Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.

abstract：:Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxi...

journal_title：Digestive diseases and sciences

authors： Masclee AA,Jansen JB,Rovati LC,Lamers CB

更新日期：1993-10-01 00:00:00

abstract：:Our purpose was to determine if the presence of duodenal diverticula predisposes to the development of pancreaticobiliary disease. Between May 1999 and February 2001, 381 patients were examined by endoscopic retrograde cholangiopancreaticography. Of these patients, 51 had periampullary diverticula. In 27 patients the ...

journal_title：Digestive diseases and sciences

authors： Yildirgan MI,Başoğlu M,Yilmaz I,Atamanalp SS,Balik AA,Aydinli B,Oztürk G

更新日期：2004-11-01 00:00:00

abstract：:Heart failure is a recognized, although uncommon, cause of massive liver cell necrosis, the clinical consequences of which are intermingled with those of cardiac insufficiency in most cases. We report the cases of six patients suffering from chronic heart failure in whom an episode of acute circulatory failure resulte...

journal_title：Digestive diseases and sciences

authors： Nouel O,Henrion J,Bernuau J,Degott C,Rueff B,Benhamou JP

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Approximately 10% of children with celiac disease (CD) have ultra-short celiac disease (USCD), where histological abnormalities are limited to the duodenal bulb. The aim of our retrospective study was to identify clinical and serological characteristics at baseline and at follow-up of children with ...

journal_title：Digestive diseases and sciences

authors： Doyev R,Cohen S,Ben-Tov A,Weintraub Y,Amir A,Galai T,Moran-Lev H,Yerushalmy-Feler A

更新日期：2019-01-01 00:00:00

abstract：:We evaluated the sequence diversity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV) in HCV-infected patients in whom the mode of transmission is unknown. The sequence diversity of HVR1 in 26 Japanese patients with chronic HCV infection of unknown mode of transmission (UT) was compared with 17 patients ...

journal_title：Digestive diseases and sciences

authors： Toyoda H,Fukuda Y,Hayakawa T,Kumada T,Nakano S,Takamatsu J,Saito H

更新日期：1999-10-01 00:00:00

abstract：:The clonality of gastric glands remains a controversial topic. Chimeric mouse studies suggested that all gastric glands were monoclonal. However, using the X-linked transgenic mouse model, we have suggested that most glands are polyclonal during development and that the fraction of monoclonal glands increases after bi...

journal_title：Digestive diseases and sciences

authors： Nomura S,Kaminishi M,Takagi N,Esumi H

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett's esophagus (BE). AIMS:We aimed to determine the prevalence of BE among patients undergoing esophagogastroduodenoscopy (EGD) in a cohort of Saudi patients. METHODS:We retros...

journal_title：Digestive diseases and sciences

authors： Alsahafi M,Mimish H,Salem F,Hijazi M,Aljahdli E,Jawa H,Bazarah S,Bokhary R,Qari Y,Mosli M

更新日期：2020-08-04 00:00:00

abstract：AIM:The aim of this study was to assess whether patients with colorectal cancer (CRC) are aware of the risk to family members and to test an educational intervention. METHODS:CRC patients were surveyed regarding their cancer, family history, understanding of familial risk of CRC, and knowledge of existing screening gu...

journal_title：Digestive diseases and sciences

authors： Rubin DT,Gandhi RK,Hetzel JT,Kinnear SH,Aronsohn A,Wood G,Yadron N

更新日期：2009-11-01 00:00:00

abstract：:The efficacy of comaruman CP, a pectin of marsh cinquefoil Comarum palustre L., was investigated using a model of acetic acid-induced colitis in mice. Mice were administered comaruman CP orally 2 days prior to rectal injection of 5% acetic acid and examined for colonic damage 24 hr later. Colonic inflammation was char...

journal_title：Digestive diseases and sciences

authors： Popov SV,Ovodova RG,Markov PA,Nikitina IR,Ovodov YS

更新日期：2006-09-01 00:00:00

abstract：:The molecular mechanisms of Helicobacter pylori associated tumor development are poorly understood. The spectra of genetic alterations in neoplasms may provide clues to the molecular carcinogenesis of a tumor and may be relevant for the prognosis of the patients. We investigated the p53 mutation pattern and the protei...

journal_title：Digestive diseases and sciences

authors： Kubicka S,Claas C,Staab S,Kühnel F,Zender L,Trautwein C,Wagner S,Rudolph KL,Manns M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Liver fibrosis is a common scarring response to chronic liver injury. It is a precursor to cirrhosis and liver carcinoma. Hepatic stimulator substance (HSS), a known liver-specific but species-nonspecific growth factor, has been shown to protect hepatocytes from various toxins. METHODS:We have investigated ...

journal_title：Digestive diseases and sciences

authors： Yi X,Song M,Yuan Y,Zhang X,Chen W,Li J,Tong M,Liu G,You S,Kong X

更新日期：2012-08-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity has been associated with mucosal growth and injury, yet, little information is available on ODC activity during gastric ulcer healing. We measured ODC activity in the ulcer base submucosa and the surrounding mucosa at 1 cm and 2 cm and assessed ulcer surface healing and a histolo...

journal_title：Digestive diseases and sciences

authors： Marcuard SP,Silverman JF,Finley JL,Seidel ER

更新日期：1992-07-01 00:00:00

abstract：:Serum and urine concentrations of pancreatic polypeptide (PP) were measured during experimental acute hemorrhagic pancreatitis and small-bowel infarction in dogs. The mean serum PP concentration in animals with pancreatitis increased markedly after 1 hr and remained elevated, while the mean serum PP concentration in t...

journal_title：Digestive diseases and sciences

authors： Pappas TN,Yovos JG,Ellison EC,O'Dorisio TM,Cataland S,Pace WG,Carey LC

更新日期：1981-11-01 00:00:00

abstract：:In a randomized trial, 75 patients with an endoscopically confirmed and symptomatic duodenal (N = 50) or prepyloric (N = 25) ulcer were allocated to cimetidine treatment (1 g/day) either regularly for four weeks (standard treatment group) or regularly for a minimum of one week and thereafter only until the symptoms we...

journal_title：Digestive diseases and sciences

authors： Gustavsson S,Adami HO,Lööf L,Nyberg A,Nyrén O

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Human hepatocellular carcinoma (HCC) is one of the most common fatal cancers and an important health problem worldwide, but its mechanism is still unclear. Microtubule (MT) kinesin motor proteins orchestrate a variety of cellular processes (e.g. mitosis, motility and organelle transportation) and have been i...

journal_title：Digestive diseases and sciences

authors： Huang X,Liu F,Zhu C,Cai J,Wang H,Wang X,He S,Liu C,Yao L,Ding Z,Zhang Y,Zhang T

更新日期：2014-04-01 00:00:00

abstract：:Chemiluminescence (CL) analysis of monocytes and polymorphonuclear cells (PMNs) was performed on 13 patients with Crohn's disease (CD) and 10 healthy volunteers. The percentages of monocyte populations in mononuclear cells obtained from the patients with CD were greater than those from the healthy volunteers, but the ...

journal_title：Digestive diseases and sciences

authors： Kitahora T,Suzuki K,Asakura H,Yoshida T,Suematsu M,Watanabe M,Aiso S,Tsuchiya M

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND AND AIM:Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. METHODS:Fro...

journal_title：Digestive diseases and sciences

authors： Ashktorab H,Entezari O,Nouraie M,Dowlati E,Frederick W,Woods A,Lee E,Brim H,Smoot DT,Ghadyari F,Kamangar F,Razjouyan H

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Sorafenib, a drug that inhibits Raf serine/threonine kinases mediating cell proliferation and receptor tyrosine kinases involved in angiogenesis, is approved for treatment of advanced hepatocellular carcinoma. AIMS:To explore the efficacy and safety of sorafenib for treating advanced HCC, and to identify cl...

journal_title：Digestive diseases and sciences

authors： Xie B,Wang DH,Spechler SJ

更新日期：2012-05-01 00:00:00

abstract：:We conducted a randomized prospective study with extended intraesophageal pH monitoring on two consecutive nights to test the hypothesis that a waterbed (WB) might increase recumbent acid exposure compared to a regular bed (RB). We studied 10 controls (mean age 29 years; five males, five females) with no history of re...

journal_title：Digestive diseases and sciences

authors： Wang JC,Castell DO,Sinclair JW,Wu WC

更新日期：1989-10-01 00:00:00

abstract：:Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus john...

journal_title：Digestive diseases and sciences

authors： Southcott E,Tooley KL,Howarth GS,Davidson GP,Butler RN

更新日期：2008-07-01 00:00:00

abstract：:Metronidazole has been used to treat pouchitis, but there are no controlled data that show it is effective. Chronic unremitting pouchitis is a form of the disorder particularly difficult to manage. Diarrhea is the main symptom of pouchitis, which results from acute inflammation of the mucosa of an ileal reservoir. To ...

journal_title：Digestive diseases and sciences

authors： Madden MV,McIntyre AS,Nicholls RJ

更新日期：1994-06-01 00:00:00

abstract：:The article "Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials", written by Remo Panaccione, John D. Isaacs, Lea Ann Chen, Wenjin Wang, Amy Marren, Kenneth Kwok, Lisy Wang, Gary Chan and Chinyu Su, was originally published electronically on...

journal_title：Digestive diseases and sciences

authors： Panaccione R,Isaacs JD,Chen LA,Wang W,Marren A,Kwok K,Wang L,Chan G,Su C

更新日期：2020-10-10 00:00:00

abstract：:We compared the stress-strain distributions obtained from isolated segments of the guinea pig duodenum, jejunum, and distal ileum, and the relation between the elastic properties and the collagen content. The segments were immersed in Krebs-Ringer solution containing 10(-2) M MgCl2 to abolish contractile activity. Ste...

journal_title：Digestive diseases and sciences

authors： Storkholm JH,Villadsen GE,Jensen SL,Gregersen H

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Tyrosine phosphorylation and dephosphorylation by protein tyrosine kinases and phosphatases (PTPs), respectively, play crucial roles in cellular signal transduction. Protein phosphatase non-receptor type 11 (PTPN11) is a positive signaling PTP that activates RAS and ERK signaling. Also, the PTPN11 binds with...

journal_title：Digestive diseases and sciences

authors： Kim JS,Shin OR,Kim HK,Cho YS,An CH,Lim KW,Kim SS

更新日期：2010-06-01 00:00:00

abstract：:Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylorihas been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demon...

journal_title：Digestive diseases and sciences

authors： Aydemir S,Bayraktaroglu T,Sert M,Sokmen C,Atmaca H,Mungan G,Gun BD,Borazan A,Ustundag Y

更新日期：2005-11-01 00:00:00

abstract：:The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated aci...

journal_title：Digestive diseases and sciences

authors： Gaginella TS,Bertko RJ,Müller RK,Gallo-Torres H,Sullivan AC

更新日期：1985-04-01 00:00:00

abstract：:The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). We investigated nine patients with mild-moderate CP (MCP), eight patients with severe CP and steathorrea (SCP), and 17 he...

journal_title：Digestive diseases and sciences

authors： Pieramico O,Nelson DK,Glasbrenner B,Malfertheiner P

更新日期：1994-01-01 00:00:00

abstract：:We prospectively assessed the relationship between nodular gastritis and Helicobacter pylori infection. Of 1409 adults who underwent endoscopy for persistent dyspepsia between June 2004 and August 2005, 41 (2.9%) patients were diagnosed with nodular gastritis (11 [27%] men and 30 [73%] women). The mean age was 45.9 ye...

journal_title：Digestive diseases and sciences

authors： Chen MJ,Wang TE,Chang WH,Liao TC,Lin CC,Shih SC

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Capsule endoscopy (CE) has the problem that lumen visualization is impaired by bubbles, bile, and debris. The benefits of bowel preparation are still controversial and the best method remains to be determined. The objective of this study was to evaluate the effect of the method of bowel preparation ...

journal_title：Digestive diseases and sciences

authors： Park SC,Keum B,Seo YS,Kim YS,Jeen YT,Chun HJ,Um SH,Kim CD,Ryu HS

更新日期：2011-06-01 00:00:00

abstract：:A large retrospective autopsy study of patients was analyzed to evaluate the major etiologic and pathologic factors contributing to fatal acute pancreatitis (AP). From an autopsy population of 50,227 patients, 405 cases were identified where AP was defined as the official primary cause of death. AP was classified acco...

journal_title：Digestive diseases and sciences

authors： Renner IG,Savage WT 3rd,Pantoja JL,Renner VJ

更新日期：1985-10-01 00:00:00