Double-balloon enteroscopy and small bowel tumors: a South-European single-center experience.


:Small bowel tumors are rare, accounting for 1-2% of all gastrointestinal neoplasms. We sought to determine the diagnostic and therapeutic impact of double-balloon enteroscopy (DBE) in patients with small bowel tumors. Between January 2005 and March 2008, 78 patients underwent 96 DBE. All nine patients (seven males; mean age 68 +/- 11.3 years) with small bowel tumors were retrospectively reviewed. Clinical presentation was: mid-gastrointestinal bleeding or iron-deficient anemia (55.6%); abdominal pain (22.2%); nausea/vomiting and abdominal distension (22.2%). Five patients had abnormal findings in previous capsule endoscopy and four in previous radiologic examinations. Route of insertion was exclusively oral and abnormal lesions were detected in all patients (jejunum 8; ileum 1). Biopsies were taken in seven patients and provided definitive histological diagnosis in all except one. There were no complications of DBE. Surgical resection took place in eight patients. Final histologic diagnosis were: primary carcinoma (33.3%), gastrointestinal stromal tumor (GIST) (33.3%), malignant lymphoma (22.2%), and carcinoid tumor (11.1%). Mean follow-up time was 15.4 +/- 12.7 months (range 2-34 months). Six patients were submitted to chemotherapy. Two patients died. Small bowel tumors are common in patients submitted to DBE. Given its safety and diagnostic capabilities, DBE should be considered the gold-standard method in the study of these neoplasms.


Dig Dis Sci


Almeida N,Figueiredo P,Lopes S,Gouveia H,Leitão MC




Has Abstract


2009-07-01 00:00:00












  • Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis.

    abstract:BACKGROUND:Cholangiocarcinoma is a devastating disease with a 2% 5-year survival if the disease has spread outside the liver. The enzyme aspartate beta-hydroxylase (ASPH) has been demonstrated to be highly expressed in cholangiocarcinoma but not in normal bile ducts and found to stimulate tumor cell migration. In addit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Nagaoka K,Ogawa K,Ji C,Cao KY,Bai X,Mulla J,Cheng Z,Wands JR,Huang CK

    更新日期:2020-05-22 00:00:00

  • Gastric emptying of solids and liquids for evaluation for gastroparesis.

    abstract:BACKGROUND:Gastric emptying scintigraphy (GES) of solids is typically used to evaluate for gastroparesis. AIMS:The purpose of this study was to determine the value of simultaneously measuring gastric emptying of liquids and solids for assessing patients for delayed gastric emptying. METHODS:A total of 596 patients at...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sachdeva P,Malhotra N,Pathikonda M,Khayyam U,Fisher RS,Maurer AH,Parkman HP

    更新日期:2011-04-01 00:00:00

  • Protective effect of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model.

    abstract::Nonalcoholic steatohepatitis (NASH) is characterized by diffuse fatty infiltration in the liver and ballooning degeneration and inflammation in hepatocytes. We aimed to study the protective effect of soy isoflavones on experimental NASH and their effects on plasma paraoxanese and arylesterase levels in rats. Twenty-ei...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ustundag B,Bahcecioglu IH,Sahin K,Duzgun S,Koca S,Gulcu F,Ozercan IH

    更新日期:2007-08-01 00:00:00

  • Measurement of esophageal reflux by scintigraphy.

    abstract::Gastroesophageal reflux and clearance of the refluxed material can be measured by plotting a time-activity curve from an esophageal area of interest after 1 mCi of 99mTc sulfur colloid is placed in the stomach. Control subjects do not have peaks exceeding a value twice that of the baseline count levels. Reflux patient...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Velasco N,Pope CE 2nd,Gannan RM,Roberts P,Hill LD

    更新日期:1984-11-01 00:00:00

  • Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients.

    abstract:BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Achitei D,Ciobica A,Balan G,Gologan E,Stanciu C,Stefanescu G

    更新日期:2013-05-01 00:00:00

  • Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer.

    abstract::The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kamada T,Haruma K,Kusunoki H,Miyamoto M,Ito M,Kitadai Y,Yoshihara M,Chayama K,Tahara K,Kawamura Y

    更新日期:2003-04-01 00:00:00

  • Oral specific desensitization in food-allergic children.

    abstract::The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food alle...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Patriarca G,Nucera E,Pollastrini E,Roncallo C,De Pasquale T,Lombardo C,Pedone C,Gasbarrini G,Buonomo A,Schiavino D

    更新日期:2007-07-01 00:00:00

  • Fecal clearance of alpha1-antitrypsin with lansoprazole can detect protein-losing gastropathy.

    abstract::Detecting plasma protein loss from the stomach is quite difficult by measuring fecal alpha1-AT clearance because alpha1-AT is rapidly destroyed in the gastric juice at values below pH 3. We examined protein loss from the stomach using fecal alpha1-AT clearance with lansoprazole, a proton pump inhibitor. A 38-year-old ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Takeda H,Nishise S,Furukawa M,Nagashima R,Shinzawa H,Takahashi T

    更新日期:1999-11-01 00:00:00

  • Quantitative distribution of radiolabeled 5-aminosalicylic acid enemas in patients with left-sided ulcerative colitis.

    abstract::Rectally administered suspensions of 5-aminosalicylic acid (5-ASA) are topically effective in treating left-sided ulcerative colitis. The extent to which the contents of these enemas are distributed to inflamed mucosal linings has not previously been determined. This study was undertaken to validate a technique for la...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Vitti RA,Meyers F,Knight LC,Siegel JA,Malmud LS,Fisher RS

    更新日期:1989-11-01 00:00:00

  • Prevalence, etiology, and prognostic significance of upper gastrointestinal hemorrhage in diabetic ketoacidosis.

    abstract::We reviewed the discharge records of all diabetic ketoacidosis hospitalizations over 30 months for the presence of clinically significant upper gastrointestinal hemorrhage. Of 284 hospitalizations in 193 patients, hemorrhage occurred in 26 hospitalizations (9%) in 25 patients (13%). None required invasive therapy to a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Faigel DO,Metz DC

    更新日期:1996-01-01 00:00:00

  • The questionable efficacy of topical pharyngeal anesthesia in combination with propofol sedation in gastroscopy.

    abstract:BACKGROUND:Topical pharyngeal anesthesia as an adjunct to intravenous sedation to facilitate gastroscopy has been widely acknowledged; however, its efficacy has not been established when it is used in patients under deep sedation with propofol. AIMS:To demonstrate the limited value of topical pharyngeal anesthesia in ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Tsai HI,Tsai YF,Liou SC,Su MY,Lin CC,Chang CJ,Yu HP

    更新日期:2012-10-01 00:00:00

  • Antizyme mRNA distribution and regulation in rat small intestinal enterocytes.

    abstract::The protein ornithine decarboxylase antizyme (AZ) is inhibitory to both polyamine transport and synthesis. Experiments were performed to examine the distribution and regulation of AZ mRNA in cells of the small intestinal epithelium, a tissue exposed to high concentrations of extracellular polyamines and high levels of...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gill JE,Christian JF,Seidel ER

    更新日期:2002-07-01 00:00:00

  • Intravenous cyclosporine in attacks of ulcerative colitis: short-term and long-term responses.

    abstract::The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one po...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Carbonnel F,Boruchowicz A,Duclos B,Soulé JC,Lerebours E,Lémann M,Belaïche J,Colombel JF,Cosnes J,Gendre JP

    更新日期:1996-12-01 00:00:00

  • Antral axial forces postprandially and after erythromycin in organic and functional dysmotilities.

    abstract::Our aims were to measure antral axial forces in patients with suspected upper gut dysmotilities and to compare the number of antral contractions detected by an axial force catheter and by manometric sensors in the distal antrum and pylorus. Fifteen patients (2 men, 13 women; mean age 42 years) underwent studies for 3 ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Surrenti E,Camilleri M,Kammer PP,Prather CM,Schei AJ,Hanson RB

    更新日期:1996-04-01 00:00:00

  • Metastatic carcinoma of the gallbladder from renal cancer presenting as intraluminal polypoid mass.

    abstract::We report a rare case of secondary involvement of the gallbladder by metastatic renal cell carcinoma. A 71-year-old man was diagnosed as having a polypoid mass within the gallbladder when he underwent right nephrectomy for a renal cell carcinoma. A preoperative diagnosis of simultaneous carcinoma of the gallbladder wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Satoh H,Iyama A,Hidaka K,Nakashiro H,Harada S,Hisatsugu T

    更新日期:1991-04-01 00:00:00

  • Prevalence and Impact of Post-traumatic Stress Disorder in Gastrointestinal Conditions: A Systematic Review.

    abstract::Psychological distress is often observed in patients with gastrointestinal illness. To date, there has been limited research conducted to assess the prevalence and impact of post-traumatic stress disorder (PTSD) in gastrointestinal cohorts. The aim of this systematic review is to review the evidence for the prevalence...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Glynn H,Möller SP,Wilding H,Apputhurai P,Moore G,Knowles SR

    更新日期:2021-01-12 00:00:00

  • What does pain or discomfort in irritable bowel syndrome mean?

    abstract::Despite many studies on pain of functional gastrointestinal disorders (FGID), the pain mechanism of FGID is not well understood, and pain treatment of FGID is not established. Following our former functional dyspepsia (FD) study, we proposed two subgroups of patients with irritable bowel syndrome (IBS), pain and disco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Handa M,Nukina H,Ando K,Kubo C

    更新日期:2004-04-01 00:00:00

  • Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury.

    abstract::Intestinal injury 4-48 hr after cytotoxic therapy (etoposide phosphate, 100 mg/kg body weight [bw], intravenously [i.v.]) was studied in rats using ligated intestinal loops. Chromium-51 ethylenediaminetetraacetic acid ((51)Cr-EDTA) and rubidium-86 chloride ((86)RbCl) were deposited intraluminally to determine the exte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Abel E,Ekman T,Warnhammar E,Hultborn R,Jennische E,Lange S

    更新日期:2005-09-01 00:00:00

  • Can serum fetuin-A be regarded as an inflammatory marker among patients with familial Mediterranean fever?

    abstract:BACKGROUND/AIM:Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Oncu K,Yazgan Y,Tanoglu A,Kaplan M,Ermis F,Ipcioglu OM,Kara M,Kucuk I,Ozari HO

    更新日期:2013-11-01 00:00:00

  • Transjugular liver biopsy in 52 patients with an automated Trucut-type needle.

    abstract::A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the s...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: De Hoyos A,Loredo ML,Martínez-Ríos MA,Gil MR,Kuri J,Cárdenas M

    更新日期:1999-01-01 00:00:00

  • Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.

    abstract::The effect of ischemia-reperfusion and 48-hr fasting on apoptosis was characterized in rat gastric mucosa and compared to small intestinal mucosa. Under halothane anesthesia, the celiac artery or superior mesenteric artery in the rat was occluded for 60 min followed by reperfusion. Occlusion of the celiac artery reduc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fukuyama K,Iwakiri R,Noda T,Kojima M,Utsumi H,Tsunada S,Sakata H,Ootani A,Fujimoto K

    更新日期:2001-03-01 00:00:00

  • Colon PillCam: why not just take a pill?

    abstract::This review article deals with the clinical value of capsule endoscopy for visualization of the colon. Since its introduction in 2006, the colon capsule endoscopy underwent major technological improvements. The improved performance of colon capsule endoscopy is reviewed based on three multicenter prospective studies. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Eliakim R,Adler SN

    更新日期:2015-03-01 00:00:00

  • Colonoscopy: the current king of the hill in the USA.

    abstract::Colonoscopy is the dominant colorectal cancer screening strategy in the USA. There are no randomized controlled trials completed of screening colonoscopy, but multiple lines of evidence establish that colonoscopy reduces colorectal cancer incidence in both the proximal and distal colon. Colonoscopy is highly operator ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Rex DK

    更新日期:2015-03-01 00:00:00

  • Signet ring carcinoma of the pancreas, a rare variant with very high CEA values. Immunohistologic comparison with adenocarcinoma.

    abstract::Signet ring carcinoma of the pancreas is rare. We report a case which was remarkable for (1) diffuse, infiltrating growth which suggested chronic pancreatitis at laparotomy, and (2) an associated very high circulating carcinoembryonic antigen (CEA) level of 6400 ng/ml. The case report and autopsy are presented. Twelve...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tracey KJ,O'Brien MJ,Williams LF,Klibaner M,George PK,Saravis CA,Zamcheck N

    更新日期:1984-06-01 00:00:00

  • Efficacy of Vonoprazan-Based Triple Therapy for Helicobacter pylori Eradication: A Multicenter Study and a Review of the Literature.

    abstract:BACKGROUND:Eradication therapies for Helicobacter pylori infection are advancing as new acid inhibitory reagents approved. The aim of this study was to assess the efficacy and safety of vonoprazan-based triple treatment. MATERIALS AND METHODS:Triple therapy with vonoprazan and two antibiotics (amoxicillin and clarithr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究,评审


    authors: Tanabe H,Ando K,Sato K,Ito T,Goto M,Sato T,Fujinaga A,Kawamoto T,Utsumi T,Yanagawa N,Ichiishi E,Otake T,Kohgo Y,Nomura Y,Ueno N,Sugano H,Kashima S,Moriichi K,Fujiya M,Okumura T

    更新日期:2017-11-01 00:00:00

  • Disruption of canine jejunal interdigestive myoelectrical activity by artificial ileocolonic sphincter. Studies of intestinal motor response to surgically fashioned sphincter substitute.

    abstract::We studied the effects of an ileocolonic sphincter substitute on canine small intestine motor activity. Recordings of fasting and postprandial myoelectrical activity were performed in three groups of animals in whom the following procedures had been performed: (1) electrode placement alone, intestinal continuity undis...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Quigley EM,Thompson JS,Lof J

    更新日期:1989-09-01 00:00:00

  • Manometric diagnosis of diffuse esophageal spasm.

    abstract::There are no requirements concerning the amplitude of simultaneous contractions among the present criteria for the manometric diagnosis of diffuse esophageal spasm. The purpose of this investigation was to determine whether the current criteria effectively identify an appropriately homogenous patient population. Sixty...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Allen ML,DiMarino AJ Jr

    更新日期:1996-07-01 00:00:00

  • Predictive Factors of Atelectasis Following Endoscopic Resection.

    abstract:BACKGROUND AND AIM:Atelectasis is one of the pulmonary complications associated with anesthesia. Little is known about atelectasis following endoscopic procedures under deep sedation. This study evaluated the frequency, risk factors, and clinical course of atelectasis after endoscopic resection. METHODS:A total of 349...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Choe JW,Jung SW,Song JK,Shim E,Choo JY,Kim SY,Hyun JJ,Koo JS,Yim HJ,Lee SW

    更新日期:2016-01-01 00:00:00

  • Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease (NAFLD).

    abstract:BACKGROUND:A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). AIMS:To determine if the nutritional intake, intestinal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Volynets V,Küper MA,Strahl S,Maier IB,Spruss A,Wagnerberger S,Königsrainer A,Bischoff SC,Bergheim I

    更新日期:2012-07-01 00:00:00

  • Liver injuries induced by herbal medicine, syo-saiko-to (xiao-chai-hu-tang).

    abstract::Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Itoh S,Marutani K,Nishijima T,Matsuo S,Itabashi M

    更新日期:1995-08-01 00:00:00