Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury.

abstract：:Suspected risk factors for adenocarcinoma of the small bowel in Crohn's disease include surgically excluded small bowel loops, chronic fistulous disease, and male sex. Review of all seven University of Chicago cases failed to confirm any suspected risk factor. A case-control study was performed to identify possible al...

journal_title：Digestive diseases and sciences

authors： Lashner BA

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Antiviral therapy in addition to immunoprophylaxis at birth has been shown to further reduce perinatal transmission of hepatitis B virus (HBV) in highly viremic women. AIMS:The aim of this study was to describe the use of tenofovir disoproxil fumarate (TDF) prophylaxis to reduce maternal HBV DNA levels and ...

journal_title：Digestive diseases and sciences

authors： Tsai PJ,Chang A,Yamada S,Tsai N,Bartholomew ML

更新日期：2014-11-01 00:00:00

abstract：:In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...

journal_title：Digestive diseases and sciences

authors： Vahouny GV,Satchithanandam S,Lightfoot F,Grau L,Haas-Smith S,Kritchevsky D,Cassidy MM

更新日期：1984-05-01 00:00:00

abstract：:The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...

journal_title：Digestive diseases and sciences

authors： Prieto M,Gómez-Lechón MJ,Hoyos M,Castell JV,Carrasco D,Berenguer J

更新日期：1988-07-01 00:00:00

abstract：:Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver ...

journal_title：Digestive diseases and sciences

authors： Lee HS,Jung KH,Park IS,Kwon SW,Lee DH,Hong SS

更新日期：2009-04-01 00:00:00

abstract：:Liver transplantation is the only effective treatment of familial amyloidotic polyneuropathy type I (FAP). The aim of the present investigation was to identify factors at the time of submission for transplantation that had impact on survival, with special reference to gastrointestinal disturbances. All 28 liver-transp...

journal_title：Digestive diseases and sciences

authors： Suhr O,Danielsson A,Rydh A,Nyhlin N,Hietala SO,Steen L

更新日期：1996-10-01 00:00:00

abstract：:We examined the effect of cyclooxygenase (COX) inhibitors on dextran sulfate sodium (DSS)-induced ulcerative colitis in rats and investigated the role of COX isozymes in the pathogenesis of this model. Experimental colitis was induced by treatment with 2.5% DSS in drinking water for 6 days. Indomethacin (a nonselectiv...

journal_title：Digestive diseases and sciences

authors： Okayama M,Hayashi S,Aoi Y,Nishio H,Kato S,Takeuchi K

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) criteria are histologically categorized by early gastric cancer (EGC) with differentiated- and undifferentiated-type histology. However, EGC is histologically heterogenous and there have been no separate criteria for EGC with mixed-type histology [EGC-MH; differentiated...

journal_title：Digestive diseases and sciences

authors： Bang CS,Yang YJ,Lee JJ,Baik GH

更新日期：2020-01-01 00:00:00

abstract：:Using northern blot analysis and immunohistochemistry, we assessed the expression and distribution of human epidermal growth factor receptor-1 (HER-1), HER-2, and HER-3 in pancreatic tissues obtained from patients with acute pancreatitis (AP). Overall, HER-1, HER-2, and HER-3 mRNA levels were similar in the normal pan...

journal_title：Digestive diseases and sciences

authors： Ebert M,Friess H,Büchler MW,Korc M

更新日期：1995-10-01 00:00:00

abstract：:Tramadol and morphine were compared for treatment of severe chronic pancreatitis pain and their interaction with gut motor function. Oral tramadol or morphine doses were titrated double-blinded and randomized for five days in 25 patients and pain, side effects, bowel function, orocecal and colonic transit, anal restin...

journal_title：Digestive diseases and sciences

authors： Wilder-Smith CH,Hill L,Osler W,O'Keefe S

更新日期：1999-06-01 00:00:00

abstract：:The original version of the article unfortunately contained an error in the unit used for 'Distance of propagation'. The distance of propagation should be in the unit 'cm' rather than 'mm' throughout the manuscript. ...

journal_title：Digestive diseases and sciences

authors： Jaung R,Varghese C,Lin AY,Paskaranandavadivel N,Du P,Rowbotham D,Dinning P,O'Grady G,Bissett I

更新日期：2020-08-08 00:00:00

abstract：:Excessive spontaneous swallowing has been associated with a variety of common gastrointestinal symptoms including abdominal pain, heartburn, and bloating and may contribute to disorders such as hiatus hernia, duodenal ulcer, and irritable bowel syndrome. The present study investigated the hypothesis that changes in em...

journal_title：Digestive diseases and sciences

authors： Cuevas JL,Cook EW 3rd,Richter JE,McCutcheon M,Taub E

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Concanavalin A is known to activate T cells and to cause liver injury and hepatitis, mediated in part by secretion of TNFα from macrophages. Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been shown to prevent tissue damage in various animal models of inflammation. The objectives of this stu...

journal_title：Digestive diseases and sciences

authors： Wardi J,Ernst O,Lilja A,Aeed H,Katz S,Ben-Nachum I,Ben-Dror I,Katz D,Bernadsky O,Kandhikonda R,Avni Y,Fraser IDC,Weinstain R,Biro A,Zor T

更新日期：2018-12-01 00:00:00

abstract：:Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver f...

journal_title：Digestive diseases and sciences

authors： Stamoulis I,Kouraklis G,Theocharis S

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The antibiotic rifaximin is used to treat non-constipated irritable bowel syndrome (IBS). Methane production is associated with constipation and its severity in constipation-predominant IBS (C-IBS). A previous retrospective study suggested that rifaximin and neomycin was superior to neomycin alone in improvi...

journal_title：Digestive diseases and sciences

authors： Pimentel M,Chang C,Chua KS,Mirocha J,DiBaise J,Rao S,Amichai M

更新日期：2014-06-01 00:00:00

abstract：:We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, under baseline condi...

journal_title：Digestive diseases and sciences

authors： Méndez A,Casadevall M,Wachter CH,Elizalde JI,Del Rivero M,Heinemann A,Holzer P,Quintero E,Piqué JM

更新日期：1997-09-01 00:00:00

abstract：:The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtim...

journal_title：Digestive diseases and sciences

authors： Muzaffar J,Madan K,Sharma MP,Kar P

更新日期：2006-12-01 00:00:00

abstract：:An important histologic feature of inflammatory bowel disease (IBD) is infiltration of the colonic mucosa with neutrophils. To investigate the nature of the chemotactic agents responsible for this infiltration, colonic mucosa from three normals and nine patients with inflammatory bowel disease (seven ulcerative coliti...

journal_title：Digestive diseases and sciences

authors： Lobos EA,Sharon P,Stenson WF

更新日期：1987-12-01 00:00:00

abstract：:The hydrogen (H2) lactose breath test (BT) is a test commonly used for the diagnosis of hypolactasia. However, its sensitivity is not always good. In the last few years, the new Quick Lactase Test (QLT) has been developed for endoscopic diagnosis of adult-type hypolactasia. The aim of this study was to compare the eff...

journal_title：Digestive diseases and sciences

authors： Ojetti V,La Mura R,Zocco MA,Cesaro P,De Masi E,La Mazza A,Cammarota G,Gasbarrini G,Gasbarrini A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Activation of the transcription factor NF-κB and expression of pro-inflammatory mediators have been considered as major events of acute pancreatitis (AP). Karyopherin alpha 2 (KPNA2), a member of the importin α family, reportedly modulates p65 subcellular localization. AIM:This study aimed to investigate th...

journal_title：Digestive diseases and sciences

authors： Cai Y,Shen Y,Gao L,Chen M,Xiao M,Huang Z,Zhang D

更新日期：2016-03-01 00:00:00

abstract：:We describe a 28-yr-old woman who presented with severe, recurrent cholangitis due to Caroli's disease in association with congenital hepatic fibrosis. Cystic dilatation of the segmental bile ducts was diffuse, but predominated in the right lobe and left medial segment of the liver. Extended right lobectomy was follow...

journal_title：Digestive diseases and sciences

authors： Ramond MJ,Huguet C,Danan G,Rueff B,Benhamou JP

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:The performance characteristics of colonic sensation and motility measurements are unclear. AIM:To compare left colon compliance, tone, and sensation in males and females and to evaluate inter and intra-individual coefficients of variation (COV) in these measurements. METHODS:Data were acquired using stand...

journal_title：Digestive diseases and sciences

authors： Odunsi ST,Camilleri M,Bharucha AE,Papathanasopoulos A,Busciglio I,Burton D,Zinsmeister AR

更新日期：2010-03-01 00:00:00

abstract：:The aims of this study were to determine the impact of irritable bowel syndrome on quality of life using a well-standardized measure, the SF-36, and to determine whether apparent impairments may be due to neuroticism. Undergraduate students with irritable bowel syndrome who had consulted a physician (41 females, 42 ma...

journal_title：Digestive diseases and sciences

authors： Whitehead WE,Burnett CK,Cook EW 3rd,Taub E

更新日期：1996-11-01 00:00:00

abstract：:Infection with Helicobacter pylori is associated with the development of gastric cancer. To study whether the infection with H. pylori strains expressing the vacuolating cytotoxin (VacA) and/or the cytotoxin-associated protein (CagA) is associated with an increased risk of developing gastric adenocarcinoma, sera of 90...

journal_title：Digestive diseases and sciences

authors： Rudi J,Kolb C,Maiwald M,Zuna I,von Herbay A,Galle PR,Stremmel W

更新日期：1997-08-01 00:00:00

abstract：:Radionuclide gastric solid-phase emptying was studied in 10 subjects with diabetic gastroparesis comparing the acute intravenous administration of cisapride (2.5, 5, 10 mg), placebo, and metoclopramide (10 mg). No hemodynamic or electrocardiographic changes were noted. While both cisapride and metoclopramide normalize...

journal_title：Digestive diseases and sciences

authors： McHugh S,Lico S,Diamant NE

更新日期：1992-07-01 00:00:00

abstract：:The efficacy of tiotidine, a new H2-receptor antagonist, in reducing nocturnal acid secretion of duodenal ulcer patients (N = 12, ages 21-60 years) was investigated. Different doses of tiotidine, 25, 50, 100, and 150 mg or placebo, were given as a single oral dose and acid secretion collected overnight. Tiotidine prod...

journal_title：Digestive diseases and sciences

authors： Valenzuela JE,Strecker RB,Douglas AP

更新日期：1981-05-01 00:00:00

abstract：:Microvesicular steatosis is a potentially severe manifestation of valproic acid hepatotoxicity due to an acquired impairment of mitochondrial function. Tests currently used to investigate mitochondrial fonction are cumbersome and cannot be used routinely. We report on a noninvasive breath test using [13C]methionine fo...

journal_title：Digestive diseases and sciences

authors： Spahr L,Negro F,Rubbia-Brandt L,Marinescu O,Goodman K,Jordan M,Frossard JL,Hadengue A

更新日期：2001-12-01 00:00:00

abstract：:The release of intestinal gastrin was examined using the isolated vascularly and luminally perfused rat duodenum. Results show that duodenal gastrin was released into both the intestinal lumen and circulation. The basal release of immunoreactive gastrin (IRG) into the lumen was 23.3 +/- 1.8 pg/min and that into the va...

journal_title：Digestive diseases and sciences

authors： Fujimiya M,Kwok YN

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Alcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming growth factor-β superfamily, has been studied in diseases with muscle wasting; however, the role of myostatin in AH is unknown. AIMS:To investigate the association between my...

journal_title：Digestive diseases and sciences

authors： Shamseddeen H,Madathanapalli A,Are VS,Shah VH,Sanyal AJ,Tang Q,Liang T,Gelow K,Zimmers TA,Chalasani N,Desai AP

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Amoxicillin, metronidazole, proton pump inhibitor, bismuth quadruple therapy had been shown to reliably achieve high eradication rates. The role of individual components remains undefined. AIM:To identify the additional benefit/role of bismuth in amoxicillin, metronidazole, proton pump inhibitor, bismuth qu...

journal_title：Digestive diseases and sciences

authors： Luo L,Ji Y,Yu L,Huang Y,Liang X,Graham DY,Lu H

更新日期：2020-12-01 00:00:00