The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis.

abstract：:Although transient increases in intracellular Ca2+ ([Ca2+]i) underlie a number of important physiological processes, sustained elevations in [Ca2+]i mediate damage to a number of tissues and cell types including gastric mucosal cells. Increases in [Ca2+]i can activate phospholipid hydrolysis via increases in phospholi...

journal_title：Digestive diseases and sciences

authors： Tepperman BL,Soper BD

更新日期：1999-03-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is present in up to 75% of patients with chronic refractory ear, nose, and throat (ENT) symptoms, and proton pump inhibitor (PPI) therapy induces symptom relief in the majority of these patients. It has been suggested that endoscopic findings and quantification of esophageal acid...

journal_title：Digestive diseases and sciences

authors： Poelmans J,Feenstra L,Tack J

更新日期：2006-02-01 00:00:00

abstract：:The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors ...

journal_title：Digestive diseases and sciences

authors： Weinberg DS,So C,Ruggeri B,Biswas S,Barber M,Waldman S

更新日期：2000-03-01 00:00:00

abstract：:To study the efficacy of standard blood tests of liver function (LFTs) and technetium-99m liver scan followed by laparoscopy in the diagnosis of solid malignant tumors of the liver, 100 consecutive patients were evaluated who had these tests because of clinical suspicion of liver neoplasm. Malignant liver tumors were ...

journal_title：Digestive diseases and sciences

authors： Lightdale CJ,Winawer SJ,Kurtz RC,Knapper WH

更新日期：1979-08-01 00:00:00

abstract：:Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

journal_title：Digestive diseases and sciences

authors： Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

更新日期：1996-12-01 00:00:00

abstract：:A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...

journal_title：Digestive diseases and sciences

authors： Miyake T,Ariyoshi J,Suzaki T,Oishi M,Sakai M,Ueda S

更新日期：1980-01-01 00:00:00

abstract：:Aging and gastrointestinal malignancies, including that of the stomach are associated with increased activation of EGF-receptor (EGFR). Although the intracellular events that regulate this process are poorly understood, we hypothesize that loss of ERRP (EGFR-related protein; GenBank accession number AF187818), a recen...

journal_title：Digestive diseases and sciences

authors： Majumdar AP,Du J,Hatfield JS,Levi E,Adsay V,Schmelz EM,Nagothu KK,Jaszewski R,Kucuk O,Sarkar FH

更新日期：2003-05-01 00:00:00

abstract：:Sera from Japanese patients with chronic liver disease were tested for hepatitis B virus (HBV) markers and antibodies to hepatitis C virus (anti-HCV), and the results were correlated to the presence of hepatocellular carcinoma. In chronic non-A, non-B liver disease, anti-HCV prevalence was high both in patients with h...

journal_title：Digestive diseases and sciences

authors： Yuki N,Hayashi N,Kasahara A,Hagiwara H,Katayama K,Fusamoto H,Kamada T

更新日期：1992-01-01 00:00:00

abstract：:Data about colonic mucosa transport of short-chain fatty acids in cirrhotic patients are still lacking. The aim of the present study was to compare the rectal mucosa transport of n-butyrate and its effect on transport of other electrolytes and endoluminal pH in normal subjects and in cirrhotic patients by using a rect...

journal_title：Digestive diseases and sciences

authors： Onori L,Pimpo MT,Palumbo GC,Gili L,Marchetti G,Saltarelli P,Aggio A,Frieri G

更新日期：2001-10-01 00:00:00

abstract：:Twenty-four patients with chronic active HCV infection, nonresponders to a previous treatment cycle with recombinant interferon-alpha (r-IFNA), underwent retreatment with leukocyte (LE-) IFN-alpha. This was administered at the dose of 3 MU three times a week, for either six months (group A) or 12 months (group B). All...

journal_title：Digestive diseases and sciences

authors： Scotto G,Grimaldi M

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...

journal_title：Digestive diseases and sciences

authors： Achitei D,Ciobica A,Balan G,Gologan E,Stanciu C,Stefanescu G

更新日期：2013-05-01 00:00:00

abstract：:The effect of luminal 150 mmol saline, 0.05-0.2% (w/v) lysolecithin, and 5-20% (v/v) ethanol was studied on the mucosal morphology of the proximal small intestine in conscious guinea pigs as well as on the mucosal penetration and transfer to portal venous blood of luminal horseradish peroxidase (HRP). No ultrastructur...

journal_title：Digestive diseases and sciences

authors： Talbot RW,Foster JR,Hermon-Taylor J,Grant DA

更新日期：1984-11-01 00:00:00

abstract：:Glycoprotein and glycolipid constituents were examined in purified microvillus and basolateral membranes isolated from rat small intestinal epithelial cells. SDS-polyacrylamide gel electrophoresis showed that the molecular weights of most of the major proteins from microvillus membranes were over 100 kD, whereas the m...

journal_title：Digestive diseases and sciences

authors： Morita A,Siddiqui B,Erickson RH,Kim YS

更新日期：1989-04-01 00:00:00

abstract：:Hemorrhage into the biliary tract, known as hemobilia, is discussed almost exclusively in the surgical literature. Internists should also be aware of this entity. Two cases of hemobilia from hepatic artery aneurysm that ruptured into the biliary tract are presented. Both patients developed pancreatitis in addition to ...

journal_title：Digestive diseases and sciences

authors： Kaplan RP,Kaplan L,Panish J,Treiman R

更新日期：1980-02-01 00:00:00

abstract：:The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a mea...

journal_title：Digestive diseases and sciences

authors： Stacher G,Granser GV,Bergmann H,Kugi A,Stacher-Janotta G,Höbart J

更新日期：1991-09-01 00:00:00

abstract：:The effect of 5-hydroxytryptamine (5HT) was studied in circular and longitudinal muscle from the proximal and distal colon of New Zealand white rabbits. 5HT stimulated a dose-dependent isometric contraction of distal and proximal circular muscle that was greater than in distal longitudinal muscle (P less than 0.01). 5...

journal_title：Digestive diseases and sciences

authors： Ng WW,Jing J,Hyman PE,Snape WJ Jr

更新日期：1991-02-01 00:00:00

abstract：:The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...

journal_title：Digestive diseases and sciences

authors： Coremans G,Janssens J,Vantrappen G,Chaussade S,Ceccatelli P

更新日期：1988-12-01 00:00:00

abstract：:Health-care-seeking behaviors related to bowel complaints may vary between ethnic groups. A survey of a nonpatient population in El Paso, Texas, was conducted in order to examine differences in health care behavior related to bowel dysfunction, and in the perception of health and bowel function, in Hispanics and non-H...

journal_title：Digestive diseases and sciences

authors： Zuckerman MJ,Guerra LG,Drossman DA,Foland JA,Gregory GG

更新日期：1996-01-01 00:00:00

abstract：:Leptin is an adipocyte-derived hormone involved in the homeostasis of body composition. An imbalance in leptin regulation has been observed in patients with liver cirrhosis. We aimed to assess serum and ascitic leptin levels in a group of patients with decompensated liver cirrhosis and to evaluate the relationship of ...

journal_title：Digestive diseases and sciences

authors： Giannini E,Romagnoli P,Tenconi GL,Botta F,Malfatti F,Chiarbonello B,Mamone M,Barreca T,Testa R

更新日期：2004-02-01 00:00:00

abstract：:It has previously been shown that mucosal nitric oxide synthase (NOS) is involved in acid-induced duodenal mucosal alkaline secretion. The primary aim of the present study was to elucidate which isoform of NOS is responsible in rats. Immunohistochemistry showed that inducible NOS (iNOS) was constitutively expressed in...

journal_title：Digestive diseases and sciences

authors： Holm M,Powell T,Casselbrant A,Johansson B,Fändriks L

更新日期：2001-08-01 00:00:00

abstract：:While transilluminating guinea pig gastric wall, we noticed foci of irregular compression of submucosal veins and arteries, featuring parallel bands across arteries, with complete cessation of blood flow, mucosal pallor, and shrinkage of the area. Other features demonstrated that this was not due to artifactual pressu...

journal_title：Digestive diseases and sciences

authors： Piasecki CK,Thrasivoulou C

更新日期：1993-07-01 00:00:00

abstract：:The aims of this study were to determine the impact of irritable bowel syndrome on quality of life using a well-standardized measure, the SF-36, and to determine whether apparent impairments may be due to neuroticism. Undergraduate students with irritable bowel syndrome who had consulted a physician (41 females, 42 ma...

journal_title：Digestive diseases and sciences

authors： Whitehead WE,Burnett CK,Cook EW 3rd,Taub E

更新日期：1996-11-01 00:00:00

abstract：:Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...

journal_title：Digestive diseases and sciences

authors： Defilippi C,Madrid AM,Salas K,Michea L,Lagos N

更新日期：2000-04-01 00:00:00

abstract：:The aim of this study was to assess the potential of leflunomide, an immunosuppressant in rheumatoid arthritis, as a second-line immunosuppression treatment of patients with Crohn's disease refractory or intolerant to azathioprine. The study cohort consisted of 24 patients. The primary end point was steroid-free remis...

journal_title：Digestive diseases and sciences

authors： Holtmann MH,Gerts AL,Weinman A,Galle PR,Neurath MF

更新日期：2008-04-01 00:00:00

abstract：:The purpose of the present study was to investigate the Helicobacter pylori eradication potency of combined amoxicillin-omeprazole treatment in patients with duodenal ulcer disease and to compare the efficacy of two omeprazole and amoxicillin doses concerning H. pylori eradication, ulcer healing, pain relief, and safe...

journal_title：Digestive diseases and sciences

authors： Labenz J,Rühl GH,Bertrams J,Börsch G

更新日期：1994-07-01 00:00:00

abstract：:Seven subjects were given one day's treatment with full doses of either aspirin, ibuprofen, or placebo, and then their stomachs were washed out three times at intervals of 10 min, for five successive days. The blood in the recoveries was estimated chemically. After compensating for gastric emptying, the rate of bleedi...

journal_title：Digestive diseases and sciences

authors： Hunt JN

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease. AIMS:The aim of this study was to determine the effects of feeding a red meat diet with and without resista...

journal_title：Digestive diseases and sciences

authors： Le Leu RK,Young GP,Hu Y,Winter J,Conlon MA

更新日期：2013-12-01 00:00:00

abstract：:In a young woman with Takayasu's arteritis, standard roentgenographic studies suggested a diagnosis of Crohn's ileocolitis. Mesenteric angiography was performed and revealed specific abnormalities diagnostic of Crohn's disease, namely, the zoning sign in the cecum with a hypervascular inner layer and a hypovascular ou...

journal_title：Digestive diseases and sciences

authors： Friedman CJ,Tegtmeyer CJ

更新日期：1979-12-01 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by mucocutaneous pigmentation, hamartomatous polyposis of the gastrointestinal tract, and an increased risk for the development of both gastrointestinal and extraintestinal malignancies. Germline mutation of the STK11 gene, which en...

journal_title：Digestive diseases and sciences

authors： Gao Y,Zhang FM,Huang S,Wang X,Zhang P,Huang XD,Ji GZ,Fan ZN

更新日期：2010-04-01 00:00:00

abstract：:Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies o...

journal_title：Digestive diseases and sciences

authors： Rothstein RD,Alavi A,Reynolds JC

更新日期：1993-08-01 00:00:00