Should a colonoscopy be recommended for healthy individuals with increased carcinoembryonic antigen levels? A case-control study.


BACKGROUND AND AIM:Despite the limitations of screening or early diagnosis of colorectal cancers (CRC), carcinoembryonic antigen (CEA) is frequently measured in practice and during health promotion programs. The aim of this study was to evaluate the role of colonoscopy in healthy individuals with elevated CEA levels. METHODS:From January 2003 to November 2008, 117,731 healthy persons underwent an opportunistic screening program in two health promotion centers; 1,497 subjects (1.3%) showed an elevated CEA level (>5 ng/ml). Among them, 174 patients were recruited to undergo a colonoscopy to determine if colorectal malignancies were present. A total of 372 age- and sex-matched persons were selected as controls from among the healthy subjects who had a normal level of CEA and had received surveillance colonoscopy. The primary outcome was the incidences of CRC in elevated CEA and normal CEA groups. The secondary outcome was the predictive factors of CRC in the elevated CEA group. RESULTS:The incidence of CRC was higher in the group with higher CEA-levels than in the group with normal CEA levels (4.6 vs. 1.3%; P=0.031). In the CEA-elevated group, patients with CRCs were diagnosed at more advanced stages than were those in the CEA-normal group. The incidence of colorectal polyps was not different between the two groups. In the CEA-elevated group, anemia was an independent predictive factor of CRCs by multivariate analysis (P=0.002). CONCLUSION:Anemia itself is not a predictive factor of CRC in the entire population, but is an independent predictive factor of CRC in healthy individuals with an elevated level of CEA. Therefore, colonoscopy should be recommended for healthy subjects with an elevated level of CEA accompanied with anemia in the absence of other adenocarcinomas to evaluate the presence of colorectal malignancy.


Dig Dis Sci


Lee JH,Hong SP,Jeon TJ,Kang GH,Choi WC,Jeon SM,Moon CM,Park JJ,Cheon JH,Kim TI,Kim WH




Has Abstract


2011-08-01 00:00:00












  • Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome.

    abstract:AIM:The aim of this case-control study was to investigate both the distribution of MCP-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes. METHOD:Between September 1997-January 2005, 20 patients with HPS (group 1) were compared with a group of cirrhotic patients (group 2, n = 19) as w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tumgor G,Berdeli A,Arikan C,Levent E,Aydogdu S

    更新日期:2008-05-01 00:00:00

  • Double-duct sign in the era of endoscopic ultrasound: the prevalence of occult pancreaticobiliary malignancy.

    abstract:BACKGROUND AND AIM:Simultaneous dilatation of the common bile duct and pancreatic duct, "double-duct sign" (DDS), is an ominous finding concerning for pancreaticobiliary malignancy. Little evidence exists to guide the initial evaluation and subsequent follow-up for patients with DDS in the absence of jaundice or focal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cohen J,Sawhney MS,Pleskow DK,Chuttani R,Patel NJ,Sheridan J,Berzin TM

    更新日期:2014-09-01 00:00:00

  • Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats.

    abstract::Since granulocyte elastase has been shown to be involved in the pathogenesis of gastric mucosal lesion formation induced by nonsteroidal antiinflammatory drugs, inhibition of granulocyte elastase release from neutrophils may be useful in the prevention of these lesions. The objective of this study was to determine whe...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Murakami K,Okajima K,Harada N,Isobe H,Okabe H

    更新日期:1998-09-01 00:00:00

  • Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man.

    abstract::Both increased duodenogastric reflux and chronic aspirin ingestion are associated with the development of gastric ulcers in man. Animal studies suggest aspirin increases duodenogastric reflux. Prostaglandin E2 protects gastric mucosa from the effects of many injurious agents and inhibits gastric motility, but its effe...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Dooley CP,Mello WD,Valenzuela JE

    更新日期:1985-06-01 00:00:00

  • Mucosal glucosamine synthetase activity in inflammatory bowel disease.

    abstract::Abnormalities in colonic glycoprotein synthesis have been implicated in the pathogenesis of ulcerative colitis and Crohn's disease. Glucosamine synthetase is the rate-limiting step in the biosynthesis of gastrointestinal glycoprotein and has been measured in control subjects (N = 23) and patients with ulcerative colit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Winslet MC,Poxon V,Allan A,Keighley MR

    更新日期:1994-03-01 00:00:00

  • Factors Related to Upper Gastrointestinal Symptom Generation in 2275 Helicobacter pylori Seroprevalent Adults.

    abstract:BACKGROUND AND AIM:Upper gastrointestinal (UGI) symptoms are common; however, the role of Helicobacter pylori and gastric corpus atrophy in the generation of these symptoms is controversial. The aim of this study was to determine the risk factors for UGI symptoms in adults in an endemic area of H. pylori infection. ME...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lee SP,Lee SY,Kim JH,Sung IK,Park HS,Shim CS

    更新日期:2017-06-01 00:00:00

  • Efficacy and safety of endoscopic papillary large balloon dilation for large bile duct stones in elderly patients.

    abstract:BACKGROUND:Minimally invasive interventions for choledocholithiasis are preferable in elderly patients because they tend to have multiple underlying disorders or a decreased activity of daily living. Endoscopic sphincterotomy and endoscopic papillary balloon dilation have been recognized as first-line treatments for ch...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tonozuka R,Itoi T,Sofuni A,Itokawa F,Kurihara T,Tsuchiya T,Ishii K,Tsuji S,Ikeuchi N,Umeda J,Tanaka R,Honjyo M,Mukai S,Fujita M,Moriyasu F

    更新日期:2014-09-01 00:00:00

  • The role of N-acetyltransferase 2 polymorphism in the etiopathogenesis of inflammatory bowel disease.

    abstract:BACKGROUND AND PURPOSE:Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD), which are complex genetic disorders resulting from the interplay between several genetic and environmental risk factors. The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of n...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Baranska M,Trzcinski R,Dziki A,Rychlik-Sych M,Dudarewicz M,Skretkowicz J

    更新日期:2011-07-01 00:00:00

  • Gastroduodenitis. A broader concept of peptic ulcer disease.

    abstract::To evaluate the frequency and type of gastroduodenal mucosal inflammatory changes in patients with symptomatic acid peptic disease and nonulcer dyspepsia, 100 patients with gastrointestinal symptoms indicative of acid peptic disease or dyspepsia and 10 control subjects were clinically evaluated and underwent radiograp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Greenlaw R,Sheahan DG,DeLuca V,Miller D,Myerson D,Myerson P

    更新日期:1980-09-01 00:00:00

  • Randomized, double-blind, placebo-controlled trial of eight-week course of recombinant alpha-interferon for chronic non-A, non-B hepatitis.

    abstract::Forty-nine Japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-A, non-B hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a sim...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Omata M,Ito Y,Yokosuka O,Imazeki F,Tagawa M,Takano S,Hosoda K,Tada M,Ohto M,Ito K

    更新日期:1991-09-01 00:00:00

  • Differences Between Familial and Sporadic Celiac Disease.

    abstract:BACKGROUND:It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study. METHODS:Altogether 1064 patients were...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Airaksinen L,Myllymäki L,Kaukinen K,Saavalainen P,Huhtala H,Lindfors K,Kurppa K

    更新日期:2020-07-23 00:00:00

  • What does pain or discomfort in irritable bowel syndrome mean?

    abstract::Despite many studies on pain of functional gastrointestinal disorders (FGID), the pain mechanism of FGID is not well understood, and pain treatment of FGID is not established. Following our former functional dyspepsia (FD) study, we proposed two subgroups of patients with irritable bowel syndrome (IBS), pain and disco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Handa M,Nukina H,Ando K,Kubo C

    更新日期:2004-04-01 00:00:00

  • Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study.

    abstract::Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

    更新日期:1996-12-01 00:00:00

  • Cancer Center Volume and Type Impact Stage-Specific Utilization of Neoadjuvant Therapy in Rectal Cancer.

    abstract:BACKGROUND:Neoadjuvant chemoradiation reduces local recurrence in locally advanced rectal cancer, and adherence to national and societal recommendations remains unknown. OBJECTIVE:To determine variability in guideline adherence in rectal cancer treatment and investigate whether hospital volume correlated with variabil...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Midura EF,Jung AD,Daly MC,Hanseman DJ,Davis BR,Shah SA,Paquette IM

    更新日期:2017-08-01 00:00:00

  • Chronic active hepatitis associated with liver-kidney microsomal antibody of an autoimmune type. Two familial cases.

    abstract::We report the findings in two sisters with active cirrhosis and an anti-liver-kidney microsomal antibody (anti-LKM) of the autoimmune type. This unusual disease is characterized by the presence of high levels of antibodies that react with the smooth and rough endoplasmic reticulum of the liver and other tissues. Our p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Buffet C,Homberg JC,Pelletier G,Turner K,Etienne JP

    更新日期:1986-11-01 00:00:00

  • Effects of rifaximin treatment and retreatment in nonconstipated IBS subjects.

    abstract:UNLABELLED:Recent evidence suggests a role for gut bacteria and antibiotics in the pathophysiology and treatment of irritable bowel syndrome (IBS), respectively. While the benefits of the antibiotic rifaximin have demonstrated efficacy and durable improvement in symptoms over 3 months, the long-term need for retreatmen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pimentel M,Morales W,Chua K,Barlow G,Weitsman S,Kim G,Amichai MM,Pokkunuri V,Rook E,Mathur R,Marsh Z

    更新日期:2011-07-01 00:00:00

  • Donor gender does not affect liver transplantation outcome in children.

    abstract::The liver is recognized as a sex hormone-responsive organ. Gender-specific differences in liver function are known to exist. Recently, a higher failure rate for organs transplanted in adults from female donors to male recipients has been reported. This increased failure rate of livers obtained from adult females and t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pillay P,Van Thiel DH,Gavaler JS,Starzl TE

    更新日期:1990-06-01 00:00:00

  • Influence of cisapride on gastric emptying of solids and liquids monitored by 13C breath tests.

    abstract::[13C]Acetate and [13C]octanoate breath tests were used to analyze the gastric emptying of liquids and solids in healthy controls and patients with functional dyspepsia both with and without cisapride. A standard test meal was labeled with either 150 mg [13C]acetate (liquid phase labeled in the water) or with 100 mg [1...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Duan LP,Braden B,Caspary WF,Lembcke B

    更新日期:1995-10-01 00:00:00

  • Aggressive Percutaneous Catheter Drainage Protocol for Necrotic Pancreatic Collections.

    abstract:BACKGROUND:Percutaneous catheter drainage (PCD) performed pro-actively for collections in acute pancreatitis (AP) is associated with better outcomes. However, there are only a few studies describing this protocol. AIM:We aimed to evaluate an aggressive PCD protocol. METHODS:Consecutive patients with AP who underwent ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gupta P,Gupta J,Kumar C,Samanta J,Mandavdhare H,Sharma V,Sinha SK,Gupta V,Yadav TD,Dutta U,Kochhar R

    更新日期:2020-12-01 00:00:00

  • Effects of bicyclol on liver regeneration after partial hepatectomy in rats.

    abstract::Bicyclol is a synthetic antihepatitis drug with antioxidative property. The present study was performed to investigate the effect of bicyclol on liver regeneration after partial hepatectomy in rats. Bicyclol (300 mg/kg) was given to rats subjected to 70% hepatectomy three times before operation. At 6, 24, and 48 h aft...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yao XM,Zhao J,Li Y,Li Y

    更新日期:2009-04-01 00:00:00

  • Pyloric deformation from peptic disease. Radiographic evidence for incompetence rather than obstruction.

    abstract::We have used double-contrast radiographic techniques to clarify what changes in the configuration and movements of the gastroduodenal junction result when peptic lesions involve the distal gastric segment between the proximal (PPL) and the distal pyloric muscle loop (DPL). Among 50 cases of pyloric ulceration diagnose...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lu CC,Schulze-Delrieu K

    更新日期:1990-12-01 00:00:00

  • Effect of ranitidine on intragastric pH and stress-related upper gastrointestinal bleeding in patients with severe head injury.

    abstract::We conducted a double-blind, placebo-controlled study to evaluate the effects of ranitidine on intragastric pH and upper gastrointestinal tract bleeding in severe head injury patients. Within 24 hr of the precipitating trauma, 34 adults with Glasgow coma scale scores < or = 10 were randomized to a 6.25 mg/hr ranitidin...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burgess P,Larson GM,Davidson P,Brown J,Metz CA

    更新日期:1995-03-01 00:00:00

  • Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease.

    abstract::The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Maekubo H,Matsushima T,Okada F,Honma M,Ui M

    更新日期:1980-09-01 00:00:00

  • miR-146b Regulates Cell Proliferation and Apoptosis in Gastric Cancer by Targeting PTP1B.

    abstract:BACKGROUND/AIMS:The purpose of this study is to explore the inhibition or activation effects of microRNA-146 B on the expression of PTP1B in gastric cancer cells. METHODS:The expressions of PTP1B and miR-146b in gastric cancer were detected by RT-qPCR. The effects of miR-146b on cell apoptosis and proliferation of gas...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Xu J,Zhang Z,Chen Q,Yang L,Yin J

    更新日期:2020-02-01 00:00:00

  • PRKCSH genetic mutation was not found in Taiwanese patients with polycystic liver disease.

    abstract::Polycystic liver disease (PCLD) without polycystic kidney is infrequent in clinical setting. Family clustering is found in patients with PCLD, and it is inherited in an autosomal dominant fashion. Through positional cloning in North America and Europe (mostly in Dutch and Finnish descents), mutations in PRKCSH gene on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yang AM,Shih SC,Chu CH,Wang TE,Yang WS

    更新日期:2010-03-01 00:00:00

  • Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection.

    abstract:BACKGROUND:ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. AIMS:To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary functi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Matsumi A,Takenaka R,Ando C,Sato Y,Takei K,Yasutomi E,Okanoue S,Oka S,Kawai D,Kataoka J,Takemoto K,Tsugeno H,Fujiki S,Kawahara Y

    更新日期:2017-11-01 00:00:00

  • Neurohumoral control of gallbladder motility in healthy subjects and diabetic patients with or without autonomic neuropathy.

    abstract::Patients affected by diabetes mellitus are reported to have an increased incidence of gallbladder abnormalities. The pathophysiologic mechanisms for this phenomenon are unclear. In the present study ultrasonography was used to determine gallbladder emptying in response to a meal or separate cephalic or hormonal stimul...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fiorucci S,Bosso R,Scionti L,DiSanto S,Annibale B,Delle Fave G,Morelli A

    更新日期:1990-09-01 00:00:00

  • Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndrome.

    abstract:BACKGROUND AND AIMS:The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the revised Bethesda Guidelines (RBG) cannot be applied in a considerable nu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gould-Suarez M,El-Serag HB,Musher B,Franco LM,Chen GJ

    更新日期:2014-12-01 00:00:00

  • Intraluminal release of serotonin, substance P, and gastrin in the canine small intestine.

    abstract::Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ferrara A,Zinner MJ,Jaffe BM

    更新日期:1987-03-01 00:00:00

  • Effects of very long chain versus long chain triglycerides on gastrointestinal motility and hormone release in humans.

    abstract::Fish oil (a very long chain triglycerides, VLCT) has received much attention because of its favorable metabolic properties; however, its effect on gastrointestinal function has not been studied. We investigated the effects of intraduodenally administered VLCT on gut-hormone release [cholecystokinin (CCK), neurotensin,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jonkers IJ,Ledeboer M,Steens J,Smelt AH,Masclee AA

    更新日期:2000-09-01 00:00:00