Gastric functions in portal hypertension. Role of endothelin.

Abstract:

:This study investigated the effects of portal hypertension on gastric motor and secretory functions and the role of endothelin in rats. Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were subjected to tests of gastric secretory, motor, and mucosal function studies as well as gastric wall polymorphonuclear infiltration. Portal hypertension was induced by partial portal vein ligation. Portal hypertension suppressed gastric acid and total fluid secretion and delayed gastric emptying. An increase in mucosal permeability and no alteration in gastric wall myeloperoxidase activity were observed. The effects of portal hypertension on gastric secretory, motor, and mucosal functions were reversed by treatment with endothelin-A receptor blocker, BQ-485. It is concluded that portal hypertension suppresses the gastric motor and secretory functions and endothelin plays an important role in the pathophysiology of gastric alterations associated with portal hypertension.

journal_name

Dig Dis Sci

authors

Günal O,Yeğen C,Aktan AO,Yalin R,Yeğen BC

doi

10.1007/BF02282345

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

585-90

issue

3

eissn

0163-2116

issn

1573-2568

journal_volume

41

pub_type

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