Thymoquinone Augments Cisplatin-Induced Apoptosis on Esophageal Carcinoma Through Mitigating the Activation of JAK2/STAT3 Pathway.

abstract：BACKGROUND AND PURPOSE:The underlying mechanisms of nonalcoholic steatohepatitis (NASH) are poorly understood, and little is known about hepatocellular apoptosis in NASH. Cyclooxygenase (COX)-2, the key enzyme in eicosanoid metabolism, is highly expressed in NASH. COX-2 can also regulate the release of mediators of inf...

journal_title：Digestive diseases and sciences

authors： Cheng Q,Li N,Chen M,Zheng J,Qian Z,Wang X,Huang C,Xu S,Shi G

更新日期：2013-10-01 00:00:00

abstract：:Our purpose was to observe the effects of sodium phosphate (NaP) colonoscopy preparation on serum electrolytes, phosphate, and calcium and to identify factors associated with any adverse effects. In an unselected group of 100 consecutive patients attending for out patient colonoscopy, 45% of patients had raised serum ...

journal_title：Digestive diseases and sciences

authors： Ainley EJ,Winwood PJ,Begley JP

更新日期：2005-07-01 00:00:00

abstract：:Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopl...

journal_title：Digestive diseases and sciences

authors： Oh YS,Edmundowicz SA,Jonnalagadda SS,Azar RR

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM:To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS:W...

journal_title：Digestive diseases and sciences

authors： Bhandari S,Venkatesan T

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Primary malignant neoplasms of the small bowel comprise only 1-3% of all gastrointestinal malignancies. Small bowel cancers pose a significant diagnostic challenge. The recent development of video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE) have greatly facilitated evaluation of the small b...

journal_title：Digestive diseases and sciences

authors： Partridge BJ,Tokar JL,Haluszka O,Heller SJ

更新日期：2011-09-01 00:00:00

abstract：:Lansoprazole, a proton pump inhibitor, exerts prominent antiulcer activity via both antisecretory and mucosal protective actions. Although the antisecretory action has been explained by inactivation of (H+, K+)-ATPase in parietal cells, the mode of mucosal protective action remains to be elucidated. In the present stu...

journal_title：Digestive diseases and sciences

authors： Inada I,Satoh H

更新日期：1996-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is implicated in the pathology of acute liver injury and can induce lethal liver failure when simultaneously administered with D-galactosamine (D-GalN). At the present time, nonlethal liver failure, the liver injury of clinical implication, is incompletely understood following challenge by low...

journal_title：Digestive diseases and sciences

authors： Liu LM,Zhang JX,Luo J,Guo HX,Deng H,Chen JY,Sun SL

更新日期：2008-05-01 00:00:00

abstract：:The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated aci...

journal_title：Digestive diseases and sciences

authors： Gaginella TS,Bertko RJ,Müller RK,Gallo-Torres H,Sullivan AC

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

journal_title：Digestive diseases and sciences

authors： Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND AIM:To explore the CT signs which permit estimation of clinically severe portal hypertension (PH) [≥ 12 of hepatic vein pressure gradient (HVPG)]. METHODS:One-hundred and seven consecutive patients who underwent HVPG measurement in the PH group and 52 controls were included. The diameters of main portal...

journal_title：Digestive diseases and sciences

authors： Lee JY,Kim TY,Jeong WK,Kim Y,Kim J,Kim KW,Kim YH,Sohn JH

更新日期：2014-09-01 00:00:00

abstract：:A prospective study was performed in 17 patients with achalasia of the esophagus determining the manometric characteristics of the gastroesophageal sphincter, correlating it with histological analysis by biopsies taken during surgery at the distal narrowed segment of the esophagus, at the location of the sphincter. Th...

journal_title：Digestive diseases and sciences

authors： Csendes A,Smok G,Braghetto I,Ramirez C,Velasco N,Henriquez A

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proc...

journal_title：Digestive diseases and sciences

authors： Taleban S,Van Oijen MG,Vasiliauskas EA,Fleshner PR,Shen B,Ippoliti AF,Targan SR,Melmed GY

更新日期：2016-02-01 00:00:00

abstract：:Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...

journal_title：Digestive diseases and sciences

authors： Takagi S,Kinouchi Y,Chida M,Hiwatashi N,Noguchi M,Takahashi S,Shimosegawa T

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Patients with cirrhosis are at high readmission risk. Using a large statewide database, we evaluated the effect of hospital cirrhosis-related patient volume on 30-day readmissions in patients with cirrhosis. METHODS:We conducted a retrospective study of the Healthcare Cost and Utilization Project State Inpa...

journal_title：Digestive diseases and sciences

authors： Wei M,Ford J,Li Q,Jeong D,Kwong AJ,Nguyen MH,Chang MS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Tyrosine phosphorylation and dephosphorylation by protein tyrosine kinases and phosphatases (PTPs), respectively, play crucial roles in cellular signal transduction. Protein phosphatase non-receptor type 11 (PTPN11) is a positive signaling PTP that activates RAS and ERK signaling. Also, the PTPN11 binds with...

journal_title：Digestive diseases and sciences

authors： Kim JS,Shin OR,Kim HK,Cho YS,An CH,Lim KW,Kim SS

更新日期：2010-06-01 00:00:00

abstract：:Colorectal cancer results in significant morbidity and mortality in the United States. Screening is a critical component of cancer prevention. However, research has suggested that physicians may inconsistently adhere to surveillance guidelines. Since residency training can significantly impact upon future practice pat...

journal_title：Digestive diseases and sciences

authors： Borum ML

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Triglyceride-rich lipoproteins are important in dietary lipid absorption and subsequent energy distribution in the body. Their importance in the gut-lymph may have been overlooked in sepsis, the most common cause of critical illness, and in gut ischemia-reperfusion injury, a common feature of many critical i...

journal_title：Digestive diseases and sciences

authors： Hong J,Nachkebia S,Tun SM,Petzer A,Windsor JA,Hickey AJ,Phillips AR

更新日期：2018-12-01 00:00:00

abstract：:The interaction of [35S]methionine with hepatic tRNA in normal, carcinogen-treated, and partially hepatectomized rats was studied. tRNA was preferentially labeled following [35S]methionine (1.6 mCi, 25 mg/kg body wt) administration by intraperitoneal injection. The extent of [35S]methionine-tRNA interaction was impair...

journal_title：Digestive diseases and sciences

authors： Kanduc D,Quagliariello E

更新日期：1991-07-01 00:00:00

abstract：:Phlebosclerosis of the mesenteric vein is a rare condition causing chronic intestinal ischemia, it has only been reported in Japan. A 56-year-old man with liver cirrhosis and hepatic tumor presented with phlebosclerosis of mesenteric vein without any abdominal symptoms. He was admitted for examination of suspected hep...

journal_title：Digestive diseases and sciences

authors： Oshitani N,Matsumura Y,Kono M,Tamori A,Higuchi K,Matsumoto T,Seki S,Arakawa T

更新日期：2002-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer (CRC). The risk of CRC begins to increase 8 or 10 years after the diagnosis of IBD. This type of cancer is called colitis-associated CRC (CA-CRC). The molecular pathogenesis of inflammatory epithelium might play a...

journal_title：Digestive diseases and sciences

authors： Yashiro M

更新日期：2015-08-01 00:00:00

abstract：:Leptin is an adipocyte-derived hormone involved in the homeostasis of body composition. An imbalance in leptin regulation has been observed in patients with liver cirrhosis. We aimed to assess serum and ascitic leptin levels in a group of patients with decompensated liver cirrhosis and to evaluate the relationship of ...

journal_title：Digestive diseases and sciences

authors： Giannini E,Romagnoli P,Tenconi GL,Botta F,Malfatti F,Chiarbonello B,Mamone M,Barreca T,Testa R

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Ileocolic anastomosis is an essential step in the treatment to restore continuity of the gastrointestinal tract following ileocolic resection in patients with Crohn's disease (CD). However, the association between anastomotic type and surgical outcome is controversial. AIMS:The aim of this meta-analysis is ...

journal_title：Digestive diseases and sciences

authors： He X,Chen Z,Huang J,Lian L,Rouniyar S,Wu X,Lan P

更新日期：2014-07-01 00:00:00

abstract：:We report a rare case of secondary involvement of the gallbladder by metastatic renal cell carcinoma. A 71-year-old man was diagnosed as having a polypoid mass within the gallbladder when he underwent right nephrectomy for a renal cell carcinoma. A preoperative diagnosis of simultaneous carcinoma of the gallbladder wa...

journal_title：Digestive diseases and sciences

authors： Satoh H,Iyama A,Hidaka K,Nakashiro H,Harada S,Hisatsugu T

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:The use of volatile organic compounds (VOCs) in bile was recently studied and appeared promising for diagnosis of malignancy. Noninvasive diagnosis of malignant biliary strictures by using VOCs in urine has not been studied. AIM:To identify potential VOCs in urine to diagnose malignant biliary strictures. ...

journal_title：Digestive diseases and sciences

authors： Navaneethan U,Parsi MA,Lourdusamy D,Grove D,Sanaka MR,Hammel JP,Vargo JJ,Dweik RA

更新日期：2015-07-01 00:00:00

abstract：:Gas within the stomach wall is a rare occurrence. A case of intramural gas is presented. When air or gas is seen within the gastric wall on x-ray, gastric emphysema, emphysematous gastritis, or pneumatosis intestinalis is diagnosed. These classifications have become vague and contradictory. Gas in the gastric wall can...

journal_title：Digestive diseases and sciences

authors： Kussin SZ,Henry C,Navarro C,Stenson W,Clain DJ

更新日期：1982-10-01 00:00:00

abstract：:The gut smooth muscle in the intact conscious state exhibits three distinct types of contractions: rhythmic phasic contractions, tone, and ultrapropulsive contractions. The motility functions of these contractions differ markedly. The phasic contractions mix and propel the ingested food in an orderly fashion so that t...

journal_title：Digestive diseases and sciences

authors： Sarna SK

更新日期：1999-08-01 00:00:00

abstract：:The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions. We retrospect...

journal_title：Digestive diseases and sciences

authors： Akatsu T,Aiura K,Shimazu M,Ueda M,Wakabayashi G,Tanabe M,Kawachi S,Kitajima M

更新日期：2006-02-01 00:00:00

abstract：:Endoscopic photodynamic therapy with hematoporphyrin derivative was used in the primary treatment of 54 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups including 24 with esophageal squamous cell carcinoma, 14 with adenocarcinoma of the stomach or lower third of the esophagu...

journal_title：Digestive diseases and sciences

authors： Patrice T,Foultier MT,Yactayo S,Adam F,Galmiche JP,Douet MC,Le Bodic L

更新日期：1990-05-01 00:00:00

abstract：:The effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion were evaluated in a pylorus-ligated rat model. Oral administration of salicylate (50 mg/kg), aspirin (50 mg/kg), and indomethacin (3.5 mg/kg) significantly increased ulcerogenesis over the basal value by six- to sevenfold, but ib...

journal_title：Digestive diseases and sciences

authors： Wagner KA,Nandi J,King RL,Levine RA

更新日期：1995-01-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is present in up to 75% of patients with chronic refractory ear, nose, and throat (ENT) symptoms, and proton pump inhibitor (PPI) therapy induces symptom relief in the majority of these patients. It has been suggested that endoscopic findings and quantification of esophageal acid...

journal_title：Digestive diseases and sciences

authors： Poelmans J,Feenstra L,Tack J

更新日期：2006-02-01 00:00:00