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Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer.

Abstract：

:The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volunteers. Blood samples were taken before and after consumption of a test meal. The integrated 1-hr gastrin response (IGR) was taken to be the area under the SG time curve, calculated by the trapezoid method. H. pylori infection status was determined by histology, serology, and the [13C] urea breath test. The mean basal SG concentration was lower in the H. pylori-negative DU patients than in the H. pylori-positive DU patients, but an exaggerated IGR was observed in three patients (33.3%) with H. pylori-negative DU. In conclusion, our findings indicate that an exaggerated meal-stimulated gastrin response may contribute to the pathogenesis of H. pylori-negative DU.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Kamada T,Haruma K,Kusunoki H,Miyamoto M,Ito M,Kitadai Y,Yoshihara M,Chayama K,Tahara K,Kawamura Y

doi

10.1023/a:1022808003014

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

644-51

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

48

pub_type

杂志文章

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