Abstract:
BACKGROUND AND AIMS:Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR. METHODS:We used Clinical Query 2, a search tool at Beth Israel Deaconess Medical Center, to create a pool of potential NASH cirrhosis cases (n = 5415). We created a training set of 300 randomly selected patients for chart review to confirm cases of NASH cirrhosis. Test characteristics of different algorithms, consisting of diagnosis codes, laboratory values, anthropomorphic measurements, and medication records, were calculated. The algorithms with the highest positive predictive value (PPV) and the highest F score with a PPV ≥ 80% were selected for internal validation using a separate random set of 100 patients from the potential NASH cirrhosis pool. These were then externally validated in another random set of 100 individuals using the research patient data registry tool at Massachusetts General Hospital. RESULTS:The algorithm with the highest PPV of 100% on internal validation and 92% on external validation consisted of ≥ 3 counts of "cirrhosis, no mention of alcohol" (571.5, K74.6) and ≥ 3 counts of "nonalcoholic fatty liver" (571.8-571.9, K75.81, K76.0) codes in the absence of any diagnosis codes for other common causes of chronic liver disease. CONCLUSIONS:We developed and validated an EHR algorithm using diagnosis codes that accurately identifies patients with NASH cirrhosis.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Danford CJ,Lee JY,Strohbehn IA,Corey KE,Lai Mdoi
10.1007/s10620-020-06388-ysubject
Has Abstractpub_date
2020-06-13 00:00:00eissn
0163-2116issn
1573-2568pii
10.1007/s10620-020-06388-ypub_type
杂志文章abstract::An experimental model of massive (80%) small bowel resection and antiperistaltic colon interposition in between the remnant jejunum and ileum was created in rhesus monkeys. The gastrointestinal functions were assessed preoperatively and at different periods after the operation. Progressive increase in the transit time...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318183
更新日期:1985-05-01 00:00:00
abstract::Impairment of pancreatic microcirculation has often been advocated as one pathogenic mechanism in necrotizing pancreatitis. In contrast, data on pancreatic capillary perfusion in edematous pancreatitis are scarce. It was the aim of this experimental study to compare changes in pancreatic microcirculation in edematous ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087702
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abstract::The effect of chemical deafferentation, vagotomy (VGX), and gangliosympathectomy (GSX) on the density of fibers containing calcitonin gene-related peptide (CGRP) and substance P (Sub.P) in the rat gastric wall was studied. Chemical deafferentation by capsaicin abolished the density of CGRP-immunoreactive (IR) fibers, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018858208532
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abstract:BACKGROUND AND AIMS:The impact of obesity on survival following liver transplantation is unclear, and existing studies report conflicting results. Our current study aims to further delineate the impact of obesity using population-based registry data from the USA. METHODS:All US adult liver transplant recipients from 2...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3469-8
更新日期:2015-04-01 00:00:00
abstract::Helicobacter pylori infection has been linked with gastric carcinoma. Epithelial cell proliferation is an indicator of cancer risk. The aim of this study was to assess gastric epithelial cell proliferation before and after eradication therapy and to assess the efficacy of treatment of H. pylori infection using lanzopr...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
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abstract::This study investigated the effects of portal hypertension on gastric motor and secretory functions and the role of endothelin in rats. Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02282345
更新日期:1996-03-01 00:00:00
abstract::Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypers...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308088
更新日期:1992-12-01 00:00:00
abstract::The effect of the race of the donor on organ donation and on the outcome of clinical liver transplantation has not been addressed previously. The aims of this study were to determine: (1) the number of organs donated by each of the major racial groups of the United States, (2) the outcome of transplantation of these o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536746
更新日期:1990-11-01 00:00:00
abstract::This study was designed to determine the possible effects of omeprazole on human natural killer cells. Peripheral venous blood samples were taken from 20 peptic ulcer patients before and at the 14th and the 28th days of omeprazole treatment. Mononuclear cells were removed from blood and their capability of making conj...
journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005615703009
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:We hypothesized that the severity of dextran sodium sulfate (DSS)-induced colitis could differ between DSS preparations of the same molecular weight, and that this difference may be affected by the sulfur content. To test this, we used three DSS preparations of similar molecular weights but with different su...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1881-x
更新日期:2012-02-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05771-8
更新日期:2020-02-01 00:00:00
abstract::To examine the differentiating parameters between cholesterol and pigment gallstones, we compared the nucleation times, concentrations of biliary lipid and protein, and the distribution of vesicular cholesterol in gallbladder bile of 16 patients with cholesterol, eight patients with black pigment gallstones, and nine ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296790
更新日期:1993-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2376-0
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Proton pump inhibitors (PPIs) may reduce the risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. PPIs are prescribed for virtually all patients with Barrett's esophagus, irrespective of the presence of reflux symptoms, and represent a de facto chemopreventive agent in this populatio...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3186-3
更新日期:2014-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02285216
更新日期:1995-07-01 00:00:00
abstract::This study investigates whether topical prostaglandins protect isolated gastric mucosa against injury provoked by acidified "barrier-breaking" agents. Intracellular pH (pHi), apical cell membrane potential (Vcm) and intraepithelial resistances in isolated Necturus antral mucosa were measured using double-barreled liqu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005465528158
更新日期:2000-01-01 00:00:00
abstract::To ascertain how elevation of the head of the bed, bethanechol, and antacid foam tablets affect gastroesophageal reflux, we used prolonged intraesophageal pH monitoring in 55 symptomatic patients. Acid exposure was separated into reflux frequency and esophageal acid clearance time and recorded during the day in the up...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01316854
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-020-06055-2
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01535791
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297073
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2271-8
更新日期:2012-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5360-5
更新日期:2019-02-01 00:00:00
abstract::Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297052
更新日期:1987-03-01 00:00:00
abstract::Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
abstract::Biliary mucin was isolated from human hepatic bile, and its induced effects on the appearance time of cholesterol monohydrate crystals (nucleation time) and on the precipitation of calcium carbonate were studied in vitro to examine the possible significance of mucin for ductular gallstone formation. Mucin was isolated...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295919
更新日期:1993-05-01 00:00:00
abstract::Gastritis caused by Helicobacter pylori (HP) is common in patients with nonulcer dyspepsia (NUD), but an etiologic relationship between the histologic lesion and clinical symptoms is unproven. HP is inhibited by bismuth subsalicylate (BSS), a traditional remedy for dyspeptic complaints. The aim of this study was to as...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01303177
更新日期:1993-09-01 00:00:00