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Measurement of segmental transit through the gut in man. A novel approach by the biomagnetic method.

Abstract：

:The techniques commonly used to evaluate the transit of contents through the gut feature some limitations for being either inaccurate, invasive, inconvenient, or potentially dangerous for the subjects. Aim of this study was to establish a safe, noninvasive and accurate technique for the measurement of segmental oroanal transit time. We localized an orally ingested magnetic marker by means of a biomagnetic instrumentation that allows us to identify in a three-dimensional pattern the position of a biomagnetic source inside the body. The biomagnetic localizations were compared with the anatomical data obtained by magnetic resonance imaging investigations. The study was performed in 12 healthy subjects, and scans were taken every hour up to the arrival of the marker into the cecum; thereafter, scans were taken every 4 hr up to the elimination of the marker. In 99% of the isofield maps obtained from each field scan, the marker was localized within the bowel walls. The mean oroanal transit time was 56 +/- 5 hr, the mouth-to-cecum transit time was 13 +/- 1.7 hr, and the total colonic transit time was 43.5 +/- 5 hr (mean +/- SEM). Segmental colon transit did not show major differences among the regions considered, although most of the time was spent in the right colon. In fact, a good correlation was found between transit time through the right colon and oroanal and total colonic transit (r = 0.77, P < 0.02, r = 0.79, P < 0.02 respectively). In conclusion, this method might be a safe alternative to the techniques presently used in the clinical setting for the measurement of intestinal transit.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Basile M,Neri M,Carriero A,Casciardi S,Comani S,Del Gratta C,Di Donato L,Di Luzio S,Macri MA,Pasquarelli A

doi

10.1007/BF01296499

subject

Has Abstract,Author List Incomplete

pub_date

1992-10-01 00:00:00

pages

1537-43

issue

10

eissn

0163-2116

issn

1573-2568

journal_volume

37

pub_type

杂志文章

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