Rectal administration of lipopolysaccharide and ovalbumin ameliorates acute murine colitis.


BACKGROUND:Repeated challenges of lipopolysaccharide (LPS) could reduce the expression of proinflammatory cytokines in vitro, and oral administration of ovalbumin (OVA) induces mucosal tolerance in vivo. However, the effect of local administration of LPS and OVA on experimental colitis in vivo remains unknown. AIMS:This study was performed to elucidate the effect of rectal administration of LPS and OVA on an acute murine colitis induced by dextran sulfate sodium (DSS). METHODS:BALB/c mice were rectally administered LPS with or without OVA followed by 3% DSS. Colitis was assessed by disease activity index (DAI) including weight loss, stool consistency and rectal bleeding, and histopathology. Primary colon epithelial cells were isolated and the expression of Toll-like receptor 4 (TLR4) was examined using the Western blot analysis. IL-6, IFN-γ and IL-10 mRNA levels in colonic tissue were assessed using real-time RT-PCR. RESULTS:LPS administration significantly attenuated the severity of acute DSS-induced colitis as assessed by DAI and histopathologic scoring compared with the control group. Combined treatment of LPS and OVA restored body weight loss and further ameliorated the severity of acute DSS colitis. LPS pretreatment regardless of OVA administration decreased TLR4 expression. LPS and OVA pretreatment reduced IL-6 and IFN-γ mRNA expression and increased IL-10 mRNA expression compared with controls. CONCLUSION:Rectal administration of LPS attenuated acute murine colitis, possibly through TLR4 down-regulation, and combined treatment of OVA additionally ameliorated colonic inflammation associated with up-regulation of IL-10.


Dig Dis Sci


Im JP,Ye BD,Kim JM,Jung HC,Song IS,Kim JS




Has Abstract


2011-08-01 00:00:00












  • More than Just a Hole in the Wall: Evolving Management and Treatment Paradigms of Suppurative Gastritis.

    abstract::Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Coles M,Madray V,Cox K,Uy P,Sharma A

    更新日期:2020-08-01 00:00:00

  • The overlap syndromes of autoimmune hepatitis.

    abstract::Autoimmune hepatitis has two major variant phenotypes in which the features of classical disease are co-mingled with those of primary biliary cirrhosis or primary sclerosing cholangitis. These overlap syndromes lack codified diagnostic criteria, established pathogenic mechanisms, and confident management strategies. T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Czaja AJ

    更新日期:2013-02-01 00:00:00

  • Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model.

    abstract:BACKGROUND:Gut dysmotility is closely associated with proinflammatory cytokines both in irritable bowel syndrome and inflammatory bowel disease. There is a dose-response relationship between depression and these inflammatory cytokines. AIMS:In the present study, we aimed to investigate the effect of Interleukin-6 (IL-...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zhang L,Hu L,Chen M,Yu B

    更新日期:2013-08-01 00:00:00

  • Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome.

    abstract:AIM:The aim of this case-control study was to investigate both the distribution of MCP-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes. METHOD:Between September 1997-January 2005, 20 patients with HPS (group 1) were compared with a group of cirrhotic patients (group 2, n = 19) as w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tumgor G,Berdeli A,Arikan C,Levent E,Aydogdu S

    更新日期:2008-05-01 00:00:00

  • Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.

    abstract:BACKGROUND:Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation. AIMS:To study the expression profile of inflammatory and tight junction proteins in the colon f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lau WL,Liu SM,Pahlevan S,Yuan J,Khazaeli M,Ni Z,Chan JY,Vaziri ND

    更新日期:2015-05-01 00:00:00

  • Modulation of esophageal contractions by distension in vitro.

    abstract::Stimulation of the intrinsic nerves of the esophageal body leads to a twitch of the circular muscle after the end of the stimulation (the esophageal off-response), and the twitch spreads in the distal direction because of a latency gradient in the onset of the off-response between the proximal and the distal esophagus...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ren J,Schulze-Delrieu K

    更新日期:1989-04-01 00:00:00

  • Fibrin ring granulomas in hepatitis A.

    abstract::Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypers...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ruel M,Sevestre H,Henry-Biabaud E,Courouce AM,Capron JP,Erlinger S

    更新日期:1992-12-01 00:00:00

  • The human intestinal microflora.

    abstract::The major host defense mechanisms against bacterial overgrowth in the small bowel are the normal propulsive activity of the bowel itself and gastric acid secretion. Microbial interactions are a major factor in regulating the indigenous bacterial flora. Studies of the bacterial enzymes of the gut suggest that changes i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Simon GL,Gorbach SL

    更新日期:1986-09-01 00:00:00

  • Case report: primary CD30 (Ki-1)-positive anaplastic large cell lymphoma of the duodenum.

    abstract::As recently described, Ki-1 anaplastic large cell lymphoma is a distinctive subtype of non-Hodgkin's lymphoma. We report a Ki-1 anaplastic large cell lymphoma of the duodenum in a 62-year-old man. He received modified CHOP therapy and was in complete remission at 18 months. To our knowledge, this is the first report o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Yoshikawa I,Murata I,Tanaka Y,Kanagawa K,Tabaru A,Itoh H,Otsuki M

    更新日期:1996-12-01 00:00:00

  • CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway.

    abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Recent studies have reported that circular RNAs (circRNAs) are important regulators of hepatic steatosis. However, the role and mechanism of circRNA in NAFLD are poorly understood. AIMS:This study is to ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Li P,Shan K,Liu Y,Zhang Y,Xu L,Xu L

    更新日期:2019-01-01 00:00:00

  • Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes.

    abstract:BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gupta P,Virk M,Gulati A,Muktesh G,Shah J,Samanta J,Mandavdhare H,Sharma V,Dutta U,Kochhar R

    更新日期:2020-08-10 00:00:00

  • Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy.

    abstract::The role of mucosal T-cell activation in HIV-associated enteropathy is uncertain. Twenty Zambian patients with AIDS and chronic diarrhea were studied, as were nine controls. Distal duodenal biopsies were taken at endoscopy. Morphometric analysis and dual color immunofluorescence staining were performed. Villous height...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Veitch AM,Kelly P,Zulu I,MacDonald TT,Farthing MJ

    更新日期:2001-05-01 00:00:00

  • Measurement of bile acid half-life using [75Se]HCAT in health and intestinal diseases. Comparison with [75Se]HCAT abdominal retention methods.

    abstract::The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ferraris R,Galatola G,Barlotta A,Pellerito R,Fracchia M,Cottino F,de la Pierre M

    更新日期:1992-02-01 00:00:00

  • Apamin attenuated cerulein-induced acute pancreatitis by inhibition of JNK pathway in mice.

    abstract:BACKGROUND/AIM:We have previously reported that bee venom (BV) has a protective role against acute pancreatitis (AP). However, the effects of apamin, the major compound of BV, on AP have not been determined. The aim of this study was to evaluate the effects of apamin on cerulein-induced AP. METHODS:AP was induced via ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bae GS,Heo KH,Park KC,Choi SB,Jo IJ,Seo SH,Kim DG,Shin JY,Kang DG,Lee HS,Song HJ,Shin BC,Park SJ

    更新日期:2013-10-01 00:00:00

  • Bacterial translocation to mesenteric lymph nodes increases in chronic portal hypertensive rats.

    abstract:PURPOSE:Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Llamas MA,Aller MA,Marquina D,Nava MP,Arias J

    更新日期:2010-08-01 00:00:00

  • Prevalence of gallstones in patients with primary immunoglobulin deficiency. Evidence for lack of association.

    abstract::In the early 1970s an increased prevalence of gallstones was reported in adults and children with immunoglobulin deficiency. As the advent of ultrasonography has largely changed the diagnostic approach to gallstones, we have reevaluated the prevalence of cholelithiasis in a group including 37 patients with common vari...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: De Santis A,Paganelli R,Stefanoni R,Di Sabatino A,Angelico M

    更新日期:1990-06-01 00:00:00

  • Validation of the 7th edition TNM staging system for hepatocellular carcinoma: an analysis of 8,828 patients in a single medical center.

    abstract:BACKGROUND:Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kee KM,Wang JH,Lin CY,Wang CC,Cheng YF,Lu SN

    更新日期:2013-09-01 00:00:00

  • Impact of Angiotensin II Signaling Blockade on Clinical Outcomes in Patients with Inflammatory Bowel Disease.

    abstract:BACKGROUND:Preclinical data demonstrate that activation of the renin-angiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in animal models. Less is known regarding the effects of RAS i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jacobs JD,Wagner T,Gulotta G,Liao C,Li YC,Bissonnette M,Pekow J

    更新日期:2019-07-01 00:00:00

  • Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease.

    abstract:BACKGROUND:Previous studies have shown vitamin D status to be associated with disease activity in patients with inflammatory bowel disease (IBD), but its influence on the clinical course of IBD has not been established. AIMS:We aimed to analyze whether the serum 25-hydroxyvitamin D3 [25(OH)D] status is associated with...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ham NS,Hwang SW,Oh EH,Kim J,Lee HS,Park SH,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

    更新日期:2020-03-26 00:00:00

  • Omega-3 Fatty Acids and Gut Microbiota: A Reciprocal Interaction in Nonalcoholic Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease characterized with the spectrum of hepatic steatosis, inflammation, and fibrosis. The etiology of NAFLD remains incompletely understood. Numerous studies have implied that the gut microbiota (GM) is involved in the development of NAFLD, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Shama S,Liu W

    更新日期:2020-03-01 00:00:00

  • HCC: Transarterial Therapies-What the Interventional Radiologist Can Offer.

    abstract::With the increasing incidence of hepatocellular carcinoma (HCC) and its high mortality rates, effective treatment options are of urgent need, preferably in a multidisciplinary setting. In the management of those patients, interventional radiologists play a key role. In this article, we reviewed the current literature ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Vogl TJ,Gruber-Rouh T

    更新日期:2019-04-01 00:00:00

  • Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:HAb18G/CD147 expression has been associated with many tumor invasion molecules, which play important roles in recurrence and poor differentiation of esophageal squamous cell carcinoma (ESCC). However, the clinical implications of HAb18G/CD147 in ESCC are still unclear. AIMS:In this study, we clarified the c...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zhu S,Li Y,Mi L,Zhang Y,Zhang L,Gong L,Han X,Yao L,Lan M,Chen Z,Zhang W

    更新日期:2011-12-01 00:00:00

  • A fulminant hepatic failure model in the rat: involvement of interleukin-1beta and tumor necrosis factor-alpha.

    abstract::The development of a fulminant hepatic failure (FHF) model is necessary for evaluating the efficacy of extracorporeal liver support systems. Recognizing the multifaceted functions of the liver, including synthesis and degradation, we investigated blood chemistry, histological findings, and survival rate in D-galactosa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shito M,Balis UJ,Tompkins RG,Yarmush ML,Toner M

    更新日期:2001-08-01 00:00:00

  • Initial Computed Tomography Findings of Long and Distended Colon Are Risk Factors for the Recurrence of Sigmoid Volvulus.

    abstract:BACKGROUND:Sigmoid volvulus is a common condition in elderly patients with elongated colons. Although endoscopic de-torsion is effective as the primary treatment of sigmoid volvulus, elective surgery is recommended because of the high risk of recurrence and high mortality rate. AIM:The aim of this study was to determi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kusunoki R,Fujishiro H,Miyake T,Suemitsu S,Kataoka M,Fujiwara A,Tsukano K,Kotani S,Yamanouchi S,Aimi M,Tanaka M,Miyaoka Y,Kohge N,Imaoka T,Yuasa K,Kodama K,Ishihara S,Kinoshita Y

    更新日期:2020-05-14 00:00:00

  • Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cells.

    abstract::The major heat shock protein, HSP70, is known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperone." However, the influence of HSP70 on gastric mucosal healing under physical stimulation or stress is not completely understood. Rat gastric mucosal cells (R...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Odashima M,Otaka M,Matsuhashi T,Jin M,Horikawa Y,Ohba R,Itoh H,Watanabe S

    更新日期:2007-11-01 00:00:00

  • Viral and host factors that contribute to efficacy of interferon-alpha 2a therapy in patients with chronic hepatitis C.

    abstract::Using conventional statistical analysis and multiple regression analysis, we investigated the viral and host factors that influence the response to recombinant interferon-alpha 2a therapy in patients with chronic hepatitis C. A total of 36 patients was randomly assigned to three administration schedules, 12 patients i...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Matsumoto A,Tanaka E,Suzuki T,Ogata H,Kiyosawa K

    更新日期:1994-06-01 00:00:00

  • "Deathgrip" esophagus: segmental aperistalsis following electrical injury.

    abstract::We report a case of documented transient segmental aperistalsis of the distal esophagus following an accidental electrical injury. There are no other reports in the literature demonstrating this phenomenon. A review of gastrointestinal injury secondary to electrical injury is presented. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rubin BM,Doman DB,Goldberg HJ,Golding MI

    更新日期:1998-09-01 00:00:00

  • Beneficial Effects of Fecal Microbiota Transplantation on Ulcerative Colitis in Mice.

    abstract:BACKGROUND:Ulcerative colitis (UC) is a chronic condition and the most common form of inflammatory bowel disease. The goal of standard treatment is mainly to induce and maintain remission with anti-inflammatory, immunosuppressive agents, and/or colectomy. Fecal microbiota transplantation (FMT) has been used successfull...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tian Z,Liu J,Liao M,Li W,Zou J,Han X,Kuang M,Shen W,Li H

    更新日期:2016-08-01 00:00:00

  • The 3'UTR NFKBIA variant is associated with extensive colitis in Hungarian IBD patients.

    abstract:PURPOSE:In previous studies the NFKBIA 3'UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/delATTG mutation increased the risk for ulcerative colitis (UC). The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Szamosi T,Lakatos PL,Hungarian IBD Study Group.,Szilvasi A,Lakatos L,Kovacs A,Molnar T,Altorjay I,Papp M,Szabo O,Satori A,Tulassay Z,Miheller P,Horvath HC,Papp J,Tordai A,Andrikovics H

    更新日期:2009-02-01 00:00:00

  • Dissolution of cholesterol ductal stones in the biliary tree with medium-chain glycerides.

    abstract::In vitro and in vivo experiments were carried out with medium-chain glycerides. In vitro, cholesterol gallstones were rapidly dissolved by medium-chain glycerides; control experiments with saline solution failed to modify the size of the stones. In vivo, medium-chain glycerides were instilled through an intraductal tu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Uribe M,Uscanga L,Farca S,Sanjurjo JL,LaGarriga J,Ortíz JH

    更新日期:1981-07-01 00:00:00