Abstract：
:Up to 60% of patients with IBS have lowered perception thresholds in the rectum to balloon distension. The current study sought to test the hypothesis that IBS patients with normal perception thresholds in the rectum show hypersensitivity of afferent pathways in the sigmoid colon. Eleven healthy normal subjects and eight IBS patients with normal rectal perception thresholds underwent a balloon distension protocol in the sigmoid and rectum. Discomfort thresholds, receptive relaxation, compliance, and referral patterns were measured. Although IBS patients had significantly lower discomfort thresholds in the sigmoid when measured as volume, pressure, and wall tension, thresholds were similar to normals. Receptive relaxation and dynamic compliance were significantly decreased in IBS patients in the sigmoid. Referral patterns were similar during sigmoid distention in IBS patients in comparison to normals. Despite normal perception thresholds in rectum and sigmoid, IBS patients show evidence for alterations in rectosigmoid afferent mechanisms. In the sigmoid, this is seen in the form of reduced reflex relaxation and compliance and in the rectum in the form of altered viscerosomatic referral.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Lembo T,Munakata J,Naliboff B,Fullerton S,Mayer EAdoi
10.1023/a:1018817132213subject
Has Abstractpub_date
1997-06-01 00:00:00pages
1112-20issue
6eissn
0163-2116issn
1573-2568journal_volume
42pub_type
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318419
更新日期：1984-09-01 00:00:00
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308196
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Digestive diseases and sciences
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更新日期：1993-11-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：1994-01-01 00:00:00
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journal_title：Digestive diseases and sciences
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doi：10.1007/BF02064968
更新日期：1995-04-01 00:00:00
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journal_title：Digestive diseases and sciences
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更新日期：2002-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-0145-2
更新日期：2008-08-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 共识发展会议,杂志文章,评审
doi：10.1007/BF02285194
更新日期：1995-07-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308344
更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10620-006-3126-y
更新日期：2006-02-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2710-x
更新日期：2005-06-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296008
更新日期：1992-09-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295996
更新日期：1986-09-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：1994-07-01 00:00:00
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更新日期：2018-03-01 00:00:00
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更新日期：2015-07-01 00:00:00
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更新日期：2010-06-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
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更新日期：2004-06-01 00:00:00
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