Abstract:
:Published clinical trials (N = 56) of antisecretory drugs in the treatment of benign gastric ulcer were reviewed. Composite healing rates for various drug regimens were calculated using a method previously described for duodenal ulcer. Healing rates were compared with data on suppression of intragastric acidity to see if any relationship was evident. No significant correlations between the two existed, unless placebo data were included in the analysis. Correlations were stronger with suppression of total 24-hr rather than nocturnal acidity. Using Williams' method for assessing trends, it was found that an increase in antisecretory effect is not associated with a concomitant increase in healing rates. Duration of medical treatment is the single most important factor in healing of benign gastric ulcer; healing rates for all drug regimens and placebo show a consistent increase with prolongation of treatment.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Howden CW,Jones DB,Peace KE,Burget DW,Hunt RHdoi
10.1007/BF01798367subject
Has Abstractpub_date
1988-05-01 00:00:00pages
619-24issue
5eissn
0163-2116issn
1573-2568journal_volume
33pub_type
临床试验,杂志文章,评审abstract:BACKGROUND:Concerns over the hypothetical adverse effects of water absorption and the disturbance of serum sodium and potassium levels prompted a quality assurance evaluation of water exchange (WE) colonoscopy. AIM:The purpose of this study was to evaluate the balance of water infused and suctioned in WE colonoscopy, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2934-0
更新日期:2014-03-01 00:00:00
abstract::Immune (gamma) interferon is a substance produced by immunologically activated mononuclear cells. Besides its antiviral activity, interferon gamma has a crucial role in immunoregulation, by acting directly upon lymphocytes and monocytes, and interacting with other soluble mediators of the immune response. Studies of t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536683
更新日期:1988-10-01 00:00:00
abstract::We studied the anorectal manometric and urodynamic pattern of seven patients who had right and/or left frontal lobe injury to investigate the possibility that the frontal lobe area plays an important role in control of anorectal motility as it does for the urinary bladder. We found that the disturbances of anorectal m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536767
更新日期:1990-02-01 00:00:00
abstract::Alterations in insulin and glucagon levels might account for the plasma amino acid imbalance of cirrhotics. In order to verify this hypothesis we evaluated basal insulin, glucagon, branched-chain amino acids, aromatic amino acids, and free tryptophan in 13 controls and 37 cirrhotics divided on the basis of their menta...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01333703
更新日期:1979-08-01 00:00:00
abstract::The susceptibility to sepsis in obstructive jaundice may be related to bacterial translocation (BT) from the gastrointestinal tract. We evaluated BT to visceral organs and morphological changes of the intestinal mucosa in a rat model of obstructive jaundice. Animals were randomly divided into two groups: in group A th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1014733226337
更新日期:2002-04-01 00:00:00
abstract::Two hundred one consecutive patients with gallstone disease who had undergone cholecystectomy were analyzed to determine the relative frequency of occurrence of cholesterol and pigment gallstones and to identify distinguishing features of the two stone types. Cholesterol stones (CS) formed the majority (94%) of gallst...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300256
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Histological remission represents a target distinct from endoscopic healing in ulcerative colitis (UC) and seems a better predictor of clinical outcomes. AIMS:The aim of this study was to assess the ability of adalimumab to achieve histological remission in UC patients. METHODS:Single-center, retrospective...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-4935-5
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to investigate the potential of a computerized auscultation method for providing an objective, quantitative measure characteristic of irritable bowel syndrome. Bowel sounds from irritable bowel patients and normal controls were digitized using an electronic stethoscope. Computerized analy...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1018859110022
更新日期:1999-09-01 00:00:00
abstract::In some patients, proton pump inhibitors do not abolish nocturnal gastric acidity and additional evening antisecretory medication may be required. In 16 subjects with chronic heartburn, 24-hr gastric and esophageal pH were measured at baseline and again after six days of 20 mg omeprazole alone at 08:00 hr followed by ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1013749501241
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND/AIM:Transarterial chemoembolization (TACE) is the recommended treatment for patients with Barcelona stage B hepatocellular carcinoma; however, community practice varies from these American Association for the Study of Liver Diseases guidelines. In this study, we sought to assess factors determining outcome a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3247-7
更新日期:2014-11-01 00:00:00
abstract::Fifty-five children with cholestatic cirrhosis due to extrahepatic biliary atresia received a course of hepatitis B vaccine. Forty-seven received a plasma-derived vaccine and eight a recombinant vaccine. Antibody determination was evaluated before and after liver transplantation in 30 patients. Twenty-five additional ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296568
更新日期:1992-08-01 00:00:00
abstract::A gangliocytic paraganglioma (GP) is an extremely rare neurogenic tumor nearly located in the second portion of the duodenum and has been regarded as benign. We report a case of duodenal GP in a 53-year-old man. The GP arose in the second portion of the duodenum and was shown by histological examination to consist of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9370-3
更新日期:2007-06-01 00:00:00
abstract::Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus john...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0275-1
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:The C-31G polymorphism in the survivin promoter could de-repress the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0441-5
更新日期:2009-05-01 00:00:00
abstract::Hepatocyte growth factor plays a key role in liver regeneration but the role of liver in its synthesis in acute liver failure is unclear. We therefore measured hepatic expression of hepatocyte growth factor mRNA in this condition in comparison to H3 histone mRNA, a marker of cellular proliferation. Hepatocyte growth f...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005504311190
更新日期:2000-10-01 00:00:00
abstract::Our purpose is to focus attention on the cancer family history, coupled with an understanding of the natural history and extracolonic tumor spectrum of familial adenomatous polyposis (FAP), through a family study. This family report provides an example of how colorectal cancer (CRC) can be prevented by knowledgeable g...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012330626600
更新日期:2001-11-01 00:00:00
abstract::Accurate and cost-effective diagnosis of Helicobacter pylori gastritis has taken on major importance. Several serologic tests for the diagnosis of H. pylori infection are commercially available. We compared the performance of the FlexSure HP rapid IgG antibody test with the conventional HM-CAP ELISA to evaluate whethe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018832306135
更新日期:1998-01-01 00:00:00
abstract::Acid inhibition increases gastric mucosal susceptibility to damage by luminal acid. This might be due to reduced metabolic CO2 and bicarbonate whereas, during normal acid, secretion cytoprotective CO2/HCO3- production parallels acid production. Metabolic activity and mucosal damage caused by luminal acid perfusion was...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02091538
更新日期:1996-05-01 00:00:00
abstract::Irritable bowel syndrome is a frequent gastrointestinal disorder of unknown etiology. The serotonin transporter regulates the intensity and duration of serotonin signaling in the gut and is, therefore, an attractive candidate gene for irritable bowel syndrome. Previous studies investigating the 5-HTTLPR and Stin2 VNTR...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0666-3
更新日期:2009-12-01 00:00:00
abstract::The effect of psyllium hydrophilic mucilloid (PHM) when used as a laxative and/or stool softener on serum cholesterol concentrations was examined in 176 ambulatory elderly participants attending a health screening program. The change in one-year serum cholesterol concentration in subjects using PHM was compared with t...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01318205
更新日期:1991-03-01 00:00:00
abstract::Prevalence estimates for irritable bowel syndrome from surveys in Western countries are 4.4% to 22%, generally higher in women than men, and only a minority seek health care. There are few studies of bowel patterns in Asian countries. We conducted a survey of a nonpatient population in Ho Chi Minh City, Vietnam, to de...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-9005-0
更新日期:2006-05-01 00:00:00
abstract::Azithromycin (Zithromax), an erythromycin derivative that belongs to a subgroup of the macrolides known as azolides, has generally been considered to be a very safe medication. Hepatic side effects are uncommon but may include jaundice, fever, and right upper quadrant pain. Herein we describe a patient who developed a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1020170807742
更新日期:2002-10-01 00:00:00
abstract::Depletion of granulocytes and monocytes (GM) by selective apheresis (GMA) with an Adacolumn exerts an anti-inflammatory effect in patients with ulcerative colitis (UC) or rheumatoid arthritis. However, the mechanism of the anti-inflammatory effect of GMA is not fully understood yet. We investigated the effect of GMA o...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-005-9012-1
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The arrival of tacrolimus has drastically improved AALDLT recipients' survival. However, little data of tacrolimus have been reported concerning its effects on lipid metabolism for AALDLT recipients. AIM:Out aim was to investigate the relationship between tacrolimus blood concentration and lipid metabolism ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1817-5
更新日期:2012-01-01 00:00:00
abstract::A variety of human disease conditions are associated with chronic intestinal disorders or enteropathies that are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Such disruptions in the homeostasis of the gastrointestinal (GI) tract can lead to symptoms of...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-014-3322-0
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Biliary complications (BCs) occur in up to 40% of living donor liver transplant (LDLT) recipients. The aim of this study was to evaluate the efficacy of endoscopic therapy in the management of LDLT-related BCs. METHODS:A retrospective study of 100 LDLT recipients at a single transplant center over ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4367-z
更新日期:2017-01-01 00:00:00
abstract::Alterations in smooth muscle responsiveness and neural pathways in adjacent tissue may occur after local myenteric denervation. The in vitro contractile responses of both longitudinal and circular muscle to the mixed muscarinic and nicotinic cholinergic agonist carbachol were determined 15, 30, and 45 days after local...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01537588
更新日期:1990-09-01 00:00:00
abstract::Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0404-x
更新日期:2009-04-01 00:00:00
abstract::An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing and rapid regeneration of Paneth cells, which have a large amount of zinc in their cytoplasmic granules. We examined the expression pattern of transforming growth factor (TGF) -alpha and TGF-beta1 in this regenera...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010797609041
更新日期:2001-05-01 00:00:00
abstract::Turmeric is widely used in Indian cuisine. The main constituents of turmeric are curcumin and its analogues, which are well-known antioxidant compounds. In the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby incre...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-008-0550-1
更新日期:2009-08-01 00:00:00