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Role of rat large intestine in reducing diarrhea after 50% or 80% distal small bowel resection.

Abstract：

:The effects of intestinal resection on several intestinal parameters have been studied in the large intestine of rats one month after the surgical operation. The results show that both 50% and 80% distal small bowel resection increased net fluid absorption and mucosal permeability and caused expansion of the intercellular spaces of the large intestine. The increase in net fluid absorption was dependent upon the extent of the intestine removed. The cAMP and cGMP content of cecal and colonic mucosa were significantly reduced after jejunoilectomy. Changes in nucleotide levels were dependent on the length of the intestine resected. On the other hand, mucosa Na,K-ATPase specific activity was only increased in the cecum after 80% intestinal resection. The results are discussed in terms of adaptation to prevent diarrhea.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Vázquez CM,Molina MT,Ilundaín A

doi

10.1007/BF01540049

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

1713-9

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

34

pub_type

杂志文章

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