Abstract:
:Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investigate the effect of various types of water-soluble dietary fiber on colonic mucus in a rat model of spastic constipation. Oral administration of 1.5 mg/day of carrageenan and chondroitin sulfate increased the fecal excretion, epithelial mucin production, thickness of the mucous layer, and amount of luminal mucus in loperamide-administered rats. Sodium alginate, 5 mg/day, thickened the mucus layer at the fecal surface. Cellulose, 5 mg/day, increased the fecal excretion but not the colonic mucus. Carrageenan, chondroitin sulfate, and sodium alginate, but not cellulose, increased colonic mucus in the rat model of spastic constipation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Shimotoyodome A,Meguro S,Hase T,Tokimitsu I,Sakata Tdoi
10.1023/a:1010644021888subject
Has Abstractpub_date
2001-07-01 00:00:00pages
1482-9issue
7eissn
0163-2116issn
1573-2568journal_volume
46pub_type
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