Abstract：
:Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and steatohepatitis are frequent complications of liver transplantation. Nonalcoholic steatohepatitis poses a significant challenge in both pre- and post-transplant period due to its association with metabolic syndrome, coronary artery disease, chronic kidney disease, and obstructive sleep apnea. While optimal therapy is not yet available in the post-liver transplant setting, lifestyle interventions continue to remain as the mainstay of therapy for post-transplant nonalcoholic steatohepatitis. Early recognition with protocol biopsies and noninvasive modalities, along with modification of known risk factors, are the most effective methods to curtail the progression of nonalcoholic steatohepatitis in the absence of FDA-approved pharmacologic therapy.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Samji NS,Verma R,Keri KC,Singal AK,Ahmed A,Rinella M,Bernstein D,Abdelmalek MF,Satapathy SKdoi
10.1007/s10620-019-05716-1subject
Has Abstractpub_date
2019-12-01 00:00:00pages
3413-3430issue
12eissn
0163-2116issn
1573-2568pii
10.1007/s10620-019-05716-1journal_volume
64pub_type
杂志文章,评审abstract：BACKGROUND AND AIMS:Sorafenib is a proven first-line treatment recommended for hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). However, multiple treatment modalities are used in clinical practice as a first-line option. This study is a prospective, observational, multicenter, cohort study evalu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06134-4
更新日期：2021-01-01 00:00:00
abstract：AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05717-0
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association. AIM:The purpose of this study was to determine the prevalence of hypothyroidism in a ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-2006-2
更新日期：2012-02-01 00:00:00
abstract：:This study tested the hypothesis that (alginic) acid may have a preferential effect on reflux in the upright position. We evaluated the effect of a compound containing alginic acid plus antacid (extra-strength Gaviscon) versus active control antacid with equal acid-neutralizing capacity on intraesophageal acid exposur...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01307584
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:Different factors have been associated with prolonged fluoroscopy time (FT) during endoscopic retrograde cholangiopancreatography (ERCP). AIM:We hypothesize that FT depends on both the anatomical location of the pathology managed during ERCP and the complexity of the ERCP. METHODS:Three centers participate...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1007/s10620-014-3508-5
更新日期：2015-06-01 00:00:00
abstract：:Sera from Japanese patients with chronic liver disease were tested for hepatitis B virus (HBV) markers and antibodies to hepatitis C virus (anti-HCV), and the results were correlated to the presence of hepatocellular carcinoma. In chronic non-A, non-B liver disease, anti-HCV prevalence was high both in patients with h...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308344
更新日期：1992-01-01 00:00:00
abstract：:We examined the effect of cyclooxygenase (COX) inhibitors on dextran sulfate sodium (DSS)-induced ulcerative colitis in rats and investigated the role of COX isozymes in the pathogenesis of this model. Experimental colitis was induced by treatment with 2.5% DSS in drinking water for 6 days. Indomethacin (a nonselectiv...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9597-z
更新日期：2007-09-01 00:00:00
abstract：:A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmon...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1024111310345
更新日期：2003-07-01 00:00:00
abstract：:A method for isolating and characterizing intestinal lymphoid cells from colonoscopic biopsies is presented. Intraepithelial lymphocytes were separated from the lamina propria by incubation in edetic acid (EDTA) and lamina propria lymphoid cells isolated by incubation in collagenase followed by Ficoll-Hypaque density ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300700
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) criteria are histologically categorized by early gastric cancer (EGC) with differentiated- and undifferentiated-type histology. However, EGC is histologically heterogenous and there have been no separate criteria for EGC with mixed-type histology [EGC-MH; differentiated...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析
doi：10.1007/s10620-019-05761-w
更新日期：2020-01-01 00:00:00
abstract：:In enriched canine parietal cell preparations, misoprostol, an analog of prostaglandin E1 methyl ester, was rapidly deesterified to misoprostol free acid. Under this circumstance, misoprostol and misoprostol free acid exhibited equal antisecretory potency against histamine-stimulated acid secretion and bound equally w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297024
更新日期：1991-05-01 00:00:00
abstract：:Apoptosis is an important process in a wide variety of different biological systems. In addition to caspases, recently, calpains, another family of proteases, have been found to be involved in apoptosis of many cell systems. This study is designed with the aims to evaluate the possible effect of Z-LLY-FMK (a calpain i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0652-9
更新日期：2009-11-01 00:00:00
abstract：:In addition to regulating blood pressure and body fluid homeostasis, the renin-angiotensin system (RAS) is also involved in hepatic fibrogenesis. We aimed to investigate the effect of losartan, an angiotensin II (Ang II) antagonist, on CCl4-induced hepatic fibrosis in rats. Hepatic fibrosis was induced by a subcutaneo...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000043369.88701.5b
更新日期：2004-10-01 00:00:00
abstract：:The purpose of the present study was to investigate the Helicobacter pylori eradication potency of combined amoxicillin-omeprazole treatment in patients with duodenal ulcer disease and to compare the efficacy of two omeprazole and amoxicillin doses concerning H. pylori eradication, ulcer healing, pain relief, and safe...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02088052
更新日期：1994-07-01 00:00:00
abstract：:The aims of this study were to evaluate (i) the relationship between transpyloric flow (TF) assessed by Doppler ultrasonography and scintigraphy, (ii) the effects of healthy aging on TF and gastric emptying (GE), and (iii) the relationship between the glycemic response to oral glucose and TF. Ten healthy "young" (7 M,...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2555-3
更新日期：2005-04-01 00:00:00
abstract：:An important histologic feature of inflammatory bowel disease (IBD) is infiltration of the colonic mucosa with neutrophils. To investigate the nature of the chemotactic agents responsible for this infiltration, colonic mucosa from three normals and nine patients with inflammatory bowel disease (seven ulcerative coliti...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296664
更新日期：1987-12-01 00:00:00
abstract：:The current cost of endoscopically screening patients with gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) is considerable. A nonendoscopic device that allows for screening of these patients would offer significant cost savings. This pilot study evaluates the utility of cytologically diagnosing BE ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1012771328187
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND AND AIMS:The influence of direct-acting antivirals (DAAs) on chronic hepatitis C (CHC)-related hepatocellular carcinoma (HCC) remains controversial. We investigated the effect of eradicating CHC using DAAs on treatment outcomes in patients with CHC-related HCC treated with transarterial chemoembolization (TA...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06533-7
更新日期：2020-08-28 00:00:00
abstract：:In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296219
更新日期：1984-05-01 00:00:00
abstract：:Data on performance characteristics of flexible sigmoidoscopy (FS) between age groups are limited. This study evaluates screening FS in subjects > or = 75 years of age (elderly) compared with ages 50-74 years (general screening population). Data were collected on patient characteristics, insertion depth, procedural di...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-005-3022-x
更新日期：2005-11-01 00:00:00
abstract：:Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01314760
更新日期：1981-11-01 00:00:00
abstract：:A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the s...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1023/a:1026678806368
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06203-8
更新日期：2020-03-19 00:00:00
abstract：:Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplantation. In this retrospective study, we compared the efficacy, safety, and renal protective effect of sirolimus monotherapy (Group A; n = 26) with sirolimus in combination (Group B; n = ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-9026-8
更新日期：2006-10-01 00:00:00
abstract：:Our aim was to understand the mechanism of immunological changes associated with the use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for selective adsorption of granulocytes and monocytes/macrophages from peripheral blood of patients with active ulcerative colitis. The column is fil...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1015330816364
更新日期：2002-06-01 00:00:00
abstract：:Sodium butyrate is a well-recognized differentiating agent inducing alkaline phosphatase activity, one of the epithelial differentiation markers. When IEC6 cells, a nontransformed, small intestinal epithelial cell line, were cultured with butyrate, this substrate induced alkaline phosphate activity in a time- and dose...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018807524075
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:S-isomer (S) pantoprazole is known to be more effective and less dependent on cytochrome 2C19 than R-isomer (R)-pantoprazole. AIM:The purpose of this study was to compare the efficacy and safety of S-pantoprazole 20 mg versus pantoprazole 40 mg for treatment of reflux esophagitis. METHODS:This multi-center...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10620-012-2297-y
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND AND AIM:Despite the limitations of screening or early diagnosis of colorectal cancers (CRC), carcinoembryonic antigen (CEA) is frequently measured in practice and during health promotion programs. The aim of this study was to evaluate the role of colonoscopy in healthy individuals with elevated CEA levels. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1606-1
更新日期：2011-08-01 00:00:00
abstract：:Patients with symptomatic cholelithiasis who represent higher than normal surgical risks may be the most suitable candidates for medical dissolution of gallstones. Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. Complete gallstone dissolution occ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01308157
更新日期：1983-06-01 00:00:00
abstract：:Gastric antral vascular ectasia was endoscopically diagnosed in seven patients. Pathologic characteristics of this entity were defined retrospectively, by studying endoscopic pinch biopsy slides from these seven patients and antrectomy specimens from five patients. A scoring system was developed, and the seven patient...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540274
更新日期：1989-06-01 00:00:00
