Abstract:
:This study was designed to assess the central nervous system actions of human calcitonin (hCalc) and human calcitonin gene-related peptide (hCGRP) on meal-stimulated gastric acid secretion in awake beagle dogs. hCalc (0.1-1.0 nmol/kg) and hCGRP (0.01-1.0 nmol/kg) injected into the third cerebral ventricle significantly inhibited gastric acid secretion stimulated by an 8% peptone meal. hCGRP was ten times more potent than hCalc in inhibiting gastric secretion. Neither hCalc nor hCGRP significantly altered plasma gastrin concentrations compared to control values. Truncal vagotomy did not prevent the gastric inhibitory actions of hCalc and hCGRP. Ganglionic blockade with chlorisondamine completely abolished the gastric inhibitory action of hCalc but had no effect on gastric acid inhibition induced by hCGRP. The results of this study indicate that intracerebroventricular administration of hCalc and hCGRP inhibits meal-stimulated gastric acid secretion in awake dogs. Inhibition of gastric acid secretion by hCalc and hCGRP in the dog is not mediated by inhibition of gastrin release or by the vagus nerves. Human Calc but not human CGRP appears to inhibit meal-stimulated gastric acid secretion in the dog by activation of the autonomic (sympathetic) nervous system.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Lenz HJ,Brown MRdoi
10.1007/BF01296295subject
Has Abstractpub_date
1987-04-01 00:00:00pages
409-16issue
4eissn
0163-2116issn
1573-2568journal_volume
32pub_type
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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更新日期:1993-02-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/BF01295907
更新日期:1993-05-01 00:00:00
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更新日期:1985-01-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-017-4615-x
更新日期:2017-08-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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pub_type: 杂志文章,meta分析,评审
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abstract::To study the efficacy and mechanism of action of the intragastric bubble, 1- to 5-ml silicone bubbles were surgically implanted into the stomachs of 10- to 12-week-old female rats. To test the hypothesis that the satiety effects of the implant are mediated by visceral sensory nerves, a subgroup was treated as neonates...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-010-1344-9
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND AND AIMS:The present study aimed to identify the differential expressed genes that are related to acute pancreatitis. METHODS:Microarray datasets GSE109227 and GSE3644 were downloaded from the public database and analyzed to screen the genes. Afterward, integrated analysis of these genes were performed, inc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308045
更新日期:1980-12-01 00:00:00
abstract::We examined the role of capsaicin-sensitive afferent neurons in pH-dependent gastrin secretion in the rat stomach. The change in serum gastrin levels relative to changes in luminal pH (using omeprazole for luminal alkalization or 0.1 N HCl for luminal acidification) was studied after oral administration of 4% lidocain...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005570507166
更新日期:2000-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01311953
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Antibiotic prophylaxis can reduce the incidence of the first episode and recurrent episodes of spontaneous bacterial peritonitis (SBP) in high-risk cirrhotic patients. However, recent data suggest that SBP prophylaxis may be underused. It is unclear how many cases of cirrhosis that develop SBP might actually...
journal_title:Digestive diseases and sciences
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更新日期:2011-09-01 00:00:00