Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils.

Abstract:

:In this study, we examined the effect of rebamipide, a mucoprotective drug, on gastric ulcer healing in Mongolian gerbils infected with H. pylori. Male Mongolian gerbils were inoculated with H. pylori or vehicle alone 12 hr after the production of an acetic acid-induced gastric ulcer. On day 5, the gerbils inoculated with H. pylori were divided into three groups and fed rebamipide-containing diet (0.038%, 60 mg/kg, or 0.0038%, 6 mg/kg), or standard laboratory chow. The gerbils inoculated with the vehicle were fed standard laboratory chow throughout the experiment. The gerbils were killed on day 5, 15, or 30 after ulcer production, and removed stomachs were subjected to calculation of ulcer size, culture for H. pylori, and measurement of myeloperoxidase activity, a marker for neutrophil infiltration, in ulcerated tissue. Apoptotic and proliferating cells of gastric epithelium in ulcer margins were detected by the in situ DNA nick end-labeling method and immunohistochemical staining for 5-bromo-2'-deoxyuridine (BrdU), respectively. Rebamipide did not affect colonization levels of H. pylori. Infection with H. pylori did not affect ulcer size by day 5 but significantly delayed ulcer healing by days 15 and 30, accompanied by an increase in the number of apoptotic cells, a decrease in the number of BrdU-positive cells, and an increase in myeloperoxydase activity. Rebamipide prevented delay of ulcer healing and abolished these effects of H. pylori on cell kinetics and neutrophil infiltration. In conclusion, rebamipide may prevent the delay of acetic acid-induced gastric ulcer healing caused by H. pylori through modulating cell kinetics and inhibiting neutrophil infiltration.

journal_name

Dig Dis Sci

authors

Watanabe T,Higuchi K,Hamaguchi M,Tanigawa T,Wada R,Tominaga K,Fujiwara Y,Arakawa T

doi

10.1023/a:1015879421739

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

1582-9

issue

7

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

杂志文章
  • The effectiveness of the treatment of octreotide on chylous ascites after liver cirrhosis.

    abstract::Octreotide is a crucial drug used for treating patients with chylous ascites; however, there have been few reports related to octreotide that are being used in cirrhotic patients. Thus, this thesis is designed to determine the effects of octreotide on patients with chylous ascites after liver cirrhosis. Eight patients...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0566-6

    authors: Zhou DX,Zhou HB,Wang Q,Zou SS,Wang H,Hu HP

    更新日期:2009-08-01 00:00:00

  • Pancreatic Leaks and Fistulae: An Endoscopy-Oriented Classification.

    abstract:BACKGROUND:Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-017-4697-5

    authors: Mutignani M,Dokas S,Tringali A,Forti E,Pugliese F,Cintolo M,Manta R,Dioscoridi L

    更新日期:2017-10-01 00:00:00

  • Pharmacological analysis of rebound excitation in large intestine of piebald mouse model for Hirschsprung's disease.

    abstract::Pharmacological agents that might influence the poststimulus rebound contractile response (PSRR) through an action on the intrinsic inhibitory innervation of the circular muscle coat were studied in the large intestine of the piebald mouse model for Hirschsprung's disease. Tetrodotoxin (0.3-3 microM) suppressed, in a ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296453

    authors: Wood JD,Brann LR

    更新日期:1986-07-01 00:00:00

  • Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation.

    abstract::Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investiga...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1010644021888

    authors: Shimotoyodome A,Meguro S,Hase T,Tokimitsu I,Sakata T

    更新日期:2001-07-01 00:00:00

  • Practice patterns in the use of anti-tumor necrosis factor alpha agents in the management of Crohn's disease: a US national practice survey comparing experts and non-experts.

    abstract:BACKGROUND:The US Food and Drug Administration currently approves three types of anti-tumor necrosis factor α (anti-TNFα) therapy for treatment of moderate to severe Crohn's disease. There are no guidelines to clarify which of the drugs may be better suited to individual clinical scenarios. AIMS:We gathered national d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1530-9

    authors: Swaminath A,Lebwohl B,Capiak KM,Present DH

    更新日期:2011-04-01 00:00:00

  • Bleeding duodenal ulcer. Role of gastric acid hypersecretion.

    abstract::Basal gastric acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of gastric acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulce...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01307543

    authors: Collen MJ,Kalloo AN,Sheridan MJ

    更新日期:1993-02-01 00:00:00

  • Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study.

    abstract:BACKGROUND:Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). AIM:We investigated the association between air pollution exposure and IBD. METHODS:The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4249-4

    authors: Opstelten JL,Beelen RMJ,Leenders M,Hoek G,Brunekreef B,van Schaik FDM,Siersema PD,Eriksen KT,Raaschou-Nielsen O,Tjønneland A,Overvad K,Boutron-Ruault MC,Carbonnel F,de Hoogh K,Key TJ,Luben R,Chan SSM,Hart AR,Bueno-de-

    更新日期:2016-10-01 00:00:00

  • Systematic Review: Non-medical Switching of Infliximab to CT-P13 in Inflammatory Bowel Disease.

    abstract:BACKGROUND AND AIMS:Biosimilar approval, such as Inflectra™ (CT-P13) for treating ulcerative colitis (UC) and Crohn's disease (CD), has reduced direct drug costs. Though clinicians are comfortable with biosimilar use in treatment-naïve patients, there are concerns in some jurisdictions that there are insufficient data ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-06036-0

    authors: Bernard EJ,Fedorak RN,Jairath V

    更新日期:2020-08-01 00:00:00

  • Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury.

    abstract:BACKGROUND:Accumulating evidence suggests that Foxp3+ regulatory T (Treg) cells act as inhibitory mediators of inflammation; however, the in vivo mechanism underlying this protection remains elusive in liver diseases. AIMS:To clarify the in vivo role of Foxp3+ Treg cells in liver fibrosis, we used the DEREG mouse, whi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3438-2

    authors: Roh YS,Park S,Lim CW,Kim B

    更新日期:2015-07-01 00:00:00

  • Heterotopic bone formation in rectal carcinoma. Case report and literature review.

    abstract::A case of heterotopic bone formation in a primary rectal adenocarcinoma was recently observed in a 54-year-old woman. This unusual finding was present both in the diagnostic biopsy and in the subsequently resected bowel. Pertinent gross and microscopic features are presented. This report represents the twelfth case in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF01296512

    authors: Ansari MQ,Sachs IL,Max E,Alpert LC

    更新日期:1992-10-01 00:00:00

  • Elevated levels of circulating angiotensin converting enzyme in patients with hepatoportal sclerosis.

    abstract:BACKGROUND AND AIMS:Hepatoportal sclerosis (HPS) is a clinicopathologic condition that is clinically characterized by portal hypertension (varices and portosystemic collateral vessels), splenomegaly and pancytopenia, in the absence of cirrhosis. Although the etiology is obscure, a number of theories such as immunologic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1580-7

    authors: Beyazit Y,Ibis M,Purnak T,Turhan T,Kekilli M,Kurt M,Sayilir A,Onal IK,Turhan N,Tas A,Köklü S,Haznedaroglu IC

    更新日期:2011-07-01 00:00:00

  • High-fat diet promotes neuronal loss in the myenteric plexus of the large intestine in mice.

    abstract:BACKGROUND:Obesity is considered a risk factor for other chronic diseases, and diets rich in lipids can cause alterations in the intestinal functions. AIM:The aim of this study was to investigate the effects of a high-fat diet (HFD) on the myenteric plexus of the large intestine in mice. METHODS:Swiss mice were distr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3402-1

    authors: Beraldi EJ,Soares A,Borges SC,de Souza AC,Natali MR,Bazotte RB,Buttow NC

    更新日期:2015-04-01 00:00:00

  • Gastroparesis of digestible and indigestible solids in patients with insulin-dependent diabetes mellitus or functional dyspepsia.

    abstract::Gastric emptying of a solid meal and of 10 indigestible radiopaque solids was measured with scintigraphic and radiological techniques in 50 healthy volunteers (controls), 41 patients with insulin-dependent diabetes mellitus, and 50 patients with functional dyspepsia. Gastroparesis was found in 51% of our diabetic pati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088042

    authors: Caballero-Plasencia AM,Muros-Navarro MC,Martin-Ruiz JL,Valenzuela-Barranco M,de los Reyes-Garcia MC,Vilchez-Joya R,Casado-Caballero FJ,Gil-Extremera B

    更新日期:1994-07-01 00:00:00

  • Fragmentation of biliary calculi by means of extracorporeally generated piezoelectric shock waves.

    abstract::A new extracorporeal piezoelectric lithotripter was tested for its gallstone disintegration capability. A total of 177 surgically removed gallbladder stones were submitted to piezoelectric shock-wave treatment. Prior to shock-wave application, the diameter, weight, and volume of all the stones and CT density and MR si...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536364

    authors: Ell C,Kerzel W,Langer H,Heyder N,Foerster E,Domschke W

    更新日期:1989-07-01 00:00:00

  • Role of hepatitis delta virus infection in hepatocellular carcinoma.

    abstract::Hepatitis B virus (HBV) DNA integrates into the host DNA and shows a series of potentially oncogenetic properties, but HBV is not an acutely transforming virus, because HCC develops decades after infection. Other factors, namely cirrhosis, inflammation, alcohol intake, and viral superinfections, could promote the onco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297460

    authors: Verme G,Brunetto MR,Oliveri F,Baldi M,Forzani B,Piantino P,Ponzetto A,Bonino F

    更新日期:1991-08-01 00:00:00

  • Mucosal damage during intestinal anaphylaxis in the rat. Effect of betamethasone and disodium cromoglycate.

    abstract::In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epith...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01299863

    authors: D'Incà R,Hunt RH,Perdue MH

    更新日期:1992-11-01 00:00:00

  • Vasculature of various locations of canine gastrointestinal tract responds differently to intravenous isoproterenol.

    abstract::In this study we investigated the relative vascular response of different locations of the gastrointestinal tract to continuous intravenous infusion of isoproterenol (0.1 microgram kg-1 min-1 for 10 min). The vascular response of some nonsplanchnic organs was also examined. Blood flow of the arteries was measured by e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536997

    authors: Harrison DA,Dinda PK,Beck IT

    更新日期:1988-11-01 00:00:00

  • Levels of evidence in endoscopic ultrasonography: a systematic review.

    abstract:BACKGROUND AND AIMS:A prolific trend currently designates endoscopic ultrasonography (EUS) literature. We aimed to record all EUS-studies published during the past decade and evaluate them in terms of scientific quality, creating a stratification based on levels of evidence (LE). METHODS:All articles on EUS published ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-011-1961-y

    authors: Fusaroli P,Kypraios D,Eloubeidi MA,Caletti G

    更新日期:2012-03-01 00:00:00

  • Distribution and properties of neutral ceramidase activity in rat intestinal tract.

    abstract::Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1010792031910

    authors: Lundgren P,Nilsson A,Duan RD

    更新日期:2001-04-01 00:00:00

  • Fatal progressive hepatic necrosis associated with lamotrigine treatment: a case report and literature review.

    abstract::We present a case of fatal, progressive hepatotoxicity in a patient treated with lamotrigine. After presenting with a rash and fever, she developed elevated liver function tests and clinical sequelae of hepatic failure. The subacute course of her progressive liver damage is documented in serial liver biopsies. While h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1023/a:1019627618972

    authors: Overstreet K,Costanza C,Behling C,Hassanin T,Masliah E

    更新日期:2002-09-01 00:00:00

  • Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea: a population-based study.

    abstract::Various reports on the prevalence of gastroesophageal reflux disease (GERD) and uninvestigated dyspepsia have been conducted in Western countries. We sought to determine the frequency of GERD symptoms and uninvestigated dyspepsia in Korea. Telephone interviews were conducted with 1,044 individuals. Of all subjects, 7....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9842-0

    authors: Yang SY,Lee OY,Bak YT,Jun DW,Lee SP,Lee SH,Park GT,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH

    更新日期:2008-01-01 00:00:00

  • Partial hepatectomy in the treatment of Caroli's disease. Report of a case and review of the literature.

    abstract::We describe a 28-yr-old woman who presented with severe, recurrent cholangitis due to Caroli's disease in association with congenital hepatic fibrosis. Cystic dilatation of the segmental bile ducts was diffuse, but predominated in the right lobe and left medial segment of the liver. Extended right lobectomy was follow...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01318526

    authors: Ramond MJ,Huguet C,Danan G,Rueff B,Benhamou JP

    更新日期:1984-04-01 00:00:00

  • Non-invasive testing for Helicobacter pylori in patients hospitalized with peptic ulcer hemorrhage: a cost-effectiveness analysis.

    abstract:PURPOSE:Guidelines recommend routine invasive screening for Helicobacter pylori in patients with peptic ulcer hemorrhage (PUH). However, compliance with screening remains suboptimal. The aim of this study was to determine if a simplified approach based on noninvasive screening is cost effective in PUH. RESULTS:In the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0865-6

    authors: Atreja A,Fu AZ,Sanaka MR,Vargo JJ

    更新日期:2010-05-01 00:00:00

  • Differences Between Familial and Sporadic Celiac Disease.

    abstract:BACKGROUND:It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study. METHODS:Altogether 1064 patients were...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06490-1

    authors: Airaksinen L,Myllymäki L,Kaukinen K,Saavalainen P,Huhtala H,Lindfors K,Kurppa K

    更新日期:2020-07-23 00:00:00

  • Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.

    abstract::Previous studies showed that bile salts had a promoting effect on colon cancer development and this effect was inhibited by ursodeoxycholate (UDC). We recently found that both human colorectal adenomas and carcinomas were associated with a specific decrease in alkaline sphingomyelinase activity. In this work, we compa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018807600683

    authors: Duan RD,Cheng Y,Tauschel HD,Nilsson A

    更新日期:1998-01-01 00:00:00

  • Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier.

    abstract::The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. The Helicobacter pylori virulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from dif...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-013-2589-x

    authors: Wu J,Xu S,Zhu Y

    更新日期:2013-07-01 00:00:00

  • Effect of dietary turmeric on breath hydrogen.

    abstract::Turmeric is widely used in Indian cuisine. The main constituents of turmeric are curcumin and its analogues, which are well-known antioxidant compounds. In the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby incre...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10620-008-0550-1

    authors: Shimouchi A,Nose K,Takaoka M,Hayashi H,Kondo T

    更新日期:2009-08-01 00:00:00

  • Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps?

    abstract::The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions. We retrospect...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3146-7

    authors: Akatsu T,Aiura K,Shimazu M,Ueda M,Wakabayashi G,Tanabe M,Kawachi S,Kitajima M

    更新日期:2006-02-01 00:00:00

  • Effect of psyllium hydrophilic mucilloid on serum cholesterol in the elderly.

    abstract::The effect of psyllium hydrophilic mucilloid (PHM) when used as a laxative and/or stool softener on serum cholesterol concentrations was examined in 176 ambulatory elderly participants attending a health screening program. The change in one-year serum cholesterol concentration in subjects using PHM was compared with t...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01318205

    authors: Stewart RB,Hale WE,Moore MT,May FE,Marks RG

    更新日期:1991-03-01 00:00:00

  • Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.

    abstract::Minimal hepatic encephalopathy (MHE) describes patients with chronic liver disease or cirrhosis who have no clinical symptoms of brain dysfunction but perform worse on psychometric tests compared with healthy subjects. The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10620-006-9687-y

    authors: Malaguarnera M,Greco F,Barone G,Gargante MP,Malaguarnera M,Toscano MA

    更新日期:2007-11-01 00:00:00