Hepatitis C virus infection--pathobiology and implications for new therapeutic options.

Abstract:

:Despite progress in therapeutic approaches for the elimination of hepatitis C, chronic hepatitis C virus infection remains an important cause of liver disease. Therapeutic intervention with the currently available interferon-based treatment regimens is quite successful, but treatment is difficult to tolerate and is contraindicated in many patients. A better understanding of the HCV biology, immunopathology, and liver disease will help to design better therapeutic strategies. The American Association for the Study of Liver Diseases sponsored a single-topic conference on hepatitis C virus infection on March 4 and 5, 2005, to enhance our current knowledge in the areas of basic and clinical research related to antiviral and immunomodulatory therapies in hepatitis C disease. The faculty consisted of 23 invited experts in the field of viral hepatitis. The program was divided into four sections including: (a) replicative mechanisms and models; (b) viral-host interactions; and (c) antiviral drug development and new strategies; and (d) back to the bedside-current issues. This report summarizes each of the presentations sections.

journal_name

Dig Dis Sci

authors

Davis GL,Krawczynski K,Szabo G

doi

10.1007/s10620-006-9484-7

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

857-75

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

52

pub_type

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