Abstract：
:We investigated the effect of pH change on octapeptide cholecystokinin's ability to contract guinea pig gallbladder strips. In the absence of exogenous drugs, pH changes had no demonstrable effect on gallbladder tension. However, when gallbladder strips were contracted with CCK-OP at pH 7.3, increasing the pH in the muscle bath to 7.8 produced further increases in tension at each dose studied (P less than 0.025). Subsequently, decreasing the bath pH to 6.9 decreased the strip tension to less than that observed at pH 7.3 (P less than 0.025). Reversing the order in which these pH alterations were made produced similar results; a pH decrease from 7.3 to 6.9 decreased the response to CCK-OP at the two highest doses (P less than 0.025), while subsequent elevation of pH raised the tension to levels greater than those observed at pH 7.3 (P less than 0.01). Furthermore, contracting the strips at pH 8.0 and slowly decreasing pH at a rate of 0.1 pH units per minute consistently produced an acceleration of tension decay as pH fell. After contracting the strip at pH 6.7, slow increases in pH reversed the tension decay and enhanced the contractile response as pH was increased from 6.7 to 8.0. These results demonstrate that pH changes alter the gallbladder contractile response to cholecystokinin. Although this phenomenon has been reported for a number of other physiologic agents, we believe this is the first such demonstration for a peptide hormone.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
La Morte WW,Hingston S,Matolo N,Birkett DH,Williams LF Jrdoi
10.1007/BF01297218subject
Has Abstractpub_date
1982-07-01 00:00:00pages
615-23issue
7eissn
0163-2116issn
1573-2568journal_volume
27pub_type
杂志文章abstract：BACKGROUND:Marijuana may be used by some patients with gastroparesis (Gp) for its potential antiemetic, orexigenic, and pain-relieving effects. AIMS:The aim of this study was to describe the use of marijuana by patients for symptoms of Gp, assessing prevalence of use, patient characteristics, and patients' perceived b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05963-2
更新日期：2020-08-01 00:00:00
abstract：:Antagonists of nitric oxide synthesis inhibit nerve-induced hyperpolarization and relaxation of muscle from the opossum lower esophageal sphincter. These studies test the hypothesis that nitric oxide is released during stimulation of intrinsic esophageal nerves. The intrinsic nerves were stimulated with an electrical ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088117
更新日期：1994-09-01 00:00:00
abstract：:Acid inhibition after proton pump inhibitors in children is variable, and to measure it by a noninvasive method may help to tailor treatment. To study gastric acid inhibition after a single dose of PPI, by measuring urinary acid output (UAO), which decreases as parietal cells release acid into the stomach during a mea...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1016465116541
更新日期：2002-08-01 00:00:00
abstract：:The role of nitric oxide in intestinal fluid and electrolyte secretion depends upon whether the conditions under study are physiological or pathophysiological. In physiological conditions, endogenous nitric oxide seems to be a proabsorptive molecule, based on the findings that nitric oxide synthase inhibitors reverse ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1023/a:1018887525293
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Endoscopic ablation of duodenal ampullary malignancy has not been fully assessed. AIMS:The study aimed to evaluate the efficacy and safety of Endoscopic retrograde cholangiopancreatograpy (ERCP)-guided radiofrequency ablation (RFA) for inoperable ampullary cancer. METHODS:Patients with inoperable ampullary...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05849-3
更新日期：2020-05-01 00:00:00
abstract：:The purpose of this study was to investigate the histogenesis of experimental tumors in the rat esophagus. Thirty rats received 0.0015% N-methyl-N-amylnitrosamine (MNAN) in the drinking water for 12 weeks. Another 30 rats received tap water. All rats then received tap water until sacrifice. Rats from each group were s...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536636
更新日期：1988-01-01 00:00:00
abstract：:The effect on the mucosa of sodium nitrite that enters the colon from the ileum or transmucosally from the circulation is unknown. Isolated colonic mucosal cells and Roux-en-Y colostomies were used to test whether high doses of sodium nitrite (5-40 mM) had any harmful histological or inhibitory metabolic actions on th...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01320321
更新日期：1986-05-01 00:00:00
abstract：:The incidence of colorectal adenocarcinoma increased in the five major ethnic groups in Hawaii, but more in men than women. The highest rates were in the Chinese and Japanese. The site-specific time trend patterns revealed that the greatest increase occurred in rectosigmoid cancer, followed by cancer of the sigmoid co...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295978
更新日期：1981-12-01 00:00:00
abstract：:The article "Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials", written by Remo Panaccione, John D. Isaacs, Lea Ann Chen, Wenjin Wang, Amy Marren, Kenneth Kwok, Lisy Wang, Gary Chan and Chinyu Su, was originally published electronically on...
journal_title：Digestive diseases and sciences
pub_type： 已发布勘误
doi：10.1007/s10620-020-06638-z
更新日期：2020-10-10 00:00:00
abstract：:Protein kinase C (PKC) is a mediator of transmembrane signal transduction, important in cell growth and differentiation. Cell activation by extracellular signals is associated with a translocation of PKC from the cytosol to the membrane. We measured and compared PKC activity in cytosol and membrane fractions of normal...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088328
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND AND AIMS:The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD). METHODS...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-011-1915-4
更新日期：2012-03-01 00:00:00
abstract：:The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase cha...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01299852
更新日期：1992-11-01 00:00:00
abstract：:Gastroesophageal reflux disease (GERD) is a common disease in infants and children. Prolonged (24-hr) pH monitoring in the esophagus for determination of increased acid exposure has, together with endoscopy, been the only routinely implemented method for GERD diagnosis. The recently introduced multiple intraluminal im...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9731-y
更新日期：2007-09-01 00:00:00
abstract：:Previous studies have found a widely variable prevalence of dysplasia and cancer in colonic strictures in patients with ulcerative colitis. Consequently, therapeutic recommendations are conflicting. To better assess the prevalence, we reviewed the clinical and pathological findings in all 27 patients with ulcerative c...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537413
更新日期：1990-03-01 00:00:00
abstract：:Twelve patients with recurrent polyserositis (RP, familial Mediterranean fever) on colchicine prophylaxis (1.0-2.0 mg daily) for three years or more were evaluated for the presence of gastrointestinal effects possibly attributable to the drug. Two patients had bulky stools, two others had transient diarrhea, and one h...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01393768
更新日期：1982-08-01 00:00:00
abstract：:The possible role of Saccharomyces boulardii, a nonpathogenic yeast with beneficial effects on the human intestine, in the maintenance treatment of Crohn's disease has been evaluated. Thirty-two patients with Crohn's disease in clinical remission (CDAI < 150) were randomly treated for six months with either mesalamine...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1005588911207
更新日期：2000-07-01 00:00:00
abstract：:Alterations of small intestinal sensory thresholds and small intestinal dysmotility are associated with functional dyspepsia. Because gastric and duodenal afferents partly project to the same areas, we postulated that patients with functional dyspepsia and H. pylori infection would be characterized by lower duodenal s...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088548
更新日期：1996-07-01 00:00:00
abstract：:It has not been fully understood how intact protein antigens escape digestion in the course of absorption. The present study was designed to investigate the mechanism that heat stress induced an increase in intact protein antigen absorption. Human colonic cell line Caco-2 cells were treated with high temperature (37 t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-9003-2
更新日期：2006-05-01 00:00:00
abstract：:Opioids, both endogenous and exogenous, have been shown to exert a modulating influence on many gastrointestinal functions. Animal studies suggest an inhibitory role for opioids in the control of pancreatic secretion, which may be exerted through their inhibitory effect on acetylcholine release from intramural neurons...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01798363
更新日期：1988-05-01 00:00:00
abstract：INTRODUCTION:Assessment of whole gut transit, by radio-opaque markers or scintigraphy, is used to evaluate patients with constipation for slow gastrointestinal transit. Wireless capsule motility, using the SmartPill GI monitoring system, samples and transmits intraluminal pH, pressure, and temperature data from a capsu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0899-9
更新日期：2009-10-01 00:00:00
abstract：:We explored the hemodynamic effects of rapid injection of 0.9% saline and arterial blood into the canine superior mesenteric artery in anesthetized animals. Mesenteric artery blood flow and pressure were measured in the vessel distal to the site of injection. Injection rates were at or below the rate of blood flow in ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01309495
更新日期：1981-10-01 00:00:00
abstract：BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires manual quantification of tissue eosinophils. Eosinophil peroxidase (EPX) is an eosinophil-specific, cytoplasmic granule protein released during degranulation. AIMS:The objective of this study was to evaluate image analysis of EPX immunohistochemistry as a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06230-5
更新日期：2020-04-04 00:00:00
abstract：:Several techniques have been developed to diagnose Helicobacter pylori infection and two noninvasive methods are available: carbon 13-urea breath test (UBT) and serology. Measurement of IgG serum antibodies by enzyme-linked immunosorbent assay (ELISA) is a reliable and inexpensive method for detection of infection. Th...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005589700652
更新日期：2000-08-01 00:00:00
abstract：:Nearly all chronic anal fissures occur in the posterior midline of the anal canal. However, some of them are in the anterior midline and are rarely double or in the lateral anal walls. The aim of this study was to determine if the clinical, manometric and endosonographic characteristics in patients with chronic anal f...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9816-2
更新日期：2008-01-01 00:00:00
abstract：:This study was undertaken to determine whether the synthetic prostaglandin E2 analog enprostil is able to inhibit basal and postprandial hypergastrinemia induced by omeprazole. We also studied the effect of omeprazole, enprostil, and the combination of both drugs on serum pepsinogen A and C levels. Eight normal subjec...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02088350
更新日期：1994-03-01 00:00:00
abstract：:The original version of this article unfortunately contained an error in a couple of reference citation in Discussion Section, paragraph 6. The reference citation number should be changed from [6] to [9] in the below sentences so that it reads. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10620-018-5046-z
更新日期：2018-06-01 00:00:00
abstract：:The relationship between the GOT/GPT ratio in nonviral liver disorders and underlying physical condition and life-style were evaluated. The subjects were 12,808 male railway company workers who underwent an annual health checkup. Nonviral liver disorders were defined as elevated transaminases (GOT > 76 IU/liter or GPT...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1017959801493
更新日期：2002-03-01 00:00:00
abstract：:These studies were done to determine the effects of fluoride (F) on the structure and function of the canine gastric mucosa and the possible protective effects of 16,16-dimethyl-prostaglandin E2 (dmPGE2). A portion of the stomach with its vascular supply intact was mounted in a two-compartment chamber, one side of whi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018895207333
更新日期：1997-10-01 00:00:00
abstract：:The gastric acid response to a 200-ml cup of tea was measured by in situ titration in 36 patients with duodenal ulcer (DU) and 56 without duodenal ulcer (controls). Tea resulted in an acid secretory response which was almost equal to that after a maximal dose (0.04 mg/kg) of histamine. The effect of tea was mainly due...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296252
更新日期：1984-03-01 00:00:00
abstract：:The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV. Patients (n = 47) with reactivated hepatitis due to lamivudine-resistant HBV were classified into two group...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0384-x
更新日期：2008-11-01 00:00:00
