The role of sonic hedgehog reemergence during gastric cancer.

Abstract:

:Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bone marrow-derived stem cells, specifically mesenchymal stem cells (MSCs) infiltrate and engraft into the gastric mucosa in response to the chronic inflammatory environment of Helicobacter infection. In this review, MSC infiltration and changes in the cytokine and cellular profiles of later-stage chronic environments will be tied into their interactions with the Shh pathway. We will discuss how these changes shape tumorigenesis and tumor progression in the gastric mucosa. The current review focuses on the Shh signaling pathway and its role in the development of gastric cancer, specifically in response to Helicobacter pylori infection. We follow with an in-depth discussion of the regulation of the Hedgehog pathway during acute and chronic gastric inflammation with a focus on signaling within the MSC compartment.

journal_name

Dig Dis Sci

authors

Martin J,Donnelly JM,Houghton J,Zavros Y

doi

10.1007/s10620-010-1252-z

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1516-24

issue

6

eissn

0163-2116

issn

1573-2568

journal_volume

55

pub_type

杂志文章,评审
  • Periampullary Diverticula and ERCP Outcomes: A Systematic Review and Meta-Analysis.

    abstract:INTRODUCTION:Periampullary diverticulum (PAD) is most often asymptomatically found in elderly population. ERCP in the presence of PAD is technically challenging since the location and orientation of the ampulla could be altered. Various studies have reported differing results on the technical success and safety outcome...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10620-018-5314-y

    authors: Jayaraj M,Mohan BP,Dhindsa BS,Mashiana HS,Radhakrishnan G,Dhir V,Trindade AJ,Adler DG

    更新日期:2019-05-01 00:00:00

  • Effect of S-adenosyl-L-methionine on ethanol cholestasis and hepatotoxicity in isolated perfused rat liver.

    abstract::We investigated whether S-adenosyl-L-methionine (SAMe) influences the inhibitory effect of ethanol on bile secretion and ethanol hepatotoxicity in the isolated perfused rat liver. SAMe (25 mg/kg intramuscularly three times a day) was administered for three days consecutively. Liver was then isolated and perfused with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02285216

    authors: Alvaro D,Gigliozzi A,Piat C,Carli L,Bini A,La Rosa T,Furfaro S,Capocaccia L

    更新日期:1995-07-01 00:00:00

  • Gallbladder mucosal protein secretion during development of experimental cholecystitis.

    abstract::The development of experimental cholecystitis produced by lysophosphatidylcholine is associated with reversal of the normal absorptive characteristics of gallbladder mucosa, resulting in the intraluminal accumulation of water, glycoprotein, and protein. The purpose of the present study was to attempt to ascertain if t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02064215

    authors: Kaminski DL,Deshpande YG,Li A,Dysart F,Nag M

    更新日期:1995-05-01 00:00:00

  • Long-Term Outcomes and Predictors of Sustained Response in Patients with Intestinal Behcet's Disease Treated with Infliximab.

    abstract:BACKGROUND:Intestinal Behcet's disease (BD) is a specific subtype of BD. Effective drug therapy for intestinal BD remains elusive. AIMS:To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab (IFX) treatment. METHODS:The medical records were revie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4395-8

    authors: Zou J,Ji DN,Cai JF,Guan JL,Bao ZJ

    更新日期:2017-02-01 00:00:00

  • Gastritic glandularis et cystica profunda: a report of three cases with discussion of etiology and pathogenesis.

    abstract::Three cases of gastritis glandularis et cystica profunda are presented, two associated with severe chronic gastritis and the other with invasive gastric carcinoma and chronic gastritis. This poorly known entity consists of benign downgrowths of deep gastric glands through the muscularis mucosae into the submucosa. The...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297238

    authors: Honoré LH,Lewis AS,O'Hara KE

    更新日期:1979-01-01 00:00:00

  • NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite.

    abstract::NSAID use and Helicobacter pylori both cause damage to the gastric mucosa and can cause peptic ulcers. Our aim was to test the relationship between gastric mucosal polymorphonuclear leukocyte (PMN) infiltration and the severity of NSAID-induced gastric injury. H. pylori density, mucosal interleukin-8 (IL-8), and nitri...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1013251100950

    authors: Shiotani A,Yamaoka Y,El-Zimaity HM,Saeed MA,Qureshi WA,Graham DY

    更新日期:2002-01-01 00:00:00

  • Treatment decision for potential bleeders in obscure gastrointestinal bleeding during double-balloon enteroscopy.

    abstract::Double-balloon enteroscopy (DBE) is an effective tool for diagnosing and treating obscure gastrointestinal bleeding. The aim is to describe how outcomes differ with patient setting (with DBE diagnosis and intervention, with DBE diagnosis but without intervention, and without DBE diagnosis), and thus demonstrate the va...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0591-5

    authors: Lin WP,Chiu CT,Su MY,Hsu CM,Sung CM,Chen PC

    更新日期:2009-10-01 00:00:00

  • Validation of the 7th edition TNM staging system for hepatocellular carcinoma: an analysis of 8,828 patients in a single medical center.

    abstract:BACKGROUND:Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2716-8

    authors: Kee KM,Wang JH,Lin CY,Wang CC,Cheng YF,Lu SN

    更新日期:2013-09-01 00:00:00

  • Longer-term outcomes of nutritional management of Crohn's disease in children.

    abstract:BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2232-2

    authors: Lambert B,Lemberg DA,Leach ST,Day AS

    更新日期:2012-08-01 00:00:00

  • Gastric acid secretion and gastrin release in the baboon.

    abstract::Significant species differences have been demonstrated in gastric physiology, a factor that limits extrapolation of animal data to man. Primate physiology is thought to be similar to that of man; however, gastric function has not been adequately documented in the primate. In the present study six baboons (body weight ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295997

    authors: Lakhoo K,Parekh D,Lawson HH,Rogers G,Van der Walt LA,Hunter S

    更新日期:1992-09-01 00:00:00

  • Second harmonic generation imaging distinguishes both high-grade dysplasia and cancer from normal colonic mucosa.

    abstract:BACKGROUND AND AIM:Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. METHODS:Hematoxylin- and eosin-stai...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3121-7

    authors: Birk JW,Tadros M,Moezardalan K,Nadyarnykh O,Forouhar F,Anderson J,Campagnola P

    更新日期:2014-07-01 00:00:00

  • Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients.

    abstract::Chronic diarrhea and colitis are common in patients positive for human immunodeficiency virus (HIV) under highly active antiretroviral treatment (HAART). This prospective double-blind study explores the effect of mesalamine vs. placebo in HIV-positive patients. Thirteen HIV-infected patients with noninfectious chronic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10620-006-3102-6

    authors: Rodríguez-Torres M,Rodríguez-Orengo JF,Ríos-Bedoya CF,Fernández-Carbia A,Salgado-Mercado R,Marxuach-Cuétara AM

    更新日期:2006-01-01 00:00:00

  • Effects of stimulation and inhibition of acid secretion on gastric damage induced by platelet-activating factor.

    abstract::Intravenous administration of platelet-activating factor (PAF) induces extensive damage in rat gastric mucosa. The aim of the present study was to examine whether the presence or absence of acid in the gastric lumen could modify the PAF-induced gastric damage. The effects of inhibition of basal and pentagastrin-stimul...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296615

    authors: Piqué JM,Pérez Ayuso RM,Bilbao J,Terés J

    更新日期:1991-12-01 00:00:00

  • Effect of carbachol on vascular and luminal release of immunoreactive gastrin from isolated perfused rat duodenum.

    abstract::The release of intestinal gastrin was examined using the isolated vascularly and luminally perfused rat duodenum. Results show that duodenal gastrin was released into both the intestinal lumen and circulation. The basal release of immunoreactive gastrin (IRG) into the lumen was 23.3 +/- 1.8 pg/min and that into the va...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018871731595

    authors: Fujimiya M,Kwok YN

    更新日期:1997-03-01 00:00:00

  • Ultra-short Celiac Disease Is a Distinct and Milder Phenotype of the Disease in Children.

    abstract:BACKGROUND AND AIMS:Approximately 10% of children with celiac disease (CD) have ultra-short celiac disease (USCD), where histological abnormalities are limited to the duodenal bulb. The aim of our retrospective study was to identify clinical and serological characteristics at baseline and at follow-up of children with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5323-x

    authors: Doyev R,Cohen S,Ben-Tov A,Weintraub Y,Amir A,Galai T,Moran-Lev H,Yerushalmy-Feler A

    更新日期:2019-01-01 00:00:00

  • Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.

    abstract::The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtim...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s10620-006-9111-7

    authors: Muzaffar J,Madan K,Sharma MP,Kar P

    更新日期:2006-12-01 00:00:00

  • Prevention of Esophageal Strictures After Endoscopic Submucosal Dissection: A Promising Therapy Using Carboxymethyl Cellulose Sheets.

    abstract:BACKGROUND:Esophageal stricture is one of the serious adverse events following endoscopic submucosal dissection (ESD). However, optimum preventive techniques are still lacking. AIMS:Our primary objective was to evaluate the incidence of post-ESD esophageal stricture with the application of carboxymethyl cellulose (CMC...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4034-4

    authors: Lua GW,Tang J,Liu F,Li ZS

    更新日期:2016-06-01 00:00:00

  • Infectious esophagitis following liver and renal transplantation.

    abstract::Upper gastrointestinal endoscopy was performed for the evaluation of infectious esophagitis in 19 consecutive subjects evaluated prospectively before orthotopic liver transplantation (OLTx), in a separate group of 27 subjects post-OLTx, and in 21 subjects following orthotopic renal transplantation (ORTx). None of the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01535788

    authors: Alexander JA,Brouillette DE,Chien MC,Yoo YK,Tarter RE,Gavaler JS,Van Thiel DH

    更新日期:1988-09-01 00:00:00

  • Hepatic damage in neonatal rat due to E. coli endotoxin.

    abstract::Liver from neonatal rats injected with LD50 E. coli endotoxin was studied by light and electron microscopy. By 2 hr, there was margination and migration of polymorphonuclear leukocytes. Single cell necrosis was seen after 8 hr. At 16 hr, there were numerous necrotic foci in the mid-zonal region of hepatic lobules, as ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01318697

    authors: Young RS,Woods C,Towfighi J

    更新日期:1986-06-01 00:00:00

  • Helicobacter pylori protection against reflux esophagitis.

    abstract:BACKGROUND AND AIM:Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. METHODS:Fro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2349-3

    authors: Ashktorab H,Entezari O,Nouraie M,Dowlati E,Frederick W,Woods A,Lee E,Brim H,Smoot DT,Ghadyari F,Kamangar F,Razjouyan H

    更新日期:2012-11-01 00:00:00

  • Anal Crohn's disease with carcinoma in situ.

    abstract::A 36-year-old female with a six-year history of Crohn's disease of the anus and colon was found to have in situ cloacogenic carcinoma of the anus after having undergone total proctocolectomy for massive bleeding. This case further supports the association between Crohn's disease of the gastrointestinal tract and its p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01395512

    authors: Daly JJ,Madrazo A

    更新日期:1980-06-01 00:00:00

  • Prognosis of gastric carcinoma after curative surgery. A population-based study using multivariate crude and relative survival analysis.

    abstract::A population-based series of 246 gastric cancer patients operated for cure and who survived the postoperative phase was reviewed to determine prognostic factors after potentially curative treatment. The overall five-year observed survival rate was 34.8%, and the relative survival rate was 43.9%. Previous history of ga...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296435

    authors: Arveux P,Faivre J,Boutron MC,Piard F,Dusserre-Guion L,Monnet E,Hillon P

    更新日期:1992-05-01 00:00:00

  • Biomagnetic 3-dimensional spatial and temporal characterization of electrical activity of human stomach.

    abstract::Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018852208687

    authors: Allescher HD,Abraham-Fuchs K,Dunkel RE,Classen M

    更新日期:1998-04-01 00:00:00

  • Impact of Urgent Double-Balloon Enteroscopy on the Short-Term and Long-Term Outcomes in Overt Small Bowel Bleeding.

    abstract:BACKGROUND:Double-balloon enteroscopy (DBE) is a safe and useful procedure for managing small bowel bleeding. However, there are limited studies regarding the preferable timing of DBE and its impact on long-term outcomes. AIM:We aimed to evaluate the association between the timing of DBE and the long-term outcomes of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05627-1

    authors: Hashimoto R,Nakahori M,Matsuda T

    更新日期:2019-10-01 00:00:00

  • Effect of base precursors on water and electrolyte transport during oral hydration solution perfusion in secreting rat intestine.

    abstract::In situ steady-state, single-pass small intestine perfusions in rats were carried out to compare the effect of the bicarbonate and citrate World Health Organization oral rehydration solutions and a base precursor-free solution on intestinal water and electrolyte transport after inducing intestinal secretion with purif...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308341

    authors: Rolston DD,Mathan VI

    更新日期:1992-01-01 00:00:00

  • Evaluation of cytoprotection against ethanol-induced injury in gastric mucosa pretreated with misoprostol, cimetidine, or placebo.

    abstract::The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01309333

    authors: Liss RH,Letourneau RJ,Schepis JP

    更新日期:1986-02-01 00:00:00

  • Intrahepatic biliary cystadenoma. Clinical, radiological, and pathological findings.

    abstract::A 24-year-old white woman presented with abdominal discomfort associated with a firm, nonpulsatile hepatic mass. Radiological examination, which included radionuclide liver scan, abdominal ultrasonography, computed tomography, and hepatic angiography, demonstrated a large, globular, multilocular cyst arising from the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296059

    authors: Marcial MA,Hauser SC,Cibas ES,Braver J

    更新日期:1986-08-01 00:00:00

  • Endoscopic Management of Pancreatic Cysts.

    abstract::Management of pancreatic cystic lesions relies on patients' clinical presentation, imaging, and endoscopic ultrasound. Current research in basic science, radiology, and endoscopy is evolving and making progress in this condition which is relatively common in the general population. This review focuses on the recent en...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-017-4544-8

    authors: Bartel MJ,Raimondo M

    更新日期:2017-07-01 00:00:00

  • Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome.

    abstract::This analysis evaluated the association between sleep disturbance and gastrointestinal symptoms in women with and without irritable bowel syndrome (IBS), and examined the role of psychological distress in this relationship. Women with IBS (N = 82) reported considerably higher levels of sleep disturbance compared to co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005581226265

    authors: Jarrett M,Heitkemper M,Cain KC,Burr RL,Hertig V

    更新日期:2000-05-01 00:00:00

  • Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury.

    abstract::Intestinal injury 4-48 hr after cytotoxic therapy (etoposide phosphate, 100 mg/kg body weight [bw], intravenously [i.v.]) was studied in rats using ligated intestinal loops. Chromium-51 ethylenediaminetetraacetic acid ((51)Cr-EDTA) and rubidium-86 chloride ((86)RbCl) were deposited intraluminally to determine the exte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2926-9

    authors: Abel E,Ekman T,Warnhammar E,Hultborn R,Jennische E,Lange S

    更新日期:2005-09-01 00:00:00