Gut-brain chemokine changes in portal hypertensive rats.


BACKGROUND:Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat. AIM:We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis. METHODS:One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-α) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes. RESULTS:The significant increase of fractalkine in mesenteric lymph nodes (P<0.05) and its receptor (CX3CR1) in the small bowel (P<0.05) and hippocampus (P<0.01), associated with the increased expression of SDF1-α in the hippocampus (P<0.01) and the cerebellum (P<0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis. CONCLUSION:The present study revealed that portal hypertension is associated with splanchnic-brain inflammatory alterations mediated by chemokines.


Dig Dis Sci


Merino J,Aller MA,Rubio S,Arias N,Nava MP,Loscertales M,Arias J,Arias JL




Has Abstract


2011-08-01 00:00:00












  • Constipation after rectopexy for rectal prolapse. Where is the obstruction?

    abstract::The pathophysiology of constipation after rectopexy remains unclear: acquired anorectal dysfunction or preoperative colonic state are, by turns, the supposed culprit. The aim of this prospective study was to characterize the colorectal motility abnormalities encountered after such a surgical procedure. Twelve patients...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Siproudhis L,Ropert A,Gosselin A,Bretagne JF,Heresbach D,Raoul JL,Gosselin M

    更新日期:1993-10-01 00:00:00

  • Seroprevalence of Helicobacter pylori, incidence of gastric cancer, and peptic ulcer-associated hospitalizations in a Canadian Indian population.

    abstract::The living conditions of many aboriginal communities in Canada may place their residents at risk for H. pylori infection. Our aims were to determine: (1) the seroprevalence of H. pylori in a traditional Indian community, (2) the clinical relevance of H. pylori infection in this population, and (3) if H. pylori could b...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bernstein CN,McKeown I,Embil JM,Blanchard JF,Dawood M,Kabani A,Kliewer E,Smart G,Coghlan G,MacDonald S,Cook C,Orr P

    更新日期:1999-04-01 00:00:00

  • Inducible nitric oxide synthase inhibitors ameliorate hypermotility observed after T. spiralis infection in the rat.

    abstract::Trichinella spiralis infection in rodents is a well-known model of intestinal inflammation associated with hypermotility and hypersecretion. Our aim was to use this experimental model to elucidate if iNOS was involved in the development of gastrointestinal hypermotility. Rats infected with Trichinella spiralis were tr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Torrents D,Prats N,Vergara P

    更新日期:2003-06-01 00:00:00

  • What does pain or discomfort in irritable bowel syndrome mean?

    abstract::Despite many studies on pain of functional gastrointestinal disorders (FGID), the pain mechanism of FGID is not well understood, and pain treatment of FGID is not established. Following our former functional dyspepsia (FD) study, we proposed two subgroups of patients with irritable bowel syndrome (IBS), pain and disco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Handa M,Nukina H,Ando K,Kubo C

    更新日期:2004-04-01 00:00:00

  • Hemodynamic effects of rapid injection into the canine superior mesenteric artery.

    abstract::We explored the hemodynamic effects of rapid injection of 0.9% saline and arterial blood into the canine superior mesenteric artery in anesthetized animals. Mesenteric artery blood flow and pressure were measured in the vessel distal to the site of injection. Injection rates were at or below the rate of blood flow in ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jacobson ED,Eldon C,Fondacaro JD

    更新日期:1981-10-01 00:00:00

  • Dietary requirement for serum-derived bovine immunoglobulins in the clinical management of patients with enteropathy.

    abstract::A variety of human disease conditions are associated with chronic intestinal disorders or enteropathies that are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Such disruptions in the homeostasis of the gastrointestinal (GI) tract can lead to symptoms of...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Petschow BW,Burnett BP,Shaw AL,Weaver EM,Klein GL

    更新日期:2015-01-01 00:00:00

  • Antral axial forces postprandially and after erythromycin in organic and functional dysmotilities.

    abstract::Our aims were to measure antral axial forces in patients with suspected upper gut dysmotilities and to compare the number of antral contractions detected by an axial force catheter and by manometric sensors in the distal antrum and pylorus. Fifteen patients (2 men, 13 women; mean age 42 years) underwent studies for 3 ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Surrenti E,Camilleri M,Kammer PP,Prather CM,Schei AJ,Hanson RB

    更新日期:1996-04-01 00:00:00

  • A higher dose requirement of tacrolimus in active Crohn's disease may be related to a high intestinal P-glycoprotein content.

    abstract::Tacrolimus, a relatively new therapeutic option for patients with corticosteroid-refractory Crohn's disease or ulcerative colitis, is a substrate for the apically directed efflux transporter P-glycoprotein (P-gp). Duodenal biopsy specimens obtained from a patient with corticosteroid-refractory Crohn's disease and with...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Buchman AL,Paine MF,Wallin A,Ludington SS

    更新日期:2005-12-01 00:00:00

  • Metoclopramide inhibits development of esophageal varices in rat model.

    abstract::We examined the preventive effect of metoclopramide on the development of esophageal varices in a rat model. Thirty rats were divided into three groups: metoclopramide (7.5 mg/kg twice a day, intraperitoneally), control group I (saline 2 ml/kg twice a day, intraperitoneally), and control group II (incised lower esopha...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ohta M,Hashizume M,Tanoue K,Ueno K,Komori K,Ishii T,Kitano S,Sugimachi K

    更新日期:1994-09-01 00:00:00

  • Light and electron microscopic and autoradiographic studies on N-methyl-N-amylnitrosamine-induced rat esophageal carcinogenesis.

    abstract::The purpose of this study was to investigate the histogenesis of experimental tumors in the rat esophagus. Thirty rats received 0.0015% N-methyl-N-amylnitrosamine (MNAN) in the drinking water for 12 weeks. Another 30 rats received tap water. All rats then received tap water until sacrifice. Rats from each group were s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kuwayama H,Eastwood GL

    更新日期:1988-01-01 00:00:00

  • Expression of EGF-receptor related protein (ERRP) decreases in gastric mucosa during aging and carcinogenesis.

    abstract::Aging and gastrointestinal malignancies, including that of the stomach are associated with increased activation of EGF-receptor (EGFR). Although the intracellular events that regulate this process are poorly understood, we hypothesize that loss of ERRP (EGFR-related protein; GenBank accession number AF187818), a recen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Majumdar AP,Du J,Hatfield JS,Levi E,Adsay V,Schmelz EM,Nagothu KK,Jaszewski R,Kucuk O,Sarkar FH

    更新日期:2003-05-01 00:00:00

  • Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats.

    abstract:BACKGROUNDS AND AIMS:We studied the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) as a possible therapy for non-steroidal anti-inflammatory drug (NSAID)-induced intestinal ulcers. Luminal nutrients release endogenous GLP-2 from enteroendocrine L cells. Since GLP-2 is degraded by dipeptidyl peptidase IV (DPPI...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Inoue T,Higashiyama M,Kaji I,Rudenkyy S,Higuchi K,Guth PH,Engel E,Kaunitz JD,Akiba Y

    更新日期:2014-06-01 00:00:00

  • Colorectal cancer testing in the national Veterans Health Administration.

    abstract:BACKGROUND:Colorectal cancer (CRC) screening is a priority for the Veteran's Health Administration (VHA). Optimizing fecal occult blood testing (FOBT) is integral to CRC screening in health care systems. AIMS:The purpose of this study was to characterize the utilization of CRC testing in a large integrated health care...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Long MD,Lance T,Robertson D,Kahwati L,Kinsinger L,Fisher DA

    更新日期:2012-02-01 00:00:00

  • Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome.

    abstract::Probiotic bacteria exhibit a variety of properties, which are unique to a particular strain. Lactobacillus acidophilus-SDC 2012, 2013 are new strains isolated from Korean infants' feces. The potential utility of Lactobacillus acidophilus-SDC 2012, 2013 in irritable bowel syndrome (IBS) was studied. Forty IBS patients ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Sinn DH,Song JH,Kim HJ,Lee JH,Son HJ,Chang DK,Kim YH,Kim JJ,Rhee JC,Rhee PL

    更新日期:2008-10-01 00:00:00

  • Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis.

    abstract::In a double-blind study on 19 patients with the diagnosis of chronic pancreatitis, the effects of treatment with a granulated pancreatic enzyme preparation (Pankreon) were compared with those of placebo administration. One week of treatment with each preparation was preceded by one week without any medication. The pat...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Isaksson G,Ihse I

    更新日期:1983-02-01 00:00:00

  • Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study.

    abstract::We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Minocha A,Johnson WD,Abell TL,Wigington WC

    更新日期:2006-03-01 00:00:00

  • Hyperplastic polyps of the gastric antrum in patients with gastrointestinal blood loss.

    abstract::The significance of hyperplastic polyps of the gastric antrum in anemic patients with suspected gastrointestinal bleeding has not been determined. The aim of this study is to evaluate the prevalence and prognosis of such polyps in this patient group. Clinical records of patients referred to our endoscopy lab from Nove...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Al-Haddad M,Ward EM,Bouras EP,Raimondo M

    更新日期:2007-01-01 00:00:00

  • Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study.

    abstract::Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

    更新日期:1996-12-01 00:00:00

  • Immune phenotype of children with newly diagnosed and gluten-free diet-treated celiac disease.

    abstract:BACKGROUND:Recent data suggest the involvement of both the adaptive and the innate immune system in celiac disease (CD). However, little is known about the immune phenotype of children with CD and its alteration upon dietary intervention. AIMS:We characterized the prevalence of major interacting members of the adaptiv...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cseh Á,Vásárhelyi B,Szalay B,Molnár K,Nagy-Szakál D,Treszl A,Vannay Á,Arató A,Tulassay T,Veres G

    更新日期:2011-03-01 00:00:00

  • Oral IBGard™ Before Colonoscopy: A Single-Center Double-Blinded, Randomized, Placebo-Controlled Trial.

    abstract:BACKGROUND:Peppermint oil is well known to inhibit smooth muscle contractions, and its topical administration during colonoscopy is reported to reduce colonic spasms. AIMS:We aimed to assess whether oral administration of IBGard™, a sustained-release peppermint oil formulation, before colonoscopy reduces spasms and im...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Han JY,Moosvi Z,Duh E,Park S,Albers GC,Samarasena JB,Karnes W

    更新日期:2020-06-09 00:00:00

  • In vitro growth responses of bifidobacteria and enteropathogens to bovine and human lactoferrin.

    abstract::A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmon...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Griffiths EA,Duffy LC,Schanbacher FL,Dryja D,Leavens A,Neiswander RL,Qiao H,DiRienzo D,Ogra P

    更新日期:2003-07-01 00:00:00

  • Focused Education Increases Hepatocellular Cancer Screening in Patients with Cirrhosis Regardless of Functional Health Literacy.

    abstract:BACKGROUND:Health education interventions are successful in modifying lifestyle. Functional health literacy (FHL) can determine patient adherence to clinic visits and procedures and may adversely impact the success of these interventions. AIMS:We sought to evaluate the hypothesis that a health education intervention w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shaw J,Patidar KR,Reuter B,Hajezifar N,Dharel N,Wade JB,Bajaj JS

    更新日期:2020-09-05 00:00:00

  • Preoperative total parenteral nutrition for bowel resection in Crohn's disease.

    abstract::To examine the effect of preoperative total parenteral nutrition (TPN) on patients with Crohn's disease undergoing bowel resection, an historical cohort was assembled of 103 patients resected between 1982 and 1984 by a single surgical team. Preoperative, perioperative, and postoperative variables were compared between...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lashner BA,Evans AA,Hanauer SB

    更新日期:1989-05-01 00:00:00

  • Predictive factors for response to peginterferon-alpha and ribavirin treatment of chronic HCV infection in patients aged 65 years and more.

    abstract:BACKGROUND:Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients. AIMS:To evaluate the efficacy of pegylated interferon (PEG-IFN) and riba...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Giannini EG,Basso M,Savarino V,Picciotto A

    更新日期:2010-11-01 00:00:00

  • Spontaneous rupture of liver in a patient with Ehlers Danlos disease type IV.

    abstract::Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenoty...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gelbmann CM,Köllinger M,Gmeinwieser J,Leser HG,Holstege A,Schölmerich J

    更新日期:1997-08-01 00:00:00

  • Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series.

    abstract:BACKGROUND/AIM:Herbal and dietary supplement (HDS) hepatotoxicity is increasingly being reported in the USA. This case series describes the presenting clinical features and outcomes of seven patients with liver injury attributed to OxyELITE Pro enrolled in the Drug-Induced Liver Injury Network (DILIN) study. METHODS:T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Heidemann LA,Navarro VJ,Ahmad J,Hayashi PH,Stolz A,Kleiner DE,Fontana RJ

    更新日期:2016-09-01 00:00:00

  • Bombesin prevents gastric injury in the rat: role of gastrin.

    abstract::Bombesin or gastrin-releasing peptide prevents gastric injury by an unknown mechanism. Since exogenous gastrin is a gastroprotective agent, this study was undertaken to test the hypothesis that gastroprotection by bombesin involves release of endogenous gastrin. Subcutaneous bombesin (10-100 microg/kg) dose dependentl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mercer DW,Cross JM,Chang L,Lichtenberger LM

    更新日期:1998-04-01 00:00:00

  • Role of rat large intestine in reducing diarrhea after 50% or 80% distal small bowel resection.

    abstract::The effects of intestinal resection on several intestinal parameters have been studied in the large intestine of rats one month after the surgical operation. The results show that both 50% and 80% distal small bowel resection increased net fluid absorption and mucosal permeability and caused expansion of the intercell...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Vázquez CM,Molina MT,Ilundaín A

    更新日期:1989-11-01 00:00:00

  • Absorption studies after massive small bowel resection and antiperistaltic colon interposition in rhesus monkeys.

    abstract::An experimental model of massive (80%) small bowel resection and antiperistaltic colon interposition in between the remnant jejunum and ileum was created in rhesus monkeys. The gastrointestinal functions were assessed preoperatively and at different periods after the operation. Progressive increase in the transit time...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sidhu GS,Narasimharao KL,Usha Rani V,Sarkar AK,Mitra SK

    更新日期:1985-05-01 00:00:00

  • Expression of Cdx2 in early GRCL of Barrett's esophagus induced in rats by duodenal reflux.

    abstract::The intestine-specific caudal-related homeobox transcription factor Cdx2 is widely accepted to play a key role in intestinal development and differentiation in mammals. We studied the role of Cdx2 in the development of Barrett's esophagus (BE). In previous studies, we have shown a sequence of morphological changes of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tatsuta T,Mukaisho K,Sugihara H,Miwa K,Tani T,Hattori T

    更新日期:2005-03-01 00:00:00