Abstract:
:Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor beta(1) (TGF-beta(1)), and alpha-smooth muscle actin (alpha-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-beta(1), and alpha-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Lee HS,Jung KH,Park IS,Kwon SW,Lee DH,Hong SSdoi
10.1007/s10620-008-0404-xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
782-8issue
4eissn
0163-2116issn
1573-2568journal_volume
54pub_type
杂志文章abstract::Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sus...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3907-2
更新日期:2016-02-01 00:00:00
abstract::We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0595-1
更新日期:2009-10-01 00:00:00
abstract::The effect of chemical deafferentation, vagotomy (VGX), and gangliosympathectomy (GSX) on the density of fibers containing calcitonin gene-related peptide (CGRP) and substance P (Sub.P) in the rat gastric wall was studied. Chemical deafferentation by capsaicin abolished the density of CGRP-immunoreactive (IR) fibers, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018858208532
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Patients with cirrhosis are at high readmission risk. Using a large statewide database, we evaluated the effect of hospital cirrhosis-related patient volume on 30-day readmissions in patients with cirrhosis. METHODS:We conducted a retrospective study of the Healthcare Cost and Utilization Project State Inpa...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-4964-0
更新日期:2018-09-01 00:00:00
abstract::The incidence of colorectal adenocarcinoma increased in the five major ethnic groups in Hawaii, but more in men than women. The highest rates were in the Chinese and Japanese. The site-specific time trend patterns revealed that the greatest increase occurred in rectosigmoid cancer, followed by cancer of the sigmoid co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295978
更新日期:1981-12-01 00:00:00
abstract::Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction. In most cases, it is idiopathic although diabetes mellitus is another leading cause. The physiology of gastric emptying is a complex process which is influenc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-020-06287-2
更新日期:2020-06-01 00:00:00
abstract::We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid. In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02300385
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Acute variceal bleeding (AVB) in patients with cirrhosis is associated with high mortality, ranging from 12 to 20% at 6 weeks. The existing prognostic models for AVB lack precision and require further validation. AIM:In this prospective study, we aimed to develop and validate a new prognostic model for AVB,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05557-y
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1249-7
更新日期:2010-08-01 00:00:00
abstract::Recent evidence suggests a role of reactive oxygen intermediates (ROI) in intracellular signaling and regulation of gene expression. We examined whether expression of interleukin-8 (IL-8), a key cytokine in the inflammatory responses of gastric epithelial cells, is sensitive to antioxidants and oxidative stress. IL-8 ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026638014062
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Procedure-induced bleeding is a major complication after endoscopic intervention. AIMS:The aim of this study was to investigate the risk of endoscopy-related bleeding in patients with chronic hematologic thrombocytopenia. METHODS:We investigated endoscopy-related bleeding in 175 procedures performed on 108...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4427-4
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Accumulating evidence has indicated that variations of mitochondrial DNA (mtDNA) content may affect the susceptibility to hepatocellular carcinoma (HCC). However, no study has been conducted to evaluate the association of circulating mtDNA content and the risk of liver cirrhosis, a leading cause of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3523-1
更新日期:2015-06-01 00:00:00
abstract::A detailed comparison was made of the bile acid composition in gallstones (brown pigment stones) and paired bile and liver from both affected and unaffected lobes by gallstones, which were taken at operation from 16 patients with hepatolithiasis, with the aim of elucidating whether stone formation is derived from poss...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297095
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND AND AIM:The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4120-7
更新日期:2016-08-01 00:00:00
abstract::We evaluated the alveolar-arterial oxygen difference (deltaA-a) and the ratio between PaO2 and the fractional concentration of inspired oxygen (P/F) in acute pancreatitis. Eleven patients had mild uncomplicated disease, six showed acute abdominal fluid collections, six had acute abdominal collections and asymptomatic ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1019668728058
更新日期:2002-09-01 00:00:00
abstract::Wilson disease, an autosomal recessive disorder due to mutations of the ATP7B gene, is characterized by copper accumulation and toxicity in the liver and subsequently in other organs, mainly the brain and cornea. A new missense mutation (T1288R) of the ATP7B gene has recently been discovered in a Wilson disease patien...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9666-3
更新日期:2007-10-01 00:00:00
abstract::The present paper evaluates the efficiency of Nissen fundoplication as an antireflux technique in a series of 51 patients with different grades of esophagitis. Follow-up time averaged 6.6 years. The evaluation includes a clinical assessment, endoscopic study, and 24-hr pH monitoring. The results reveal an acceptable r...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01307574
更新日期:1992-04-01 00:00:00
abstract::The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087561
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Hepatic encephalopathy (HE) is a serious neuropsychiatric complication in both acute and chronic liver disease. AIMS:To establish the utility of a portable noninvasive method to measure ammonia in the breath of healthy subjects and patients with HE. METHODS:The study included 106 subjects: 44 women and 62 ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1858-9
更新日期:2012-01-01 00:00:00
abstract::In a young woman with Takayasu's arteritis, standard roentgenographic studies suggested a diagnosis of Crohn's ileocolitis. Mesenteric angiography was performed and revealed specific abnormalities diagnostic of Crohn's disease, namely, the zoning sign in the cecum with a hypervascular inner layer and a hypovascular ou...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01311953
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:MELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy of estimates of survival. AIMS:To assess and compare the prognostic ability ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5360-5
更新日期:2019-02-01 00:00:00
abstract::Simultaneous recordings of gastric manometry and myoelectrical activity were made in 10 patients with gastroparesis. Intravenous erythromycin (100 mg) was administered in the fasting state for a period of 30 min. Subcutaneous injection of octreotide (100 microg) was administered before one of the four identical test m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018876021156
更新日期:1998-01-01 00:00:00
abstract::Patients with persistently normal ALT affected with HCV-related chronic hepatitis exist. The natural history of liver disease in these patients was demonstrated to be very slow and progression to cirrhosis likely absent. The case we report describes the occurrence of hepatocellular carcinoma (HCC) in a patient with pe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1020527118782
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Ileocolic anastomosis is an essential step in the treatment to restore continuity of the gastrointestinal tract following ileocolic resection in patients with Crohn's disease (CD). However, the association between anastomotic type and surgical outcome is controversial. AIMS:The aim of this meta-analysis is ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析
doi:10.1007/s10620-014-3039-0
更新日期:2014-07-01 00:00:00
abstract::We report the findings in two sisters with active cirrhosis and an anti-liver-kidney microsomal antibody (anti-LKM) of the autoimmune type. This unusual disease is characterized by the presence of high levels of antibodies that react with the smooth and rough endoplasmic reticulum of the liver and other tissues. Our p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296532
更新日期:1986-11-01 00:00:00
abstract::Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01307557
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Fecal Occult Blood Test (FOBT) is an accepted screening test for colorectal cancer (CRC). It has been shown to decrease mortality by up to 30%. The outcome of screening failures has not been adequately studied. AIMS:The purpose of this study was to assess the outcome of patients who were diagnosed with CRC ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2702-1
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients. AIMS:To evaluate the efficacy of pegylated interferon (PEG-IFN) and riba...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1408-x
更新日期:2010-11-01 00:00:00
abstract::The value of a "bread-barium" swallow for diagnosis of disordered esophageal motility was examined in 53 patients, 20 of whom complained of dysphagia, 20 retrosternal chest pain, and 13 heartburn; a further 19 subjects served as controls. Esophageal manometry in the patients with dysphagia and chest pain revealed majo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295808
更新日期:1983-12-01 00:00:00
abstract::We prospectively assessed the relationship between nodular gastritis and Helicobacter pylori infection. Of 1409 adults who underwent endoscopy for persistent dyspepsia between June 2004 and August 2005, 41 (2.9%) patients were diagnosed with nodular gastritis (11 [27%] men and 30 [73%] women). The mean age was 45.9 ye...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9281-3
更新日期:2007-10-01 00:00:00