当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Viral and host factors that contribute to efficacy of interferon-alpha 2a therapy in patients with chronic hepatitis C.

Viral and host factors that contribute to efficacy of interferon-alpha 2a therapy in patients with chronic hepatitis C.

Abstract：

:Using conventional statistical analysis and multiple regression analysis, we investigated the viral and host factors that influence the response to recombinant interferon-alpha 2a therapy in patients with chronic hepatitis C. A total of 36 patients was randomly assigned to three administration schedules, 12 patients in each. Response to treatment was set as the criterion variable. Four variables were statistically significant in the conventional method in predicting a good therapeutic outcome: HCV genotype III and IV, lower histology activity index (HAI) score for liver, higher total dose of interferon administration, and lower serum HCV RNA concentration. In multiple regression analysis, a combination of the above four variables resulted in a higher multiple correlation coefficient (R = 0.84, P < 0.0001) using a stepwise method. Of those four, HCV genotype had the highest absolute value of standard partial regression coefficient (0.51). The HCV RNA concentration was correlated with HCV genotype and HAI score, whereas HCV genotype and HAI score showed no correlation. Thus, HCV RNA concentration was not statistically significant in multiple regression analysis. These findings indicate that HCV genotype, HAI score, and schedule of administration can be important predictors of the response to interferon therapy.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Matsumoto A,Tanaka E,Suzuki T,Ogata H,Kiyosawa K

doi

10.1007/BF02093793

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

1273-80

issue

6

eissn

0163-2116

issn

1573-2568

journal_volume

39

pub_type

临床试验,杂志文章,随机对照试验

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact.

    abstract：:Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The pre...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-015-3772-z

    authors： Lin CW,Huang XL,Liu HL,Wang Y

    更新日期：2015-12-01 00:00:00

  • Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers.

    abstract：OBJECTIVE:The majority of ghrelin producing cells (GPC) are present in the fundic gland of the stomach and recognized as X/A like cells. The detailed distribution of GPC in the stomach is still unknown in healthy and pathological subjects. METHODS:We investigated the detailed distribution of GPC in the stomach, especi...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1986-2

    authors： Takiguchi S,Adachi S,Yamamoto K,Morii E,Miyata H,Nakajima K,Yamasaki M,Kangawa K,Mori M,Doki Y

    更新日期：2012-05-01 00:00:00

  • Transenteral bowel preparation for colonoscopy is more comfortable than the traditional method with no inferiority in efficacy.

    abstract：BACKGROUND:Transenteral (TE) administration of a bowel cleanser prior to colonoscopy avoids the discomfort associated with drinking a large volume of unpalatable cleanser. AIM:To explore patient comfort, preference for future colonoscopy, the efficacy and adverse events associated with TE bowel preparation. METHODS:B...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s10620-014-3344-7

    authors： Jung SW,Jung DH,Shin YC,Moh IH,Yoo H,Jang SI,Shin SR,Kim JB,Park SH,Lee MS

    更新日期：2015-01-01 00:00:00

  • Protective effects of caffeic acid phenethyl ester on intestinal ischemia-reperfusion injury.

    abstract：AIM:Intestinal ischemia reperfusion (IR) causes tissue injury in two ways, starting a pro-inflammatory cascade and oxidative stress. The aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), which has antioxidant and anti-inflammatory properties, against intestinal...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0405-9

    authors： Yildiz Y,Serter M,Ek RO,Ergin K,Cecen S,Demir EM,Yenisey C

    更新日期：2009-04-01 00:00:00

  • Effects of rifaximin treatment and retreatment in nonconstipated IBS subjects.

    abstract：UNLABELLED:Recent evidence suggests a role for gut bacteria and antibiotics in the pathophysiology and treatment of irritable bowel syndrome (IBS), respectively. While the benefits of the antibiotic rifaximin have demonstrated efficacy and durable improvement in symptoms over 3 months, the long-term need for retreatmen...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1728-5

    authors： Pimentel M,Morales W,Chua K,Barlow G,Weitsman S,Kim G,Amichai MM,Pokkunuri V,Rook E,Mathur R,Marsh Z

    更新日期：2011-07-01 00:00:00

  • Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.

    abstract：:Previous studies showed that bile salts had a promoting effect on colon cancer development and this effect was inhibited by ursodeoxycholate (UDC). We recently found that both human colorectal adenomas and carcinomas were associated with a specific decrease in alkaline sphingomyelinase activity. In this work, we compa...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1018807600683

    authors： Duan RD,Cheng Y,Tauschel HD,Nilsson A

    更新日期：1998-01-01 00:00:00

  • Role of carbonic anhydrase in basal and stimulated bicarbonate secretion by the guinea pig duodenum.

    abstract：:The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02087561

    authors： Muallem R,Reimer R,Odes HS,Schwenk M,Beil W,Sewing KF

    更新日期：1994-05-01 00:00:00

  • Infliximab Dose Escalation as an Effective Strategy for Managing Secondary Loss of Response in Ulcerative Colitis.

    abstract：BACKGROUND:The outcomes of infliximab dose escalation in ulcerative colitis (UC) have not been well evaluated. AIMS:To assess the short- and long-term outcomes of infliximab dose escalation in a cohort of patients with UC. METHODS:This was a multicenter, retrospective, cohort study. All consecutive UC patients who ha...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10620-015-3735-4

    authors： Taxonera C,Barreiro-de Acosta M,Calvo M,Saro C,Bastida G,Martín-Arranz MD,Gisbert JP,García-Sánchez V,Marín-Jiménez I,Bermejo F,Chaparro M,Ponferrada Á,Martínez-Montiel MP,Pajares R,de Gracia C,Olivares D,Alba C,Mendoza

    更新日期：2015-10-01 00:00:00

  • Metabolic base production and mucosal vulnerability during acid inhibition in a mammalian stomach in vitro.

    abstract：:Acid inhibition increases gastric mucosal susceptibility to damage by luminal acid. This might be due to reduced metabolic CO2 and bicarbonate whereas, during normal acid, secretion cytoprotective CO2/HCO3- production parallels acid production. Metabolic activity and mucosal damage caused by luminal acid perfusion was...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02091538

    authors： Glauser M,Bauerfeind P,Feil W,Riegler M,Fraser R,Blum AL

    更新日期：1996-05-01 00:00:00

  • Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man.

    abstract：:Both increased duodenogastric reflux and chronic aspirin ingestion are associated with the development of gastric ulcers in man. Animal studies suggest aspirin increases duodenogastric reflux. Prostaglandin E2 protects gastric mucosa from the effects of many injurious agents and inhibits gastric motility, but its effe...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01320256

    authors： Dooley CP,Mello WD,Valenzuela JE

    更新日期：1985-06-01 00:00:00

  • Prostaglandins and sulfhydryls may mediate gastric protection induced by verapamil in rats.

    abstract：:Verapamil, a type-1 calcium-channel blocker, given intraperitoneally, macroscopically protected the gastric mucosa of rats from 96% ethanol-induced lesions in a dose-dependent fashion. This effect was significant when verapamil at 10 or 20 mg/kg was given 1 hr before ethanol. Histopathologically, verapamil prevented t...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297083

    authors： Gutiérrez-Cabano CA

    更新日期：1993-11-01 00:00:00

  • Interferon-alpha therapy for chronic hepatitis C in special patient populations.

    abstract：:Interferon-alpha therapy for chronic hepatitis C in special patient populations raises a number of issues. Patients with hemophilia, kidney disease requiring hemodialysis, mixed cryoglobulinemia, HIV infection, and those receiving an allograft share some characteristics that complicate the treatment of hepatitis C vir...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02087888

    authors： Marcellin P,Boyer N,Behamou JP,Erlinger S

    更新日期：1996-12-01 00:00:00

  • Gastroesophageal sphincter pressure and histological changes in distal esophagus in patients with achalasia of the esophagus.

    abstract：:A prospective study was performed in 17 patients with achalasia of the esophagus determining the manometric characteristics of the gastroesophageal sphincter, correlating it with histological analysis by biopsies taken during surgery at the distal narrowed segment of the esophagus, at the location of the sphincter. Th...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01308293

    authors： Csendes A,Smok G,Braghetto I,Ramirez C,Velasco N,Henriquez A

    更新日期：1985-10-01 00:00:00

  • Diagnostic Delay Is Associated with a Greater Risk of Early Surgery in a French Cohort of Crohn's Disease Patients.

    abstract：AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-016-4189-z

    authors： Nahon S,Lahmek P,Paupard T,Lesgourgues B,Chaussade S,Peyrin-Biroulet L,Abitbol V

    更新日期：2016-11-01 00:00:00

  • Through-the-scope balloon dilation for endoscopic ultrasound staging of stenosing esophageal cancer.

    abstract：:Dilation of malignant esophageal strictures often is required to complete staging by endoscopic ultrasound (EUS). This study was designed to determine the successful dilation rate (ability to complete staging) and complication rate of through-the-scope (TTS) balloon dilation for malignant esophageal strictures during ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10620-006-9488-3

    authors： Jacobson BC,Shami VM,Faigel DO,Larghi A,Kahaleh M,Dye C,Pedrosa M,Waxman I

    更新日期：2007-03-01 00:00:00

  • Coagulation protein function: enhancement of the anticoagulant effect of acetaldehyde by sulfated glycosaminoglycans.

    abstract：:In view of the increased anticoagulant effect of acetaldehyde-treated heparin, other glycosaminoglycans (GAGs) such as chondroitin sulfates A and C, dermatan sulfate (chondroitin sulfate B), heparan sulfate, and hyaluronic acid were tested for anticoagulant activity before and after exposure to acetaldehyde. Clotting ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1010668005729

    authors： Brecher AS,Adamu MT

    更新日期：2001-09-01 00:00:00

  • Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients.

    abstract：:The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment,...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01324739

    authors： Roda E,Roda A,Sama C,Festi D,Mazzella G,Aldini R,Barbara L

    更新日期：1979-02-01 00:00:00

  • Comparison between botulinum injection and removable covered self-expanding metal stents for the treatment of achalasia.

    abstract：BACKGROUND:Intrasphincteric injection of botulinum toxin (BTX) and removable self-expanding metal stents (SEMS) have both been used for the treatment of achalasia. AIM:To compare the effectiveness and long-term outcome of SEMS placement and BTX injection in patients with achalasia. METHODS:A total of 110 patients wit...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10620-013-2564-6

    authors： Cai XB,Dai YM,Wan XJ,Zeng Y,Liu F,Wang D,Zhou H

    更新日期：2013-07-01 00:00:00

  • Endoscopic biopsy is diagnostic in gastric antral vascular ectasia. The "watermelon stomach".

    abstract：:Gastric antral vascular ectasia was endoscopically diagnosed in seven patients. Pathologic characteristics of this entity were defined retrospectively, by studying endoscopic pinch biopsy slides from these seven patients and antrectomy specimens from five patients. A scoring system was developed, and the seven patient...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01540274

    authors： Gilliam JH 3rd,Geisinger KR,Wu WC,Weidner N,Richter JE

    更新日期：1989-06-01 00:00:00

  • Effects of high-fiber diet on fecal blood content (HemoQuant assay) in healthy subjects.

    abstract：:Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297143

    authors： Slavin JL,Melcher EA,Sundeen M,Schwartz S

    更新日期：1991-07-01 00:00:00

  • Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice.

    abstract：BACKGROUND:The chemokine SDF-1 and its receptor CXCR4 are essential for the proper functioning of multiple organs. In the liver, cholangiocytes and hepatic progenitor cells (HPCs) are the main cells that produce SDF-1, and SDF-1 is thought to be essential for HPC-stimulated liver regeneration. AIMS:In this study, CXCR...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2239-8

    authors： Tsuchiya A,Imai M,Kamimura H,Takamura M,Yamagiwa S,Sugiyama T,Nomoto M,Heike T,Nagasawa T,Nakahata T,Aoyagi Y

    更新日期：2012-11-01 00:00:00

  • Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe.

    abstract：:Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disea...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/s10620-016-4330-z

    authors： Simon TG,Corey KE,Chung RT,Giugliano R

    更新日期：2016-12-01 00:00:00

  • Computerized auscultation applied to irritable bowel syndrome.

    abstract：:The purpose of this study was to investigate the potential of a computerized auscultation method for providing an objective, quantitative measure characteristic of irritable bowel syndrome. Bowel sounds from irritable bowel patients and normal controls were digitized using an electronic stethoscope. Computerized analy...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1018859110022

    authors： Craine BL,Silpa M,O'Toole CJ

    更新日期：1999-09-01 00:00:00

  • Role of NF-kappaB and AP-1 on Helicobater pylori-induced IL-8 expression in AGS cells.

    abstract：:Oxygen radicals are important regulators in Helicobacter pylori-induced gastric ulceration and carcinogenesis. IL-8 may be regulated by oxidant-sensitive transcription factors, NF-kappaB, and AP-1. The present study aims to investigate whether H. pylori-induced IL-8 expression is regulated by NF-kappaB and AP-1 in gas...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1021963007225

    authors： Chu SH,Kim H,Seo JY,Lim JW,Mukaida N,Kim KH

    更新日期：2003-02-01 00:00:00

  • Hydroxysteroid 17-Beta Dehydrogenase 6 Is a Prognostic Biomarker and Correlates with Immune Infiltrates in Hepatocellular Carcinoma.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a common malignancy worldwide with poor outcomes. Therefore, it is important to identify a valuable prognostic biomarker for HCC. The present study aimed to identify novel prognostic biomarkers for HCC and evaluate the potential role of hub genes in HCC. METHODS:Weighted ge...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-021-06832-7

    authors： Wu M,Jiang L

    更新日期：2021-01-26 00:00:00

  • Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.

    abstract：:The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtim...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s10620-006-9111-7

    authors： Muzaffar J,Madan K,Sharma MP,Kar P

    更新日期：2006-12-01 00:00:00

  • Can endoscopic ultrasound-guided fine needle aspiration offer clinical benefit for thick-walled gallbladders?

    abstract：BACKGROUND:No previous studies have compared cytology obtained under endoscopic transpapillary gallbladder drainage (ETGD) and EUS-guided fine needle aspiration (EUS-FNA) for thick-walled gallbladders. AIM:The present study investigated the diagnostic yield of bile cytology under ETGD and EUS-FNA for gallbladder tumor...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10620-014-3100-z

    authors： Ogura T,Kurisu Y,Masuda D,Imoto A,Onda S,Kamiyama R,Hayashi M,Mohamed M,Uchiyama K,Higuchi K

    更新日期：2014-08-01 00:00:00

  • Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver.

    abstract：BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-010-1249-7

    authors： Dhiman RK,Kurmi R,Thumburu KK,Venkataramarao SH,Agarwal R,Duseja A,Chawla Y

    更新日期：2010-08-01 00:00:00

  • Asynchrony in circadian rhythms of gastric function in the rat. A model for gastric mucosal injury.

    abstract：:A model for gastric mucosal injury is proposed in which a key pathogenetic event is the disruption in the normal relationships among several circadian rhythms of gastric function. In the rat a circadian rhythm in acid secretion was found to be out of phase with a circadian rhythm in gastric pepsin secretion, another a...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02087766

    authors： Moore JG,Larsen KR,Barattini P,Dayton MT

    更新日期：1994-08-01 00:00:00

  • Health-related quality of life in patients with Crohn's disease: influence of surgical operation--a prospective trial.

    abstract：:Improvement of health-related quality of life (HRQOL) is a major determinant in decision-making for surgery in patients with Crohn's disease (CD). This study was designed to investigate the short- and long-term effect of surgical resection for CD on HRQOL. Sixteen patients were investigated within one week before surg...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1026600428484

    authors： Tillinger W,Mittermaier C,Lochs H,Moser G

    更新日期：1999-05-01 00:00:00