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Heat stress increases protein antigen transport across the intestinal epithelium via a mechanism of impairing proteolytic enzymatic activity.

Abstract：

:It has not been fully understood how intact protein antigens escape digestion in the course of absorption. The present study was designed to investigate the mechanism that heat stress induced an increase in intact protein antigen absorption. Human colonic cell line Caco-2 cells were treated with high temperature (37 to 43 degrees C) for 60 min. Epithelial permeability was evaluated by horseradish peroxidase (HRP) flux and dextran flux. Activity of the major intracellular proteolytic enzyme, acid phosphatase, in Caco-2 cells was determined. HRP products in Caco-2 cells were observed by electron microscopy (EM) and analyzed with a computerized image processing system. Heat stress significantly increased intact protein HRP transport across Caco-2 monolayers, decreased acid phosphatase activity of the cells, and significantly reduced transepithelial electric resistance of Caco-2 cells. EM results showed that HRP transport across Caco-2 monolayers occurred mainly via the intracellular pathway.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Yang PC,Wang CS

doi

10.1007/s10620-005-9003-2

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

1003-11

issue

5

eissn

0163-2116

issn

1573-2568

journal_volume

51

pub_type

杂志文章

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