Gut-brain chemokine changes in portal hypertensive rats.


BACKGROUND:Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat. AIM:We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis. METHODS:One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-α) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes. RESULTS:The significant increase of fractalkine in mesenteric lymph nodes (P<0.05) and its receptor (CX3CR1) in the small bowel (P<0.05) and hippocampus (P<0.01), associated with the increased expression of SDF1-α in the hippocampus (P<0.01) and the cerebellum (P<0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis. CONCLUSION:The present study revealed that portal hypertension is associated with splanchnic-brain inflammatory alterations mediated by chemokines.


Dig Dis Sci


Merino J,Aller MA,Rubio S,Arias N,Nava MP,Loscertales M,Arias J,Arias JL




Has Abstract


2011-08-01 00:00:00












  • Spasm of gastric muscularis mucosae might play a key role in causing focal mucosal ischemia and ulceration. An experimental study in guinea pigs.

    abstract::While transilluminating guinea pig gastric wall, we noticed foci of irregular compression of submucosal veins and arteries, featuring parallel bands across arteries, with complete cessation of blood flow, mucosal pallor, and shrinkage of the area. Other features demonstrated that this was not due to artifactual pressu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Piasecki CK,Thrasivoulou C

    更新日期:1993-07-01 00:00:00

  • Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury.

    abstract:BACKGROUND:Accumulating evidence suggests that Foxp3+ regulatory T (Treg) cells act as inhibitory mediators of inflammation; however, the in vivo mechanism underlying this protection remains elusive in liver diseases. AIMS:To clarify the in vivo role of Foxp3+ Treg cells in liver fibrosis, we used the DEREG mouse, whi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Roh YS,Park S,Lim CW,Kim B

    更新日期:2015-07-01 00:00:00

  • Interferon in the management of chronic hepatitis B.

    abstract::Many drugs have been used in the treatment of chronic hepatitis B, but with the exception of interferon, none have proved to be effective. Several studies have found that a sustained loss of viral replication occurs in approximately 40% of patients who started with a 16-week course of recombinant interferon alfa-2b gi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Perrillo RP

    更新日期:1993-04-01 00:00:00

  • Elevated levels of circulating angiotensin converting enzyme in patients with hepatoportal sclerosis.

    abstract:BACKGROUND AND AIMS:Hepatoportal sclerosis (HPS) is a clinicopathologic condition that is clinically characterized by portal hypertension (varices and portosystemic collateral vessels), splenomegaly and pancytopenia, in the absence of cirrhosis. Although the etiology is obscure, a number of theories such as immunologic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Beyazit Y,Ibis M,Purnak T,Turhan T,Kekilli M,Kurt M,Sayilir A,Onal IK,Turhan N,Tas A,Köklü S,Haznedaroglu IC

    更新日期:2011-07-01 00:00:00

  • Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.

    abstract::Minimal hepatic encephalopathy (MHE) describes patients with chronic liver disease or cirrhosis who have no clinical symptoms of brain dysfunction but perform worse on psychometric tests compared with healthy subjects. The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Malaguarnera M,Greco F,Barone G,Gargante MP,Malaguarnera M,Toscano MA

    更新日期:2007-11-01 00:00:00

  • Short-term effects of bile diversion on postgastrectomy gastric histology.

    abstract::Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bechi P,Amorosi A,Mazzanti R,Buccarelli A,Pantalone D,Cortesini C

    更新日期:1988-10-01 00:00:00

  • Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease.

    abstract::The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Maekubo H,Matsushima T,Okada F,Honma M,Ui M

    更新日期:1980-09-01 00:00:00

  • Expression of gastric antisecretory and prostaglandin E receptor binding activity of misoprostol by misoprostol free acid.

    abstract::In enriched canine parietal cell preparations, misoprostol, an analog of prostaglandin E1 methyl ester, was rapidly deesterified to misoprostol free acid. Under this circumstance, misoprostol and misoprostol free acid exhibited equal antisecretory potency against histamine-stimulated acid secretion and bound equally w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tsai BS,Kessler LK,Stolzenbach J,Schoenhard G,Bauer RF

    更新日期:1991-05-01 00:00:00

  • Hepatitis A, hepatitis B, and combination hepatitis vaccines for immunoprophylaxis: an update.

    abstract::Since the publication of the last extensive review of hepatitis vaccines, use of inactivated hepatitis A vaccines has been extended to high-risk regions of the United States and specific patient groups, such as those with chronic liver disease, and use of the recombinant hepatitis B vaccines has been recommended for o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Koff RS

    更新日期:2002-06-01 00:00:00

  • Effect of esomeprazole 40 mg vs omeprazole 40 mg on 24-hour intragastric pH in patients with symptoms of gastroesophageal reflux disease.

    abstract::Maintenance of intragastric pH > 4 is vital for effective management of gastroesophageal reflux disease (GERD). Esomeprazole 40 mg, the first proton pump inhibitor developed as an optical isomer, demonstrates improved acid inhibition over omeprazole 20 mg. Our aim was to compare esomeprazole 40 mg with omeprazole 40 m...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Röhss K,Hasselgren G,Hedenström H

    更新日期:2002-05-01 00:00:00

  • Pancreaticopleural fistula: report of two cases and review of the literature.

    abstract::Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Oh YS,Edmundowicz SA,Jonnalagadda SS,Azar RR

    更新日期:2006-01-01 00:00:00

  • Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection.

    abstract:BACKGROUND AND AIM:The purpose of this study was to examine the association between celiac disease (CD) and prior respiratory syncytial virus (RSV) infection or any viral bronchiolitis. METHODS:This was a retrospective case-control study. During 2006-2008 small intestinal biopsy data were collected from Sweden's 28 pa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tjernberg AR,Ludvigsson JF

    更新日期:2014-07-01 00:00:00

  • Efficacy of 5-aminosalicylic acid enemas versus hydrocortisone enemas in ulcerative colitis.

    abstract::A controlled trial has been carried out in order to compare the efficacy of enemas containing a high dosage of 5-ASA (4 g) versus enemas containing hydrocortisone 100 mg. The trial was conducted on 86 patients, 44 of whom received 5-ASA and 42 received hydrocortisone. The results were favorable in terms of clinical, s...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Campieri M,Gionchetti P,Belluzzi A,Brignola C,Migaldi M,Tabanelli GM,Bazzocchi G,Miglioli M,Barbara L

    更新日期:1987-12-01 00:00:00

  • Inhibitory effect of small amounts of cellulose on colonic carcinogenesis with low-dose carcinogen.

    abstract::This study set out to evaluate the effects of dietary fiber on cancer development in the large bowel under in vivo experimental conditions as similar as possible to those under which this cancer develops in vivo in humans. Forty-eight Sprague-Dawley rats were divided into three groups that were fed either a nonfiber d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Iwane S,Nakaji S,Ohta M,Tamura K,Sakamoto J,Munakata A,Sugawara K

    更新日期:2002-06-01 00:00:00

  • Direct-Acting Antivirals Improve Treatment Outcomes in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: A Nationwide, Multi-center, Retrospective Cohort Study.

    abstract:BACKGROUND AND AIMS:The influence of direct-acting antivirals (DAAs) on chronic hepatitis C (CHC)-related hepatocellular carcinoma (HCC) remains controversial. We investigated the effect of eradicating CHC using DAAs on treatment outcomes in patients with CHC-related HCC treated with transarterial chemoembolization (TA...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Hyun HK,Cho EJ,Park SY,Hong YM,Kim SS,Kim HY,Heo NY,Park JG,Sinn DH,Kang W,Jeong SW,Song MJ,Park H,Lee D,Lee YS,Cho SB,An CS,Rhee HJ,Lee HW,Kim BK,Park JY,Kim DY,Ahn SH,Han KH,Lee JH,Yu SJ,Kim YJ,Yoo

    更新日期:2020-08-28 00:00:00

  • Correction to: Crohn's Disease Only Visible on Small Bowel Capsule Endoscopy: A New Entity.

    abstract::The original version of the article unfortunately contained an error in the surname of the second author, Dr. Ferdinando D'Amico in the author group. ...

    journal_title:Digestive diseases and sciences

    pub_type: 已发布勘误


    authors: Chateau T,D'Amico F,Zallot C,Mathieu N,Peyrin-Biroulet L

    更新日期:2020-09-25 00:00:00

  • Comparison of ultrasound-secretin test and sphincter of Oddi manometry in patients with recurrent acute pancreatitis.

    abstract::Manometry is considered the gold standard for evaluating sphincter of Oddi dysfunction. It has recently been demonstrated that the ultrasound (US) secretin test proposed a few years ago as a noninvasive test for the study of sphincter of Oddi dysfunction yields a substantial percentage of pathological findings in pati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Di Francesco V,Brunori MP,Rigo L,Toouli J,Angelini G,Frulloni L,Bovo P,Filippini M,Vaona B,Talamini G,Cavallini G

    更新日期:1999-02-01 00:00:00

  • Rapid on-site evaluation of endoscopic ultrasound core biopsy specimens has excellent specificity and positive predictive value for gastrointestinal lesions.

    abstract:BACKGROUND:Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) is a safe and effective way to sample lesions in the gastrointestinal tract. Rapid on-site specimen evaluation (ROSE) improves the accuracy of EUS-FNA. While data suggests that EUS with fine-needle biopsy (EUS-FNB) is effective, it remains unclear...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Krishnan K,Dalal S,Nayar R,Keswani RN,Keefer L,Komanduri S

    更新日期:2013-07-01 00:00:00

  • The perception of gastroenterology fellows towards the relationship between hand size and endoscopic training.

    abstract::Some endoscopic trainees find it difficult to manipulate an endoscope's controls, possibly due to small hand size. To assess this, a survey was mailed to all gastroenterology fellows in the US. Two hundred twenty-seven of 1,295 (17.5%) fellows responded. Median surgical glove size was 7.5. Ninety-three respondents (41...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cohen DL,Naik JR,Tamariz LJ,Madanick RD

    更新日期:2008-07-01 00:00:00

  • Protection against gastric ischemia-reperfusion injury by nitric oxide generators.

    abstract::Nitric oxide appears to play an important role in maintaining gastric mucosal integrity. This study aimed to investigate whether a nitric oxide donor (sodium nitroprusside) or stimulation of endogenous nitric oxide synthesis (with acetylcholine) protects against gastric ischemia-reperfusion injury. Rats were subjected...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Andrews FJ,Malcontenti-Wilson C,O'Brien PE

    更新日期:1994-02-01 00:00:00

  • Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats.

    abstract::To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ohe K,Yokoya H,Kitaura T,Kunita T,Miyoshi A

    更新日期:1980-11-01 00:00:00

  • Human colon cancer cells deficient in DCC produce abnormal transcripts in progression of carcinogenesis.

    abstract::Expressive loss of the tumor suppressor deleted in colon cancer (DCC) may be superior to lymph node status in predicting patient survival for intermediate stage colon cancer. A polymerase chain reaction (PCR)-based method for detecting DCC would be ideal as a prognostic indicator. DCC is an alternatively spliced molec...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Huerta S,Srivatsan ES,Venkatasan N,Livingston EH

    更新日期:2001-09-01 00:00:00

  • Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestinal manifestation.

    abstract::Isolated case reports in which symptomatic hearing loss develops suddenly during the course of inflammatory bowel disease (IBD) have been reported, but the presence of subclinical sensorineural hearing loss (SNHL) associated with IBD has been investigated in only two preliminary studies. In order to research this furt...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Akbayir N,Caliş AB,Alkim C,Sökmen HM,Erdem L,Ozbal A,Bölükbaş F,Akbayir N

    更新日期:2005-10-01 00:00:00

  • Mechanical characteristics of distension-evoked peristaltic contractions in the esophagus of systemic sclerosis patients.

    abstract:BACKGROUND:Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. AIMS:To apply, for the first time in gastrointestinal (GI) patien...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gregersen H,Villadsen GE,Liao D

    更新日期:2011-12-01 00:00:00

  • Celiac disease: similar presentations in the elderly and young adults.

    abstract:BACKGROUND/AIMS:Studies have shown that celiac disease can affect individuals in all age groups. However, few studies have described the disease in the elderly. The goal of this study is to characterize celiac disease in the elderly by comparing to a population of young adults with celiac disease. METHODS:Review of a ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mukherjee R,Egbuna I,Brar P,Hernandez L,McMahon DJ,Shane EJ,Bhagat G,Green PH

    更新日期:2010-11-01 00:00:00

  • New enema treatments for inflammatory bowel disease.

    abstract::Two new preparations are under clinical trial for use in the treatment of ulcerative proctitis and left-sided colitis. One is 5-aminosalicylate, a component of sulfasalazine. This substance has virtually no immunomodulating capabilities. Evidence for efficacy equal to that of sulfasalazine in acute colitis has been ob...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Karp LC,Targan SR

    更新日期:1988-03-01 00:00:00

  • Similar response to entecavir 0.5 and 1.0 mg in treatment-naïve chronic hepatitis B patients: a case-control study.

    abstract:BACKGROUND AND AIMS:The dose recommendation for entecavir (ETV) is 0.5 mg daily for treatment-naïve chronic hepatitis B (CHB) patients and 1.0 mg daily for lamivudine-refractory patients; however, few data are available for the efficacy of a 1.0-mg daily dose in treatment-naïve CHB patients. Our goal is to examine the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ha NB,Ha NB,Chaung KT,Trinh HN,Nguyen HA,Nguyen KK,Nguyen MH

    更新日期:2014-01-01 00:00:00

  • A Prospective Study on Contrast-Enhanced Endoscopic Ultrasound for Differential Diagnosis of Pancreatic Cystic Neoplasms.

    abstract:BACKGROUND AND AIMS:To determine the value of contrast-enhanced endoscopic ultrasound (CE-EUS) for differentiation of pancreatic cystic neoplasms (PCNs). METHODS:From April 2015 to December 2017, 82 patients were enrolled in this study. All patients were confirmed to have PCNs by surgical pathology. Prior to surgery, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zhong L,Chai N,Linghu E,Li H,Yang J,Tang P

    更新日期:2019-12-01 00:00:00

  • Microscopic colitis in children.

    abstract:BACKGROUND:Microscopic colitis typically presents with chronic watery nonbloody diarrhea with normal endoscopy findings but abnormal inflammatory histopathological findings. As it is mainly a condition of the elderly, pediatric data is scarce. AIMS:To describe and characterize children with microscopic colitis. METHO...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: El-Matary W,Girgis S,Huynh H,Turner J,Diederichs B

    更新日期:2010-07-01 00:00:00

  • Selection of HCV NS5A quasispecies during IFN therapy in patients with chronic HCV.

    abstract::Interferon treatment of chronic hepatitis C virus infection is successful in a minority of patients. The sequence of the interferon sensitivity determining region (ISDR) of the NS5A protein may determine the outcome of therapy in patients infected with HCV genotype 1. To determine whether IFN treatment caused selectio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Paterson M,Laxton C,Goldin RD,Ackrill AM,Foster GR

    更新日期:2001-07-01 00:00:00