Protein kinase C activity as a potential marker for colorectal neoplasia.

Abstract:

:Protein kinase C (PKC) is a mediator of transmembrane signal transduction, important in cell growth and differentiation. Cell activation by extracellular signals is associated with a translocation of PKC from the cytosol to the membrane. We measured and compared PKC activity in cytosol and membrane fractions of normal and neoplastic colorectal tissue. Total and membrane-associated PKC activity in normal colorectal tissue was greater in patients (N = 16) with colorectal cancer compared to that from patients with a normal colonoscopy (N = 16), P < 0.01. A similar trend was noted in PKC activity of normal colorectal tissue from patients with adenomas compared to patients with a normal colonoscopy. PKC activity (total, membrane-associated, percent membrane) was not different in neoplastic colorectal tissue compared to that of adjacent normal tissue. However, there was a considerable range of PKC activity noted in all groups, which would limit the utility of PKC activity as a marker for colorectal neoplasia.

journal_name

Dig Dis Sci

authors

McGarrity TJ,Peiffer LP

doi

10.1007/BF02088328

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

458-63

issue

3

eissn

0163-2116

issn

1573-2568

journal_volume

39

pub_type

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