当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Antifibrotic Effects of 1,25(OH)2D3 on Nonalcoholic Steatohepatitis in Female Mice.

Antifibrotic Effects of 1,25(OH)2D3 on Nonalcoholic Steatohepatitis in Female Mice.

Abstract：

BACKGROUND:Postmenopausal women have a higher risk of nonalcoholic steatohepatitis (NASH) along with an increase in age, and vitamin D deficiency occurs in some patients with NASH. AIM:We performed ovariectomy (OVX) surgery on female mice to mimic menopause, fed them a choline-deficient high-fat (CDHF) diet to induce NASH, and then investigated the effects of treatment with 1,25(OH)2D3. METHODS:Seven-week-old C57BL/6J female mice were separated into five experimental groups: SHAM, OVX, and OVX + intraperitoneal (i.p.) injection of 1,25(OH)2D3 (0.0008, 0.004, and 0.02 μg/kg). All groups were fed a CDHF diet for 8 weeks. Injections took place twice per week throughout the experimental period. Blood samples and liver tissue were collected for analyzing liver histological changes, serum biochemical indicators of hepatic function, and hepatic genes associated with fibrosis. RESULTS:Supplementation of 1,25(OH)2D3 in CDHF-diet mice showed decreased serum levels of ALT, AST, indicating the improvement in overall liver function, and suppressed histological NASH regarding fibrosis stage, lobular inflammation, and steatosis compared to the OVX group. Primary fibrotic markers of TGF-β, TIMP-1, α-SMA, and COL1A1 were significantly lower in the 1,25(OH)2D3 groups than in the OVX group. Furthermore, down-regulated levels of SMAD2 and SMAD3 were also observed in 1,25(OH)2D3 groups. CONCLUSION:Supplementation of 1,25(OH)2D3 may ameliorate liver fibrosis and improve liver function in OVX mice with NASH induced by a CDHF diet, suggesting the therapeutic effects on postmenopause with NASH.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Ma L,Ishigami M,Honda T,Yokoyama S,Yamamoto K,Ishizu Y,Kuzuya T,Hayashi K,Hirooka Y,Goto H

doi

10.1007/s10620-019-05560-3

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

2581-2590

issue

9

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-019-05560-3

journal_volume

64

pub_type

杂志文章

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • A pancreatic extract-enriched diet corrects ileal mucosa atrophy in endotoxemic aged rats.

    abstract：:An altered adaptive response of the pancreas and small intestine to nutritional stress has an adverse impact upon nutritional status in elderly humans or senescent rats. We evaluated the effects of a pancreatic extract nutritional supplement on intestinal mucosa adaptation in LPS-treated aged rats. Endotoxemic rats we...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1026614605555

    authors： Farges MC,Raul F,Cezard JP,Davot P,Meunier MT,Cynober L,Vasson MP

    更新日期：1998-10-01 00:00:00

  • Low ERCP Volume Is Associated with More Industry Representative Interactions but Similar Training of Nurses.

    abstract：BACKGROUND:Data on ERCP nurses and associate (ERCP-NA) training and comfort are lacking. Healthcare industry representative (HCIR) influence may be greater in low-volume units (LVUs) due to decreased procedure and device familiarity. AIM:The aim of this study was to compare ERCP-NA training, safety, and HCIR relations...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-015-3926-z

    authors： Keswani RN,Malpas P,Lynch SE,Coté GA

    更新日期：2016-03-01 00:00:00

  • Earlier Anti-Tumor Necrosis Factor Therapy of Crohn's Disease Correlates with Slower Progression of Bowel Damage.

    abstract：INTRODUCTION:Crohn's disease (CD) follows a relapsing and remitting course incurring cumulative bowel damage over time. The question of whether or not the timing of the initiating biologic therapy affects long-term disease progression remains unanswered. Herein, we calculated rates of change in the Lémann index-which q...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5434-4

    authors： Panchal H,Wagner M,Chatterji M,Taouli B,McBride R,Patterson JR,Ungaro R,Dubinsky M,Cho J,Sachar DB

    更新日期：2019-11-01 00:00:00

  • Adalimumab for Induction of Histological Remission in Moderately to Severely Active Ulcerative Colitis.

    abstract：BACKGROUND:Histological remission represents a target distinct from endoscopic healing in ulcerative colitis (UC) and seems a better predictor of clinical outcomes. AIMS:The aim of this study was to assess the ability of adalimumab to achieve histological remission in UC patients. METHODS:Single-center, retrospective...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-4935-5

    authors： Fernández-Blanco JI,Fernández-Díaz G,Cara C,Vera MI,Olivares D,Taxonera C

    更新日期：2018-03-01 00:00:00

  • Urinary choloyl-PABA excretion in diagnosing small intestinal bacterial overgrowth: evaluation of a new noninvasive method.

    abstract：:The synthetic substrate cholyl-PABA, developed by conjugating cholic acid with paraaminobenzoic acid, is hydrolyzed by the bacterial enzyme cholyl hydrolase to release free PABA. This study aimed to evaluate whether quantitating urinary excretion of PABA after oral administration of cholyl-PABA can detect small intest...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1005428703993

    authors： Bardhan PK,Feger A,Kogon M,Muller J,Gillessen D,Beglinger C,Gyr N

    更新日期：2000-03-01 00:00:00

  • PRKCSH genetic mutation was not found in Taiwanese patients with polycystic liver disease.

    abstract：:Polycystic liver disease (PCLD) without polycystic kidney is infrequent in clinical setting. Family clustering is found in patients with PCLD, and it is inherited in an autosomal dominant fashion. Through positional cloning in North America and Europe (mostly in Dutch and Finnish descents), mutations in PRKCSH gene on...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-009-0776-6

    authors： Yang AM,Shih SC,Chu CH,Wang TE,Yang WS

    更新日期：2010-03-01 00:00:00

  • Hepatic steatosis in hepatitis C virus genotype 3 infection: does it correlate with body mass index, fibrosis, and HCV risk factors?

    abstract：:Hepatic steatosis is a recognized feature of hepatitis C viral infection, particularly in genotype 3. The demographics and the associations contributing to moderate to severe steatosis in genotype 3 are not very well studied. The aim of this study is to determine the demographics and association of steatosis with fibr...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/b:ddas.0000011597.92851.56

    authors： Sharma P,Balan V,Hernandez J,Rosati M,Williams J,Rodriguez-Luna H,Schwartz J,Harrison E,Anderson M,Byrne T,Vargas HE,Douglas DD,Rakela J

    更新日期：2004-01-01 00:00:00

  • Different interdigestive antroduodenal motility patterns in chronic antral gastritis with and without Helicobacter pylori infection.

    abstract：:Fasting antroduodenal motor activity was studied in 15 dyspeptic patients with chronic superficial antral gastritis and Helicobacter pylori infection (group A), 10 dyspeptic patients with chronic superficial antral gastritis without Helicobacter pylori infection (group B), and eight healthy control subjects (group C) ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01299905

    authors： Testoni PA,Bagnolo F,Masci E,Colombo E,Tittobello A

    更新日期：1993-12-01 00:00:00

  • Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway.

    abstract：OBJECTIVE:The regulation of apoptosis of intestinal mucosal cells is important in maintenance of normal intestinal physiology. SUMMARY:Sphingosine-1-phosphate (S1P) has been shown to play a critical role in cellular protection to otherwise lethal stimuli in several nonintestinal tissues. METHODS:The current study det...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0393-9

    authors： Greenspon J,Li R,Xiao L,Rao JN,Marasa BS,Strauch ED,Wang JY,Turner DJ

    更新日期：2009-03-01 00:00:00

  • Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells.

    abstract：:Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-010-1191-8

    authors： Liu J,Qu XJ,Xu L,Zang Y,Qu JL,Hou KZ,Liu YP

    更新日期：2010-12-01 00:00:00

  • Evidence for an inherited predisposition to alcoholic pancreatitis. A controlled HLA typing study.

    abstract：:To investigate the role of heredity in alcoholic pancreatitis, an HLA typing study has been performed. Patients with alcoholic pancreatitis exhibited an increased frequency of HLA Bw 39 when compared with the general population [13.6% vs 3.3%, P (corrected) less than 0.02; relative risk 4.7]. Alcoholics without pancre...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01312945

    authors： Wilson JS,Gossat D,Tait A,Rouse S,Juan XJ,Pirola RC

    更新日期：1984-08-01 00:00:00

  • In vitro tests overestimate in vivo neutralizing capacity of antacids in presence of food.

    abstract：:The neutralizing capacity of two antacids (Alucol = A, Syntrogel = S), differing both in their composition and theoretical neutralizing capacity, was evaluated in vitro and in vivo. In vitro at pH 3.5, 1 ml of A or S neutralizes 3.9 and 1.6 meq of acid, respectively, in an aqueous solution. When tested in vivo in the ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01320257

    authors： Berchtold P,Reinhart WH,Niederhäuser U,Koller U,Halter F

    更新日期：1985-06-01 00:00:00

  • Inhibition of canine gastric secretion by the prostanoid Ro 22-6923.

    abstract：:The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated aci...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01403843

    authors： Gaginella TS,Bertko RJ,Müller RK,Gallo-Torres H,Sullivan AC

    更新日期：1985-04-01 00:00:00

  • Halofuginone, a specific inhibitor of collagen type 1 synthesis, ameliorates oxidant colonic damage in rats with experimental colitis.

    abstract：:To evaluate the effect of halofuginone on trinitrobenzene sulfonic acid (TNBS)-induced colonic injury, rats were given halofuginone (40 microg/kg, intraperitoneally) or saline 1 h before the induction of colitis, and the injections were continued twice daily for 3 days until they were decapitated. High macroscopic and...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-009-0798-0

    authors： Karakoyun B,Yüksel M,Ercan F,Salva E,Işik I,Yeğen BC

    更新日期：2010-03-01 00:00:00

  • Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique.

    abstract：:A new technique for the long-term ambulatory detection of enterogastric and nonacid gastroesophageal reflux has been conceived, developed, and validated. It is based on the use of a fiberoptic sensor that utilizes the optical properties of bile. In vitro studies have shown good precision, good stability, sensitivity o...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296082

    authors： Bechi P,Pucciani F,Baldini F,Cosi F,Falciai R,Mazzanti R,Castagnoli A,Passeri A,Boscherini S

    更新日期：1993-07-01 00:00:00

  • Diagnostic Delay Is Associated with a Greater Risk of Early Surgery in a French Cohort of Crohn's Disease Patients.

    abstract：AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-016-4189-z

    authors： Nahon S,Lahmek P,Paupard T,Lesgourgues B,Chaussade S,Peyrin-Biroulet L,Abitbol V

    更新日期：2016-11-01 00:00:00

  • Rates of Prevalent Colorectal Cancer Occurrence in Persons 75 Years of Age and Older: A Population-Based National Study.

    abstract：BACKGROUND/AIMS:There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, popul...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5073-9

    authors： Chouhan V,Mansoor E,Parasa S,Cooper GS

    更新日期：2018-07-01 00:00:00

  • Xenon-inhalation computed tomography for noninvasive quantitative measurement of tissue blood flow in pancreatic tumor.

    abstract：BACKGROUND AND AIMS:The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD). METHODS...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10620-011-1915-4

    authors： Kubota M,Murakami T,Nagano H,Eguchi H,Marubashi S,Kobayashi S,Wada H,Tanemura M,Dono K,Nakamori S,Sakon M,Monden M,Mori M,Doki Y

    更新日期：2012-03-01 00:00:00

  • Gastric acid secretion in cold urticaria.

    abstract：:Four patients with cold urticaria and six control subjects were studied. Gastric acid output was measured for 1 hr before and 1 hr after the immersion of both hands in ice cold water. The mean acid output fell in the control group by 16.3%. Acid output in the cold urticaria patients rose in each case following the col...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01315214

    authors： Lass N,Doron O,Gilat T

    更新日期：1980-07-01 00:00:00

  • Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs.

    abstract：:The mechanisms of pentagastrin-induced gastric mucosal blood flow (GMBF) response were investigated in anesthetized rats. A rat stomach was mounted on an ex vivo chamber, perfused with saline, and GMBF was measured by a laser Doppler flowmetry simultaneously with acid secretion. Pentagastrin infused intravenously prod...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02282323

    authors： Kato S,Okabe S,Takeuchi K

    更新日期：1996-03-01 00:00:00

  • Genetic polymorphisms of GSTT1, GSTM1, GSTP1, MnSOD, and catalase in nonhereditary chronic pancreatitis: evidence of xenobiotic stress and impaired antioxidant capacity.

    abstract：:Epidemiological studies have demonstrated a variety of potential environmental factors that may alter susceptibility to chronic pancreatitis (CP) through oxidative/xenobiotic stress; however, a direct causal and mechanistic role has not been established. We aimed (1) to determine the prevalence of functional genetic p...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-005-2790-7

    authors： Rahman SH,Nanny C,Ibrahim K,O'Reilly D,Larvin M,Kingsnorth AJ,McMahon MJ

    更新日期：2005-07-01 00:00:00

  • Alterations of bile acid composition in gallstones, bile, and liver of patients with hepatolithiasis, and their etiological significance.

    abstract：:A detailed comparison was made of the bile acid composition in gallstones (brown pigment stones) and paired bile and liver from both affected and unaffected lobes by gallstones, which were taken at operation from 16 patients with hepatolithiasis, with the aim of elucidating whether stone formation is derived from poss...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297095

    authors： Shoda J,Tanaka N,He BF,Matsuzaki Y,Osuga T,Miyazaki H

    更新日期：1993-11-01 00:00:00

  • Lichen planus involving the esophagus.

    abstract：:Lichen planus is a common mucocutaneus disorder that rarely involves the esophagus. We report two challenging cases presenting with recurrent dysphagia originally suspected due to gastroesophageal reflux. Subsequent evaluation revealed peculiar endoscopic findings of desquamative esophagitis leading to the diagnosis o...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1023/a:1011943805711

    authors： Ukleja A,DeVault KR,Stark ME,Achem SR

    更新日期：2001-10-01 00:00:00

  • Can Sertraline and Nortriptyline Protect the Neurons in Submucosal and Myenteric Plexuses of Rat's Colon Against Stress?

    abstract：BACKGROUND:The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyli...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05600-y

    authors： Noorafshan A,Yousefi M,Hosseini L,Karbalay-Doust S

    更新日期：2019-09-01 00:00:00

  • Antioxidant effect of T-type calcium channel blockers in gastric injury.

    abstract：:It is known that calcium ion has an important role in the cellular function. For this reason, calcium channel blockers may have a protective action against gastric injury which is induced by various stimuli. In this study, the influence of mibefradil on ethanol-induced gastric injury was investigated in rats. Mibefrad...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1014712621794

    authors： Bilici D,Banoğlu ZN,Kiziltunç A,Avci B,Ciftçioğlu A,Bilici S

    更新日期：2002-04-01 00:00:00

  • Overlap syndromes of autoimmune hepatitis: an open question.

    abstract：:The headword "overlap syndromes" of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. These syndromes often represent a diagnostic and therapeutic challenge for hepatologists; it remains unclear whether these overlap syndromes form distinct ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-012-2378-y

    authors： Durazzo M,Premoli A,Paschetta E,Belci P,Spandre M,Bo S

    更新日期：2013-02-01 00:00:00

  • Reduced postprandial blood glucose levels in recently diagnosed non-insulin-dependent diabetics secondary to pharmacologically induced delayed gastric emptying.

    abstract：:In a previous study we demonstrated that patients with recently diagnosed non-insulin-dependent diabetes mellitus (NIDDM) had significantly increased gastric emptying rates of glucose solutions compared with those of nondiabetic sex- and age-matched controls. This finding of rapid gastric emptying contrasts with the d...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296773

    authors： Phillips WT,Schwartz JG,McMahan CA

    更新日期：1993-01-01 00:00:00

  • Somatostatin enhances cAMP-dependent short-circuit current in human colon via somatostatin receptor subtype-2.

    abstract：:Somatostatin inhibits colonic ion secretion in animal models and cultured intestinal cell lines via somatostatin receptor subtype 2 and subtype 1, respectively. In a recent in vitro ion transport study of the human colon, somatostatin was shown to stimulate short-circuit current, a measure of electrogenic ion transpor...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1012392307462

    authors： Hope N,Butt G,Ross I,Warhurst G,Arn M,Grigor M,Lubcke R,Barbezat GO

    更新日期：2001-11-01 00:00:00

  • Rectal administration of lipopolysaccharide and ovalbumin ameliorates acute murine colitis.

    abstract：BACKGROUND:Repeated challenges of lipopolysaccharide (LPS) could reduce the expression of proinflammatory cytokines in vitro, and oral administration of ovalbumin (OVA) induces mucosal tolerance in vivo. However, the effect of local administration of LPS and OVA on experimental colitis in vivo remains unknown. AIMS:Th...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1630-1

    authors： Im JP,Ye BD,Kim JM,Jung HC,Song IS,Kim JS

    更新日期：2011-08-01 00:00:00

  • Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.

    abstract：:Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1022832608466

    authors： Kim HJ,Lee SK,Kim MH,Seo DW,Min YI

    更新日期：2003-04-01 00:00:00