Abstract:
:Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could be detected in ovarian cancer cell lines, (2) if functional gastrin releasing peptide receptors (GRP-R) are present, and (3) whether gastrin gene expression is altered by GRP. Five ovarian cancer cell lines (SW626, OVCA 420, OVCA 429, OVCA 432, and OVCA 433) were analyzed. We identified gastrin gene and peptide expression in the SW626 cell line but not in the OVCA lines. SW626 cells express a functional GRP-R that is correctly coupled to the Ca2+ signaling pathway. Treatment of SW626 cells with bombesin, the amphibian equivalent of GRP, inhibited expression of the gastrin gene in a time- and dose-dependent fashion. The SW626 ovarian cancer cell line will provide a useful model to further define regulation and expression of both the gastrin gene and peptide in ectopic (nongastrointestinal) tissues.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Kim HJ,Evers BM,Banker NA,Greeley GH Jr,Hellmich MR,Thompson JC,Townsend CM Jrdoi
10.1023/a:1018846311239subject
Has Abstractpub_date
1998-07-01 00:00:00pages
1465-73issue
7eissn
0163-2116issn
1573-2568journal_volume
43pub_type
杂志文章abstract::Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010792031910
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND AIMS:To determine the value of contrast-enhanced endoscopic ultrasound (CE-EUS) for differentiation of pancreatic cystic neoplasms (PCNs). METHODS:From April 2015 to December 2017, 82 patients were enrolled in this study. All patients were confirmed to have PCNs by surgical pathology. Prior to surgery, ...
journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-019-05718-z
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abstract:BACKGROUND:Proton pump inhibitors (PPIs) are widely prescribed to treat gastrointestinal diseases. However, concerns have been raised regarding their long-term use. Gastric acid suppression may decrease iron absorption, and it remains uncertain whether iron-deficiency anemia may result from chronic PPI therapy. AIMS:W...
journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-011-1589-y
更新日期:2011-08-01 00:00:00
abstract::This review article deals with the clinical value of capsule endoscopy for visualization of the colon. Since its introduction in 2006, the colon capsule endoscopy underwent major technological improvements. The improved performance of colon capsule endoscopy is reviewed based on three multicenter prospective studies. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3534-y
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01538066
更新日期:1989-09-01 00:00:00
abstract::The objective of this study was to investigate the effects of types of dialysis treatments on hepatitis C virus infection and the epidemiologic properties of hepatitis C virus (HCV) infection at three Baskent University hospitals, in Ankara, Adana, and Izmir, Turkey, in 655, 326, and 118 patients with end-stage renal ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
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abstract::This study set out to evaluate the effects of dietary fiber on cancer development in the large bowel under in vivo experimental conditions as similar as possible to those under which this cancer develops in vivo in humans. Forty-eight Sprague-Dawley rats were divided into three groups that were fed either a nonfiber d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1015310211821
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3895-2
更新日期:2016-02-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4618-7
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-019-05560-3
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3149-8
更新日期:2014-09-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0889-y
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB). Their detection has been limited by the inability to endoscopically examine the entire small intestine. This has changed with the introduction of capsule endoscopy (CE) and double balloon enteroscopy (D...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-007-0110-0
更新日期:2008-08-01 00:00:00
abstract::Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We explored Msi-1 expression and its potential implications in the human stomach. Reverse transcription-PCR revea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9858-5
更新日期:2008-02-01 00:00:00
abstract::Mannitol (molecular weight 182), lactulose (342), and polyethylene glycol 400 (range 242-550) absorption was studied in 25 controls, 22 untreated celiacs, and 13 treated celiacs. Untreated celiacs absorbed less mannitol and more lactulose than controls. Absorption of higher as well as lower molecular-weight polyethyle...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318423
更新日期:1984-09-01 00:00:00
abstract::The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial he...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9595-1
更新日期:2007-05-01 00:00:00
abstract::Gastritis, an inflammatory state in gastric mucosa, can be induced experimentally in various ways. The present study considered the iodoacetamide model (Iodo). Omega-3 fatty acids (fish oil), black seed oil, and curcuminoids (natural products) in addition to omeprazole (synthetic proton-pump inhibitor) were tested. Su...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0246-6
更新日期:2008-07-01 00:00:00
abstract::To understand whether direct transmission of H. pylori occurs from infected mouse to noninfected mouse, the system using a mouse model we developed previously was tested. Six nude mice were challenged with H. pylori inocula; one group consisted of one challenged nude mouse 1 week after inoculation raised with four non...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2710-x
更新日期:2005-06-01 00:00:00
abstract::Hepatic steatosis is a recognized feature of hepatitis C viral infection, particularly in genotype 3. The demographics and the associations contributing to moderate to severe steatosis in genotype 3 are not very well studied. The aim of this study is to determine the demographics and association of steatosis with fibr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000011597.92851.56
更新日期:2004-01-01 00:00:00
abstract::The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308330
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND AND AIMS:To study pre-operative and peri-operative course and outcome on follow up after pancreaticoduodenenctomy (PD) for resectable pancreatic cancer amongst patients receiving self-expanding metal stents (SEMS). METHODS:Medical charts of consecutively reviewed patients (2005-2009) with resectable pancrea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1815-7
更新日期:2011-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297143
更新日期:1991-07-01 00:00:00
abstract::Manometry is considered the gold standard for evaluating sphincter of Oddi dysfunction. It has recently been demonstrated that the ultrasound (US) secretin test proposed a few years ago as a noninvasive test for the study of sphincter of Oddi dysfunction yields a substantial percentage of pathological findings in pati...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026658618605
更新日期:1999-02-01 00:00:00
abstract::The significance of hyperplastic polyps of the gastric antrum in anemic patients with suspected gastrointestinal bleeding has not been determined. The aim of this study is to evaluate the prevalence and prognosis of such polyps in this patient group. Clinical records of patients referred to our endoscopy lab from Nove...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9182-5
更新日期:2007-01-01 00:00:00
abstract::Growth factors, such as epidermal growth factor (EGF), are known to protect upper gut mucosa against irritants and to enhance healing of ulcerative lesions in animal models. A number of salivary growth factors are found in human saliva. The aim of this study was to determine if salivary growth factors and cytokines ar...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005615703009
更新日期:2001-03-01 00:00:00
abstract::As recently described, Ki-1 anaplastic large cell lymphoma is a distinctive subtype of non-Hodgkin's lymphoma. We report a Ki-1 anaplastic large cell lymphoma of the duodenum in a 62-year-old man. He received modified CHOP therapy and was in complete remission at 18 months. To our knowledge, this is the first report o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF02100125
更新日期:1996-12-01 00:00:00
abstract::Hepatitis B virus (HBV) DNA integrates into the host DNA and shows a series of potentially oncogenetic properties, but HBV is not an acutely transforming virus, because HCC develops decades after infection. Other factors, namely cirrhosis, inflammation, alcohol intake, and viral superinfections, could promote the onco...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297460
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. AIMS:To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary functi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4750-4
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To prospectively evaluate the frequency of upper gastrointestinal symptoms and associated disorders in morbidly obese patients with endoscopy and histology prior to their gastric bypass surgery in comparison with age- and sex-matched nonobese control subjects. METHODS:All patients who were scheduled to under...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0485-6
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Liver fibrosis stage determines risk of morbidity and mortality from chronic hepatitis C virus (HCV) infection. Prior data have shown long-term reversal of liver fibrosis, measured by vibration-controlled transient elastography (VCTE), in patients successfully treated with interferon-based therapies. AIM:Ou...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4749-x
更新日期:2018-02-01 00:00:00