Screening colonoscopy for colorectal cancer in asymptomatic people: a meta-analysis.

Abstract:

OBJECTIVE:The preferred method for screening asymptomatic people for colorectal cancer (CRC) is colonoscopy, according to the new American guidelines. The aim of our study was to perform a meta-analysis of the prospective cohorts using total colonoscopy for screening this population for CRC. We looked for the diagnostic yield of the procedure as well as for its safety in a screening setting. METHODS:We included papers with more than 500 participants and only those reporting diagnostic yield of adenoma (and/or advanced adenoma) and CRC. Nested analysis were performed for secondary endpoints of complications and CRC stages when this information was available. All analyses were performed with StatDirect Statistical software, version 2.6.1 ( http://www.statsdirect.com ). RESULTS:Our search yielded ten studies of screening colonoscopy conducted in asymptomatic people that met our inclusion criteria, with a total of 68,324 participants. Colonoscopy was complete and reached the cecum in 97% of the procedures. Colorectal cancer was found in 0.78% of the participants (95% confidence interval 0.13-2.97%). Stage I or II were found in 77% of the patients with CRC. Advanced adenoma was found in 5% of the cases (95% confidence interval 4-6%). Complications were rare and described in five cohorts. Perforation developed in 0.01% of the cases (95% confidence interval 0.006-0.02%) and bleeding in 0.05% (95% confidence interval 0.02-0.09%). CONCLUSIONS:Our findings support the notion that colonoscopy is feasible and a suitable method for screening for CRC in asymptomatic people.

journal_name

Dig Dis Sci

authors

Niv Y,Hazazi R,Levi Z,Fraser G

doi

10.1007/s10620-008-0286-y

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

3049-54

issue

12

eissn

0163-2116

issn

1573-2568

journal_volume

53

pub_type

杂志文章,meta分析
  • Modulation of esophageal contractions by distension in vitro.

    abstract::Stimulation of the intrinsic nerves of the esophageal body leads to a twitch of the circular muscle after the end of the stimulation (the esophageal off-response), and the twitch spreads in the distal direction because of a latency gradient in the onset of the off-response between the proximal and the distal esophagus...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536324

    authors: Ren J,Schulze-Delrieu K

    更新日期:1989-04-01 00:00:00

  • Changes in serum hepatitis C virus RNA titer and response to interferon therapy in patients with chronic hepatitis C.

    abstract::Response to interferon (IFN) therapy for chronic hepatitis C has been determined by the alteration of serum alanine aminotransferase (ALT) values. However, eradication of hepatitis C virus (HCV) could be another aim of the therapy. Thus, we serially measured serum HCV RNA levels during therapy and for at least 12 mont...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02090379

    authors: Aiyama T,Yoshioka K,Hirofuji H,Kusakabe A,Yamada M,Tanaka K,Kakumu S

    更新日期:1994-10-01 00:00:00

  • Anatomical Location of Pathology Is Predictive of Prolonged Fluoroscopy Time During ERCP: A Multicenter American Study.

    abstract:BACKGROUND:Different factors have been associated with prolonged fluoroscopy time (FT) during endoscopic retrograde cholangiopancreatography (ERCP). AIM:We hypothesize that FT depends on both the anatomical location of the pathology managed during ERCP and the complexity of the ERCP. METHODS:Three centers participate...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-014-3508-5

    authors: Alkhatib AA,Abdel Jalil AA,Faigel DO,Pannala R,Crowell M,Harrison ME

    更新日期:2015-06-01 00:00:00

  • Muscle shortening along the normal esophagus during swallowing.

    abstract::Longitudinal shortening of the esophagus during peristaltic contraction has been previously analyzed globally using spaced mucosal clips. This method gives a relatively crude measurement. In this study, local longitudinal shortening (LLS) was evaluated using simultaneous high-resolution endoluminal ultrasound (HREUS) ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3092-4

    authors: Dai Q,Korimilli A,Thangada VK,Chung CY,Parkman H,Brasseur J,Miller LS

    更新日期:2006-01-01 00:00:00

  • Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea: a population-based study.

    abstract::Various reports on the prevalence of gastroesophageal reflux disease (GERD) and uninvestigated dyspepsia have been conducted in Western countries. We sought to determine the frequency of GERD symptoms and uninvestigated dyspepsia in Korea. Telephone interviews were conducted with 1,044 individuals. Of all subjects, 7....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9842-0

    authors: Yang SY,Lee OY,Bak YT,Jun DW,Lee SP,Lee SH,Park GT,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH

    更新日期:2008-01-01 00:00:00

  • Submandibular gland peptide-T (SGP-T) inhibits intestinal anaphylaxis.

    abstract::A novel peptide, submandibular gland peptide-T (SGP-T), which reduces allergen-induced hypotension, was examined for effects on intestinal anaphylaxis. Hooded-Lister rats were sensitized to egg albumin and prepared for the measurement of in vivo myoelectric activity of the jejunum. The disruption of migrating myoelect...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018847608184

    authors: Mathison R,Tan D,Oliver M,Befus D,Scott B,Davison JS

    更新日期:1997-11-01 00:00:00

  • Predictors of mortality in patients with hepatocellular carcinoma undergoing transarterial chemoembolization.

    abstract:BACKGROUND/AIM:Transarterial chemoembolization (TACE) is the recommended treatment for patients with Barcelona stage B hepatocellular carcinoma; however, community practice varies from these American Association for the Study of Liver Diseases guidelines. In this study, we sought to assess factors determining outcome a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3247-7

    authors: Barman PM,Sharma P,Krishnamurthy V,Willatt J,McCurdy H,Moseley RH,Su GL

    更新日期:2014-11-01 00:00:00

  • Endoscopic management of Barrett's esophagus: advances in endoscopic techniques.

    abstract::Barrett's esophagus (BE) is a well-known premalignant condition that can be associated with the development of dysplasia and adenocarcinoma. In the past, esophagectomy was the standard treatment for patients with BE with high grade dysplasia (HGD) and early cancer (EC). However, esophagectomy is not necessarily the on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-012-2279-0

    authors: Azarm A,Lukolic I,Shukla M,Concha-Parra R,Gress F

    更新日期:2012-12-01 00:00:00

  • Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability.

    abstract::Our aim was to investigate whether there are changes in permeability to sucrose in asymptomatic Helicobacter pylori gastritis. Nineteen asymptomatic subjects with Helicobacter pylori-associated gastritis with no or mild mucosal atrophy and 19 age- and sex-matched normal controls were studied by peroral load of sucrose...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018809913230

    authors: Borch K,Sjöstedt C,Hannestad U,Söderholm JD,Franzén L,Mårdh S

    更新日期:1998-04-01 00:00:00

  • Direct transmission of H. pylori from challenged to nonchallenged mice in a single cage.

    abstract::To understand whether direct transmission of H. pylori occurs from infected mouse to noninfected mouse, the system using a mouse model we developed previously was tested. Six nude mice were challenged with H. pylori inocula; one group consisted of one challenged nude mouse 1 week after inoculation raised with four non...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2710-x

    authors: Karita M,Matsumoto S,Kamei T,Shinohara K,Sugiyama T

    更新日期:2005-06-01 00:00:00

  • Chronic hepatitis C without anti-hepatitis C antibodies by second-generation assay. A clinicopathologic study and demonstration of the usefulness of a third-generation assay.

    abstract::To study the clinicopathologic features of hepatitis C viremic patients negative for hepatitis C antibodies (anti-HCV) by current second-generation assay, we categorized 139 consecutive histologically verified patients with chronic non-A, non-B hepatitis into three groups: 121 (87%) were positive for second-generation...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02208599

    authors: Kao JH,Lai MY,Hwang YT,Yang PM,Chen PJ,Sheu JC,Wang TH,Hsu HC,Chen DS

    更新日期:1996-01-01 00:00:00

  • Effects of rebamipide in combination with lansoprazole and amoxicillin on Helicobacter pylori-infected gastric ulcer patients.

    abstract::The aim of this study was to compare the additive effect of rebamipide with that of teprenone in combination with dual therapy on H. pylori eradication. A total of 102 H. pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lanso...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kato M,Asaka M,Sugiyama T,Kudo M,Nishikawa K,Sukegawa M,Hokari K,Katagiri M,Sato F,Kagaya H,Takeda H

    更新日期:1998-09-01 00:00:00

  • Hepatitis C virus infection--pathobiology and implications for new therapeutic options.

    abstract::Despite progress in therapeutic approaches for the elimination of hepatitis C, chronic hepatitis C virus infection remains an important cause of liver disease. Therapeutic intervention with the currently available interferon-based treatment regimens is quite successful, but treatment is difficult to tolerate and is co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-006-9484-7

    authors: Davis GL,Krawczynski K,Szabo G

    更新日期:2007-04-01 00:00:00

  • Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults.

    abstract:BACKGROUND:Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter. METHODS:We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility featur...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-015-3645-5

    authors: O'Dwyer RH,Acosta A,Camilleri M,Burton D,Busciglio I,Bharucha AE

    更新日期:2015-08-01 00:00:00

  • Effects of octreotide and erythromycin on gastric myoelectrical and motor activities in patients with gastroparesis.

    abstract::Simultaneous recordings of gastric manometry and myoelectrical activity were made in 10 patients with gastroparesis. Intravenous erythromycin (100 mg) was administered in the fasting state for a period of 30 min. Subcutaneous injection of octreotide (100 microg) was administered before one of the four identical test m...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018876021156

    authors: Chen JD,Lin ZY,Edmunds MC 3rd,McCallum RW

    更新日期:1998-01-01 00:00:00

  • Surface structure of single-gland adenoma in familial adenomatous polyposis.

    abstract::Magnifying videoendoscopic observation of a minute lesion with a single IIIL type cryptal orifice was reported. This minute lesion was a single-gland adenoma accompanied histopathologically by a bud of adenomatous gland and was located in the upper part of the mucosa. This finding regarding a pit pattern should make p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1020143529123

    authors: Tamura S,Nakajo K,Kitamura M,Kamiji I,Onishi S

    更新日期:2002-10-01 00:00:00

  • Responsiveness to Change and Minimally Important Differences of the Patient-Reported Outcomes Measurement Information System Gastrointestinal Symptoms Scales.

    abstract:BACKGROUND:The NIH-sponsored Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal (GI) Symptoms scales were developed to assess patients' GI symptoms in clinical settings. AIMS:To assess responsiveness to change and provide minimally important difference (MID) estimates for the PROMIS GI ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-017-4499-9

    authors: Khanna D,Hays RD,Shreiner AB,Melmed GY,Chang L,Khanna PP,Bolus R,Whitman C,Paz SH,Hays T,Reise SP,Spiegel B

    更新日期:2017-05-01 00:00:00

  • Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestinal manifestation.

    abstract::Isolated case reports in which symptomatic hearing loss develops suddenly during the course of inflammatory bowel disease (IBD) have been reported, but the presence of subclinical sensorineural hearing loss (SNHL) associated with IBD has been investigated in only two preliminary studies. In order to research this furt...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2964-3

    authors: Akbayir N,Caliş AB,Alkim C,Sökmen HM,Erdem L,Ozbal A,Bölükbaş F,Akbayir N

    更新日期:2005-10-01 00:00:00

  • Evaluation of early atherosclerosis in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present. AIMS:The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease. METHODS:Thirty-nine pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2148-x

    authors: Kayahan H,Sari I,Cullu N,Yuksel F,Demir S,Akarsu M,Goktay Y,Unsal B,Akpinar H

    更新日期:2012-08-01 00:00:00

  • Persistence of Campylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis.

    abstract::Campylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum, four from antrum, and four from body and fundus, were taken before and after four weeks of cimetidine trea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296375

    authors: Hui WM,Lam SK,Chau PY,Ho J,Lui I,Lai CL,Lok AS,Ng MM

    更新日期:1987-11-01 00:00:00

  • Community-based health preferences for proctocolectomy: a race comparison.

    abstract::Our objective was to determine whether there are dominating racial differences in patient preferences for surgery that may explain the disparities in proctocolectomy utilization between African Americans (AA) and whites. We used the time trade-off technique to measure health preferences for undergoing ileal pouch anal...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9915-0

    authors: Nguyen GC,Tuskey A,Bayless TM,LaVeist TA,Brant SR

    更新日期:2008-03-01 00:00:00

  • In vitro growth responses of bifidobacteria and enteropathogens to bovine and human lactoferrin.

    abstract::A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmon...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1024111310345

    authors: Griffiths EA,Duffy LC,Schanbacher FL,Dryja D,Leavens A,Neiswander RL,Qiao H,DiRienzo D,Ogra P

    更新日期:2003-07-01 00:00:00

  • Curative Criteria After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinomas.

    abstract:BACKGROUND:According to the Japanese Esophageal Society (JES) guidelines, risk factors for lymph node (LN) metastasis in the muscularis mucosa (MM)/submucosa to a depth of up to 200 μm (SM1) in cases of esophageal squamous cell carcinomas (ESCCs) include the presence of lymphatic invasion (ly), venous invasion (v), inf...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5029-0

    authors: Mizumoto T,Hiyama T,Oka S,Yorita N,Kuroki K,Kurihara M,Yoshifuku Y,Sanomura Y,Urabe Y,Murakami Y,Arihiro K,Tanaka S,Chayama K

    更新日期:2018-06-01 00:00:00

  • Gut-brain chemokine changes in portal hypertensive rats.

    abstract:BACKGROUND:Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1625-y

    authors: Merino J,Aller MA,Rubio S,Arias N,Nava MP,Loscertales M,Arias J,Arias JL

    更新日期:2011-08-01 00:00:00

  • Cardiac Metaplasia: Follow, Treat, or Ignore?

    abstract::Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-018-5063-y

    authors: Spechler SJ

    更新日期:2018-08-01 00:00:00

  • Breath ammonia measurement in Helicobacter pylori infection.

    abstract::Our aim was to define the utility of breath ammonia measurement in assessing Helicobacter pylori infection. Volunteers breathed into a device containing three fiberoptic NH3 sensors at baseline and after ingesting 300 mg of urea. Breath ammonia levels were compared to the [14C]urea breath test. Thirteen subjects were ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1020568227868

    authors: Kearney DJ,Hubbard T,Putnam D

    更新日期:2002-11-01 00:00:00

  • High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-alpha levels.

    abstract::Leptin is an adipocyte-derived hormone involved in the homeostasis of body composition. An imbalance in leptin regulation has been observed in patients with liver cirrhosis. We aimed to assess serum and ascitic leptin levels in a group of patients with decompensated liver cirrhosis and to evaluate the relationship of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000017451.48031.b6

    authors: Giannini E,Romagnoli P,Tenconi GL,Botta F,Malfatti F,Chiarbonello B,Mamone M,Barreca T,Testa R

    更新日期:2004-02-01 00:00:00

  • Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.

    abstract::The effect of ischemia-reperfusion and 48-hr fasting on apoptosis was characterized in rat gastric mucosa and compared to small intestinal mucosa. Under halothane anesthesia, the celiac artery or superior mesenteric artery in the rat was occluded for 60 min followed by reperfusion. Occlusion of the celiac artery reduc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005695031233

    authors: Fukuyama K,Iwakiri R,Noda T,Kojima M,Utsumi H,Tsunada S,Sakata H,Ootani A,Fujimoto K

    更新日期:2001-03-01 00:00:00

  • Primary histiocytic lymphoma of the esophagus.

    abstract::Squamous cell carcinoma represents the most common primary malignant lesion of the esophagus (1). The initial manifestation of lymphosarcoma infrequently occurs in the gastrointestinal tract, and in one large series, there were no lymphosarcomas presenting in the esophagus (2). In the case described below, a primary h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01324907

    authors: Berman MD,Falchuk KR,Trey C,Gramm HF

    更新日期:1979-11-01 00:00:00

  • Intraoperative radiation enhances decline of pancreatic exocrine function after pancreatic head resection.

    abstract::Intraoperative radiation therapy has been introduced to improve survival rates after resection of biliopancreatic cancer. Early and late effects of intraoperative radiation on the exocrine and endocrine functions of the residual pancreas were examined in 54 patients with pancreatic head resection. Of the 54 patients, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005529430847

    authors: Yamaguchi K,Nakamura K,Kimura M,Yokohata K,Noshiro H,Chijiiwa K,Tanaka M

    更新日期:2000-06-01 00:00:00