Abstract：
:There is a lack of information about the effect of omeprazole or other antisecretory drugs on intraduodenal pH. Aim of the study was to document the variation over time of intraduodenal pH during a 24-hr period and to simultaneously study the effect of omeprazole 40 mg once daily on intragastric and intraduodenal pH in healthy H. pylori-negative subjects. In a randomized, placebo-controlled study, eight subjects (five women, three men, mean age 22.7 years) received oral 40 mg omeprazole or placebo once daily for eight days. On day 7, intragastric and intraduodenal pH was measured continuously for 24 hr, using two miniature glass-membrane electrodes placed in the stomach (fundus) and in the distal third of the duodenum. The 24-hr median intraduodenal pH was 5.95 with placebo and 5.85 with omeprazole. Median intragastric pH was 1.68 without and 4.93 with omeprazole. During omeprazole therapy, intragastric pH fell below 4.0 in five of eight subjects. In the 2- and 3-hr postprandial periods, the percentage of time with pH < 5 was significantly reduced with omeprazole. In healthy subjects, 24-hr median and postprandial pH in the distal part of the duodenum was lower than previously thought. Omeprazole significantly reduced the percentage of time with pH < 5 postprandially. At night, intragastric pH fell below 4.0 with omeprazole 40 mg once daily. Omeprazole does not change 24-hr median intraduodenal pH significantly.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Gan KH,Geus WP,Lamers CB,Heijerman HGdoi
10.1023/a:1018827003641subject
Has Abstractpub_date
1997-11-01 00:00:00pages
2304-9issue
11eissn
0163-2116issn
1573-2568journal_volume
42pub_type
临床试验,杂志文章,随机对照试验abstract：:Impaired gallbladder emptying is one of the various factors suggested to be involved in the pathogenesis of gallstones. The present study was undertaken to determine whether gallbladder emptying, endogenous cholecystokinin (CCK) secretion, or their interrelation is altered in patients with gallstones. After intraduode...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536255
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:SEL1L gene product is implicated in the endoplasmic reticulum (ER)-associated protein degradation and Unfolded Protein Response pathways. This gene and associated miRNAs have been indicated as predictive and prognostic markers of pancreatic cancer. AIM:Explore the role of SEL1L in colorectal cancer (CRC) pr...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01316582
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journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-008-0361-4
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doi：10.1007/s10620-013-3020-3
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF01311727
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journal_title：Digestive diseases and sciences
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更新日期：1992-03-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：1995-09-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
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更新日期：1999-01-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1987-11-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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journal_title：Digestive diseases and sciences
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更新日期：1993-11-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2005-10-01 00:00:00
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journal_title：Digestive diseases and sciences
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