Cycling, a manometric phenomenon due to repetitive episodes of gastroesophageal reflux and clearance.


:We studied intraesophageal pressure changes in patients with symptoms of gastroesophageal reflux and an abnormal 24-hr pH monitoring record (N = 52). Our method was simultaneous esophageal manometry and pH monitoring. We observed a three-component esophageal manometric sequence (EMS). When this sequence recurred over and over, we termed this phenomenon "cycling." We found cycling in 35% of the patients (18/52). Those with cycling had lower basal LES pressures, more acid exposure, and an increased incidence of endoscopic esophagitis. That cycling resulted from repeated reflux events and their esophageal clearance was documented by scintigraphy during simultaneous manometry and pH monitoring (N = 7 patients). Cycling was found on the routine esophageal manometry record of 25% of symptomatic patients (N = 112) with an abnormal 24-hr pH score. In conclusion, cycling represents an esophageal manometric phenomenon due to repetitive reflux events. Its recognition during esophageal manometry may denote a severe reflux diathesis.


Dig Dis Sci


Shay SS,Eggli D,Oliver G,Peura DA,Johnson LF




Has Abstract


1989-09-01 00:00:00












  • Effects of ethanol on cytoplasmic peptidases of the jejunal epithelial cell of the hamster.

    abstract::Although ethanol has been reported to inhibit intestinal amino acid absorption and peptide hydrolysis by the brush border membrane (BBM) peptidases, its effect on other events of protein absorption (such as peptide hydrolysis by cytosol peptidases, absorption of peptides across the BBM, and translocation of amino acid...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Dinda PK,Beck IT

    更新日期:1984-01-01 00:00:00

  • Jejunal perforation possibly induced by slow-release potassium in a patient with Crohn's disease.

    abstract::A case of small bowel ulceration and perforation possibly due to therapy with Klotrix in a patient with Crohn's disease is presented. Following emergent surgery with creation of a diverting loop jejunostomy, subsequent reestablishment of intestinal continuity was carried out with excellent clinical results. Gastrointe...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Brower RA

    更新日期:1986-12-01 00:00:00

  • Diverticulosis and the risk of interval colorectal cancer.

    abstract:BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subg...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cooper GS,Xu F,Schluchter MD,Koroukian SM,Barnholtz Sloan JS

    更新日期:2014-11-01 00:00:00

  • Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats.

    abstract::The Wnt/beta-catenin pathway has been proposed as promoting intestinal stem cell division. Wnt ligands activate cytoplasmic beta-catenin and increase nuclear translocation of beta-catenin that binds to the Tcf-4 transcription factor. The aim of this study was to investigate beta-catenin expression in the stem cell reg...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Camac KS,Thompson FM,Cummins AG

    更新日期:2007-05-01 00:00:00

  • Capsule endoscopy for obscure GI bleeding: therapeutic yield of follow-up procedures.

    abstract::Positive findings on capsule endoscopy (CE) often prompt a follow-up procedure with therapeutic intent. Our purpose was to review the therapeutic yield of subsequent procedural interventions based on positive CE findings. The medical records of all patients who underwent CE between June 2002 and February 2005 for obsc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Baichi MM,Arifuddin RM,Mantry PS

    更新日期:2007-05-01 00:00:00

  • Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis.

    abstract:BACKGROUND:Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM:To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS:W...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bhandari S,Venkatesan T

    更新日期:2017-08-01 00:00:00

  • Disseminated aseptic abscesses associated with Crohn's disease: a new entity?

    abstract::Our purpose is to describe seven cases of disseminated aseptic abscesses with regard to clinical, biological, radiological, and histological information, treatment, and outcome. Data were collected on seven Caucasian patients who had proven sterile deep abscesses diagnosed in French university hospitals. The onset of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: André M,Aumaître O,Papo T,Kemeny JL,Vital-Durand D,Rousset H,Ninet J,Pointud P,Charlotte F,Godeau B,Schmidt J,Marcheix JC,Piette JC

    更新日期:1998-02-01 00:00:00

  • Bombesin prevents gastric injury in the rat: role of gastrin.

    abstract::Bombesin or gastrin-releasing peptide prevents gastric injury by an unknown mechanism. Since exogenous gastrin is a gastroprotective agent, this study was undertaken to test the hypothesis that gastroprotection by bombesin involves release of endogenous gastrin. Subcutaneous bombesin (10-100 microg/kg) dose dependentl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mercer DW,Cross JM,Chang L,Lichtenberger LM

    更新日期:1998-04-01 00:00:00

  • Role of Environmental Factors in the Development of Pediatric Eosinophilic Esophagitis.

    abstract:BACKGROUND:Despite accumulating data on the pathogenesis of eosinophilic esophagitis, not much is known about risk factors for the development of the disease. The role of factors such as smoking, breastfeeding, early antibiotic exposure and other factors that have been associated with other allergic diseases has not be...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Slae M,Persad R,Leung AJ,Gabr R,Brocks D,Huynh HQ

    更新日期:2015-11-01 00:00:00

  • Transcatheter embolotherapy for gastrointestinal bleeding: a single center review of safety, efficacy, and clinical outcomes.

    abstract:PURPOSE:The purpose of this study was to assess safety, efficacy, and clinical outcomes following transcatheter arterial embolization (TAE) of acute gastrointestinal (GI) bleeding. MATERIALS AND METHODS:Ninety-five patients (male:female ratio = 53:42, mean age 62 years) that underwent 95 TAEs for GI hemorrhage between...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yap FY,Omene BO,Patel MN,Yohannan T,Minocha J,Knuttinen MG,Owens CA,Bui JT,Gaba RC

    更新日期:2013-07-01 00:00:00

  • Primary histiocytic lymphoma of the esophagus.

    abstract::Squamous cell carcinoma represents the most common primary malignant lesion of the esophagus (1). The initial manifestation of lymphosarcoma infrequently occurs in the gastrointestinal tract, and in one large series, there were no lymphosarcomas presenting in the esophagus (2). In the case described below, a primary h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Berman MD,Falchuk KR,Trey C,Gramm HF

    更新日期:1979-11-01 00:00:00

  • Women's health training in gastroenterology fellowship: a national survey of fellows and program directors.

    abstract:BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

    更新日期:2011-03-01 00:00:00

  • Participation of capsaicin-sensitive afferent nerves in the gastric mucosa of patients with Helicobacter pylori-positive or-negative chronic gastritis.

    abstract::Capsaicin-sensitive afferent nerves (CSANs) are involved in the protection of gastric mucosa. To clarify the role of CSANs in human Helicobacter pylori-negative or -positive chronic gastritis, after bacterium detection by rapid urease test, (14)C urea breath test, and specific histological staining, the immunodistribu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Dömötör A,Kereskay L,Szekeres G,Hunyady B,Szolcsányi J,Mózsik G

    更新日期:2007-02-01 00:00:00

  • The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis.

    abstract::The aim of this study was to examine the effect of the antithrombotic drugs aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of liver cirrhosis and to determine if these two drugs are beneficial in animals with advanced fibrosis or with established cirrhosis undergoing partial he...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Assy N,Hussein O,Khalil A,Luder A,Szvalb S,Paizi M,Spira G

    更新日期:2007-05-01 00:00:00

  • Endoscopic therapy of the "sump" syndrome.

    abstract::Choledochoduodenostomy may be followed by the "sump syndrome." This previously required surgical intervention. We describe the successful application of endoscopic therapy in two patients with this syndrome. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Barkin JS,Silvis S,Greenwald R

    更新日期:1980-08-01 00:00:00

  • Alleviation of experimental ulcerative colitis with the synthetic peptide, F2A4-K-NS (Fibratide).

    abstract::Recombinant fibroblast growth factors (FGFs) maintain the integrity of the gut epithelium and reduce mucosal injury in experimental inflammatory bowel disease (IBD). Chemically synthesized FGF mimetics could potentially extend the utility of FGFs by tailoring them for optimal bioactivity and oral administration, for e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lin X,Zamora PO,Takahashi K,Lui Y

    更新日期:2007-09-01 00:00:00

  • Intestinal microbiota transplantation, a simple and effective treatment for severe and refractory Clostridium difficile infection.

    abstract:BACKGROUND:Restoring normal fecal flora through intestinal microbiota transplantation (IMT) was successful in curing recurrent Clostridium difficile infection (CDI). However, only a few cases have been reported of IMT being utilized for the treatment of severe or fulminant CDI. AIM:Is IMT a simple and effective treatm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zainah H,Hassan M,Shiekh-Sroujieh L,Hassan S,Alangaden G,Ramesh M

    更新日期:2015-01-01 00:00:00

  • Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice.

    abstract:BACKGROUND:The chemokine SDF-1 and its receptor CXCR4 are essential for the proper functioning of multiple organs. In the liver, cholangiocytes and hepatic progenitor cells (HPCs) are the main cells that produce SDF-1, and SDF-1 is thought to be essential for HPC-stimulated liver regeneration. AIMS:In this study, CXCR...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tsuchiya A,Imai M,Kamimura H,Takamura M,Yamagiwa S,Sugiyama T,Nomoto M,Heike T,Nagasawa T,Nakahata T,Aoyagi Y

    更新日期:2012-11-01 00:00:00

  • Interferon-alpha therapy for chronic hepatitis C in special patient populations.

    abstract::Interferon-alpha therapy for chronic hepatitis C in special patient populations raises a number of issues. Patients with hemophilia, kidney disease requiring hemodialysis, mixed cryoglobulinemia, HIV infection, and those receiving an allograft share some characteristics that complicate the treatment of hepatitis C vir...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Marcellin P,Boyer N,Behamou JP,Erlinger S

    更新日期:1996-12-01 00:00:00

  • Effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion in pylorus-ligated rat.

    abstract::The effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion were evaluated in a pylorus-ligated rat model. Oral administration of salicylate (50 mg/kg), aspirin (50 mg/kg), and indomethacin (3.5 mg/kg) significantly increased ulcerogenesis over the basal value by six- to sevenfold, but ib...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wagner KA,Nandi J,King RL,Levine RA

    更新日期:1995-01-01 00:00:00

  • Quick test: a new test for the diagnosis of duodenal hypolactasia.

    abstract::The hydrogen (H2) lactose breath test (BT) is a test commonly used for the diagnosis of hypolactasia. However, its sensitivity is not always good. In the last few years, the new Quick Lactase Test (QLT) has been developed for endoscopic diagnosis of adult-type hypolactasia. The aim of this study was to compare the eff...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ojetti V,La Mura R,Zocco MA,Cesaro P,De Masi E,La Mazza A,Cammarota G,Gasbarrini G,Gasbarrini A

    更新日期:2008-06-01 00:00:00

  • Intragastric bile does not perturb gastric emptying of liquids in humans.

    abstract::Gastric stasis and duodenogastric reflux have each been implicated in the pathogenesis of various upper gastrointestinal disorders. However, the relationship between intragastric bile and gastric emptying has not been explored. In each of nine healthy volunteers (seven men and two women, ages 22-47 years), gastric emp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Parr NJ,Baker PR,Grime JS,Mackie CR

    更新日期:1988-03-01 00:00:00

  • Physiology and pharmacology of prostaglandins.

    abstract::Prostaglandins (PGs) are products of polyunsaturated acid metabolism, particularly arachidonic acid (AA) released from membrane phospholipids by the action of phospholipase A2 in response to a variety of physical, chemical, and neurohormonal factors. AA is rapidly metabolized to oxygenated products by two distinct enz...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Konturek SJ,Pawlik W

    更新日期:1986-02-01 00:00:00

  • The overlap syndromes of autoimmune hepatitis.

    abstract::Autoimmune hepatitis has two major variant phenotypes in which the features of classical disease are co-mingled with those of primary biliary cirrhosis or primary sclerosing cholangitis. These overlap syndromes lack codified diagnostic criteria, established pathogenic mechanisms, and confident management strategies. T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Czaja AJ

    更新日期:2013-02-01 00:00:00

  • Novel classification and pathogenetic analysis of hypoganglionosis and adult-onset Hirschsprung's disease.

    abstract:BACKGROUND AND AIMS:Researchers have not clearly described the clinical and pathogenetic features of hypoganglionosis and adult-onset Hirschsprung's disease, which cause pseudo-obstruction or intractable constipation. We conducted this study to explore these features of hypoganglionosis and adult-onset Hirschsprung's d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Do MY,Myung SJ,Park HJ,Chung JW,Kim IW,Lee SM,Yu CS,Lee HK,Lee JK,Park YS,Jang SJ,Kim HJ,Ye BD,Byeon JS,Yang SK,Kim JH

    更新日期:2011-06-01 00:00:00

  • Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine.

    abstract::We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease. The active metabolite of meperidine, normeperidine, is postulated to be the precipitating cause of the seizures, although a cholinest...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Nagler J,Hammarth PM,Poppers DM

    更新日期:2008-01-01 00:00:00

  • Palliative decompression of obstructive hilar malignancies utilizing an extrahilar biliary approach.

    abstract::Hilar cancers carry a dismal prognosis. Palliation of obstructive jaundice in patients with hilar cancer can be achieved by either surgical or nonsurgical means. Selection of the appropriate palliative measures is a challenging problem. Segmental bilioenteric anastomosis procedures were performed on 19 patients with h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yilmaz S,Kirimlioglu V,Katz DA,Caglikulekci M,Yilmaz M

    更新日期:2000-08-01 00:00:00

  • Clinical significance of discordant positive hepatitis C virus transcription-mediated amplification following end of treatment response.

    abstract:BACKGROUND:Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. METHODS:We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA+ result to assess the clinical...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Thadani A,Harley J,Rubin J,Lebovics E

    更新日期:2012-01-01 00:00:00

  • Nonalcoholic Fatty Liver Disease Demonstrates a Pre-fibrotic and Premalignant Molecular Signature.

    abstract:BACKGROUND:Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma. AIMS:In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcripti...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Almanza D,Gharaee-Kermani M,Zhilin-Roth A,Rodriguez-Nieves JA,Colaneri C,Riley T,Macoska JA

    更新日期:2019-05-01 00:00:00

  • Patterns and Outcomes in Hepatocellular Carcinoma Patients with Portal Vein Invasion: A Multicenter Prospective Cohort Study.

    abstract:BACKGROUND AND AIMS:Sorafenib is a proven first-line treatment recommended for hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). However, multiple treatment modalities are used in clinical practice as a first-line option. This study is a prospective, observational, multicenter, cohort study evalu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sinn DH,Lee HW,Paik YH,Kim DY,Kim YJ,Kim KM,Bae SH,Kim JH,Seo YS,Jang JY,Jang BK,Yim HJ,Kim HJ,Lee BS,Kim BH,Kim IH,Cho EY,Lee JI,Suh KS

    更新日期:2021-01-01 00:00:00