Abstract：
BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. Demographic data including age, gender, ethnicity, BMI, along with disease type and location, vitamin D levels, prior corticosteroid use, and anti-TNF use were recorded and evaluated with DEXA results. RESULTS:A total of 166 patients [105 Crohn's disease (CD), 61 ulcerative colitis (UC)] qualified for the study. Low BMD was found in 40%, twice as frequently in CD than in UC (p = 0.048). Higher prevalence of low BMD was associated with those of male gender (p = 0.05), Asian ethnicity (p = 0.02), and history of corticosteroid use (p = 0.001). Age, body mass index, or disease location did not increase the risk of low BMD. The overall prevalence of low vitamin D was 60%, with insufficiency (25-hydroxy levels between 20 and 30 ng/mL) found in 37% and deficiency (levels <20 ng/mL) found in 23% of the patients. Vitamin D insufficient and deficient patients were two times (p = 0.049) and almost 3 times (p = 0.02) as likely to have low BMD, respectively. CONCLUSIONS:Low vitamin D, male gender, Asian ethnicity, CD, and corticosteroid use significantly increased the risk of having low BMD, while age and disease location did not affect BMD in our IBD population. It remains important to evaluate for vitamin D nutritional deficiency and limit corticosteroid use to help prevent low BMD in IBD patients.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Abraham BP,Prasad P,Malaty HMdoi
10.1007/s10620-014-3102-xsubject
Has Abstractpub_date
2014-08-01 00:00:00pages
1878-84issue
8eissn
0163-2116issn
1573-2568journal_volume
59pub_type
杂志文章abstract：:Endoscopic papillary balloon dilatation (EPBD) has been recently used in conjunction with endoscopic sphincterotomy (EST) for the removal of common bile duct (CBD) stones. The present study was aimed at assessing the safety and outcome of sequential EPBD following EST for CBD stones. A total of 74 patients (43 females...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0534-1
更新日期：2009-07-01 00:00:00
abstract：:We have studied pepsinogen synthesis and secretion in primary monolayer cultures of canine gastric chief cells. Monolayers were formed after approximately 48 hr. Pepsinogen synthesis was studied by adding 14C-labeled amino acids to the culture medium. Basal secretion of de novo synthesized pepsinogen after 4 hr was 4 ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01535950
更新日期：1988-12-01 00:00:00
abstract：:To evaluate the frequency and significance of alpha1-antitrypsin deficiency in type 1 autoimmune hepatitis, 181 Caucasian patients were assessed for variant phenotypes. Three hundred three Caucasian patients with various other chronic liver diseases were similarly evaluated. Twenty-one of the 181 patients (12%) had he...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018875401612
更新日期：1998-08-01 00:00:00
abstract：:A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01312725
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). AIMS:To determine if the nutritional intake, intestinal ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2112-9
更新日期：2012-07-01 00:00:00
abstract：:We studied the effects of an ileocolonic sphincter substitute on canine small intestine motor activity. Recordings of fasting and postprandial myoelectrical activity were performed in three groups of animals in whom the following procedures had been performed: (1) electrode placement alone, intestinal continuity undis...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01538082
更新日期：1989-09-01 00:00:00
abstract：:An 18-year-old male who developed a pancreatic pseudocyst during the active phase of polyarteritis nodosa is described. Cytotoxic therapy with cyclophosphamide and prednisolone was unable to control the manifestation of this disease, and he required percutaneous drainage of the pseudocyst. The drainage resulted in com...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01296089
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:One of the problems associated with infliximab (IFX) treatment for Crohn's disease (CD) is loss of response during maintenance therapy. AIMS:The aim of this multicenter, retrospective, cohort study was to determine whether enteral nutrition (EN) added to the IFX therapy regimen is effective for maintaining ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2374-2
更新日期：2013-05-01 00:00:00
abstract：:The impact of treatment on progression of fibrosis in autoimmune hepatitis (AIH) is unknown. We assessed the changes in liver fibrosis before and after treatment among these patients. Nineteen AIH patients who had paired liver biopsies were studied. Of these, seven had been treated with 6 months of cyclosporine A and ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2472-5
更新日期：2005-03-01 00:00:00
abstract：:Sera from Japanese patients with chronic liver disease were tested for hepatitis B virus (HBV) markers and antibodies to hepatitis C virus (anti-HCV), and the results were correlated to the presence of hepatocellular carcinoma. In chronic non-A, non-B liver disease, anti-HCV prevalence was high both in patients with h...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308344
更新日期：1992-01-01 00:00:00
abstract：:The significance of hyperplastic polyps of the gastric antrum in anemic patients with suspected gastrointestinal bleeding has not been determined. The aim of this study is to evaluate the prevalence and prognosis of such polyps in this patient group. Clinical records of patients referred to our endoscopy lab from Nove...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9182-5
更新日期：2007-01-01 00:00:00
abstract：:Up to 60% of patients with IBS have lowered perception thresholds in the rectum to balloon distension. The current study sought to test the hypothesis that IBS patients with normal perception thresholds in the rectum show hypersensitivity of afferent pathways in the sigmoid colon. Eleven healthy normal subjects and ei...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018817132213
更新日期：1997-06-01 00:00:00
abstract：:The incidence of colorectal adenocarcinoma increased in the five major ethnic groups in Hawaii, but more in men than women. The highest rates were in the Chinese and Japanese. The site-specific time trend patterns revealed that the greatest increase occurred in rectosigmoid cancer, followed by cancer of the sigmoid co...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295978
更新日期：1981-12-01 00:00:00
abstract：:The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food alle...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-006-9245-7
更新日期：2007-07-01 00:00:00
abstract：:The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01309333
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06203-8
更新日期：2020-03-19 00:00:00
abstract：BACKGROUND:The high mobility group protein A2 (HMGA2) is an architectural transcription factor that plays an important role in the development and progression of many malignant neoplasms. High expression of HMGA2 in gastric cancer correlates with invasiveness of cancer and is an independent prognostic factor. The reaso...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2399-6
更新日期：2013-03-01 00:00:00
abstract：:An intussusception of the small intestine in association with a long tube usually occurs in the vicinity of the mercury-filled bag and can be visualized radiographically by instilling barium directly into the tube. On rare occasions, an intussusception develops in the proximal jejunum and is difficult to recognize. We...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318698
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:The endoscopic detection of esophageal cancer is suboptimal in both patients referred with dyspeptic symptoms and those enrolled in Barrett's surveillance programs. MCM5 expression in cells collected from gastric fluid may be correlated with the presence of dysplasia or adenocarcinoma. Analysis of this bioma...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05607-5
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0770-z
更新日期：2010-03-01 00:00:00
abstract：:The purpose of this study was to use simultaneous anal manometry and high-frequency endoluminal ultrasonography (EUS) to determine the relationship between resting anal pressure and cross-sectional area of the internal and external anal sphincters. Eleven normal subjects underwent simultaneous anal EUS and manometry u...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026605409557
更新日期：1998-11-01 00:00:00
abstract：:The literature regarding the effect of nicotine and cigarette smoke on gastric blood flow is conflicting. The hydrogen gas clearance technique was used to measure the effects of nicotine and cigarette smoke on basal gastric mucosal blood flow in anesthetized rats. Blood flow was measured before, during, and after trea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01320320
更新日期：1986-05-01 00:00:00
abstract：:Phosphorylation/dephosphorylation of intracellular proteins are important steps in the regulation of cell growth. Okadaic acid, an inhibitor of the serine/threonine protein phosphatases 1 and 2A, is a potent tumor promoter. This effect may be through the inhibition of dephosphorylation (termed "hyperphosphorylation") ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02093599
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:In search for a source of gastrointestinal bleeding, endoscopy frequently reveals mucosal lesions of questionable dignity. AIM:To investigate the probability of ascertaining conclusive evidence for gastrointestinal bleeding from a suspicious mucosal lesion through a single or multiple consecutive endoscopie...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2488-6
更新日期：2013-05-01 00:00:00
abstract：:Gastroenterologists are in a unique position to assist women with chronic gastrointestinal disorders in order to optimize their health prior to pregnancy. Women, whether with chronic conditions or not, and their infants are more likely to be healthy when pregnancies are planned. Achieving a planned pregnancy at the id...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-016-4383-z
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIM:Herbal and dietary supplement (HDS) hepatotoxicity is increasingly being reported in the USA. This case series describes the presenting clinical features and outcomes of seven patients with liver injury attributed to OxyELITE Pro enrolled in the Drug-Induced Liver Injury Network (DILIN) study. METHODS:T...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1007/s10620-016-4181-7
更新日期：2016-09-01 00:00:00
abstract：:The aim of this study was to assess the potential of leflunomide, an immunosuppressant in rheumatoid arthritis, as a second-line immunosuppression treatment of patients with Crohn's disease refractory or intolerant to azathioprine. The study cohort consisted of 24 patients. The primary end point was steroid-free remis...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-007-9953-7
更新日期：2008-04-01 00:00:00
abstract：:Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypers...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308088
更新日期：1992-12-01 00:00:00
abstract：:Pharmacological agents that might influence the poststimulus rebound contractile response (PSRR) through an action on the intrinsic inhibitory innervation of the circular muscle coat were studied in the large intestine of the piebald mouse model for Hirschsprung's disease. Tetrodotoxin (0.3-3 microM) suppressed, in a ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296453
更新日期：1986-07-01 00:00:00
abstract：:With the increasing incidence of hepatocellular carcinoma (HCC) and its high mortality rates, effective treatment options are of urgent need, preferably in a multidisciplinary setting. In the management of those patients, interventional radiologists play a key role. In this article, we reviewed the current literature ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-019-05542-5
更新日期：2019-04-01 00:00:00
