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Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation.

Abstract：

:The in vitro antioxidant capacity of sulfasalazine (SASP), its metabolites (SP, 5-ASA), and olsalazine (OAZ), was studied by evaluating their effects on superoxide (O2-.) production. Assay systems were the xanthine-xanthine oxidase (X/XOD) reaction and phorbol myristate acetate (PMA)-activated polymorphonuclear leukocytes (PMNs), using the cytochrome c (cyt-c) reduction assay and a luminol-dependent chemiluminescence method. 5-ASA, SASP, and OAZ showed a dose-dependent scavenger effect in both O2-. generating systems, 5-ASA being the most powerful (greater than 50% of inhibition in the PMNs system and greater than 70% in the X/XOD system at 10 microM concentration). SP had an inhibitory effect only in the PMNs system but did not modify the activity of xanthine oxidase, thus excluding a scavenger action. These data suggest that the scavenger effect of 5-ASA, SASP, and OAZ may be an important mechanism of action.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Gionchetti P,Guarnieri C,Campieri M,Belluzzi A,Brignola C,Iannone P,Miglioli M,Barbara L

doi

10.1007/BF01300752

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

174-8

issue

2

eissn

0163-2116

issn

1573-2568

journal_volume

36

pub_type

杂志文章

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