Digital ambulatory manometry of the small intestine in healthy adults. Estimates of variation within and between individuals and statistical management of incomplete MMC periods.

abstract：:The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmo...

journal_title：Digestive diseases and sciences

authors： Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

更新日期：1994-10-01 00:00:00

abstract：:Using conventional statistical analysis and multiple regression analysis, we investigated the viral and host factors that influence the response to recombinant interferon-alpha 2a therapy in patients with chronic hepatitis C. A total of 36 patients was randomly assigned to three administration schedules, 12 patients i...

journal_title：Digestive diseases and sciences

authors： Matsumoto A,Tanaka E,Suzuki T,Ogata H,Kiyosawa K

更新日期：1994-06-01 00:00:00

abstract：:Patients affected by diabetes mellitus are reported to have an increased incidence of gallbladder abnormalities. The pathophysiologic mechanisms for this phenomenon are unclear. In the present study ultrasonography was used to determine gallbladder emptying in response to a meal or separate cephalic or hormonal stimul...

journal_title：Digestive diseases and sciences

authors： Fiorucci S,Bosso R,Scionti L,DiSanto S,Annibale B,Delle Fave G,Morelli A

更新日期：1990-09-01 00:00:00

abstract：:Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

journal_title：Digestive diseases and sciences

authors： Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

更新日期：1996-12-01 00:00:00

abstract：:The indications for surgery on cavernous hemangiomas, the most common benign tumors of the liver, remain unclear. This study reviewed 43 patients with cavernous hemangioma of the liver who underwent hepatic resection from 1984 to 2000. Patients were divided into three groups based on the reasons for surgery. Group I c...

journal_title：Digestive diseases and sciences

authors： Tsai HP,Jeng LB,Lee WC,Chen MF

更新日期：2003-05-01 00:00:00

abstract：:Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bo...

journal_title：Digestive diseases and sciences

authors： Martin J,Donnelly JM,Houghton J,Zavros Y

更新日期：2010-06-01 00:00:00

abstract：:The purpose of this study was to establish if estrogen-induced hepatocyte proliferation in vitro involves the cell cycle regulators cyclin D1, p21(Cip1), and p27(Kip1). Male rat hepatocytes were cultured in presence of 17-beta-estradiol (E2) +/- ICI-182780, a pure estrogen antagonist, and [3H]-thymidine, as required. ...

journal_title：Digestive diseases and sciences

authors： Barone M,Ladisa R,Di Leo A,Spano D,Francioso D,Aglio V,Amoruso A,Francavilla A,Iolascon A

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Wnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled-Dvl proteins interaction remains largely unknown. AIMS:The present study aims to elucidate the regulation of Frizzled-Dvl interaction by WDR34. METHODS:The protein levels of WDR34 in hepatoce...

journal_title：Digestive diseases and sciences

authors： Luo X,Liu Y,Ma S,Liu L,Xie R,Wang S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The US Food and Drug Administration currently approves three types of anti-tumor necrosis factor α (anti-TNFα) therapy for treatment of moderate to severe Crohn's disease. There are no guidelines to clarify which of the drugs may be better suited to individual clinical scenarios. AIMS:We gathered national d...

journal_title：Digestive diseases and sciences

authors： Swaminath A,Lebwohl B,Capiak KM,Present DH

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:To evaluate the safety and efficacy of performing ampullary balloon dilation (ABD) following endoscopic sphincterotomy (ES). METHODS:Retrospective review of patients that underwent ABD at Thomas Jefferson University from 2000 to 2007. In all cases, dilation was performed with Hurricane RX hydrostatic balloons ...

journal_title：Digestive diseases and sciences

authors： Kowalski T,Nathwani RA,Assis D,Salese L,Banwait K,Loren D

更新日期：2009-03-01 00:00:00

abstract：:Serum levels of immunosuppressive acidic protein (IAP) were determined in 68 patients undergoing resection of colorectal cancer and 21 healthy subjects. Eighteen patients had perioperative transfusion of allogeneic blood (transfused patients) and 50 patients had no blood transfusion (nontransfused patients). Transfuse...

journal_title：Digestive diseases and sciences

authors： Iwanaga T,Suzuki H

更新日期：1999-08-01 00:00:00

abstract：:To date, tests of small intestinal passive permeability have involved the ingestion of test molecules whose permeation is assessed indirectly by measuring their urinary recovery. Excretion ratios of marker molecules (eg, lactulose-to-mannitol excretion ratio, LMER) are useful clinically. Measurement of permeability ma...

journal_title：Digestive diseases and sciences

authors： Cox MA,Lewis KO,Cooper BT

更新日期：1999-02-01 00:00:00

abstract：:A discrepancy exists on the effects of somatostatin on the absorption of nutrients: in humans, absorption was found to be reduced, whereas in rats no effects were observed. However, intestinal absorption might be influenced by the transit rate of contents. This was not considered in previous studies. Therefore, we inv...

journal_title：Digestive diseases and sciences

authors： Eisenbraun J,Ehrlein HJ

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. AIMS:This study's aims were to identify patterns of Gram-stained ...

journal_title：Digestive diseases and sciences

authors： Shimizu K,Ogura H,Tomono K,Tasaki O,Asahara T,Nomoto K,Morotomi M,Matsushima A,Nakahori Y,Yamano S,Osuka A,Kuwagata Y,Sugimoto H

更新日期：2011-06-01 00:00:00

abstract：:Acetic acid-induced pan colitis in rats leads not only to colonic injury but also to a bystander ileal injury, characterized by decreased fluid and electrolyte absorption without associated histological injury or infiltration of inflammatory cells. To examine the nature of this decreased ileal fluid and electrolyte ab...

journal_title：Digestive diseases and sciences

authors： Cui N,Madsen KL,Friend DR,Stevenson BR,Fedorak RN

更新日期：1996-02-01 00:00:00

abstract：:Endoscopic injection sclerotherapy is known to cause a variety of motility abnormalities, but the correlation between these changes and symptomatology has not been clearly defined. To assess the effects of endoscopic sclerosis of varices on esophageal function and symptoms, we prospectively studied esophageal motility...

journal_title：Digestive diseases and sciences

authors： Cohen LB,Simon C,Korsten MA,Scherl EJ,Skorniky J,Guelrud MB,Waye JD

更新日期：1985-01-01 00:00:00

abstract：UNLABELLED:Recent evidence suggests a role for gut bacteria and antibiotics in the pathophysiology and treatment of irritable bowel syndrome (IBS), respectively. While the benefits of the antibiotic rifaximin have demonstrated efficacy and durable improvement in symptoms over 3 months, the long-term need for retreatmen...

journal_title：Digestive diseases and sciences

authors： Pimentel M,Morales W,Chua K,Barlow G,Weitsman S,Kim G,Amichai MM,Pokkunuri V,Rook E,Mathur R,Marsh Z

更新日期：2011-07-01 00:00:00

abstract：:Gastritis, an inflammatory state in gastric mucosa, can be induced experimentally in various ways. The present study considered the iodoacetamide model (Iodo). Omega-3 fatty acids (fish oil), black seed oil, and curcuminoids (natural products) in addition to omeprazole (synthetic proton-pump inhibitor) were tested. Su...

journal_title：Digestive diseases and sciences

authors： Elseweidy MM,Younis NN,Amin RS,Abdallah FR,Fathy AM,Yousif ZA

更新日期：2008-07-01 00:00:00

abstract：:Achalasia is the best described motor disorder of the esophagus. Associations with familial glucocorticoid deficiency and alacrima (triple A syndrome) have been described in the pediatric population, but no attention has been paid to the possibility of this association in adults. Tear production was assessed in 20 pat...

journal_title：Digestive diseases and sciences

authors： Verma S,Brown S,Dakkak M,Bennett JR

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:There are sporadic reports in the literature in which radiologic liver and lung lesions found incidentally during follow-up metastatic surveillance were shown to be caused by toxocariasis. AIMS:The objective of the work discussed in this report was to identify common clinical and histopathological features ...

journal_title：Digestive diseases and sciences

authors： Park S,Kim YS,Kim YJ,Kyung SY,Park JW,Jeong SH,Lee SP

更新日期：2012-01-01 00:00:00

abstract：:We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a c...

journal_title：Digestive diseases and sciences

authors： Marepaily R,Micheals D,Sloan A,Hatfield J,Adsay V,Joyrich R,Ullah N,Tobi M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Colorectal cancer (CRC) screening with a fecal immunochemical test (FIT) reduces CRC mortality; however, the acceptance rate of a colonoscopy in patients with a positive FIT was not high. The aim of this study was therefore to determine whether a telephone reminder call could increase the acceptance...

journal_title：Digestive diseases and sciences

authors： Cha JM,Lee JI,Joo KR,Shin HP,Park JJ

更新日期：2011-11-01 00:00:00

abstract：:Patients with insulin-dependent diabetes mellitus, autoimmune thyroid disease, Addison's disease, and alopecia areata are at increased risk of celiac disease. We investigated whether patients with more than one autoimmune endocrinologic disorder are even more susceptible to celiac disease or have celiac-type mucosal i...

journal_title：Digestive diseases and sciences

authors： Kaukinen K,Collin P,Mykkänen AH,Partanen J,Mäki M,Salmi J

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the pre...

journal_title：Digestive diseases and sciences

authors： Foster T,Anania FA,Li D,Katz R,Budoff M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...

journal_title：Digestive diseases and sciences

authors： Gawron AJ,Staub J,Bielefeldt K

更新日期：2021-01-01 00:00:00

abstract：:A biliary form of the alpha 1-acid glycoprotein (AAG) promotes cholesterol crystallization in the lower-molecular-weight, concanavalin A-bound fraction of gallbladder bile. In addition, bile AAG concentration is higher in cholesterol gallstone patients with multiple stones than in control patients without gallstone di...

journal_title：Digestive diseases and sciences

authors： Nuutinen H,Ginanni Corradini S,Jüngst D,Lange V,Abei M,Schwarzendrube J,Williams C,Holzbach RT

更新日期：1995-06-01 00:00:00

abstract：:The major heat shock protein, HSP70, is known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperone." However, the influence of HSP70 on gastric mucosal healing under physical stimulation or stress is not completely understood. Rat gastric mucosal cells (R...

journal_title：Digestive diseases and sciences

authors： Odashima M,Otaka M,Matsuhashi T,Jin M,Horikawa Y,Ohba R,Itoh H,Watanabe S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Eosinophilic esophagitis (EoE) is associated with tissue remodeling that can result in esophageal mucosal fragility, and esophageal dilation for patients with EoE is known to cause painful mucosal lacerations. Clinicians have been admonished that patients with EoE may be exceptionally predisposed to perforat...

journal_title：Digestive diseases and sciences

authors： Jacobs JW Jr,Spechler SJ

更新日期：2010-06-01 00:00:00

abstract：:Microvesicular steatosis is a potentially severe manifestation of valproic acid hepatotoxicity due to an acquired impairment of mitochondrial function. Tests currently used to investigate mitochondrial fonction are cumbersome and cannot be used routinely. We report on a noninvasive breath test using [13C]methionine fo...

journal_title：Digestive diseases and sciences

authors： Spahr L,Negro F,Rubbia-Brandt L,Marinescu O,Goodman K,Jordan M,Frossard JL,Hadengue A

更新日期：2001-12-01 00:00:00

abstract：:Five healthy young adults developed an acute self-limiting ulcerative esophagitis. Two had definite evidence of herpes virus being present and a third one had appropriate changes in herpes simplex viral titer. All cases followed a characteristic and similar course consisting of sudden onset of odynophagia, multiple di...

journal_title：Digestive diseases and sciences

authors： Springer DJ,DaCosta LR,Beck IT

更新日期：1979-07-01 00:00:00