Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges.


:Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and steatohepatitis are frequent complications of liver transplantation. Nonalcoholic steatohepatitis poses a significant challenge in both pre- and post-transplant period due to its association with metabolic syndrome, coronary artery disease, chronic kidney disease, and obstructive sleep apnea. While optimal therapy is not yet available in the post-liver transplant setting, lifestyle interventions continue to remain as the mainstay of therapy for post-transplant nonalcoholic steatohepatitis. Early recognition with protocol biopsies and noninvasive modalities, along with modification of known risk factors, are the most effective methods to curtail the progression of nonalcoholic steatohepatitis in the absence of FDA-approved pharmacologic therapy.


Dig Dis Sci


Samji NS,Verma R,Keri KC,Singal AK,Ahmed A,Rinella M,Bernstein D,Abdelmalek MF,Satapathy SK




Has Abstract


2019-12-01 00:00:00














  • Short-term effects of bile diversion on postgastrectomy gastric histology.

    abstract::Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bechi P,Amorosi A,Mazzanti R,Buccarelli A,Pantalone D,Cortesini C

    更新日期:1988-10-01 00:00:00

  • Effect of dietary turmeric on breath hydrogen.

    abstract::Turmeric is widely used in Indian cuisine. The main constituents of turmeric are curcumin and its analogues, which are well-known antioxidant compounds. In the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby incre...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Shimouchi A,Nose K,Takaoka M,Hayashi H,Kondo T

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  • Recalibrating the Child-Turcotte-Pugh Score to Improve Prediction of Transplant-Free Survival in Patients with Cirrhosis.

    abstract:BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Slavin JL,Melcher EA,Sundeen M,Schwartz S

    更新日期:1991-07-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Choi SM,Shin JH,Kang KK,Ahn BO,Yoo M

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    abstract:BACKGROUND AND AIM:The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

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    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


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    更新日期:2020-12-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Le Blanc-Louvry I,Ducrotte P,Chayvialle JA,Coquerel A,Michot F,Ténière P

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Baichi MM,Arifuddin RM,Mantry PS

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yang J,Huang K,Qin S,Wu X,Zhao Z,Chen F

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Jung SW,Jung DH,Shin YC,Moh IH,Yoo H,Jang SI,Shin SR,Kim JB,Park SH,Lee MS

    更新日期:2015-01-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    更新日期:1999-05-01 00:00:00

  • Can Sertraline and Nortriptyline Protect the Neurons in Submucosal and Myenteric Plexuses of Rat's Colon Against Stress?

    abstract:BACKGROUND:The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyli...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Noorafshan A,Yousefi M,Hosseini L,Karbalay-Doust S

    更新日期:2019-09-01 00:00:00

  • The role of sonic hedgehog reemergence during gastric cancer.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Martin J,Donnelly JM,Houghton J,Zavros Y

    更新日期:2010-06-01 00:00:00

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    abstract::We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tursi A,Elisei W,Giorgetti GM,Brandimarte G,Aiello F

    更新日期:2009-10-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    更新日期:1985-02-01 00:00:00