Abstract：
:Mannitol (molecular weight 182), lactulose (342), and polyethylene glycol 400 (range 242-550) absorption was studied in 25 controls, 22 untreated celiacs, and 13 treated celiacs. Untreated celiacs absorbed less mannitol and more lactulose than controls. Absorption of higher as well as lower molecular-weight polyethylene glycols was reduced in untreated celiac disease. Absorption returned towards normal on treatment. Polyethylene glycol and lactulose absorption was enhanced by administering them in a hypertonic solution. Polyethylene glycol 400 but not lactulose or mannitol was lipid soluble in vitro. It was concluded that the mucosa in untreated celiac disease was more "leaky" than normal. Polyethylene glycol 400 absorption data suggested that its absorption may largely be determined by its lipid solubility and was decreased in celiac disease because of the reduced surface area of the small intestine. Polyethylene glycol 400 cannot be recommended as a suitable marker for permeability studies of the small intestine.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Ukabam SO,Cooper BTdoi
10.1007/BF01318423subject
Has Abstractpub_date
1984-09-01 00:00:00pages
809-16issue
9eissn
0163-2116issn
1573-2568journal_volume
29pub_type
杂志文章abstract：:In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296219
更新日期：1984-05-01 00:00:00
abstract：:The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02071398
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter. METHODS:We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility featur...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3645-5
更新日期：2015-08-01 00:00:00
abstract：:A retrospective multicenter analysis of 652 patients with chronic hepatitis C who have been treated with interferon (IFN) was performed to assess the effects of IFN on the clinical course and development of HCC. During a mean follow-up of 54.8 months, hepatocellular carcinoma (HCC) developed in 7.0% of the patients. T...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1023/a:1013244326874
更新日期：2002-01-01 00:00:00
abstract：:After gastrectomy, Roux-Y limb reconstruction leads to duodenojejunal motor disturbances. Because motilin and pancreatic polypeptide (PP) play a role in the regulation of digestive motility, their plasma concentrations were determined in rats after Roux-Y gastrectomy. Three months after a distal Roux-Y gastrectomy, co...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005548524334
更新日期：2000-08-01 00:00:00
abstract：:Our purpose was to observe the effects of sodium phosphate (NaP) colonoscopy preparation on serum electrolytes, phosphate, and calcium and to identify factors associated with any adverse effects. In an unselected group of 100 consecutive patients attending for out patient colonoscopy, 45% of patients had raised serum ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2780-9
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-017-4697-5
更新日期：2017-10-01 00:00:00
abstract：:Many studies have indicated changes in neuropeptides in inflammatory bowel disease (IBD), but with contradictory results. Nerve growth factor also has a potential role in the maintenance of enteric nerves and may be associated with IBD. A quantitative immunohistochemical method was used to measure area density of immu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1017943430627
更新日期：2002-03-01 00:00:00
abstract：:Azithromycin (Zithromax), an erythromycin derivative that belongs to a subgroup of the macrolides known as azolides, has generally been considered to be a very safe medication. Hepatic side effects are uncommon but may include jaundice, fever, and right upper quadrant pain. Herein we describe a patient who developed a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1020170807742
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Controlled attenuation parameter (CAP) has been developed to estimate the extent of hepatic steatosis. AIMS:The purpose was to evaluate the usefulness of CAP in assessing hepatic steatosis and its change using magnetic resonance imaging proton density fat fraction (MRI-PDFF) as reference standard. METHODS:...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05883-1
更新日期：2020-05-01 00:00:00
abstract：:A prospective study was performed in 17 patients with achalasia of the esophagus determining the manometric characteristics of the gastroesophageal sphincter, correlating it with histological analysis by biopsies taken during surgery at the distal narrowed segment of the esophagus, at the location of the sphincter. Th...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308293
更新日期：1985-10-01 00:00:00
abstract：:Capsaicin-sensitive afferent nerves (CSANs) are involved in the protection of gastric mucosa. To clarify the role of CSANs in human Helicobacter pylori-negative or -positive chronic gastritis, after bacterium detection by rapid urease test, (14)C urea breath test, and specific histological staining, the immunodistribu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9180-7
更新日期：2007-02-01 00:00:00
abstract：:Chronic pancreatitis associated with inflammatory bowel disease is now considered as extraintestinal manifestation of that disease. The clinical and radiological features of the new entity are markedly different from those of chronic calcifying pancreatitis. We report the case of a 68-year-old man presenting with a ps...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1010733308228
更新日期：2001-04-01 00:00:00
abstract：:Undernutrition is considered to have a central role in the pathogenesis of growth retardation in Crohn's disease. This may occur as a consequence of inadequate food intake, increased energy expenditure, or both. Ten growing adolescents with inactive Crohn's disease were assessed with respect to anthropometric paramete...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088741
更新日期：1996-09-01 00:00:00
abstract：:The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005449308536
更新日期：2000-03-01 00:00:00
abstract：:Gastrointestinal motor dysfunction persists in a large number of children subjected to surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining intestine. The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitia...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1015085923245
更新日期：2002-05-01 00:00:00
abstract：:Many drugs have been used in the treatment of chronic hepatitis B, but with the exception of interferon, none have proved to be effective. Several studies have found that a sustained loss of viral replication occurs in approximately 40% of patients who started with a 16-week course of recombinant interferon alfa-2b gi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01316785
更新日期：1993-04-01 00:00:00
abstract：:Patients with gallstone disease have impaired gallbladder motility. Prostaglandins are thought to be important mediators of gallbladder hypomotility. We assessed the effect of aspirin, a prostaglandin inhibitor on gallbladder resting volume and ejection fraction according to a double-blind study protocol in 20 healthy...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02212702
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND AND AIMS:The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the revised Bethesda Guidelines (RBG) cannot be applied in a considerable nu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3248-6
更新日期：2014-12-01 00:00:00
abstract：:The gastroprotective agent ecabet sodium (ecabet, 12-sulfodehydroabietic acid monosodium salt) increases the formation of prostaglandin (PG) E2 and I2 by gastric mucosa. In the present study, we examined the effect of ecabet on metabolism of arachidonic acid (AA) in rat gastric mucosal cells. Ecabet (0.1-10 mM) concen...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018885005109
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:miR-30a expression is down-regulated and regulates tumor suppressors in various cancers. AIM:We investigated the mechanisms underlying the biological role of miR-30a in CRC. METHODS:MicroRNA, mRNA, and protein expression were analyzed by quantitative real-time PCR and Western blot. The migration and invasi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-017-4763-z
更新日期：2017-11-01 00:00:00
abstract：:The effect of 5-hydroxytryptamine (5HT) was studied in circular and longitudinal muscle from the proximal and distal colon of New Zealand white rabbits. 5HT stimulated a dose-dependent isometric contraction of distal and proximal circular muscle that was greater than in distal longitudinal muscle (P less than 0.01). 5...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300751
更新日期：1991-02-01 00:00:00
abstract：:Intravenous proton pump inhibitors (IV PPIs) decrease rebleeding following endoscopic hemostasis of bleeding peptic ulcers. Oral PPIs may be equally efficacious and may significantly reduce health care costs. This study aimed to compare outcomes in patients receiving oral versus IV PPI therapy following endoscopic hem...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9684-1
更新日期：2007-07-01 00:00:00
abstract：:An international working team of 13 investigators met on two occasions to develop guidelines for standardizing the procedures used to test gastrointestinal muscle tone and sensory thresholds using a barostat. General recommendations were: (1) Use a thin-walled plastic bag that is infinitely compliant until its capacit...
journal_title：Digestive diseases and sciences
pub_type： 指南,杂志文章,实务指引
doi：10.1023/a:1018885028501
更新日期：1997-02-01 00:00:00
abstract：:The purpose of this study was to use simultaneous anal manometry and high-frequency endoluminal ultrasonography (EUS) to determine the relationship between resting anal pressure and cross-sectional area of the internal and external anal sphincters. Eleven normal subjects underwent simultaneous anal EUS and manometry u...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026605409557
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Flavonoids have been subjected to considerable investigations due to their antioxidant and anti-inflammatory properties. Yet the effects of flavonoids on the ileum and spleen against hepatic ischemia-reperfusion injury have so far not been addressed. AIMS:We aimed to investigate whether micronized purified ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-1018-7
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. AIMS:The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. METHODS:We searched M...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10620-013-2928-y
更新日期：2014-03-01 00:00:00
abstract：:This study was undertaken to determine whether the synthetic prostaglandin E2 analog enprostil is able to inhibit basal and postprandial hypergastrinemia induced by omeprazole. We also studied the effect of omeprazole, enprostil, and the combination of both drugs on serum pepsinogen A and C levels. Eight normal subjec...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02088350
更新日期：1994-03-01 00:00:00
abstract：:Probiotic bacteria exhibit a variety of properties, which are unique to a particular strain. Lactobacillus acidophilus-SDC 2012, 2013 are new strains isolated from Korean infants' feces. The potential utility of Lactobacillus acidophilus-SDC 2012, 2013 in irritable bowel syndrome (IBS) was studied. Forty IBS patients ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-007-0196-4
更新日期：2008-10-01 00:00:00
abstract：:The optimal administration of immunosuppressants such as tacrolimus (Tac) for small-for-size (SFS) grafts, where the functional liver mass is small and must regenerate, has not been reported so far. The aim of this study is to clarify the characteristics of Tac metabolism according to liver volume. Seven-week-old male...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0551-0
更新日期：2009-08-01 00:00:00
