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Remission of severe aplastic anemia associated with hepatitis B virus infection after viral clearance: potential role of lamivudine.

Abstract：

:Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive treatment but went into complete clinical remission after clearance of the hepatitis B virus. Disappearance of the hepatitis B virus occurred during lamivudine treatment and coincided with immune activation secondary to discontinuation of immunosuppressive therapy. This case was somewhat atypical in that a history of acute hepatitis preceding the aplastic anemia was absent. The observation made in this case report supports a cause-effect relationship between hepatitis B virus infection and aplastic anemia.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Bozkaya H,Yurdaydin C,Törüner M,Arat M,Bozdayi AM,Erekul S,Cinar K,Koç H,Uzunalimoğlu O

doi

10.1023/a:1016444611997

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

1782-5

issue

8

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

杂志文章

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