Abstract：
BACKGROUND:Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter. METHODS:We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility features, including colonic compliance and tone measured by colonic barostat-controlled 10-cm-long infinitely compliant balloon. Colonic compliance curves were compared to healthy control (40) and disease (47) control groups. RESULTS:Among 24 identified patients, the mean maximal colonic diameter on abdominal radiograph was 12.7 ± 0.8 cm. The cause of megacolon was idiopathic in 16 of 24 and secondary in 8 of 24. A relatively high prevalence (10/24) of comorbid pelvic floor dyssynergia was identified. At the time of this report, 16 patients had undergone colectomy. In general, megacolon presented high fasting colonic volume at relatively low pressures (16-20 mmHg), suggesting high colonic compliance; similarly, volumes at operating pressures that ensured apposition of the balloon to the colonic wall suggested low colonic tone. Median balloon volume at 44 mmHg distension was 584 mL (IQR 556.5-600) in patients with megacolon compared to 251 mL (212-281) in healthy, 240 mL (207-286) in functional constipation, and 241 mL (210.8-277.5) in diarrhea-predominant irritable bowel syndrome controls. Colon's tonic response to feeding was generally intact, and there was frequently maintained phasic contractile response to feeding. CONCLUSIONS:Chronic megacolon is a severe colonic dysmotility, manifesting radiologically with increased colonic diameter; it can be proven by measuring colonic compliance and typically requires colectomy because of failed medical therapy.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
O'Dwyer RH,Acosta A,Camilleri M,Burton D,Busciglio I,Bharucha AEdoi
10.1007/s10620-015-3645-5subject
Has Abstractpub_date
2015-08-01 00:00:00pages
2398-407issue
8eissn
0163-2116issn
1573-2568journal_volume
60pub_type
杂志文章abstract：BACKGROUND:Anemia is a common systemic complication of inflammatory bowel disease (IBD) and is associated with worse disease outcomes, quality of life, and higher healthcare costs. AIMS:The purpose of this study was to determine how anemia severity impacts healthcare resource utilization and if treatment of anemia was...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06590-y
更新日期：2020-09-05 00:00:00
abstract：:A comparative study of three different high-dose regimens of interferon-alpha-2b (IFN) was conducted in patients with chronic hepatitis C to determine which was better at obtaining a sustained remission. A total of 126 patients were assigned randomly to one of three groups: group A was given 10 million international u...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF01316789
更新日期：1993-04-01 00:00:00
abstract：:Omentum was shown to exhibit angiogenic activity, but its role in healing of chronic gastric ulcers is unknown. This study was designed to compare the effects of omentum and basic fibroblast growth factor (bFGF), a potent angiogenic factor, on healing of chronic gastric ulcers in rats. Several series of rats with gast...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087559
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4+ T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn's d...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05945-4
更新日期：2020-06-01 00:00:00
abstract：:Polycystic liver disease (PCLD) without polycystic kidney is infrequent in clinical setting. Family clustering is found in patients with PCLD, and it is inherited in an autosomal dominant fashion. Through positional cloning in North America and Europe (mostly in Dutch and Finnish descents), mutations in PRKCSH gene on...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0776-6
更新日期：2010-03-01 00:00:00
abstract：:The wound-healing property of Preparation-H, a widely used over-the-counter hemorrhoidal product was investigated in a randomized, controlled, double-blind trial. Artificial ulcers were created in the rectum of 12 healthy male volunteers and the size of these ulcers followed until complete healing by visual examinatio...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01318426
更新日期：1984-09-01 00:00:00
abstract：:Gastrointestinal motor dysfunction persists in a large number of children subjected to surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining intestine. The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitia...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1015085923245
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Proton pump inhibitors (PPIs) are widely prescribed to treat gastrointestinal diseases. However, concerns have been raised regarding their long-term use. Gastric acid suppression may decrease iron absorption, and it remains uncertain whether iron-deficiency anemia may result from chronic PPI therapy. AIMS:W...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1589-y
更新日期：2011-08-01 00:00:00
abstract：:Growing evidence suggests that complex gene and environment interactions underlie a number of diseases including chronic inflammatory diseases of the digestive system. The rapid advances in information and technology provide opportunities to discover the risks or etiology for a variety of disorders within individual p...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-005-3033-7
更新日期：2005-12-01 00:00:00
abstract：:This manuscript is a secondary analysis of a large multicenter randomized controlled trial. The primary study is Cross RK et al., A Randomized Controlled Trial of TELEmedicine for patients with Inflammatory Bowel Disease (TELE-IBD). Am J Gastroenterol, 2019 Mar. ...
journal_title：Digestive diseases and sciences
pub_type： 已发布勘误
doi：10.1007/s10620-019-05953-4
更新日期：2020-02-01 00:00:00
abstract：:The mechanisms of pentagastrin-induced gastric mucosal blood flow (GMBF) response were investigated in anesthetized rats. A rat stomach was mounted on an ex vivo chamber, perfused with saline, and GMBF was measured by a laser Doppler flowmetry simultaneously with acid secretion. Pentagastrin infused intravenously prod...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02282323
更新日期：1996-03-01 00:00:00
abstract：:A previous study showed that supine gastroesophageal reflux occurs mainly in the early nighttime period and is greater if the patient retires within 2 hr of a meal. We analyzed 306 consecutive esophageal pH studies between January and July 2003. Ninety-two patients had abnormal supine reflux. The recumbent period was ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9707-y
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:The principle of treating-to-target has been successfully applied to many diseases with significant improvement in patient care and as a useful guidance for healthcare providers. Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3483-x
更新日期：2015-05-01 00:00:00
abstract：:A patient with congenital asucrasia was investigated using in vivo differential urinary disaccharide excretion. Impaired hydrolysis of sucrose and isomaltose, but normal lactase activity, were demonstrated and confirmed by in vitro estimation. The technique of differential disaccharide excretion can now be used to ass...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536167
更新日期：1989-01-01 00:00:00
abstract：:The living conditions of many aboriginal communities in Canada may place their residents at risk for H. pylori infection. Our aims were to determine: (1) the seroprevalence of H. pylori in a traditional Indian community, (2) the clinical relevance of H. pylori infection in this population, and (3) if H. pylori could b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026689103952
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB). Their detection has been limited by the inability to endoscopically examine the entire small intestine. This has changed with the introduction of capsule endoscopy (CE) and double balloon enteroscopy (D...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1007/s10620-007-0110-0
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Primary malignant neoplasms of the small bowel comprise only 1-3% of all gastrointestinal malignancies. Small bowel cancers pose a significant diagnostic challenge. The recent development of video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE) have greatly facilitated evaluation of the small b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1640-z
更新日期：2011-09-01 00:00:00
abstract：:The effects of 10-day bilateral adrenalectomy on morphometry, proliferation, and apoptosis were determined in the small intestine of 3-month-old Sprague-Dawley rats. The activities of sucrase, lactase, and its respective mRNA, aminopeptidase N, and intestinal alkaline phosphatase were also evaluated. Adrenalectomy lea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1010611228730
更新日期：2001-06-01 00:00:00
abstract：:Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297056
更新日期：1987-03-01 00:00:00
abstract：:Despite many studies on pain of functional gastrointestinal disorders (FGID), the pain mechanism of FGID is not well understood, and pain treatment of FGID is not established. Following our former functional dyspepsia (FD) study, we proposed two subgroups of patients with irritable bowel syndrome (IBS), pain and disco...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000026301.47638.92
更新日期：2004-04-01 00:00:00
abstract：:We have used double-contrast radiographic techniques to clarify what changes in the configuration and movements of the gastroduodenal junction result when peptic lesions involve the distal gastric segment between the proximal (PPL) and the distal pyloric muscle loop (DPL). Among 50 cases of pyloric ulceration diagnose...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540562
更新日期：1990-12-01 00:00:00
abstract：:This study was designed to determine the effect of a newly synthesized benzimidazole derivative NC-1300-B on H+, K+-ATPase (proton pump) in the hog gastric mucosa and on the basal gastric acid secretion and necrotizing agent-induced gastric lesions in rats. NC-1300-B inhibited the proton pump in a concentration-depend...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536998
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma. AIMS:In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcripti...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5398-4
更新日期：2019-05-01 00:00:00
abstract：:In recent years, three-dimensional (3-D) printing technology has become a standard tool that is used in several medical applications such as education, surgical training simulation and planning, and doctor-patient communication. Although liver surgery is ideally complemented by the use of preoperative 3-D-printed mode...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06326-y
更新日期：2020-08-01 00:00:00
abstract：:This study was designed to determine the possible effects of omeprazole on human natural killer cells. Peripheral venous blood samples were taken from 20 peptic ulcer patients before and at the 14th and the 28th days of omeprazole treatment. Mononuclear cells were removed from blood and their capability of making conj...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9869-2
更新日期：2008-02-01 00:00:00
abstract：:Opioids, both endogenous and exogenous, have been shown to exert a modulating influence on many gastrointestinal functions. Animal studies suggest an inhibitory role for opioids in the control of pancreatic secretion, which may be exerted through their inhibitory effect on acetylcholine release from intramural neurons...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01798363
更新日期：1988-05-01 00:00:00
abstract：:The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01535939
更新日期：1988-12-01 00:00:00
abstract：:The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308176
更新日期：1992-02-01 00:00:00
abstract：:The intestine-specific caudal-related homeobox transcription factor Cdx2 is widely accepted to play a key role in intestinal development and differentiation in mammals. We studied the role of Cdx2 in the development of Barrett's esophagus (BE). In previous studies, we have shown a sequence of morphological changes of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2452-9
更新日期：2005-03-01 00:00:00
abstract：:The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308330
更新日期：1980-09-01 00:00:00
