Abstract:
:The time-dependent appearance of phospholipase A2 (PLA2) activity in the preservation media of ischemic rat intestinal grafts is described. In controls, Ca2+-dependent, secretory PLA2 activity accumulated rapidly during the first 6 hr of ischemia, followed by a linear increase for up to 48 hr. LDH levels, by contrast, increased linearly throughout the 48 hr of ischemia. Addition of inhibitors of PLA2, cyclooxygenase, and lipooxygenase blocked accumulation of PLA2, but not LDH. PX-13, a novel PLA2 inhibitor, was most effective: 40 microM inhibited release by 86%, while 25 microM indomethacin (cyclooxygenase blocker) or nordihydroguiaretic acid (lipooxygenase blocker) inhibited 41 and 36%, respectively. That appearance of PLA2 activity, but not LDH, is attenuated by inhibitors of the eicosanoid cascade suggests a secretory event rather than leakage from dying cells. The secreted PLA2 is most likely the proinflammatory sPLA2 that has been implicated as a stress-induced protein and priming agent in ischemia-reperfusion injury.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Sonnino RE,Pigatt L,Schrama A,Burchett S,Franson Rdoi
10.1023/a:1018876717308subject
Has Abstractpub_date
1997-05-01 00:00:00pages
972-81issue
5eissn
0163-2116issn
1573-2568journal_volume
42pub_type
杂志文章abstract::Insulinlike growth factor-1 (IGF-1) is an anabolic hormone synthesized by the liver upon stimulation by growth hormone (GH). IGF-1 exerts important effects on renal hemodynamics and renal sodium handling. The bioactivity of this hormone is influenced by its binding proteins (BP) of which IGF-BP3 favors retention in th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010631800505
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5311-1
更新日期:2019-01-01 00:00:00
abstract::Autoimmune hepatitis has a variable clinical phenotype, and the absence of conventional autoantibodies does not preclude its diagnosis or need for treatment. The goals of this review are to describe the frequency and nature of autoantibody-negative autoimmune hepatitis, indicate its outcome after corticosteroid treatm...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-011-2017-z
更新日期:2012-03-01 00:00:00
abstract:AIM:The aim of this study was to assess whether patients with colorectal cancer (CRC) are aware of the risk to family members and to test an educational intervention. METHODS:CRC patients were surveyed regarding their cancer, family history, understanding of familial risk of CRC, and knowledge of existing screening gu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0940-z
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires quantification of esophageal eosinophilia. AIMS:The aims of this study were to assess inter- and intraobserver reliability for measuring esophageal eosinophil counts and to validate a novel method of determining tissue eosinophil density using digitized h...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-1005-z
更新日期:2010-07-01 00:00:00
abstract::The effect of chemical deafferentation, vagotomy (VGX), and gangliosympathectomy (GSX) on the density of fibers containing calcitonin gene-related peptide (CGRP) and substance P (Sub.P) in the rat gastric wall was studied. Chemical deafferentation by capsaicin abolished the density of CGRP-immunoreactive (IR) fibers, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018858208532
更新日期:1997-06-01 00:00:00
abstract::Depletion of granulocytes and monocytes (GM) by selective apheresis (GMA) with an Adacolumn exerts an anti-inflammatory effect in patients with ulcerative colitis (UC) or rheumatoid arthritis. However, the mechanism of the anti-inflammatory effect of GMA is not fully understood yet. We investigated the effect of GMA o...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-005-9012-1
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND AND AIM:There is no consensus regarding the benefit of eradicating Helicobacter pylori (H. pylori) infection in patients with functional dyspepsia (FD). We intended to compare the symptom response to H. pylori eradication in FD patients in presence or absence of microscopic duodenitis (MD). METHODS:Patients...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3285-1
更新日期:2015-01-01 00:00:00
abstract::Cirrhotic patients with hepatocellular carcinoma (HCC) frequently develop hepatic encephalopathy. Metabolic etiology of encephalopathy is less often considered in these patients. Although paraneoplastic hypercalcemia may be associated with several malignant tumors, it has also been described in HCC [1-4], and may caus...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9159-4
更新日期:2007-11-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0184-8
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1569-2
更新日期:2011-07-01 00:00:00
abstract::The gut smooth muscle in the intact conscious state exhibits three distinct types of contractions: rhythmic phasic contractions, tone, and ultrapropulsive contractions. The motility functions of these contractions differ markedly. The phasic contractions mix and propel the ingested food in an orderly fashion so that t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract::Gastric emptying of a solid meal and of 10 indigestible radiopaque solids was measured with scintigraphic and radiological techniques in 50 healthy volunteers (controls), 41 patients with insulin-dependent diabetes mellitus, and 50 patients with functional dyspepsia. Gastroparesis was found in 51% of our diabetic pati...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02088042
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Whether addition of prokinetics to proton pump inhibitors improves esophageal peristalsis and symptoms in patients with gastroesophageal reflux disease (GERD) remains unknown. AIM:We evaluated the effect of mosapride, a 5-HT4 agonist, and PPI cotherapy in patients with GERD on esophageal motility using high...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-012-2430-y
更新日期:2013-04-01 00:00:00
abstract::A novel peptide, submandibular gland peptide-T (SGP-T), which reduces allergen-induced hypotension, was examined for effects on intestinal anaphylaxis. Hooded-Lister rats were sensitized to egg albumin and prepared for the measurement of in vivo myoelectric activity of the jejunum. The disruption of migrating myoelect...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018847608184
更新日期:1997-11-01 00:00:00
abstract::Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297143
更新日期:1991-07-01 00:00:00
abstract::Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01314760
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND:The relation of gastrointestinal (GI) complaints to IgE-mediated allergy is not well understood. Increased numbers of "IgE-armed" mast cells have been observed in duodenal mucosa of patients with functional GI complaints. AIMS:To explore whether total IgE and atopic sensitization were associated with functi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3835-1
更新日期:2016-01-01 00:00:00
abstract::Intravenous proton pump inhibitors (IV PPIs) decrease rebleeding following endoscopic hemostasis of bleeding peptic ulcers. Oral PPIs may be equally efficacious and may significantly reduce health care costs. This study aimed to compare outcomes in patients receiving oral versus IV PPI therapy following endoscopic hem...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9684-1
更新日期:2007-07-01 00:00:00
abstract::Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-020-06356-6
更新日期:2020-08-01 00:00:00
abstract::Metronidazole has been used to treat pouchitis, but there are no controlled data that show it is effective. Chronic unremitting pouchitis is a form of the disorder particularly difficult to manage. Diarrhea is the main symptom of pouchitis, which results from acute inflammation of the mucosa of an ileal reservoir. To ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02093783
更新日期:1994-06-01 00:00:00
abstract::Endoscopic biopsies are being increasingly utilized to investigate cytokine profiles in normal and diseased intestine. To evaluate the adequacy of mucosal biopsies as a source of cytokine-specific mRNA, we measured their content of interleukin-1 beta (IL-1 beta) and interleukin-2 (IL-2) mRNA by reverse transcription-p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02285198
更新日期:1995-07-01 00:00:00
abstract:AIMS:The purpose of this retrospective study was to assess clinical outcomes of endoscopic bougie dilation of esophageal strictures after radiation therapy for head and neck cancer, and to assess the risk factors which affect the treatment success. METHODS:Thirty-one patients with esophageal stricture due to radiation...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1875-8
更新日期:2012-02-01 00:00:00
abstract::Patients with long-standing ulcerative colitis (UC) or Crohn's colitis are at increased risk of developing colorectal cancer (CRC). Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3979-z
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) screening is cost-effective and prevents death from CRC if used appropriately. Physicians do not recommend CRC screening according to guidelines. Physician-related factors associated with CRC screening knowledge are unknown. AIMS:We tested the accuracy of CRC screening knowledge in a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5339-2
更新日期:2019-02-01 00:00:00
abstract::Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005439525762
更新日期:2000-04-01 00:00:00
abstract::Assessment of disease activity by clinical parameters in ulcerative colitis is still controversial. Different clinical indexes have been proposed. Colonoscopy provides detailed information on mucosal damage. The aim of this study was to identify, among 21 clinical and laboratory parameters, which were predictive of en...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-1590-4
更新日期:2005-02-01 00:00:00
abstract:UNLABELLED:The lactulose breath test (LBT) and gastroenterocolonic scintigraphy (GECS) can both be used to measure orocecal transit time (OCTT). The aims of this study were (1) to measure OCTT by LBT and GECS and (2) to determine whether lactulose alters orocecal transit. METHODS:Eight normal subjects underwent simult...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1018864400566
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Obesity and diabetes are risk factors for advanced alcoholic liver disease, and both are components of the metabolic syndrome. We aimed to assess the prevalence of metabolic syndrome and its components in a contemporary US cohort of adults with alcoholic liver disease and compare it to a historic co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06056-1
更新日期:2020-11-01 00:00:00
abstract::A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01312725
更新日期:1980-01-01 00:00:00