Role of hypothermia in the production of gastric ulcers in a rat spinal cord transection model.

Abstract:

:An association between hypothermia and gastric ulceration has been reported in rats in cervical cord section and in restraint models. The present study was designed to determine this relationship in cervical and in lumbar cord sectioned Sprague-Dawley rats. Ambient temperatures were varied by placing the sectioned animals in a room-temperature (23 degrees), incubator (28 degrees), or cold-room (4 degrees) environment for 8 hr. Rectal temperatures were recorded at the beginning and end of all experimental conditions. The endpoint of each study was the presence or absence of ulcers on naked eye examination. The length of each ulcer was measured and the lengths were totaled for each stomach. Cervical section rats became hypothermic at room temperature and developed extensive linear ulcerations of the glandular stomachs. A warm environment reduced both the decrement in core temperature and the degree of ulceration. Lumbar section rats only became hypothermic when exposed to cold and then developed significant ulcers. Hypothermia plays an important role in ulcerogenesis, but other factors are also important since not all the hypothermic rats developed ulcers and exposure of sham-operated rats to cold led to occasional pinpoint ulcer formation in spite of maintenance of a stable core temperature.

journal_name

Dig Dis Sci

authors

Sigman HH,Gillich A

doi

10.1007/BF01307976

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

60-4

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

26

pub_type

杂志文章
  • Correction to: Relationship Between Abdominal Symptoms and Fructose Ingestion in Children with Chronic Abdominal Pain.

    abstract::The original version of this article unfortunately contained an error in a couple of reference citation in Discussion Section, paragraph 6. The reference citation number should be changed from [6] to [9] in the below sentences so that it reads. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10620-018-5046-z

    authors: Hammer V,Hammer K,Memaran N,Huber WD,Hammer K,Hammer J

    更新日期:2018-06-01 00:00:00

  • Durability of antiviral response in HBeAg-positive chronic hepatitis B patients who maintained virologic response for one year after lamivudine discontinuation.

    abstract::The purpose of this study is to determine the long-term relapse rate and associated risk factors in HBeAg-positive chronic hepatitis B (CHB) patients who had maintained virologic response (VR) for 1 year after lamivudine (LMV) discontinuation. We enrolled 55 treatment-naive HBeAg-positive CHB patients who achieved and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0508-3

    authors: Kim JH,Lee SJ,Joo MK,Kim CH,Choi JH,Jung YK,Yim HJ,Yeon JE,Park JJ,Kim JS,Bak YT,Byun KS

    更新日期:2009-07-01 00:00:00

  • Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon.

    abstract::It is known that the muscularis mucosae and mucosa are not pharmacologically homogeneous throughout the rat colon. The aim of this study was to simultaneously characterize all three neurokinin (NK) receptors in the muscularis mucosae and mucosa along the length of the rat colon. Strips of proximal, mid, and distal col...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3163-6

    authors: Appleyard CB,Morales M,Percy WH

    更新日期:2006-03-01 00:00:00

  • Thyroid, renal, and hepatic function tests following cholecystography with high-dose contrast agents.

    abstract::Serum biochemical tests were observed for about three weeks following oral cholecystography with fractionated high doses (6 g) of iopanoic acid (Telepaque) or sodium ipodate (Biloptin) in 24 and 29 patients, respectively. Both agents produced similar effects. No significant changes were seen in renal or hepatic functi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308063

    authors: Reiner RG,Lawson MJ,Marshall J,Read TR,Beng CG,Davies GT,Tucker WG,Grant AK

    更新日期:1980-05-01 00:00:00

  • Nutritional implications of chronic dyspepsia in childhood.

    abstract::Chronic dyspepsia is common in children. However, the association of individual predominant symptoms with gastric emptying and their impact on nutritional status are poorly defined. We therefore studied 31 children (mean age 11 years, 14 boys) with chronic dyspepsia and classified their predominant symptoms (PS) by th...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1013299016879

    authors: Papadopoulou A,Vazeou A,Siafakas C,Papadimitriou A,Bartsocas C

    更新日期:2002-01-01 00:00:00

  • Factors affecting methane production in humans. Gastrointestinal diseases and alterations of colonic flora.

    abstract::Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297052

    authors: Peled Y,Weinberg D,Hallak A,Gilat T

    更新日期:1987-03-01 00:00:00

  • Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.

    abstract:BACKGROUND:Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM. AIMS:The purpose of the present s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05577-8

    authors: Uchida M,Kobayashi O,Yoshida M,Miwa M,Miura R,Saito H,Nagakura Y

    更新日期:2019-09-01 00:00:00

  • Triolein breath test of fat absorption in patients with chronic liver disease.

    abstract::We have compared the [14C]triolein breath test for fat malabsorption with fecal fat excretion corrected for marker pellet recovery in 23 subjects with chronic liver disease. The breath test identified 15 of the 17 subjects with abnormal fecal fat excretion (sensitivity 88%). However, four of the six subjects with norm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01798358

    authors: Absalom SR,Saverymuttu SH,Maxwell JD,Levin GE

    更新日期:1988-05-01 00:00:00

  • Concurrent inflammatory bowel disease and myelodysplastic syndrome: report of nine new cases and a review of the literature.

    abstract::Nine patients with concurrent myelodysplastic syndrome (MDS) and inflammatory bowel disease (IBD) were examined. Median age at diagnosis of these patients was similar to the usual age of patients at diagnosis of IBD only. There was a strong predominance of Crohn's disease (seven of nine cases), with an unusually high ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-007-0090-0

    authors: Wang Z,Zhou Y,Liu Y

    更新日期:2008-07-01 00:00:00

  • Effect of esomeprazole 40 mg vs omeprazole 40 mg on 24-hour intragastric pH in patients with symptoms of gastroesophageal reflux disease.

    abstract::Maintenance of intragastric pH > 4 is vital for effective management of gastroesophageal reflux disease (GERD). Esomeprazole 40 mg, the first proton pump inhibitor developed as an optical isomer, demonstrates improved acid inhibition over omeprazole 20 mg. Our aim was to compare esomeprazole 40 mg with omeprazole 40 m...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1023/a:1015009300955

    authors: Röhss K,Hasselgren G,Hedenström H

    更新日期:2002-05-01 00:00:00

  • Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging. Role of capsaicin-sensitive sensory neurons.

    abstract::We examined the influences of aging on gastric damage and gastric mucosal blood flow (GMBF) responses induced by acid back-diffusion, following the barrier disruption, and investigated the relation of capsaicin-sensitive sensory nerves to these changes. Male Fischer rats 3, 13, and 24 months old were used. Under ureth...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02093826

    authors: Miyake H,Inaba N,Kato S,Takeuchi K

    更新日期:1996-02-01 00:00:00

  • Novel expression and regulation of gastrin gene in human ovarian cancer cell line, SW626.

    abstract::Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could b...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018846311239

    authors: Kim HJ,Evers BM,Banker NA,Greeley GH Jr,Hellmich MR,Thompson JC,Townsend CM Jr

    更新日期:1998-07-01 00:00:00

  • Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers.

    abstract::The effects of the water-soluble and delayed-release formulations of a nonsteroidal antiinflammatory drug, diclofenac, on the healing of gastroduodenal mucosal lesions were compared in a double-blind, double cross-over, placebo-controlled endoscopic study conducted in 14 healthy volunteers. Severe endoscopic lesions (...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01297025

    authors: Stadler P,Armstrong D,Margalith D,Saraga E,Stolte M,Lualdi P,Mautone G,Blum AL

    更新日期:1991-05-01 00:00:00

  • Prevalence of hypothyroidism in nonalcoholic fatty liver disease.

    abstract:BACKGROUND:A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association. AIM:The purpose of this study was to determine the prevalence of hypothyroidism in a ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-2006-2

    authors: Pagadala MR,Zein CO,Dasarathy S,Yerian LM,Lopez R,McCullough AJ

    更新日期:2012-02-01 00:00:00

  • Dabigatran Reduces Liver Fibrosis in Thioacetamide-Injured Rats.

    abstract:BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5311-1

    authors: Lee KC,Hsu WF,Hsieh YC,Chan CC,Yang YY,Huang YH,Hou MC,Lin HC

    更新日期:2019-01-01 00:00:00

  • Experimental studies to estimate the intestinal viability in a rat strangulated ileus model using a dielectric parameter.

    abstract::This study aimed at establishment of adequate evaluation of intestinal viability before release of the strangulated intestine by measuring electrical properties. In rats a 20-cm segment of the distal ileum and mesentery was strangulated. The intestine was strangulated for 0, 2, 15, 45, 90, and 120 min. The conductance...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000026310.71607.4c

    authors: Matsuo H,Hirose H,Mori Y,Takagi H,Iwata H,Yamada T,Sakamoto K,Yasumura M

    更新日期:2004-04-01 00:00:00

  • Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat.

    abstract::The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02090369

    authors: Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

    更新日期:1994-10-01 00:00:00

  • Pulmonary involvement in chronic pancreatitis.

    abstract::Although the association between acute pancreatitis and pleuropulmonary damage is well documented, so far no information on lung function in patients with chronic pancreatitis is available. In this study functional, radiological, and clinical investigations have been carried out in 42 patients affected by chronic calc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01312477

    authors: Masoero G,Spinaci S,Arossa W,Andriulli A,Gaia E,De Pretis G,Dobrilla G,De la Pierre M

    更新日期:1984-10-01 00:00:00

  • Gastroduodenal mucosal prostaglandin generation in patients with Helicobacter pylori before and after treatment with bismuth subsalicylate.

    abstract::To determine whether Helicobacter pylori has an effect on gastroduodenal mucosal prostaglandin generation, mucosal biopsies were obtained from the gastric body, antrum, and duodenal bulb of 30 patients who were undergoing upper gastrointestinal endoscopy for clinical indications. One biopsy from the gastric body and o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01298870

    authors: Avunduk C,Suliman M,Gang D,Polakowski N,Eastwood GL

    更新日期:1991-04-01 00:00:00

  • Fecal clearance of alpha1-antitrypsin with lansoprazole can detect protein-losing gastropathy.

    abstract::Detecting plasma protein loss from the stomach is quite difficult by measuring fecal alpha1-AT clearance because alpha1-AT is rapidly destroyed in the gastric juice at values below pH 3. We examined protein loss from the stomach using fecal alpha1-AT clearance with lansoprazole, a proton pump inhibitor. A 38-year-old ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026625308572

    authors: Takeda H,Nishise S,Furukawa M,Nagashima R,Shinzawa H,Takahashi T

    更新日期:1999-11-01 00:00:00

  • Recalibrating the Child-Turcotte-Pugh Score to Improve Prediction of Transplant-Free Survival in Patients with Cirrhosis.

    abstract:BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4239-6

    authors: Kaplan DE,Dai F,Skanderson M,Aytaman A,Baytarian M,D'Addeo K,Fox R,Hunt K,Knott A,Mehta R,Pedrosa M,Pocha C,Valderrama A,Taddei T,VOCAL Study Group.

    更新日期:2016-11-01 00:00:00

  • Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit.

    abstract:INTRODUCTION:Assessment of whole gut transit, by radio-opaque markers or scintigraphy, is used to evaluate patients with constipation for slow gastrointestinal transit. Wireless capsule motility, using the SmartPill GI monitoring system, samples and transmits intraluminal pH, pressure, and temperature data from a capsu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0899-9

    authors: Maqbool S,Parkman HP,Friedenberg FK

    更新日期:2009-10-01 00:00:00

  • Diverticulitis in Morbidly Obese Adults: A Rise in Hospitalizations with Worse Outcomes According to National US Data.

    abstract:BACKGROUND AND AIMS:Obesity is a known risk factor for diverticulitis. Our objective was to examine the less investigated impact of morbid obesity (MO) on admissions and clinical course of diverticulitis in a US representative database. METHODS:We retrospectively queried the 2010-2014 Nationwide Readmission Database t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-06002-w

    authors: Patel K,Krishna SG,Porter K,Stanich PP,Mumtaz K,Conwell DL,Clinton SK,Hussan H

    更新日期:2020-09-01 00:00:00

  • Dopamine-induced migrating myoelectrical complex-like activity in human duodenum.

    abstract::The effect of dopamine on human gastric and small intestinal interdigestive motility was investigated in 12 subjects. Intestinal motility was recorded by means of a four-lumen polyvinyl probe with four open tips located 15 cm apart, continuously perfused with distilled water. In each subject during the same study, aft...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01311668

    authors: Marzio L,Neri M,Di Giammarco AM,Cuccurullo F,Lanfranchi GA

    更新日期:1986-04-01 00:00:00

  • Increased Prevalence of Obesity and Metabolic Syndrome in Patients with Alcoholic Fatty Liver Disease.

    abstract:BACKGROUND AND AIMS:Obesity and diabetes are risk factors for advanced alcoholic liver disease, and both are components of the metabolic syndrome. We aimed to assess the prevalence of metabolic syndrome and its components in a contemporary US cohort of adults with alcoholic liver disease and compare it to a historic co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06056-1

    authors: Singh A,Amin H,Garg R,Gupta M,Lopez R,Alkhouri N,MCCullough A

    更新日期:2020-11-01 00:00:00

  • COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells.

    abstract::Growth factors upregulate cyclooxygenase-2 (COX-2) expression and extracellular signal-regulated kinase (ERK) activity, yet little is known regarding the interaction between COX-2 and ERK in terms of mitogenic signal transduction pathways in gastric epithelial cells. Therefore, we examined the role of COX-2 in EGF-ind...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000007860.87503.09

    authors: Sasaki E,Tominaga K,Watanabe T,Fujiwara Y,Oshitani N,Matsumoto T,Higuchi K,Tarnawski AS,Arakawa T

    更新日期:2003-12-01 00:00:00

  • Total body weight loss of ≥ 10 % is associated with improved hepatic fibrosis in patients with nonalcoholic steatohepatitis.

    abstract:BACKGROUND:Given the rising epidemics of obesity and metabolic syndrome, nonalcoholic steatohepatitis (NASH) is now the most common cause of liver disease in the developed world. Effective treatment for NASH, either to reverse or prevent the progression of hepatic fibrosis, is currently lacking. AIM:To define the pred...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3380-3

    authors: Glass LM,Dickson RC,Anderson JC,Suriawinata AA,Putra J,Berk BS,Toor A

    更新日期:2015-04-01 00:00:00

  • PRKCSH genetic mutation was not found in Taiwanese patients with polycystic liver disease.

    abstract::Polycystic liver disease (PCLD) without polycystic kidney is infrequent in clinical setting. Family clustering is found in patients with PCLD, and it is inherited in an autosomal dominant fashion. Through positional cloning in North America and Europe (mostly in Dutch and Finnish descents), mutations in PRKCSH gene on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0776-6

    authors: Yang AM,Shih SC,Chu CH,Wang TE,Yang WS

    更新日期:2010-03-01 00:00:00

  • Risk factors for small bowel cancer in Crohn's disease.

    abstract::Suspected risk factors for adenocarcinoma of the small bowel in Crohn's disease include surgically excluded small bowel loops, chronic fistulous disease, and male sex. Review of all seven University of Chicago cases failed to confirm any suspected risk factor. A case-control study was performed to identify possible al...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296557

    authors: Lashner BA

    更新日期:1992-08-01 00:00:00

  • Duodenal ulcer. Incidence, risk factors, and predictive value of plasma pepsinogen.

    abstract::In 1958 the Yale freshman class gave blood samples as part of a study intended to determine the predictive value of plasma pepsinogen (PP) for the subsequent development of duodenal ulcer (DU). We report a long-term follow-up of this cohort. A self-administered questionnaire designed to ascertain information about the...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296515

    authors: Chuong JJ,Fisher RL,Chuong RL,Spiro HM

    更新日期:1986-11-01 00:00:00