A higher dose requirement of tacrolimus in active Crohn's disease may be related to a high intestinal P-glycoprotein content.

abstract：BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...

journal_title：Digestive diseases and sciences

authors： Dhiman RK,Kurmi R,Thumburu KK,Venkataramarao SH,Agarwal R,Duseja A,Chawla Y

更新日期：2010-08-01 00:00:00

abstract：:Modafinil may be a potentially effective treatment for primary biliary cirrhosis (PBC)-related fatigue. About 42 patients were given a 3-day trial of 100-200 mg modafinil. Response was defined as increased energy, decreased somnolence and sleep requirements, and improved daily function. Patients with positive response...

journal_title：Digestive diseases and sciences

authors： Ian Gan S,de Jongh M,Kaplan MM

更新日期：2009-10-01 00:00:00

abstract：:This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNM...

journal_title：Digestive diseases and sciences

authors： Ding WJ,Fang JY,Chen XY,Peng YS

更新日期：2008-08-01 00:00:00

abstract：:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently develop hepatic encephalopathy. Metabolic etiology of encephalopathy is less often considered in these patients. Although paraneoplastic hypercalcemia may be associated with several malignant tumors, it has also been described in HCC [1-4], and may caus...

journal_title：Digestive diseases and sciences

authors： Tudela P,Soldevila B,Mòdol JM,Domènech E

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Intestinal failure is the most critical complication of Crohn's disease. Intestinal failure requires home parenteral nutrition, which worsens the quality of life of the patients and sometimes causes life-threatening complications. AIMS:The purpose of this study was to investigate the incidence and risk fact...

journal_title：Digestive diseases and sciences

authors： Watanabe Y,Miyoshi N,Fujino S,Takahashi H,Haraguchi N,Hata T,Matsuda C,Yamamoto H,Doki Y,Mori M,Mizushima T

更新日期：2019-08-01 00:00:00

abstract：:Fasting antroduodenal motor activity was studied in 15 dyspeptic patients with chronic superficial antral gastritis and Helicobacter pylori infection (group A), 10 dyspeptic patients with chronic superficial antral gastritis without Helicobacter pylori infection (group B), and eight healthy control subjects (group C) ...

journal_title：Digestive diseases and sciences

authors： Testoni PA,Bagnolo F,Masci E,Colombo E,Tittobello A

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the revised Bethesda Guidelines (RBG) cannot be applied in a considerable nu...

journal_title：Digestive diseases and sciences

authors： Gould-Suarez M,El-Serag HB,Musher B,Franco LM,Chen GJ

更新日期：2014-12-01 00:00:00

abstract：:Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...

journal_title：Digestive diseases and sciences

authors： Ferrara A,Zinner MJ,Jaffe BM

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Studies examining the mortality risk of inflammatory bowel disease (IBD) have yielded conflicting results, and most do not account for recent advancements made in the treatment of Crohn's disease (CD) and ulcerative colitis (UC). We aim to assess the overall, premature, and cause-specific mortality in IBD pa...

journal_title：Digestive diseases and sciences

authors： Nocerino A,Feathers A,Ivanina E,Durbin L,Swaminath A

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...

journal_title：Digestive diseases and sciences

authors： Feng Y,Han Z,Gu B,Li X,Wang B,Guo F,Praseedom RK,Wang F,Cheng H,Lucas A,Li Y,Chen H

更新日期：2020-09-01 00:00:00

abstract：:Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...

journal_title：Digestive diseases and sciences

authors： Slavin JL,Melcher EA,Sundeen M,Schwartz S

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) may be initiated following disruption of the intestinal epithelial barrier. This disruption, in turn, permits luminal antigens unfettered access to the mucosal immune system and leads to an uncontrolled inflammatory response. Glycoalkaloids, which are found in potatoes, disru...

journal_title：Digestive diseases and sciences

authors： Iablokov V,Sydora BC,Foshaug R,Meddings J,Driedger D,Churchill T,Fedorak RN

更新日期：2010-11-01 00:00:00

abstract：:Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...

journal_title：Digestive diseases and sciences

authors： Bechi P,Amorosi A,Mazzanti R,Buccarelli A,Pantalone D,Cortesini C

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Sorafenib is a proven first-line treatment recommended for hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). However, multiple treatment modalities are used in clinical practice as a first-line option. This study is a prospective, observational, multicenter, cohort study evalu...

journal_title：Digestive diseases and sciences

authors： Sinn DH,Lee HW,Paik YH,Kim DY,Kim YJ,Kim KM,Bae SH,Kim JH,Seo YS,Jang JY,Jang BK,Yim HJ,Kim HJ,Lee BS,Kim BH,Kim IH,Cho EY,Lee JI,Suh KS

更新日期：2021-01-01 00:00:00

abstract：:Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however,...

journal_title：Digestive diseases and sciences

authors： Lundgren P,Nilsson A,Duan RD

更新日期：2001-04-01 00:00:00

abstract：:This study aimed at establishment of adequate evaluation of intestinal viability before release of the strangulated intestine by measuring electrical properties. In rats a 20-cm segment of the distal ileum and mesentery was strangulated. The intestine was strangulated for 0, 2, 15, 45, 90, and 120 min. The conductance...

journal_title：Digestive diseases and sciences

authors： Matsuo H,Hirose H,Mori Y,Takagi H,Iwata H,Yamada T,Sakamoto K,Yasumura M

更新日期：2004-04-01 00:00:00

abstract：:Both increased duodenogastric reflux and chronic aspirin ingestion are associated with the development of gastric ulcers in man. Animal studies suggest aspirin increases duodenogastric reflux. Prostaglandin E2 protects gastric mucosa from the effects of many injurious agents and inhibits gastric motility, but its effe...

journal_title：Digestive diseases and sciences

authors： Dooley CP,Mello WD,Valenzuela JE

更新日期：1985-06-01 00:00:00

abstract：:Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplantation. In this retrospective study, we compared the efficacy, safety, and renal protective effect of sirolimus monotherapy (Group A; n = 26) with sirolimus in combination (Group B; n = ...

journal_title：Digestive diseases and sciences

authors： Maheshwari A,Torbenson MS,Thuluvath PJ

更新日期：2006-10-01 00:00:00

abstract：:The purpose of this study was to determine the effects of altering gastric emptying on postprandial plasma glucose concentration after a physiologic meal in patients with type II diabetes mellitus (T II DM). Nine T II DM patients underwent a double-blind, randomized, three-way crossover study, receiving erythromycin 2...

journal_title：Digestive diseases and sciences

authors： Gonlachanvit S,Hsu CW,Boden GH,Knight LC,Maurer AH,Fisher RS,Parkman HP

更新日期：2003-03-01 00:00:00

abstract：:The indications for surgery on cavernous hemangiomas, the most common benign tumors of the liver, remain unclear. This study reviewed 43 patients with cavernous hemangioma of the liver who underwent hepatic resection from 1984 to 2000. Patients were divided into three groups based on the reasons for surgery. Group I c...

journal_title：Digestive diseases and sciences

authors： Tsai HP,Jeng LB,Lee WC,Chen MF

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The dose recommendation for entecavir (ETV) is 0.5 mg daily for treatment-naïve chronic hepatitis B (CHB) patients and 1.0 mg daily for lamivudine-refractory patients; however, few data are available for the efficacy of a 1.0-mg daily dose in treatment-naïve CHB patients. Our goal is to examine the ...

journal_title：Digestive diseases and sciences

authors： Ha NB,Ha NB,Chaung KT,Trinh HN,Nguyen HA,Nguyen KK,Nguyen MH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Gut dysmotility is closely associated with proinflammatory cytokines both in irritable bowel syndrome and inflammatory bowel disease. There is a dose-response relationship between depression and these inflammatory cytokines. AIMS:In the present study, we aimed to investigate the effect of Interleukin-6 (IL-...

journal_title：Digestive diseases and sciences

authors： Zhang L,Hu L,Chen M,Yu B

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Lysyl oxidase (LOX) is frequently overexpressed in a variety of malignancies and involved in tumor invasion and metastasis. Furthermore, it has been shown that LOX is closely related to vascular endothelial growth factor (VEGF). AIMS:In this study, we aimed to investigate the exact role of LOX and the corre...

journal_title：Digestive diseases and sciences

authors： Zhu J,Huang S,Wu G,Huang C,Li X,Chen Z,Zhao L,Zhao Y

更新日期：2015-10-01 00:00:00

abstract：:A population-based series of 246 gastric cancer patients operated for cure and who survived the postoperative phase was reviewed to determine prognostic factors after potentially curative treatment. The overall five-year observed survival rate was 34.8%, and the relative survival rate was 43.9%. Previous history of ga...

journal_title：Digestive diseases and sciences

authors： Arveux P,Faivre J,Boutron MC,Piard F,Dusserre-Guion L,Monnet E,Hillon P

更新日期：1992-05-01 00:00:00

abstract：:Our purpose was to evaluate the relationship between the clinical and histological features in a cohort of patients who had gastroesophageal reflux-related lesions diagnosed after upper digestive endoscopy. In all, 589 patients scheduled for elective endoscopy in a multicentric prospective study were evaluated. Multip...

journal_title：Digestive diseases and sciences

authors： Aste H,Bonelli L,Ferraris R,Conio M,Lapertosa G

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) g...

journal_title：Digestive diseases and sciences

authors： Xiao AH,Chang SY,Stevoff CG,Komanduri S,Pandolfino JE,Keswani RN

更新日期：2020-08-16 00:00:00

abstract：BACKGROUND:Heat shock protein 70-2 (HSP70-2) has a cytoprotective role in various conditions and also protects the gastric mucosa. Recently, polymorphism of HSP70-2 at position 1267 was suggested to be associated with carcinogenesis. We investigated the association of this polymorphism with the risk of gastric cancer i...

journal_title：Digestive diseases and sciences

authors： Shibata T,Arisawa T,Tahara T,Yoshioka D,Maruyama N,Fujita H,Kamiya Y,Nakamura M,Nagasaka M,Iwata M,Takahama K,Watanabe M,Hirata I,Nakano H

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Mast cells (MCs), PAR2 and TRPV1, play a key role in the regulation of visceral pain. Several studies have found that probiotics regulate visceral sensitivity. AIMS:The purpose of the current study was to explore the role of MC-PAR2-TRPV1 in VH and the mechanism of VSL#3 in a rat model of VH. METHODS:A tot...

journal_title：Digestive diseases and sciences

authors： Li YJ,Dai C,Jiang M

更新日期：2019-05-01 00:00:00

abstract：:Rabeprazole achieves more potent acid suppression than other proton pump inhibitors. Therefore it is administered at reduced as well as high dosages in eradication therapy for Helicobacter pylori; however, there is incomplete assessment of the efficacy of a reduced dosage of rabeprazole as might be employed in therapy...

journal_title：Digestive diseases and sciences

authors： Shimatani T,Inoue M,Kuroiwa T,Xu J,Tazuma S,Horikawa Y,Nakamura M

更新日期：2005-07-01 00:00:00

abstract：:The early rebound in serum HCV RNA during HCV dynamic studies with high-dose interferon may be due to de novo infection with interferon escape quasispecies. We simultaneously measured serum alanine aminotransferase (ALT) and HCV RNA at rapid intervals in chronic HCV liver disease patients during interferon therapy alo...

journal_title：Digestive diseases and sciences

authors： Lake-Bakaar G,Ruffini L,Kuzmic P

更新日期：2003-01-01 00:00:00