Abstract:
:This study set out to evaluate the effects of dietary fiber on cancer development in the large bowel under in vivo experimental conditions as similar as possible to those under which this cancer develops in vivo in humans. Forty-eight Sprague-Dawley rats were divided into three groups that were fed either a nonfiber diet or a 3 g or 10 g/100 g cellulose diet in this experiment, and all groups received doses of a mild carcinogen, 1,2-dimethylhydrazine (5 mg/kg body weight) for 50 weeks. Following endoscopic observation of the large bowel, we found that the induction rates of tumor in the cellulose groups were significantly lower than that in the nonfiber diet group, both endoscopically and histologically. No differences were seen between the 3% and 10% cellulose groups in suppressing carcinogenesis. It is likely that the inhibitory effect of 3% cellulose could be confirmed only by a long-term experiment on carcinogenesis following the administration of a low dose of carcinogen.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Iwane S,Nakaji S,Ohta M,Tamura K,Sakamoto J,Munakata A,Sugawara Kdoi
10.1023/a:1015310211821subject
Has Abstractpub_date
2002-06-01 00:00:00pages
1257-65issue
6eissn
0163-2116issn
1573-2568journal_volume
47pub_type
杂志文章abstract::Current research in gene delivery to the liver is focused on the intravenous, intraarterial, intraportal, or intratumoral route. Another possible route for gene delivery is via the common bile duct through endoscopic retrograde cholangiopancreatography (ERCP). Whether bile and pancreatic juice have any effect on gene ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005431703317
更新日期:2000-02-01 00:00:00
abstract::The aim of this study was to review the impact of infliximab therapy on children with treatment-resistant Crohn's disease. Treatment resistance was defined as clinically active disease despite >4 months of immunosuppressive therapy. The outcome variables were time to first remission, duration of remission and the need...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-8102-1
更新日期:2007-12-01 00:00:00
abstract::Prostaglandins (PGs) are products of polyunsaturated acid metabolism, particularly arachidonic acid (AA) released from membrane phospholipids by the action of phospholipase A2 in response to a variety of physical, chemical, and neurohormonal factors. AA is rapidly metabolized to oxygenated products by two distinct enz...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF01309317
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Postmenopausal women have a higher risk of nonalcoholic steatohepatitis (NASH) along with an increase in age, and vitamin D deficiency occurs in some patients with NASH. AIM:We performed ovariectomy (OVX) surgery on female mice to mimic menopause, fed them a choline-deficient high-fat (CDHF) diet to induce ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05560-3
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD. DESIGN:We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Pat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06517-7
更新日期:2020-08-04 00:00:00
abstract::The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026634721351
更新日期:1999-10-01 00:00:00
abstract::Misoprostol, a synthetic prostaglandin E1 methyl ester analog with gastric antisecretory and cytoprotective properties, prevents the development of acute experimental gastric and duodenal ulcers in various animal models. This study was designed as a multicenter randomized double-blind parallel-group comparison of the ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01309404
更新日期:1985-11-01 00:00:00
abstract::The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase cha...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299852
更新日期:1992-11-01 00:00:00
abstract::Patients with Zollinger-Ellison syndrome whose gastric acid secretion or symptoms were not controlled by cimetidine in conventional dosage were selected for studies of responsiveness of their acid secretion to increasing doses of cimetidine, used either alone or in combination with a long-acting anticholinergic agent,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296756
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-014-3488-5
更新日期:2015-05-01 00:00:00
abstract::Isolated case reports in which symptomatic hearing loss develops suddenly during the course of inflammatory bowel disease (IBD) have been reported, but the presence of subclinical sensorineural hearing loss (SNHL) associated with IBD has been investigated in only two preliminary studies. In order to research this furt...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2964-3
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0770-z
更新日期:2010-03-01 00:00:00
abstract::The efficacy of tiotidine, a new H2-receptor antagonist, in reducing nocturnal acid secretion of duodenal ulcer patients (N = 12, ages 21-60 years) was investigated. Different doses of tiotidine, 25, 50, 100, and 150 mg or placebo, were given as a single oral dose and acid secretion collected overnight. Tiotidine prod...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01313586
更新日期:1981-05-01 00:00:00
abstract::To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01338527
更新日期:1980-11-01 00:00:00
abstract::Lipopolysaccharide (LPS) is implicated in the pathology of acute liver injury and can induce lethal liver failure when simultaneously administered with D-galactosamine (D-GalN). At the present time, nonlethal liver failure, the liver injury of clinical implication, is incompletely understood following challenge by low...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9994-y
更新日期:2008-05-01 00:00:00
abstract::Two patients experienced hepatotoxicity associated with erythromycin estolate (Ilosone) usage, followed 13 and 15 years later by an hepatotoxic reaction with administration of erythromycin ethylsuccinate (E.E.S.). These cases provide further evidence for erythromycin ethylsuccinate-associated hepatotoxicity and demons...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01393764
更新日期:1982-08-01 00:00:00
abstract::Hyperglycemia slows gastric emptying and increases the intensity of perception of gastric distension during fasting and small intestinal nutrient stimulation. In order to examine the possibility that abnormalities of gastric electrical rhythm may be associated with the effects of hyperglycemia, the gastric electrical ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/a:1018851227051
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Both 22- and 25-gauge needles are used for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lesions, yet limited data exist on whether either offers an advantage over the other in terms of specimen cellularity and quality. AIM:The aim of this study was to compare sample quality for 22- and...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-009-0906-1
更新日期:2009-10-01 00:00:00
abstract::We assessed the characteristics of muscarinic neural transmission in the vagal inhibitory pathway to the lower esophageal sphincter (LES) of anesthetized opossums. LES relaxation was induced by electrical stimulation of the cervical vagus. Measurements were made of LES relaxation before and after intravenous administr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300200
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Corticosteroids and pentoxifylline reduce short-term mortality in severe alcoholic hepatitis (SAH), but not to the extent desired. Combining both drugs may lead to better survival, but has not yet been studied. AIM:To compare the efficacy of corticosteroids plus pentoxifylline with that of corticosteroids a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-012-2097-4
更新日期:2012-06-01 00:00:00
abstract::Nongranulomatous chronic idiopathic enterocolitis is characterized by sudden onset of severe watery diarrhea, malabsorption, exudative enteropathy, frequent appearance of shallow ulcerations, and variable degrees of villus atrophy. In the absence of infectious and pharmacologic causes, the presence of a predominantly ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1023/a:1026415218942
更新日期:2000-11-01 00:00:00
abstract::Twelve patients with recurrent polyserositis (RP, familial Mediterranean fever) on colchicine prophylaxis (1.0-2.0 mg daily) for three years or more were evaluated for the presence of gastrointestinal effects possibly attributable to the drug. Two patients had bulky stools, two others had transient diarrhea, and one h...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01393768
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND AND AIM:Dietary fiber shortens gut transit time, but data on the effects of fiber components (including resistant starch, RS) on intestinal contractility are limited. We have examined RS effects in male Sprague-Dawley rats fed either a high-amylose maize starch (HAMS) or a wholemeal made from high-amylose wh...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3537-8
更新日期:2015-06-01 00:00:00
abstract::It has been shown that acupuncture relieves symptoms of abdominal pain and bloating in patients with irritable bowel syndrome (IBS). However, the mechanism of beneficial effects of acupuncture still remains unproven. The aim of the present study was to investigate the mechanisms of the antinociceptive effects of acupu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2770-y
更新日期:2005-07-01 00:00:00
abstract::In a subset of patients with gastroesophageal reflux disease (GERD), symptoms persist in spite of proton pump inhibitor (PPI) therapy. Endoscopic gastroplication (EG) was reported to provide a novel therapeutic option in GERD. To evaluate symptomatic and objective outcome of EG in PPI refractory GERD, consecutive GERD...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-1610-4
更新日期:2005-02-01 00:00:00
abstract::Octreotide is an effective therapeutic option in controlling secretory diarrhea of varied etiology. However, marked patient-to-patient differences in the antidiarrheal effects necessitate titration of octreotide dose in individual patients to achieve optimal symptom control. A consensus development panel established g...
journal_title:Digestive diseases and sciences
pub_type: 共识发展会议,杂志文章,评审
doi:10.1007/BF02285194
更新日期:1995-07-01 00:00:00
abstract::The question of whether alcohol drinking is a risk factor for fatty liver as shown by ultrasonography was investigated by both cross-sectional and longitudinal approaches in Japanese undergoing a health checkup. In this cross-sectional study, 32,438 males (49.0 +/- 11.9 years old) and 31,009 females (48.2 +/- 11.6 yea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0693-0
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Scant data exist about accidental occupational injuries in endoscopy suites. This work systematically analyzes injuries, identifies workplace hazards, and proposes hazard remediation to potentially reduce risks. METHODS:A retrospective study was performed on 14 previously unreported injuries among 120 end...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1498-5
更新日期:2011-02-01 00:00:00
abstract:UNLABELLED:There is a wide choice of fecal occult blood tests (FOBTs) for colorectal cancer screening. GOAL:To highlight the issues applicable when choosing a FOBT, in particular which FOBT is best suited to the range of screening scenarios. Four scenarios characterize the constraints and expectations of screening pro...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-014-3445-3
更新日期:2015-03-01 00:00:00
abstract::The value of intense nutritional support in inflammatory bowel disease is still debated. Claims have been made that total enteral nutrition is as effective as total parental nutrition. In this review, the use of parenteral and enteral nutritional support as primary therapy in patients with inflammatory bowel disease h...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF02064990
更新日期:1995-04-01 00:00:00