Should a colonoscopy be recommended for healthy individuals with increased carcinoembryonic antigen levels? A case-control study.


BACKGROUND AND AIM:Despite the limitations of screening or early diagnosis of colorectal cancers (CRC), carcinoembryonic antigen (CEA) is frequently measured in practice and during health promotion programs. The aim of this study was to evaluate the role of colonoscopy in healthy individuals with elevated CEA levels. METHODS:From January 2003 to November 2008, 117,731 healthy persons underwent an opportunistic screening program in two health promotion centers; 1,497 subjects (1.3%) showed an elevated CEA level (>5 ng/ml). Among them, 174 patients were recruited to undergo a colonoscopy to determine if colorectal malignancies were present. A total of 372 age- and sex-matched persons were selected as controls from among the healthy subjects who had a normal level of CEA and had received surveillance colonoscopy. The primary outcome was the incidences of CRC in elevated CEA and normal CEA groups. The secondary outcome was the predictive factors of CRC in the elevated CEA group. RESULTS:The incidence of CRC was higher in the group with higher CEA-levels than in the group with normal CEA levels (4.6 vs. 1.3%; P=0.031). In the CEA-elevated group, patients with CRCs were diagnosed at more advanced stages than were those in the CEA-normal group. The incidence of colorectal polyps was not different between the two groups. In the CEA-elevated group, anemia was an independent predictive factor of CRCs by multivariate analysis (P=0.002). CONCLUSION:Anemia itself is not a predictive factor of CRC in the entire population, but is an independent predictive factor of CRC in healthy individuals with an elevated level of CEA. Therefore, colonoscopy should be recommended for healthy subjects with an elevated level of CEA accompanied with anemia in the absence of other adenocarcinomas to evaluate the presence of colorectal malignancy.


Dig Dis Sci


Lee JH,Hong SP,Jeon TJ,Kang GH,Choi WC,Jeon SM,Moon CM,Park JJ,Cheon JH,Kim TI,Kim WH




Has Abstract


2011-08-01 00:00:00












  • Reversal of megaduodenum and duodenal dysmotility associated with improvement in nutritional status in primary anorexia nervosa.

    abstract::Anorexia nervosa is considered one type of eating disorder that may result in severe malnutrition. Patients with this disorder commonly complain of postprandial nausea, abdominal pain, and distension. We describe the radiologic and motility abnormalities associated with anorexia nervosa in a 21-year-old female. Barium...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Buchman AL,Ament ME,Weiner M,Kodner A,Mayer EA

    更新日期:1994-02-01 00:00:00

  • Saccharomyces boulardii in maintenance treatment of Crohn's disease.

    abstract::The possible role of Saccharomyces boulardii, a nonpathogenic yeast with beneficial effects on the human intestine, in the maintenance treatment of Crohn's disease has been evaluated. Thirty-two patients with Crohn's disease in clinical remission (CDAI < 150) were randomly treated for six months with either mesalamine...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Guslandi M,Mezzi G,Sorghi M,Testoni PA

    更新日期:2000-07-01 00:00:00

  • Knockdown of Long Non-coding RNA LINC00200 Inhibits Gastric Cancer Progression by Regulating miR-143-3p/SERPINE1 Axis.

    abstract:BACKGROUND:An increasing number of studies have found that long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and tumor progression, whereas their molecular mechanisms of function remain largely unknown. AIMS:This study was aimed to explore the biological function and underlying mechanism of a new...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: He W,Zhang D,Li D,Zhu D,Geng Y,Wang Q,He J,Wu J

    更新日期:2020-11-03 00:00:00

  • Pneumothorax following ERCP: report of four cases and review of the literature.

    abstract::We report four patients with pneumothorax as a complication of ERCP with sphincterotomy. With conservative treatment all patients recovered. Previously, 16 comparable cases have been reported in the literature. The main risk factor for this rare complication seems (pre-cut) sphincterotomy. Pneumothorax is usually righ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Schepers NJ,van Buuren HR

    更新日期:2012-08-01 00:00:00

  • Comparative study of plasma pancreatic polypeptide responses to food, secretin, and bombesin in normal subjects and in patients with chronic pancreatitis.

    abstract::Plasma pancreatic polypeptide (PP) responses to food, secretin (1 CU/kg, intravenous) and bombesin (60 pmol/kg/20 min intravenous) were compared in 14 normal subjects and in 17 patients with chronic pancreatitis and pancreatic insufficiency. Basal plasma PP concentrations were significantly higher in normal subjects t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lamers CB,Diemel CM,Jansen JB

    更新日期:1984-02-01 00:00:00

  • Can endoscopic ultrasound-guided fine needle aspiration offer clinical benefit for thick-walled gallbladders?

    abstract:BACKGROUND:No previous studies have compared cytology obtained under endoscopic transpapillary gallbladder drainage (ETGD) and EUS-guided fine needle aspiration (EUS-FNA) for thick-walled gallbladders. AIM:The present study investigated the diagnostic yield of bile cytology under ETGD and EUS-FNA for gallbladder tumor...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Ogura T,Kurisu Y,Masuda D,Imoto A,Onda S,Kamiyama R,Hayashi M,Mohamed M,Uchiyama K,Higuchi K

    更新日期:2014-08-01 00:00:00

  • Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis.

    abstract:BACKGROUND:The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results. AIM:To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility. METHODS:We performed an extensive search of relevant studies and carried ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审


    authors: Wang J,Pan HF,Hu YT,Zhu Y,He Q

    更新日期:2010-07-01 00:00:00

  • Dynamic involvement of the inducible type of nitric oxide synthase in acid-induced duodenal mucosal alkaline secretion in the rat.

    abstract::It has previously been shown that mucosal nitric oxide synthase (NOS) is involved in acid-induced duodenal mucosal alkaline secretion. The primary aim of the present study was to elucidate which isoform of NOS is responsible in rats. Immunohistochemistry showed that inducible NOS (iNOS) was constitutively expressed in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Holm M,Powell T,Casselbrant A,Johansson B,Fändriks L

    更新日期:2001-08-01 00:00:00

  • Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial.

    abstract:BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sureshkumar S,Omang A,Anandhi A,Rajesh BS,Abdulbasith KM,Vijayakumar C,Palanivel C,Pazhanivel M,Kate V

    更新日期:2020-11-18 00:00:00

  • Diverticulosis and the risk of interval colorectal cancer.

    abstract:BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subg...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cooper GS,Xu F,Schluchter MD,Koroukian SM,Barnholtz Sloan JS

    更新日期:2014-11-01 00:00:00

  • Endoscopic management of Barrett's esophagus: advances in endoscopic techniques.

    abstract::Barrett's esophagus (BE) is a well-known premalignant condition that can be associated with the development of dysplasia and adenocarcinoma. In the past, esophagectomy was the standard treatment for patients with BE with high grade dysplasia (HGD) and early cancer (EC). However, esophagectomy is not necessarily the on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Azarm A,Lukolic I,Shukla M,Concha-Parra R,Gress F

    更新日期:2012-12-01 00:00:00

  • Glucagon-like peptide-2 induces a specific pattern of adaptation in remnant jejunum.

    abstract::Glucagon-like peptide-2 (GLP-2) is an enteroendocrine hormone which is uniquely trophic for the intestine; a physiological role in regulating nutrient absorptive capacity is becoming apparent. GLP-2, independent of enteral feeding, stimulates a classical pattern of intestinal adaptation in terminal ileum following res...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sigalet DL,Bawazir O,Martin GR,Wallace LE,Zaharko G,Miller A,Zubaidi A

    更新日期:2006-09-01 00:00:00

  • Measurement of segmental transit through the gut in man. A novel approach by the biomagnetic method.

    abstract::The techniques commonly used to evaluate the transit of contents through the gut feature some limitations for being either inaccurate, invasive, inconvenient, or potentially dangerous for the subjects. Aim of this study was to establish a safe, noninvasive and accurate technique for the measurement of segmental oroana...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Basile M,Neri M,Carriero A,Casciardi S,Comani S,Del Gratta C,Di Donato L,Di Luzio S,Macri MA,Pasquarelli A

    更新日期:1992-10-01 00:00:00

  • Prevalence of Helicobacter pylori Positive Non-cardia Gastric Adenocarcinoma Is Low and Decreasing in a US Population.

    abstract:BACKGROUND:Helicobacter pylori infection is an established causal factor for non-cardia gastric cancer. H. pylori negative gastric cancer prevalence among US patients is unclear. METHODS:This retrospective cohort study examined H. pylori prevalence among consecutive patients with incident non-cardia gastric adenocarci...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Nguyen TH,Mallepally N,Hammad T,Liu Y,Thrift AP,El-Serag HB,Tan MC

    更新日期:2020-08-01 00:00:00

  • Long-Term Follow-Up Study of Liver-Related Outcome After Bilio-Pancreatic Diversion in Patients with Initial, Significant Liver Damage.

    abstract:BACKGROUND:Obesity is associated with NAFLD, and bariatric surgery has significant impact on this liver disease, with reported improvement in hepatic fibrosis. AIMS:To investigate the effects of bariatric surgery on long-term liver disease-related outcome in obese patients with nonalcoholic fatty liver disease (NAFLD)...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Giannini EG,Coppo C,Romana C,Camerini GB,De Cian F,Scopinaro N,Papadia FS

    更新日期:2018-07-01 00:00:00

  • Clinical significance of discordant positive hepatitis C virus transcription-mediated amplification following end of treatment response.

    abstract:BACKGROUND:Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. METHODS:We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA+ result to assess the clinical...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Thadani A,Harley J,Rubin J,Lebovics E

    更新日期:2012-01-01 00:00:00

  • Collagenous colitis with involvement of terminal ileum.

    abstract::We present a case of collagenous colitis with evidence of terminal ileal involvement. The patient suffered from chronic watery diarrhea of three months' duration, and colonoscopy revealed a normal endoscopic appearance. Histologic examination of biopsies revealed a broad subepithelial band of collagen, with similar hi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lewis FW,Warren GH,Goff JS

    更新日期:1991-08-01 00:00:00

  • Comparison of Immune Microenvironment Between Colon and Liver Metastatic Tissue in Colon Cancer Patients with Liver Metastasis.

    abstract:BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zhou SN,Pan WT,Pan MX,Luo QY,Zhang L,Lin JZ,Zhao YJ,Yan XL,Yuan LP,Zhang YX,Yang DJ,Qiu MZ

    更新日期:2020-03-19 00:00:00

  • Mucosal glucosamine synthetase activity in inflammatory bowel disease.

    abstract::Abnormalities in colonic glycoprotein synthesis have been implicated in the pathogenesis of ulcerative colitis and Crohn's disease. Glucosamine synthetase is the rate-limiting step in the biosynthesis of gastrointestinal glycoprotein and has been measured in control subjects (N = 23) and patients with ulcerative colit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Winslet MC,Poxon V,Allan A,Keighley MR

    更新日期:1994-03-01 00:00:00

  • Drug and treatment efficacy of chenodeoxycholic acid in 97 patients with cholelithiasis and increased surgical risk.

    abstract::Patients with symptomatic cholelithiasis who represent higher than normal surgical risks may be the most suitable candidates for medical dissolution of gallstones. Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. Complete gallstone dissolution occ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Tangedahl T,Carey WD,Ferguson DR,Forsythe S,Williams M,Paradis K,Hightower NC

    更新日期:1983-06-01 00:00:00

  • Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis.

    abstract:BACKGROUND:Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM:To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS:W...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bhandari S,Venkatesan T

    更新日期:2017-08-01 00:00:00

  • Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene.

    abstract:OBJECTIVES:Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD. DESIGN:We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Talukdar R,Aslam M,Reddy DN,Nabi Z,Shava U,Ravikanth VV,Avanthi S,Govardhan B

    更新日期:2020-08-04 00:00:00

  • Granular cell tumor of the esophagus: natural history, diagnosis, and therapy.

    abstract::Five cases of granular cell tumor of the esophagus are reported. In four cases, the tumor was an asymptomatic, incidental finding. In one case, a larger granular cell tumor presented with dysphagia and required local surgical excision. Long-term follow-up in three cases revealed no evidence of tumor progression. Esoph...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Brady PG,Nord HJ,Connar RG

    更新日期:1988-10-01 00:00:00

  • Hypercalcemic encephalopathy in a patient with hepatocellular carcinoma.

    abstract::Cirrhotic patients with hepatocellular carcinoma (HCC) frequently develop hepatic encephalopathy. Metabolic etiology of encephalopathy is less often considered in these patients. Although paraneoplastic hypercalcemia may be associated with several malignant tumors, it has also been described in HCC [1-4], and may caus...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tudela P,Soldevila B,Mòdol JM,Domènech E

    更新日期:2007-11-01 00:00:00

  • Novel expression and regulation of gastrin gene in human ovarian cancer cell line, SW626.

    abstract::Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could b...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim HJ,Evers BM,Banker NA,Greeley GH Jr,Hellmich MR,Thompson JC,Townsend CM Jr

    更新日期:1998-07-01 00:00:00

  • Prospective controlled assessment of impact of feedback on gastroenterology trainees in outpatient practice.

    abstract:BACKGROUND AND AIMS:Previous studies have demonstrated the value of systematic feedback in enhancing endoscopic procedure performance. It remains unknown whether feedback may play a role in modifying physician performance in outpatient practice. This study aimed to assess the impact of systematic feedback on duration o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Harewood GC

    更新日期:2011-10-01 00:00:00

  • Chronic abdominal wall pain. Diagnostic validity and costs.

    abstract::Chronic abdominal wall pain (CAWP) is common and frequently mistaken for visceral pain. We determined the stability of this diagnosis with Main Outcome Measures of: (a) change of pain intensity after local anesthetic-corticosteroid injection, (b) pain relief after three or more months follow-up, and (c) costs of diagn...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Greenbaum DS,Greenbaum RB,Joseph JG,Natale JE

    更新日期:1994-09-01 00:00:00

  • Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying.

    abstract:BACKGROUND AND AIM:Diabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E (ApoE), which is secreted by astrocytes and has neuroprotective effects ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fukuhara S,Masaoka T,Nishimura S,Nakamura M,Matsuzaki J,Tsugawa H,Miyoshi S,Mori H,Kawase S,Shibata S,Okano H,Kanai T,Suzuki H

    更新日期:2017-12-01 00:00:00

  • Participation of capsaicin-sensitive afferent nerves in the gastric mucosa of patients with Helicobacter pylori-positive or-negative chronic gastritis.

    abstract::Capsaicin-sensitive afferent nerves (CSANs) are involved in the protection of gastric mucosa. To clarify the role of CSANs in human Helicobacter pylori-negative or -positive chronic gastritis, after bacterium detection by rapid urease test, (14)C urea breath test, and specific histological staining, the immunodistribu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Dömötör A,Kereskay L,Szekeres G,Hunyady B,Szolcsányi J,Mózsik G

    更新日期:2007-02-01 00:00:00

  • Hepatitis C virus does not cause nonalcoholic steatohepatitis.

    abstract::The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase cha...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rogers DW,Lee CH,Pound DC,Kumar S,Cummings OW,Lumeng L

    更新日期:1992-11-01 00:00:00