Durability of antiviral response in HBeAg-positive chronic hepatitis B patients who maintained virologic response for one year after lamivudine discontinuation.


:The purpose of this study is to determine the long-term relapse rate and associated risk factors in HBeAg-positive chronic hepatitis B (CHB) patients who had maintained virologic response (VR) for 1 year after lamivudine (LMV) discontinuation. We enrolled 55 treatment-naive HBeAg-positive CHB patients who achieved and maintained VR until 1 year after LMV discontinuation. Delayed relapse was defined as an elevation of HBV DNA after sustained VR for 1 year. During follow-up, 16 of 55 patients (29%) showed delayed relapse. Beginning 1 year after LMV discontinuation, the cumulative rates of relapse after 2 and 4 years were 29 and 44%, respectively. In multivariate analysis, age (P = 0.029) and >2,000 copies/ml HBV DNA 3 months after LMV discontinuation (P = 0.047) were significant predictors of delayed relapse. Delayed relapse is not infrequent, even in patients who maintain VR for 1 year after LMV discontinuation. Therefore, LMV maintenance therapy might be considered in HBeAg-positive CHB patients who achieve VR.


Dig Dis Sci


Kim JH,Lee SJ,Joo MK,Kim CH,Choi JH,Jung YK,Yim HJ,Yeon JE,Park JJ,Kim JS,Bak YT,Byun KS




Has Abstract


2009-07-01 00:00:00












  • Triolein breath test of fat absorption in patients with chronic liver disease.

    abstract::We have compared the [14C]triolein breath test for fat malabsorption with fecal fat excretion corrected for marker pellet recovery in 23 subjects with chronic liver disease. The breath test identified 15 of the 17 subjects with abnormal fecal fat excretion (sensitivity 88%). However, four of the six subjects with norm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Absalom SR,Saverymuttu SH,Maxwell JD,Levin GE

    更新日期:1988-05-01 00:00:00

  • Effect of S-adenosyl-L-methionine on ethanol cholestasis and hepatotoxicity in isolated perfused rat liver.

    abstract::We investigated whether S-adenosyl-L-methionine (SAMe) influences the inhibitory effect of ethanol on bile secretion and ethanol hepatotoxicity in the isolated perfused rat liver. SAMe (25 mg/kg intramuscularly three times a day) was administered for three days consecutively. Liver was then isolated and perfused with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Alvaro D,Gigliozzi A,Piat C,Carli L,Bini A,La Rosa T,Furfaro S,Capocaccia L

    更新日期:1995-07-01 00:00:00

  • Low acid output in Pima Indians. A possible cause for the rarity of duodenal ulcer in this population.

    abstract::Duodenal ulcer has not been observed in full-heritage Pima Indians, while gastric cancer is relatively frequent. To investigate possible underlying factors for this phenomenon, we determined gastric acid output, gastric emptying rate, and plasma levels of gastrin, pepsinogen I, and pepsinogen II in apparently healthy ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sasaki H,Nagulesparan M,Samloff IM,Straus E,Sievers ML,Dubois A

    更新日期:1984-09-01 00:00:00

  • The prevalence and clinical correlates of nonalcoholic fatty liver disease (NAFLD) in African Americans: the multiethnic study of atherosclerosis (MESA).

    abstract:BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the pre...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Foster T,Anania FA,Li D,Katz R,Budoff M

    更新日期:2013-08-01 00:00:00

  • Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma.

    abstract::Infection with Helicobacter pylori is associated with the development of gastric cancer. To study whether the infection with H. pylori strains expressing the vacuolating cytotoxin (VacA) and/or the cytotoxin-associated protein (CagA) is associated with an increased risk of developing gastric adenocarcinoma, sera of 90...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rudi J,Kolb C,Maiwald M,Zuna I,von Herbay A,Galle PR,Stremmel W

    更新日期:1997-08-01 00:00:00

  • Local and systemic effects of intraduodenal exposure to topical gallstone solvents ethyl propionate and methyl tert-butyl ether in the rabbit.

    abstract::During topical dissolution of gallstones, solvent can escape to the duodenum causing toxic effects that have not yet been adequately quantified. We compared the local intestinal cytotoxic and systemic hepatotoxic effects of two gallstone solvents, methyl tert-butyl ether and ethyl propionate, on the rabbit's duodenum....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Clerici C,Gentili G,Zakko SF,Balò S,Miglietti M,Giansanti M,Modesto R,Guttermuth CF,Morelli A

    更新日期:1997-03-01 00:00:00

  • Usefulness of assessing circulating levels of resistin, ghrelin, and IL-18 in alcoholic acute pancreatitis.

    abstract:OBJECTIVES:Acute pancreatitis (AP) is a severe inflammatory disease with high mortality and morbidity rates. We have previously demonstrated that resistin may represent an early marker of inflammation in AP. It was also revealed that ghrelin may have anti-inflammatory potential. However, the role of adipohormones in AP...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Daniel P,Leśniowski B,Jasińska A,Pietruczuk M,Małecka-Panas E

    更新日期:2010-10-01 00:00:00

  • Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism.

    abstract::We examined the effect of sildenafil, an inhibitor of phosphodiesterase subtype 5, that catalyzes hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP), on indomethacin-induced small-intestinal ulceration in rats and investigated the mechanism of this action, especially in relation to endogenous nitric oxide (NO)....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kato N,Mashita Y,Kato S,Mitsufuji S,Yoshikawa T,Takeuchi K

    更新日期:2009-11-01 00:00:00

  • Treatment of Crohn's disease with leflunomide as second-line immunosuppression : a phase 1 open-label trial on efficacy, tolerability and safety.

    abstract::The aim of this study was to assess the potential of leflunomide, an immunosuppressant in rheumatoid arthritis, as a second-line immunosuppression treatment of patients with Crohn's disease refractory or intolerant to azathioprine. The study cohort consisted of 24 patients. The primary end point was steroid-free remis...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Holtmann MH,Gerts AL,Weinman A,Galle PR,Neurath MF

    更新日期:2008-04-01 00:00:00

  • Insulin and myoelectric activity of the small intestine of the pig.

    abstract::The effect of insulin on the myoelectric activity of the small intestine was determined in conscious pigs. Animals were implanted with electrodes along the small intestine, a strain gage on the stomach and catheters in both saphenous arteries. Feeding modified the migrating myoelectric complex (MMC), a cyclic pattern ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rayner V,Weekes TE,Bruce JB

    更新日期:1981-01-01 00:00:00

  • A one-year follow-up study of endoluminal gastroplication (Endocinch) in GERD patients refractory to proton pump inhibitor therapy.

    abstract::In a subset of patients with gastroesophageal reflux disease (GERD), symptoms persist in spite of proton pump inhibitor (PPI) therapy. Endoscopic gastroplication (EG) was reported to provide a novel therapeutic option in GERD. To evaluate symptomatic and objective outcome of EG in PPI refractory GERD, consecutive GERD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Arts J,Lerut T,Rutgeerts P,Sifrim D,Janssens J,Tack J

    更新日期:2005-02-01 00:00:00

  • Impact of Angiotensin II Signaling Blockade on Clinical Outcomes in Patients with Inflammatory Bowel Disease.

    abstract:BACKGROUND:Preclinical data demonstrate that activation of the renin-angiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in animal models. Less is known regarding the effects of RAS i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jacobs JD,Wagner T,Gulotta G,Liao C,Li YC,Bissonnette M,Pekow J

    更新日期:2019-07-01 00:00:00

  • Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia.

    abstract:BACKGROUND:MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. AIMS:To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. METHODS:This...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tanaka F,Takashima S,Nadatani Y,Otani K,Hosomi S,Kamata N,Taira K,Nagami Y,Tanigawa T,Fukumoto S,Watanabe T,Murakami Y,Kawada N,Fujiwara Y

    更新日期:2020-12-01 00:00:00

  • Antral axial forces postprandially and after erythromycin in organic and functional dysmotilities.

    abstract::Our aims were to measure antral axial forces in patients with suspected upper gut dysmotilities and to compare the number of antral contractions detected by an axial force catheter and by manometric sensors in the distal antrum and pylorus. Fifteen patients (2 men, 13 women; mean age 42 years) underwent studies for 3 ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Surrenti E,Camilleri M,Kammer PP,Prather CM,Schei AJ,Hanson RB

    更新日期:1996-04-01 00:00:00

  • Microendoscopic nasointestinal feeding tube placement in mechanically ventilated patients with gastroparesis.

    abstract::Gastroparesis often precludes gastric enteral nutrition (EN) in critically ill patients. Our aim was to determine the feasibility of bedside microendoscopic placement of nasointestinal feeding tubes to facilitate enteral nutrition in critically ill patients with poor gastric emptying. Nine mechanically ventilated pati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Taylor SJ,Przemioslo R,Manara AR

    更新日期:2003-04-01 00:00:00

  • Complications in celiac disease under gluten-free diet.

    abstract::We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tursi A,Elisei W,Giorgetti GM,Brandimarte G,Aiello F

    更新日期:2009-10-01 00:00:00

  • Viral and host factors that contribute to efficacy of interferon-alpha 2a therapy in patients with chronic hepatitis C.

    abstract::Using conventional statistical analysis and multiple regression analysis, we investigated the viral and host factors that influence the response to recombinant interferon-alpha 2a therapy in patients with chronic hepatitis C. A total of 36 patients was randomly assigned to three administration schedules, 12 patients i...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Matsumoto A,Tanaka E,Suzuki T,Ogata H,Kiyosawa K

    更新日期:1994-06-01 00:00:00

  • Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury.

    abstract::Intestinal injury 4-48 hr after cytotoxic therapy (etoposide phosphate, 100 mg/kg body weight [bw], intravenously [i.v.]) was studied in rats using ligated intestinal loops. Chromium-51 ethylenediaminetetraacetic acid ((51)Cr-EDTA) and rubidium-86 chloride ((86)RbCl) were deposited intraluminally to determine the exte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Abel E,Ekman T,Warnhammar E,Hultborn R,Jennische E,Lange S

    更新日期:2005-09-01 00:00:00

  • Role of gastric emptying in functional dyspepsia: a scintigraphic study of 94 subjects.

    abstract::Many physiological factors can alter gastric emptying, and the role of gastric emptying in functional dyspepsia is controversial. The aim of this study was to assess the effects of different factors (age, sex, the degree of dyspeptic and irritable bowel symptoms, lactase deficiency, smoking habits, the use of antiinfl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Koskenpato J,Kairemo K,Korppi-Tommola T,Färkkilä M

    更新日期:1998-06-01 00:00:00

  • Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles.

    abstract::Nos2 knockout mice were compared to wild-type mice for susceptibility to colitis in response to a diet supplemented with deoxycholate, a bile acid increased in the colon of individuals on a high-fat diet. Wild-type mice fed a fat-related diet, supplemented with 0.2% DOC, develop colonic inflammation associated with in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bernstein H,Holubec H,Bernstein C,Ignatenko NA,Gerner E,Dvorak K,Besselsen D,Blohm-Mangone KA,Padilla-Torres J,Dvorakova B,Garewal H,Payne CM

    更新日期:2007-03-01 00:00:00

  • Mechanical properties and collagen content differ between isolated guinea pig duodenum, jejunum, and distal ileum.

    abstract::We compared the stress-strain distributions obtained from isolated segments of the guinea pig duodenum, jejunum, and distal ileum, and the relation between the elastic properties and the collagen content. The segments were immersed in Krebs-Ringer solution containing 10(-2) M MgCl2 to abolish contractile activity. Ste...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Storkholm JH,Villadsen GE,Jensen SL,Gregersen H

    更新日期:1998-09-01 00:00:00

  • Balloon-Occluded Retrograde Transvenous Obliteration (BRTO) for Treatment of Gastric Varices: Review and Meta-Analysis.

    abstract:AIM:To perform a systematic review and meta-analysis of the effectiveness and complications of BRTO for gastric varices. MATERIALS AND METHODS:A systematic review was performed to identify relevant articles. Inclusion criteria were applied to select studies with at least ten patients with acute bleeding or at-risk gas...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审


    authors: Park JK,Saab S,Kee ST,Busuttil RW,Kim HJ,Durazo F,Cho SK,Lee EW

    更新日期:2015-06-01 00:00:00

  • Comparison of effects of nifedipine, propantheline bromide, and the combination on esophageal motor function in normal volunteers.

    abstract::Both intracellular calcium ions and neural input are important in esophageal smooth muscle contraction. The aim of this study was to compare the effects of well-tolerated doses of the calcium-channel blocker, nifedipine (20 mg sublingually/buccally) with the anticholinergic, propantheline bromide (15 mg orally) and th...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hongo M,Traube M,McCallum RW

    更新日期:1984-04-01 00:00:00

  • Disseminated aseptic abscesses associated with Crohn's disease: a new entity?

    abstract::Our purpose is to describe seven cases of disseminated aseptic abscesses with regard to clinical, biological, radiological, and histological information, treatment, and outcome. Data were collected on seven Caucasian patients who had proven sterile deep abscesses diagnosed in French university hospitals. The onset of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: André M,Aumaître O,Papo T,Kemeny JL,Vital-Durand D,Rousset H,Ninet J,Pointud P,Charlotte F,Godeau B,Schmidt J,Marcheix JC,Piette JC

    更新日期:1998-02-01 00:00:00

  • Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats.

    abstract::Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lee HS,Jung KH,Park IS,Kwon SW,Lee DH,Hong SS

    更新日期:2009-04-01 00:00:00

  • Ampulla of Vater/duodenal wall spasm diagnosed by antroduodenal manometry.

    abstract::Patients with chronic epigastric to right upper quadrant pain are often considered to have gallbladder of sphincter of Oddi dysfunction, but standard tests are nondiagnostic. In 62 consecutive patients with this compliant undergoing antroduodenal manometry, we correlated a change on duodenal motility with spasm of the...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Koussayer T,Ducker TE,Clench MH,Mathias JR

    更新日期:1995-08-01 00:00:00

  • Proton Pump Inhibitors Independently Protect Against Early Allograft Injury or Chronic Rejection After Lung Transplantation.

    abstract:BACKGROUND:Acid reflux has been associated with poor outcomes following lung transplantation. Unlike surgical fundoplication, the role of noninvasive, pharmacologic acid suppression remains uncertain. AIMS:To assess the relationship between post-transplant acid suppression with proton pump inhibitors (PPI) or histamin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lo WK,Goldberg HJ,Boukedes S,Burakoff R,Chan WW

    更新日期:2018-02-01 00:00:00

  • Hepatitis B vaccine response before and after transplantation in 55 extrahepatic biliary atresia children.

    abstract::Fifty-five children with cholestatic cirrhosis due to extrahepatic biliary atresia received a course of hepatitis B vaccine. Forty-seven received a plasma-derived vaccine and eight a recombinant vaccine. Antibody determination was evaluated before and after liver transplantation in 30 patients. Twenty-five additional ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sokal EM,Ulla L,Otte JB

    更新日期:1992-08-01 00:00:00

  • Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.

    abstract:BACKGROUND:Adenosine deaminase acting on RNA 1 (ADAR1) is known to mediate deamination of adenosine-to-inosine through binding to double-stranded RNA, the phenomenon known as RNA editing. Currently, the function of ADAR1 in gastric cancer is unclear. AIMS:This study was aimed at investigating RNA editing-dependent and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cho CJ,Jung J,Jiang L,Lee EJ,Kim DS,Kim BS,Kim HS,Jung HY,Song HJ,Hwang SW,Park Y,Jung MK,Pack CG,Myung SJ,Chang S

    更新日期:2018-07-01 00:00:00

  • Long-term follow-up of 2529 patients reveals gastric ulcers rarely become malignant.

    abstract::To examine the relationship between peptic ulcer and gastric cancer, we investigated 2529 patients with peptic ulcer diagnosed from 1963 to 1975. During the follow-up period of 9-23 years, we found 38 in whom gastric cancer developed or who died of gastric cancer. Included were nine in whom gastric cancer was detected...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lee S,Iida M,Yao T,Shindo S,Okabe H,Fujishima M

    更新日期:1990-06-01 00:00:00