Abstract：
:Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We explored Msi-1 expression and its potential implications in the human stomach. Reverse transcription-PCR revealed that Msi-1 levels were significantly higher in the corpus than in antrum in Helicobacter pylori (Hp)-infected patients (n = 49) (P < 0.00001) in paired biopsy samples, whereas they were low and comparable at these two sites in Hp-negative patients (n = 31). Msi-1 levels were significantly higher in the Hp-infected corpus (n = 107) than in the Hp-negative corpus (n = 69) (P < 0.00000001). Immunohistochemistry and in situ hybridization demonstrated that Msi-1 was expressed at the base and neck/isthmus region of the fundic glands and partly co-expressed in Ki-67-positive cells in the corpus and antrum. Msi-1 levels correlated with Hp density (P < 0.05). Based on these results, we conclude that Hp infection strongly induces Msi-1 in the corpus. Given its expression in dividing cells, Msi-1 may modulate the state of gastric progenitor cells.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Murata H,Tsuji S,Tsujii M,Nakamura T,Fu HY,Eguchi H,Asahi K,Okano H,Kawano S,Hayashi Ndoi
10.1007/s10620-007-9858-5subject
Has Abstractpub_date
2008-02-01 00:00:00pages
363-9issue
2eissn
0163-2116issn
1573-2568journal_volume
53pub_type
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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