Abstract:
BACKGROUND AND AIM:Dietary fiber shortens gut transit time, but data on the effects of fiber components (including resistant starch, RS) on intestinal contractility are limited. We have examined RS effects in male Sprague-Dawley rats fed either a high-amylose maize starch (HAMS) or a wholemeal made from high-amylose wheat (HAW) on ileal and colonic contractility ex vivo and expression of genes associated with smooth muscle contractility. METHODS:Rats were fed diets containing 19 % fat, 20 % protein, and either low-amylose maize starch (LAMS), HAMS, wholemeal low-amylose wheat (LAW) or HAW for 11 week. Isolated ileal and proximal colonic sections were induced to contract electrically, or by receptor-independent (KCl) or receptor-dependent agents. Colonic gene expression was assessed using an Affymetrix microarray. RESULTS:Ileal contractility was unaffected by treatment. Maximal proximal colonic contractility induced electrically or by angiotensin II or carbachol was lower for rats fed HAMS and LAW relative to those fed LAMS (P < 0.05). The colonic expression of genes, including cholinergic receptors (Chrm2, Chrm3), serotonin receptors (Htr5a, Htr7), a protease-activated receptor (F2r), a prokineticin receptor (Prokr1), prokineticin (Prok1), and nitric oxide synthase 2 (Nos2), was altered by dietary HAMS relative to LAMS (P < 0.05). HAW did not significantly affect these genes or colonic contractility relative to effects of LAMS. CONCLUSIONS:RS and other fiber components could influence colorectal health through modulation of stool transit time via effects on muscular contractility.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Patten GS,Kerr CA,Dunne RA,Shaw JM,Bird AR,Regina A,Morell MK,Lockett TJ,Molloy PL,Abeywardena MY,Topping DL,Conlon MAdoi
10.1007/s10620-015-3537-8subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1624-32issue
6eissn
0163-2116issn
1573-2568journal_volume
60pub_type
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