Influence of spasmolytic analgesics on motility of sphincter of Oddi.

Abstract:

:The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, while N-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.

journal_name

Dig Dis Sci

authors

Brandstätter G,Schinzel S,Wurzer H

doi

10.1007/BF02088751

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

1814-8

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

41

pub_type

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