sedation. This study evaluated the frequency, risk factors, and clinical course of atelectasis after endoscopic resection. METHODS:A total of 349...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3844-0
更新日期:2016-01-01 00:00:00
abstract::Tacrolimus, a relatively new therapeutic option for patients with corticosteroid-refractory Crohn's disease or ulcerative colitis, is a substrate for the apically directed efflux transporter P-glycoprotein (P-gp). Duodenal biopsy specimens obtained from a patient with corticosteroid-refractory Crohn's disease and with...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-3053-3
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND AND AIM:Simultaneous dilatation of the common bile duct and pancreatic duct, "double-duct sign" (DDS), is an ominous finding concerning for pancreaticobiliary malignancy. Little evidence exists to guide the initial evaluation and subsequent follow-up for patients with DDS in the absence of jaundice or focal ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3133-3
更新日期:2014-09-01 00:00:00
abstract::This study was designed to determine the effect of a newly synthesized benzimidazole derivative NC-1300-B on H+, K+-ATPase (proton pump) in the hog gastric mucosa and on the basal gastric acid secretion and necrotizing agent-induced gastric lesions in rats. NC-1300-B inhibited the proton pump in a concentration-depend...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536998
更新日期:1988-11-01 00:00:00
abstract::Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1191-8
更新日期:2010-12-01 00:00:00
abstract::We have investigated the presence, duration, and clinical significance of granulocyte accumulation, using indium-111 granulocyte scanning, in patients following uncomplicated intestinal anastomosis. Eight patients underwent intestinal resection and anastomosis (right hemicolectomy, 5; sigmoid colectomy, 2; ileal resec...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318118
更新日期:1986-03-01 00:00:00
abstract::Recording of evoked potential responses represents an objective and quantifiable method to study visceral afferent sensory pathways in humans. We examined the evoked responses to mechanical distension (balloon) and electrical stimulation of the proximal and distal esophagus. A standard manometric catheter with a latex...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026667123187
更新日期:1998-11-01 00:00:00
abstract::In this study, we examined the effect of rebamipide, a mucoprotective drug, on gastric ulcer healing in Mongolian gerbils infected with H. pylori. Male Mongolian gerbils were inoculated with H. pylori or vehicle alone 12 hr after the production of an acetic acid-induced gastric ulcer. On day 5, the gerbils inoculated ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1015879421739
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-017-4697-5
更新日期:2017-10-01 00:00:00
abstract::The purpose of this study was to determine the effects of altering gastric emptying on postprandial plasma glucose concentration after a physiologic meal in patients with type II diabetes mellitus (T II DM). Nine T II DM patients underwent a double-blind, randomized, three-way crossover study, receiving erythromycin 2...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/a:1022528414264
更新日期:2003-03-01 00:00:00
abstract::A muscarinic receptor subtype 1 (M1) antagonist, pirenzepine, recently has been shown to be relatively free of the usual anticholinergic side effects on esophageal smooth muscle and thus has been implicated for the treatment of gastroesophageal reflux disease (GERD). However, the effect of pirenzepine on GERD remains ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01308187
更新日期:1992-02-01 00:00:00
abstract::A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01312725
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Antiviral therapy in addition to immunoprophylaxis at birth has been shown to further reduce perinatal transmission of hepatitis B virus (HBV) in highly viremic women. AIMS:The aim of this study was to describe the use of tenofovir disoproxil fumarate (TDF) prophylaxis to reduce maternal HBV DNA levels and ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-014-3230-3
更新日期:2014-11-01 00:00:00
abstract::Crohn's disease (CD) is a heterogeneous disorder. A genetic linkage to chromosome 16 (IBD1) has been previously observed and replicated in unrelated populations. Recently, in this region, NOD2/CARD15 has been identified as a susceptibility gene. The aim of this report is to determine whether this gene is implicated in...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-1290-0
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Current guidelines recommend starting colorectal cancer (CRC) surveillance 8-10 years after inflammatory bowel disease (IBD) onset. Recent studies report that the incidence of CRC within 8-10 years of IBD onset (i.e., early CRC) ranges from 12 to 42%. AIMS:To describe the current prevalence of early CRC in ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05554-1
更新日期:2019-08-01 00:00:00
abstract::The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1022808003014
更新日期:2003-04-01 00:00:00
abstract::Slow transit constipation (STC) is a severe motility disorder, which in the majority of cases is of unknown etiology. In some, symptoms arise de novo in childhood, but a proportion of patients present in later life, including after pelvic surgery or childbirth. Our aims were: (1) to describe our current knowledge of t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1023/a:1005665218647
更新日期:2001-02-01 00:00:00
abstract::The neutralizing capacity of two antacids (Alucol = A, Syntrogel = S), differing both in their composition and theoretical neutralizing capacity, was evaluated in vitro and in vivo. In vitro at pH 3.5, 1 ml of A or S neutralizes 3.9 and 1.6 meq of acid, respectively, in an aqueous solution. When tested in vivo in the ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320257
更新日期:1985-06-01 00:00:00
abstract::A prospective study was performed in 17 patients with achalasia of the esophagus determining the manometric characteristics of the gastroesophageal sphincter, correlating it with histological analysis by biopsies taken during surgery at the distal narrowed segment of the esophagus, at the location of the sphincter. Th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308293
更新日期:1985-10-01 00:00:00
abstract::In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296219
更新日期:1984-05-01 00:00:00
abstract::Infection with Helicobacter increases the transcellular passage of macromolecules across the epithelium, and this effect can be prevented by a gastroprotective agent rebamipide. The aim was to gain insight into the mechanisms involved. The HT29-19A intestinal epithelial cells grown on microporous filters as monolayers...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010664626431
更新日期:2001-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-019-05582-x
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06055-2
更新日期:2020-09-01 00:00:00
abstract::The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01550972
更新日期:1988-07-01 00:00:00
abstract::Lymphomatous involvement of the liver may present as acute liver failure but is an absolute contraindication for liver transplantation. Therefore it is imperative to diagnose such patients since survival in this group is poor and recurrence is high. We describe two patients with acute liver failure referred for liver ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF02093804
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND AIM:Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. METHODS:Fro...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2349-3
更新日期:2012-11-01 00:00:00
abstract::Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive trea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1016444611997
更新日期:2002-08-01 00:00:00