Abstract：
:We examined the effect of cyclooxygenase (COX) inhibitors on dextran sulfate sodium (DSS)-induced ulcerative colitis in rats and investigated the role of COX isozymes in the pathogenesis of this model. Experimental colitis was induced by treatment with 2.5% DSS in drinking water for 6 days. Indomethacin (a nonselective COX inhibitor), SC-560 (a selective COX-1 inhibitor), or celecoxib (a selective COX-2 inhibitor) was given PO twice daily for 6 days, during the first 3 or last 3 days of the experimental period. Daily treatment with 2.5% DSS for 6 days caused damage to the colon, with a decrease in body weight gain and colon length as well as an increase of myeloperoxidase (MPO) activity. All COX inhibitors given for 6 days significantly worsened the severity of DSS-induced colonic damage with increased MPO activity. The aggravation was also observed by SC-560 given for the first 3 days or by celecoxib given for the last 3 days. The expression of COX-2 mRNA in the colon was upregulated on day 3 during DSS treatment, with significant increase of prostaglandin E(2) PGE(2) production. The PGE(2) content on day 3 during DSS treatment was inhibited by both indomethacin and SC-560, but not by celecoxib; on day 6 it was suppressed by both indomethacin and celecoxib, but not SC-560. These results suggest that endogenous prostaglandins (PGs) afford protection against colonic ulceration, yet the COX isozyme responsible for the production of PGs differs depending on the stage of ulceration; COX-1 in the early stage and COX-2 in the late stage.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Okayama M,Hayashi S,Aoi Y,Nishio H,Kato S,Takeuchi Kdoi
10.1007/s10620-006-9597-zsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
2095-103issue
9eissn
0163-2116issn
1573-2568journal_volume
52pub_type
杂志文章abstract：INTRODUCTION:Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06348-6
更新日期：2020-05-23 00:00:00
abstract：:Little is known about the accuracy of intraesophageal pH monitoring, ie, do false negatives occur? This study was designed based on the assumption that if two pH probes are placed equidistant from a distal acid source, and the probes measure different values, then one probe might miss acid if it were there alone. We p...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540333
更新日期：1989-05-01 00:00:00
abstract：:The effects of the water-soluble and delayed-release formulations of a nonsteroidal antiinflammatory drug, diclofenac, on the healing of gastroduodenal mucosal lesions were compared in a double-blind, double cross-over, placebo-controlled endoscopic study conducted in 14 healthy volunteers. Severe endoscopic lesions (...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01297025
更新日期：1991-05-01 00:00:00
abstract：:Heme oxygenase (HO)-1, the rate-limiting enzyme in heme degradation, is induced by oxidative stress and its major end product, bilirubin, is a potent physiological antioxidant. We studied the induction of HO-1 and bilirubin production in intestinal mucosa using a rat model of sepsis. E. coli lipopolysaccharide was adm...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005626622203
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients. AIMS:To evaluate the efficacy of pegylated interferon (PEG-IFN) and riba...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1408-x
更新日期：2010-11-01 00:00:00
abstract：:In vitro and in vivo experiments were carried out with medium-chain glycerides. In vitro, cholesterol gallstones were rapidly dissolved by medium-chain glycerides; control experiments with saline solution failed to modify the size of the stones. In vivo, medium-chain glycerides were instilled through an intraductal tu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01367677
更新日期：1981-07-01 00:00:00
abstract：:Twenty-four patients with chronic active HCV infection, nonresponders to a previous treatment cycle with recombinant interferon-alpha (r-IFNA), underwent retreatment with leukocyte (LE-) IFN-alpha. This was administered at the dose of 3 MU three times a week, for either six months (group A) or 12 months (group B). All...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1026693901012
更新日期：1998-10-01 00:00:00
abstract：:Some patients referred for esophagogastroduodenoscopy (EGD) to evaluate symptoms of dysphagia have normal endoscopies. How best to manage these patients is unclear. We reviewed our experience with empiric esophageal dilation in this setting. Over a five-year period, 40 consecutive patients with esophageal dysphagia an...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088225
更新日期：1996-06-01 00:00:00
abstract：:The present study aimed to investigate the role of nitric oxide on the oxidative damage in isolated rabbit gastric cells exposed to hypoxia-reoxygenation. Nitric oxide synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester, a nitric oxide donor, sodium nitroprusside, and superoxide dismutase were...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018886919532
更新日期：1998-05-01 00:00:00
abstract：:The gut smooth muscle in the intact conscious state exhibits three distinct types of contractions: rhythmic phasic contractions, tone, and ultrapropulsive contractions. The motility functions of these contractions differ markedly. The phasic contractions mix and propel the ingested food in an orderly fashion so that t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-01 00:00:00
abstract：:Somatostatin analog SMS 201-995 causes a dose-related suppression of the release and/or action of several gastrointestinal hormones and impairs several anterior pituitary functions. Some patients with illness involving abnormal hormonal activity have responded to treatment with SMS 201-995, including resolution of sev...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296623
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2510-z
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. AIMS:To apply, for the first time in gastrointestinal (GI) patien...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1777-9
更新日期：2011-12-01 00:00:00
abstract：:To date few therapies have been shown to reliably prevent the evolution of Crohn's disease (CD). The traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), has both immunomodulatory and anti-inflammatory activities. Our aim was to investigate the potential efficacy of T2, the major constituent of extracts...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9747-y
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Diagnosis of pediatric inflammatory bowel diseases (IBD) remains challenging. We aimed at the value of immunohistochemical assessment of CD30+ lymphocytes in the intestinal mucosa in differential diagnosis between pediatric Crohn's disease (CD) and ulcerative colitis (UC) and its utility as a predictor of fu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5018-3
更新日期：2018-07-01 00:00:00
abstract：:The aims of this study were to evaluate (i) the relationship between transpyloric flow (TF) assessed by Doppler ultrasonography and scintigraphy, (ii) the effects of healthy aging on TF and gastric emptying (GE), and (iii) the relationship between the glycemic response to oral glucose and TF. Ten healthy "young" (7 M,...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2555-3
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Regenerating islet-derived 3 (Reg3) is abnormally expressed in several human digestive system diseases, including chronic pancreatitis (CP) and pancreatic cancer (PC). AIM:The purpose of this study was to clarify the mechanism of the enhanced expression of Reg3 in inflammation-induced PC. METHODS:C57BL/6 m...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3787-5
更新日期：2015-12-01 00:00:00
abstract：:The in vitro antioxidant capacity of sulfasalazine (SASP), its metabolites (SP, 5-ASA), and olsalazine (OAZ), was studied by evaluating their effects on superoxide (O2-.) production. Assay systems were the xanthine-xanthine oxidase (X/XOD) reaction and phorbol myristate acetate (PMA)-activated polymorphonuclear leukoc...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300752
更新日期：1991-02-01 00:00:00
abstract：:The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026634721351
更新日期：1999-10-01 00:00:00
abstract：:Gallbladder dynamics, cholecystokinin (CCK), and pancreatic polypeptide (PP) release were studied in 14 patients with chronic pancreatitis (CP) (2 females, 12 males; age range 24-56 years) and 12 control subjects (4 females, 8 males, 21-50 years). On day 1, gallbladder contractility was investigated after ceruletide i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01316503
更新日期：1993-03-01 00:00:00
abstract：:Free radical damage in reflux esophagitis of rats induced by 24-hr duodenojejunal ligation was studied. Oxygen free radicals were selectively blocked. Groups were: sham operation, reflux, reflux + superoxide dismutase (SOD), catalase, dimethylthiourea, allopurinol, and inactivated SOD or inactivated catalase alone or ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02065541
更新日期：1995-06-01 00:00:00
abstract：:Not much is known about the relationship between portal hemodynamics and the grades of cirrhosis. Using pulsed Doppler ultrasonography, we studied portal vein diameter, portal flow velocity, and portal blood flow rate in 37 patients with liver cirrhosis (11 Child's A, 13 Child's B, and 13 Child's C) and 10 healthy con...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018814624307
更新日期：1998-02-01 00:00:00
abstract：:Hepatocellular carcinoma represents an increasing therapeutic challenge due to its high incidence and early metastasis. Numerous studies have demonstrated the influence of the vascular system on tumor growth and development. In addition, the role of leukocyte-endothelium interaction in tumor vessels is of particular s...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000030100.05979.b7
更新日期：2004-05-01 00:00:00
abstract：:Several epidemiological studies have demonstrated a close association between Helicobacter pylori infection and carcinoma of the mid- or distal stomach. If this can be shown to be a causal association, eradication of the organism may prevent later development of cancer. Several mechanisms have been proposed by which H...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:The effects of chronic normovolemic anemia on gastric microcirculation and gastric mucosal susceptibility to ethanol-induced gastric damage were investigated in anesthetized rats. Blood exchange by a plasma expander during four consecutive days rendered the animals anemic with a 34% decrease in the baseline hematocrit...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087418
更新日期：1994-04-01 00:00:00
abstract：:Leptin is a 16-kDa nonglycosylated protein primarily secreted from the adipocytes of white fat; minor levels of regulated leptin expression also occurs at other sites such as placenta, skeletal muscle, the stomach fundus, and culture-activated hepatic stellate cells (HSCs). Leptin is primarily involved in the regulati...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-006-9126-0
更新日期：2006-10-01 00:00:00
abstract：:We report a case of localized jejunal amyloidosis occurring in a 74-year-old man who experienced an episode of digestive bleeding while he was receiving oral anticoagulation. It illustrates a rare entity, characterized by an endoscopic aspect of polypoid, pseudotumoral formations. Histologically, submucosal connective...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005536901678
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Average-risk women aged 50-59 years have a lower incidence and mortality of colorectal cancer relative to age-matched men, calling into question the benefit of screening colonoscopy in this age group. AIMS:We aimed to determine whether FOBT is an effective initial screening test in 50-59-year-old women. ME...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5156-7
更新日期：2018-10-01 00:00:00
abstract：:The time-dependent appearance of phospholipase A2 (PLA2) activity in the preservation media of ischemic rat intestinal grafts is described. In controls, Ca2+-dependent, secretory PLA2 activity accumulated rapidly during the first 6 hr of ischemia, followed by a linear increase for up to 48 hr. LDH levels, by contrast,...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018876717308
更新日期：1997-05-01 00:00:00
abstract：:Positive findings on capsule endoscopy (CE) often prompt a follow-up procedure with therapeutic intent. Our purpose was to review the therapeutic yield of subsequent procedural interventions based on positive CE findings. The medical records of all patients who underwent CE between June 2002 and February 2005 for obsc...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9542-1
更新日期：2007-05-01 00:00:00
