Durability of antiviral response in HBeAg-positive chronic hepatitis B patients who maintained virologic response for one year after lamivudine discontinuation.

Abstract:

:The purpose of this study is to determine the long-term relapse rate and associated risk factors in HBeAg-positive chronic hepatitis B (CHB) patients who had maintained virologic response (VR) for 1 year after lamivudine (LMV) discontinuation. We enrolled 55 treatment-naive HBeAg-positive CHB patients who achieved and maintained VR until 1 year after LMV discontinuation. Delayed relapse was defined as an elevation of HBV DNA after sustained VR for 1 year. During follow-up, 16 of 55 patients (29%) showed delayed relapse. Beginning 1 year after LMV discontinuation, the cumulative rates of relapse after 2 and 4 years were 29 and 44%, respectively. In multivariate analysis, age (P = 0.029) and >2,000 copies/ml HBV DNA 3 months after LMV discontinuation (P = 0.047) were significant predictors of delayed relapse. Delayed relapse is not infrequent, even in patients who maintain VR for 1 year after LMV discontinuation. Therefore, LMV maintenance therapy might be considered in HBeAg-positive CHB patients who achieve VR.

journal_name

Dig Dis Sci

authors

Kim JH,Lee SJ,Joo MK,Kim CH,Choi JH,Jung YK,Yim HJ,Yeon JE,Park JJ,Kim JS,Bak YT,Byun KS

doi

10.1007/s10620-008-0508-3

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

1572-7

issue

7

eissn

0163-2116

issn

1573-2568

journal_volume

54

pub_type

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