Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats.

Abstract:

:Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor beta(1) (TGF-beta(1)), and alpha-smooth muscle actin (alpha-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-beta(1), and alpha-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.

journal_name

Dig Dis Sci

authors

Lee HS,Jung KH,Park IS,Kwon SW,Lee DH,Hong SS

doi

10.1007/s10620-008-0404-x

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

782-8

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

54

pub_type

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