Rectal administration of lipopolysaccharide and ovalbumin ameliorates acute murine colitis.


BACKGROUND:Repeated challenges of lipopolysaccharide (LPS) could reduce the expression of proinflammatory cytokines in vitro, and oral administration of ovalbumin (OVA) induces mucosal tolerance in vivo. However, the effect of local administration of LPS and OVA on experimental colitis in vivo remains unknown. AIMS:This study was performed to elucidate the effect of rectal administration of LPS and OVA on an acute murine colitis induced by dextran sulfate sodium (DSS). METHODS:BALB/c mice were rectally administered LPS with or without OVA followed by 3% DSS. Colitis was assessed by disease activity index (DAI) including weight loss, stool consistency and rectal bleeding, and histopathology. Primary colon epithelial cells were isolated and the expression of Toll-like receptor 4 (TLR4) was examined using the Western blot analysis. IL-6, IFN-γ and IL-10 mRNA levels in colonic tissue were assessed using real-time RT-PCR. RESULTS:LPS administration significantly attenuated the severity of acute DSS-induced colitis as assessed by DAI and histopathologic scoring compared with the control group. Combined treatment of LPS and OVA restored body weight loss and further ameliorated the severity of acute DSS colitis. LPS pretreatment regardless of OVA administration decreased TLR4 expression. LPS and OVA pretreatment reduced IL-6 and IFN-γ mRNA expression and increased IL-10 mRNA expression compared with controls. CONCLUSION:Rectal administration of LPS attenuated acute murine colitis, possibly through TLR4 down-regulation, and combined treatment of OVA additionally ameliorated colonic inflammation associated with up-regulation of IL-10.


Dig Dis Sci


Im JP,Ye BD,Kim JM,Jung HC,Song IS,Kim JS




Has Abstract


2011-08-01 00:00:00












  • Familial adenomatous polyposis and extracolonic cancer.

    abstract::Our purpose is to focus attention on the cancer family history, coupled with an understanding of the natural history and extracolonic tumor spectrum of familial adenomatous polyposis (FAP), through a family study. This family report provides an example of how colorectal cancer (CRC) can be prevented by knowledgeable g...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lynch HT,Thorson AG,McComb RD,Franklin BA,Tinley ST,Lynch JF

    更新日期:2001-11-01 00:00:00

  • Giant hyperplastic polyposis of the colon.

    abstract::A patient with multiple large hyperplastic (metaplastic) polyps of the colon is reported. Hundreds of polyps, some over 3 cm in size, were distributed uniformly throughout the large bowel. There was no evidence of polyps in the stomach or small intestine. The polyps, except for their large size, had the histologic fea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sumner HW,Wasserman NF,McClain CJ

    更新日期:1981-01-01 00:00:00

  • Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial.

    abstract:BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sureshkumar S,Omang A,Anandhi A,Rajesh BS,Abdulbasith KM,Vijayakumar C,Palanivel C,Pazhanivel M,Kate V

    更新日期:2020-11-18 00:00:00

  • The Novel Scoring System for 30-Day Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding.

    abstract:BACKGROUND:Although the mortality rates for non-variceal upper gastrointestinal bleeding (NVUGIB) have recently decreased, it remains a significant medical problem. AIM:The main aim of this prospective multicenter database study was to construct a clinically useful predictive scoring system by using our predictors and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Hwang S,Jeon SW,Kwon JG,Lee DW,Ha CY,Cho KB,Jang B,Park JB,Park YS,Daegu-Gyengbuk Gastrointestinal Study Group (DGSG).

    更新日期:2016-07-01 00:00:00

  • Clarithromycin resistance, but not CYP2C-19 polymorphism, has a major impact on treatment success in 7-day treatment regimen for cure of H. pylori infection: a multiple logistic regression analysis.

    abstract::Mutations in the gene encoding the CYP2C-19 enzyme for PPI metabolism have been shown to enhance the chance for a cure in a H. pylori-positive patients using a two-week dual-therapy regimen involving omeprazole and amoxicillin. However, the impact of CYP2C-19 genetic polymorphism on eradication rates of a one-week tri...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Miwa H,Misawa H,Yamada T,Nagahara A,Ohtaka K,Sato N

    更新日期:2001-11-01 00:00:00

  • Gastric bilirubin monitoring to assess duodenogastric reflux.

    abstract::Duodenogastric reflux (DGR) was assessed with 24-hour gastric bilirubin monitoring in 345 patients (219 men; 49 +/- 13 years) with foregut symptoms and 41 healthy subjects (24 men, 28 +/- 5 years). Bilirubin exposure was measured as percent time above absorbance level 0.25 and excessive DGR was defined above the 95th ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fein M,Freys SM,Sailer M,Maroske J,Tigges H,Fuchs KH

    更新日期:2002-12-01 00:00:00

  • Zinc and the liver: an active interaction.

    abstract::Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Stamoulis I,Kouraklis G,Theocharis S

    更新日期:2007-07-01 00:00:00

  • Experimental studies to estimate the intestinal viability in a rat strangulated ileus model using a dielectric parameter.

    abstract::This study aimed at establishment of adequate evaluation of intestinal viability before release of the strangulated intestine by measuring electrical properties. In rats a 20-cm segment of the distal ileum and mesentery was strangulated. The intestine was strangulated for 0, 2, 15, 45, 90, and 120 min. The conductance...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Matsuo H,Hirose H,Mori Y,Takagi H,Iwata H,Yamada T,Sakamoto K,Yasumura M

    更新日期:2004-04-01 00:00:00

  • Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects.

    abstract::There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Grisham MB,Ware K,Marshall S,Yamada T,Sandhu IS

    更新日期:1992-09-01 00:00:00

  • Hydralazine-induced liver injury.

    abstract::A 68-year-old man developed hepatic injury with no hypersensitivity reaction after three years of hydralazine therapy. The liver injury histologically showed centrilobular zonal necrosis. Clinical, biochemical, and histological recovery followed discontinuation of the drug. Challenge tests and serial liver biopsies re...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Itoh S,Yamaba Y,Ichinoe A,Tsukada Y

    更新日期:1980-11-01 00:00:00

  • Various S-GOT/S-GPT ratios in nonviral liver disorders and related physical conditions and life-style.

    abstract::The relationship between the GOT/GPT ratio in nonviral liver disorders and underlying physical condition and life-style were evaluated. The subjects were 12,808 male railway company workers who underwent an annual health checkup. Nonviral liver disorders were defined as elevated transaminases (GOT > 76 IU/liter or GPT...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mukai M,Ozasa K,Hayashi K,Kawai K

    更新日期:2002-03-01 00:00:00

  • Blinded prospective comparison of the performance of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of the pancreas and peri-pancreatic lesions.

    abstract:BACKGROUND:Both 22- and 25-gauge needles are used for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lesions, yet limited data exist on whether either offers an advantage over the other in terms of specimen cellularity and quality. AIM:The aim of this study was to compare sample quality for 22- and...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Lee JH,Stewart J,Ross WA,Anandasabapathy S,Xiao L,Staerkel G

    更新日期:2009-10-01 00:00:00

  • Safety and Efficacy of Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis in Long-Term Dialysis: A Propensity Score Analysis.

    abstract:BACKGROUND AND AIM:Previous studies evaluating the safety of endoscopic retrograde cholangiopancreatography (ERCP) in patients with end-stage renal disease (ESRD) undergoing hemodialysis reported an increased risk of post-procedural bleeding. We investigated the safety and efficacy of ERCP for the treatment of choledoc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim SB,Kim KH,Kim TN

    更新日期:2018-11-01 00:00:00

  • Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer.

    abstract::The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kamada T,Haruma K,Kusunoki H,Miyamoto M,Ito M,Kitadai Y,Yoshihara M,Chayama K,Tahara K,Kawamura Y

    更新日期:2003-04-01 00:00:00

  • Gender differences in gastrointestinal, psychological, and somatic symptoms in irritable bowel syndrome.

    abstract::In the United States, more women than men seek health-care services for symptoms of irritable bowel syndrome (IBS). A number of explanations are given for this gender difference including the higher rates of somatic non-gastrointestinal symptoms and increased psychological distress reported by women with IBS. However,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cain KC,Jarrett ME,Burr RL,Rosen S,Hertig VL,Heitkemper MM

    更新日期:2009-07-01 00:00:00

  • Achalasia presenting after operative and nonoperative trauma.

    abstract::Achalasia has been described following fundoplication and is attributed to vagal nerve damage during surgery. Similarly, other traumatic events to the distal esophagus may be linked to the development of achalasia. Operative and nonoperative trauma as a possible factor in the development of achalasia was studied. A re...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shah RN,Izanec JL,Friedel DM,Axelrod P,Parkman HP,Fisher RS

    更新日期:2004-11-01 00:00:00

  • Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults.

    abstract:BACKGROUND:Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter. METHODS:We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility featur...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: O'Dwyer RH,Acosta A,Camilleri M,Burton D,Busciglio I,Bharucha AE

    更新日期:2015-08-01 00:00:00

  • Gastric mucosal blood flow regulation in response to different stimuli.

    abstract::We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, under baseline condi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Méndez A,Casadevall M,Wachter CH,Elizalde JI,Del Rivero M,Heinemann A,Holzer P,Quintero E,Piqué JM

    更新日期:1997-09-01 00:00:00

  • Cardiac Metaplasia: Follow, Treat, or Ignore?

    abstract::Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Spechler SJ

    更新日期:2018-08-01 00:00:00

  • Irritable bowel syndrome. Still far from a positive diagnosis.

    abstract::The diagnosis of irritable bowel syndrome requires the exclusion of any associated organic disease: a positive diagnosis would avoid expensive and potentially dangerous diagnostic procedures. A scoring system has been proposed for positive diagnosis where more than 44 points excluded organic digestive disease. The aim...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Frigerio G,Beretta A,Orsenigo G,Tadeo G,Imperiali G,Minoli G

    更新日期:1992-02-01 00:00:00

  • Balloon-Occluded Retrograde Transvenous Obliteration (BRTO) for Treatment of Gastric Varices: Review and Meta-Analysis.

    abstract:AIM:To perform a systematic review and meta-analysis of the effectiveness and complications of BRTO for gastric varices. MATERIALS AND METHODS:A systematic review was performed to identify relevant articles. Inclusion criteria were applied to select studies with at least ten patients with acute bleeding or at-risk gas...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审


    authors: Park JK,Saab S,Kee ST,Busuttil RW,Kim HJ,Durazo F,Cho SK,Lee EW

    更新日期:2015-06-01 00:00:00

  • Experience with the new 4-way, 5.5-mm ultrathin endoscope: a case series.

    abstract:BACKGROUND AND STUDY AIMS:Use of ultrathin (ut) endoscopes is sometimes limited by their design (outer diameter, tip angulation and image quality). New ut-endoscopes are being designed to address these limitations. A new ut-endoscope, XGIF-PV70N5 (Olympus America Inc.), with an outer diameter of 5.5 mm, 4-way angulatio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Agrawal D,Wong RC,Isenberg G,Faulx A,Chak A

    更新日期:2011-03-01 00:00:00

  • Impact of microcirculatory flow pattern changes on the development of acute edematous and necrotizing pancreatitis in rabbit pancreas.

    abstract::Impairment of pancreatic microcirculation has often been advocated as one pathogenic mechanism in necrotizing pancreatitis. In contrast, data on pancreatic capillary perfusion in edematous pancreatitis are scarce. It was the aim of this experimental study to compare changes in pancreatic microcirculation in edematous ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Klar E,Schratt W,Foitzik T,Buhr H,Herfarth C,Messmer K

    更新日期:1994-12-01 00:00:00

  • Lack of correlation between serum lipoproteins and biliary cholesterol saturation in patients with gallstones.

    abstract::It has been suggested that elevated serum lipoprotein cholesterol levels may be a determinant of biliary cholesterol saturation and cholesterol gallstone disease. The aim of this study was to correlate serum lipoprotein cholesterol and apolipoprotein levels with biliary cholesterol saturation in patients with gallston...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Marks JW,Cleary PA,Albers JJ

    更新日期:1984-12-01 00:00:00

  • Bile acid composition in brown pigment stones.

    abstract::The bile acids in brown pigment stones and gallbladder bile were fractionated into free acids, glycine and taurine conjugates, and sulfates using diethylaminohydroxypropyl Sephadex LH-20 (DEAP-LH-20) column chromatography and were quantitated by gas chromatography. Twenty-eight cases of brown pigment stones were studi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Akiyoshi T,Nakayama F

    更新日期:1990-01-01 00:00:00

  • Nerve-mediated nitric oxide production by opossum lower esophageal sphincter.

    abstract::Antagonists of nitric oxide synthesis inhibit nerve-induced hyperpolarization and relaxation of muscle from the opossum lower esophageal sphincter. These studies test the hypothesis that nitric oxide is released during stimulation of intrinsic esophageal nerves. The intrinsic nerves were stimulated with an electrical ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Murray J,Bates JN,Conklin JL

    更新日期:1994-09-01 00:00:00

  • Antiulcer drugs and gastric cancer.

    abstract::Inhibitors of gastric acid secretion are efficient drugs in the treatment of acid-related diseases. However, by reducing gastric acidity, hypergastrinemia develops. Gastrin regulates its target cell, the enterochromaffin (ECL) cell, both functionally and tropicaly. Long-term hypergastrinemia in whatever species studie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Waldum HL,Gustafsson B,Fossmark R,Qvigstad G

    更新日期:2005-10-01 00:00:00

  • Heterogeneity of HPLC profiles of human class II MHC-bound peptides isolated from intestine with inflammatory bowel disease.

    abstract::Studies of the T-cell-receptor repertoire and oligoclonal expansion of lamina propria T cells in patients with Crohn's disease suggest restricted antigen processing in this disease. We examined HPLC elution profiles of HLA-DR-bound peptides isolated from human intestine. Surgical samples of colon and ileum were obtain...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Oshitani N,Hato F,Jinno Y,Sawa Y,Hara J,Nakamura S,Matsumoto T,Arakawa T,Kitano A,Kitagawa S,Kuroki T

    更新日期:2002-09-01 00:00:00

  • Insulin and glucagon levels in liver cirrhosis. Relationship with plasma amino acid imbalance of chronic hepatic encephalopathy.

    abstract::Alterations in insulin and glucagon levels might account for the plasma amino acid imbalance of cirrhotics. In order to verify this hypothesis we evaluated basal insulin, glucagon, branched-chain amino acids, aromatic amino acids, and free tryptophan in 13 controls and 37 cirrhotics divided on the basis of their menta...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Marchesini G,Forlani G,Zoli M,Angiolini A,Scolari MP,Bianchi FB,Pisi E

    更新日期:1979-08-01 00:00:00

  • Inducible nitric oxide synthase inhibitors ameliorate hypermotility observed after T. spiralis infection in the rat.

    abstract::Trichinella spiralis infection in rodents is a well-known model of intestinal inflammation associated with hypermotility and hypersecretion. Our aim was to use this experimental model to elucidate if iNOS was involved in the development of gastrointestinal hypermotility. Rats infected with Trichinella spiralis were tr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Torrents D,Prats N,Vergara P

    更新日期:2003-06-01 00:00:00