Abstract:
:We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, under baseline conditions and following intravenous infusion of vasopressin or pentagastrin, isovolemic hemodilution, or gastric perfusion with HCl-taurocholate. Blood flow changes following vasopressin or hemodilution were significantly larger in the left gastric artery than in the gastric mucosa. In contrast, the increment in blood flow associated with pentagastrin-stimulated acid secretion was significantly greater in the gastric mucosa than in the extramural artery. Barrier disruption with acid-taurocholate induced similar changes in both measurement sites. The gastric hyperemia induced by either mechanism was significantly attenuated by blockade of NO synthesis. These data demonstrate that although functional changes in GMBF are primarily supported by changes in blood flow at the extramural gastric arteries, the gastric mucosal microvasculature is also under the influence of independent local control mechanisms.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Méndez A,Casadevall M,Wachter CH,Elizalde JI,Del Rivero M,Heinemann A,Holzer P,Quintero E,Piqué JMdoi
10.1023/a:1018807009266subject
Has Abstractpub_date
1997-09-01 00:00:00pages
1873-9issue
9eissn
0163-2116issn
1573-2568journal_volume
42pub_type
杂志文章abstract::This study determined how the luminal surface hydrophobicity and transmucosal potential difference (PD) of canine gastric mucosa changed during the recovery period after the tissue was challenged with acidified aspirin. Luminal aspirin reduced both the contact angle and PD of mucosae incubated in Ussing chambers. Afte...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02065551
更新日期:1995-06-01 00:00:00
abstract::Diseases of the ileocecal junction are mostly ulcerative. The aim of this study was to investigate the value of colonoscopy on the diagnosis of the causes of ileocecal ulcer. Clinical manifestations, diagnosis, and endoscopic and histopathologic features of 52 hospitalized cases of ileocecal ulcer were retrospectively...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9548-8
更新日期:2007-11-01 00:00:00
abstract::The aim of this study was to compare the additive effect of rebamipide with that of teprenone in combination with dual therapy on H. pylori eradication. A total of 102 H. pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lanso...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Minimally invasive interventions for choledocholithiasis are preferable in elderly patients because they tend to have multiple underlying disorders or a decreased activity of daily living. Endoscopic sphincterotomy and endoscopic papillary balloon dilation have been recognized as first-line treatments for ch...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3156-9
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Suppressive activity of recurrence by interferon-free direct-acting antivirals (DAA) is not elucidated after curative treatment of hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 177 patients received DAA after curative manners of HCC: 89 patients underwent DAA therapy after initial HCC trea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4739-z
更新日期:2017-10-01 00:00:00
abstract::We describe a 28-yr-old woman who presented with severe, recurrent cholangitis due to Caroli's disease in association with congenital hepatic fibrosis. Cystic dilatation of the segmental bile ducts was diffuse, but predominated in the right lobe and left medial segment of the liver. Extended right lobectomy was follow...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318526
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Sorafenib is a proven first-line treatment recommended for hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). However, multiple treatment modalities are used in clinical practice as a first-line option. This study is a prospective, observational, multicenter, cohort study evalu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06134-4
更新日期:2021-01-01 00:00:00
abstract::Previous studies have found a widely variable prevalence of dysplasia and cancer in colonic strictures in patients with ulcerative colitis. Consequently, therapeutic recommendations are conflicting. To better assess the prevalence, we reviewed the clinical and pathological findings in all 27 patients with ulcerative c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01537413
更新日期:1990-03-01 00:00:00
abstract::Liver transplantation is the only effective treatment of familial amyloidotic polyneuropathy type I (FAP). The aim of the present investigation was to identify factors at the time of submission for transplantation that had impact on survival, with special reference to gastrointestinal disturbances. All 28 liver-transp...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02093589
更新日期:1996-10-01 00:00:00
abstract::Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and steatohepatitis are frequent complications of liver transplantation. Non...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-019-05716-1
更新日期:2019-12-01 00:00:00
abstract::Octreotide is an effective therapeutic option in controlling secretory diarrhea of varied etiology. However, marked patient-to-patient differences in the antidiarrheal effects necessitate titration of octreotide dose in individual patients to achieve optimal symptom control. A consensus development panel established g...
journal_title:Digestive diseases and sciences
pub_type: 共识发展会议,杂志文章,评审
doi:10.1007/BF02285194
更新日期:1995-07-01 00:00:00
abstract::A pathogenic role of nitric oxide has been suggested in acute and chronic intestinal inflammation. We took the opportunity offered by studies in patients with excluded colon, which represents a model of chronic intestinal inflammation with no exogenous nitrite or nitrate supply, to evaluate the quantity and the qualit...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018885217154
更新日期:1997-12-01 00:00:00
abstract::Our aim was to compare standard liver function tests (serum bilirubin, serum albumin and prothrombin concentration), with lidocaine and monoethylglycinexylidide pharmacokinetic parameters, after oral lidocaine administration, to assess hepatic function of cirrhotic individuals. Twenty-one consecutive cirrhotic patient...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1026630313038
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results. AIM:To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility. METHODS:We performed an extensive search of relevant studies and carried ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10620-009-0978-y
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The principle of treating-to-target has been successfully applied to many diseases with significant improvement in patient care and as a useful guidance for healthcare providers. Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3483-x
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Accumulating evidence has indicated that variations of mitochondrial DNA (mtDNA) content may affect the susceptibility to hepatocellular carcinoma (HCC). However, no study has been conducted to evaluate the association of circulating mtDNA content and the risk of liver cirrhosis, a leading cause of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3523-1
更新日期:2015-06-01 00:00:00
abstract::The protective effect of a human strain of Bifidobacterium bifidum (B. bifidum) against murine group A rotavirus (MRV) was examined in the intestines of BALB/c infected mice. In experiments designed to determine whether B. bifidum mediated MRV shedding during diarrheal disease, pregnant dams (and their expected litter...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087647
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is universal and tends to be more aggressive. Data on post-transplant HCV genotype 4 treatment is scarce. The aim of this study is to assess the safety and efficacy of pegylated interferon alpha-2a (PEG-IFN) in combination with ribavirin in ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1526-5
更新日期:2011-06-01 00:00:00
abstract::Stimulation of the intrinsic nerves of the esophageal body leads to a twitch of the circular muscle after the end of the stimulation (the esophageal off-response), and the twitch spreads in the distal direction because of a latency gradient in the onset of the off-response between the proximal and the distal esophagus...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536324
更新日期:1989-04-01 00:00:00
abstract::Canine and human exocrine pancreatic secretion into the duodenum during fasting is cyclical and related to intestinal motility. To characterize the composition of pure pancreatic juice during the cyclically recurring sequence of propagated motor events (interdigestive motor complex) and to establish whether pancreatic...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01367667
更新日期:1981-07-01 00:00:00
abstract::Isoamylase distribution in the urine of normal individuals and patients admitted to the hospital with hyperamylasemia was determined by a wheat inhibitor mmethod and compared to results obtained by cellulose-acetate electrophoresis. We report two cases where the inhibitor ethod failed to give accurate results in urine...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01311727
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:It is not known whether transjugular intrahepatic porto-systemic shunt (TIPS) is safe in patients with advanced liver cirrhosis. The aim of our study was to evaluate the impact of TIPS on transplant-free survival in patients with liver cirrhosis and MELD score ≥15. METHODS:All adult patients who underwent T...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4185-3
更新日期:2017-02-01 00:00:00
abstract::We investigated the effect of pH change on octapeptide cholecystokinin's ability to contract guinea pig gallbladder strips. In the absence of exogenous drugs, pH changes had no demonstrable effect on gallbladder tension. However, when gallbladder strips were contracted with CCK-OP at pH 7.3, increasing the pH in the m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297218
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:The incidence of Clostridium difficile infection is increasing in the United States. The aim of our investigation is to compare short-term and long-term outcomes of patients admitted with an ulcerative colitis (UC) flare and co-existent C. difficile infection to those of non-infected patients. METHODS:A his...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0749-9
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Notch signaling is required for the maintenance of intestinal epithelial proliferation. Dysfunction of this signaling pathway is associated with the loss of proliferated crypt epithelial cells. AIM:The aim of this study was to investigate the role of Notch signaling in small bowel resection (SBR)-associated...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2680-3
更新日期:2013-09-01 00:00:00
abstract::Dientamoeba fragilis is an intestinal protozoan parasite associated with gastrointestinal symptoms. This study was undertaken in a semicommunal group reported to have a high prevalence of this parasite. Stools were collected from 81 adult group members. Intestinal parasites were observed in stool specimens of 45 (56%)...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01324950
更新日期:1983-04-01 00:00:00
abstract::The effects of chronic normovolemic anemia on gastric microcirculation and gastric mucosal susceptibility to ethanol-induced gastric damage were investigated in anesthetized rats. Blood exchange by a plasma expander during four consecutive days rendered the animals anemic with a 34% decrease in the baseline hematocrit...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087418
更新日期:1994-04-01 00:00:00
abstract::The original version of the article unfortunately contained an error in article title. The corrected title is 'Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose'. ...
journal_title:Digestive diseases and sciences
pub_type: 已发布勘误
doi:10.1007/s10620-019-05527-4
更新日期:2019-07-01 00:00:00
abstract::The effects of somatostatin on diarrhea and on small intestinal flow of water and electrolytes (slow-marker perfusion technique) in a patient with pancreatic cholera are reported. Continuous intravenous infusion of somatostatin (8 micrograms/kg/hr) suppressed the diarrhea, but a rebound was observed after somatostatin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295657
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4+ T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn's d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05945-4
更新日期:2020-06-01 00:00:00