Abstract:
:The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated acid secretion at an oral dose of 0.5 mg/kg. The effect lasted for 4 hr and was of greater intensity than that observed with 5 mg/kg cimetidine. The ED50 for Ro 22-6923 in this model was 0.25 mg/kg and 0.09 mg/kg for oral and intrapouch administration, respectively. Natural prostaglandin E2 was inactive up to 1 mg/kg orally, but had an ED50 of 0.08 mg/kg when administered directly into the pouch. The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Gaginella TS,Bertko RJ,Müller RK,Gallo-Torres H,Sullivan ACdoi
10.1007/BF01403843subject
Has Abstractpub_date
1985-04-01 00:00:00pages
340-5issue
4eissn
0163-2116issn
1573-2568journal_volume
30pub_type
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journal_title:Digestive diseases and sciences
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