Abstract:
OBJECTIVE:This study focused on unhealed gastrocutaneous fistulas to resolve whether standard drugs that promote healing of gastric ulcers may simultaneously have the same effect on cutaneous wounds, and corticosteroid aggravation, and to demonstrate why peptides such as BPC 157 exhibit a greater healing effect. Therefore, with the fistulas therapy, we challenge the wound/growth factors theory of the analogous nonhealing of wounds and persistent gastric ulcers. METHODS:The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 microg/kg) (12 ml/rat/day) or intraperitoneally (10 microg/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]. RESULTS:Greater anti-ulcer potential and efficiency in wound healing compared with standard agents favor BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally. Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically. Standard anti-ulcer agents, after a delay, improve firstly skin healing and then stomach mucosal healing, but not fistula leaking and bursting strength (except for atropine). CONCLUSION:We conclude that BPC 157 may resolve analogous nonhealing of wounds and persistent gastric ulcers better than standard agents.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Skorjanec S,Dolovski Z,Kocman I,Brcic L,Blagaic Boban A,Batelja L,Coric M,Sever M,Klicek R,Berkopic L,Radic B,Drmic D,Kolenc D,Ilic S,Cesarec V,Tonkic A,Zoricic I,Mise S,Staresinic M,Ivica M,Lovric Bencic M,Anicdoi
10.1007/s10620-008-0332-9subject
Has Abstractpub_date
2009-01-01 00:00:00pages
46-56issue
1eissn
0163-2116issn
1573-2568journal_volume
54pub_type
杂志文章abstract:BACKGROUND/AIMS:There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, popul...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5073-9
更新日期:2018-07-01 00:00:00
abstract::We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid. In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02300385
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a common disease with intestinal dysmotility, whose mechanism remains elusive. TMEM16A is a calcium-activated chloride channel (CaCC) involved in intestinal slow-wave generation. AIMS:To investigate whether TMEM16A is involved in colonic dysmotility in IBS. METHODS:A rat m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5261-7
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abstract:PURPOSE:Studies investigating the association between aspirin use and gastric cancer risk have reported conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. RESULTS:Two investigators independently searched the Medline, PubMed, Embase, and Academic Searc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10620-009-0915-0
更新日期:2010-06-01 00:00:00
abstract::The double pylorus is a fistulous communication between the gastric antrum and duodenal bulb. In most instances, it is believed to be a complication of peptic ulcer disease. In prior reports, the longest follow-up has been only 5 years. We report four cases of double pylorus, three of which have been followed medicall...
journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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abstract::Free radical damage in reflux esophagitis of rats induced by 24-hr duodenojejunal ligation was studied. Oxygen free radicals were selectively blocked. Groups were: sham operation, reflux, reflux + superoxide dismutase (SOD), catalase, dimethylthiourea, allopurinol, and inactivated SOD or inactivated catalase alone or ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02065541
更新日期:1995-06-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2008-01-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/BF01299905
更新日期:1993-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02090075
更新日期:1994-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1982-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Digestive diseases and sciences
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更新日期:2010-03-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析
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journal_title:Digestive diseases and sciences
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更新日期:1991-02-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2002-06-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2016-10-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-007-0009-9
更新日期:2008-05-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2015-02-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2018-07-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02090063
更新日期:1994-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00